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Taste SensitivityOptUmamiNCT07421466

Umami Taste Intensity and Meal Intake

A study testing Hedonic mapping and Ad libitum risotto test meal in people with Taste Sensitivity and Umami Taste Perception, run by Wageningen University at 1 site in Netherlands.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Sweet and salty tastes can influence food intake. Increased intensity of these tastes has been shown to decrease food intake and increase satiation compared to the less intense taste, independent of palatability. Read more about this study

Who is it for?
Ages 18 to 55 yearsHealthy volunteers can take part
What is being tested?
Hedonic mapping and Ad libitum risotto test meal
Could I receive a placebo?
No, everyone receives an active treatment
How many people
47 participants
Where
1 siteNetherlands
Study dates
15 Sep 2025to 21 Oct 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 55 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Self-reported healthy;
  • BMI between 18.5 and 25 kg/m2;
  • Age between 18 and 55 years old;
  • Able to visit the research facilities on the Wageningen campus for hedonic mapping (once) and for the risotto lunch meal (three times);
  • Able to provide informed consent.

Who cannot join

  • Diagnosed with smell- or taste disorder(s);
  • Use of medication that could influence taste ability and/or food intake behaviour;
  • Food allergy or intolerance to any of the ingredients used in the ad libitum test meal;
  • Consumption of more than 14 (women) or 21 (men) glasses of alcohol per week;
  • Student or personnel of the Health Research Unit at Wageningen University

Trial locations and contacts

1 site in 1 country.

Netherlands1 site
  • Department of Human Nutrition, Wageningen University

    Wageningen, Gelderland

Other trials in Netherlands

About this study

Official title: The Effect of High Versus Low Versus Ideal Umami Taste Intensity Based on Individual Palatability Ratings in a Risotto Mixed Meal on ad Libitum Meal Intake

Sweet and salty tastes can influence food intake. Increased intensity of these tastes has been shown to decrease food intake and increase satiation compared to the less intense taste, independent of palatability. Umami taste intensity has been shown to reduce subsequent food intake, especially when paired with protein content in foods. Taste can be related with nutrient content of the diet, with sweet foods having carbohydrates, salty foods containing sodium, and umami foods containing protein.

However, no study has yet investigated the impact of umami and food intake, using the approach of similar palatability and differing taste intensity levels. Given its relationship with nutrient signaling, it is important to explore the relationship between umami intensity and satiation. Therefore, this study aims to compare ad libitum food intake of two levels with similar palatability and differing umami taste intensities (high and low) to food intake from a meal with optimum taste intensity.

Read more

Study population 40-50 healthy, normal weight participants from Wageningen and surroundings will be included. Previous studies have applied this method in sweet and salty tastes with 15-59 participants.

Test session 1: Hedonic mapping Determine individual's most preferred level of umami taste in 6 risotto samples, using pairwise staircase comparison. Samples will contain a fixed level of salt (0.2 w/w%), and MSG concentrations ranging from 0.2-2.1 w/w%. Per individual, The optimal tasting MSG intensity will be selected based on forced choice.

Test session 2, 3 and 4: ad libitum risotto lunch meals In a randomized cross-over design, participants will receive the optimum, high and low MSG risotto. The following will be measured:

  • Test meal consumption (primary outcome);
  • Meal liking after one bite;
  • Water consumption;
  • Absolute taste intensity ratings of the meal;
  • Relative taste intensity ratings of the meal;
  • Habitual dietary taste exposure (tasteFFQ).

Study procedures Subjects will be provided with a standardized breakfast and to not consume anything between breakfast and lunch session. This will be validated upon arrival to the lunch meal. They will also be asked to refrain from eating for one hour after the test session. Participants will be asked to fill in the tasteFFQ, to investigate the link between dietary taste patterns and hedonic umami taste ratings.

Data analysis Data will be analyzed using Rstudio. First, normality will be assessed, and data will be normalized if needed. Difference in food intake in grams between the three intensities will be compared using ANOVA. A post-hoc test will be applied if statistical outcomes are significant. Categorical variables will be compared using Chi-square test.

Being tested
Hedonic mapping, Ad libitum risotto test meal
Keywords
umami, savoury, ad libitum, taste intensity, palatability, food intake, hedonic mapping, PCA, MSG

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Hedonic mappingOther

    During the first session, participants will be presented with 2 risotto samples simultaneously, differing in MSG content and thus umami taste intensity, by PCA. First, samples will be presented in ascending concentration, with the best rated sample (forced choice) from the previous round, and the next concentration. This will be replicated in descending order. Based on these individual outcomes, umami taste intensities of the ad libitum test meals will be calculated per participant.

  • Ad libitum risotto test mealOther

    During the ad libitum test meal, participants will be presented with 1200 grams of risotto with either high-, low-, or optimum umami taste intensity.

Study groups in NCT07421466
Study groupRoleWhat they receive
Low umami taste intensityExperimentalThe low umami intensity meal will have a taste intensity corresponding with a lower than ideal than the MSG concentration in the sample that came out as 'winner' by forced choice during the first test session in which umami taste preferences per individual will be assessed by hedonic mapping (PCA). The palatability ratings of the lower than ideal will correspond to the palatability ratings of the higher than ideal condition.
Receives: Other: Hedonic mapping; Other: Ad libitum risotto test meal
Ideal umami taste intensityExperimentalThe ideal umami intensity meal will have a taste intensity corresponding with the MSG concentration in the sample that came out as 'winner' by forced choice during the first test session in which umami taste preferences per individual will be assessed by hedonic mapping (PCA).
Receives: Other: Hedonic mapping; Other: Ad libitum risotto test meal
high umami taste intensityExperimentalThe high umami intensity meal will have a taste intensity corresponding with a higher than ideal than the MSG concentration in the sample that came out as 'winner' by forced choice during the first test session in which umami taste preferences per individual will be assessed by hedonic mapping (PCA). The palatability ratings of the higher than ideal will correspond to the palatability ratings of the lower than ideal condition.
Receives: Other: Hedonic mapping; Other: Ad libitum risotto test meal

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Difference in food intake from ad libitum test meal between taste intensity conditions

    Difference in food intake in volume (grams) from the ad libitum test meal between the three (high-, low- and ideal) umami taste intensities.

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

Secondary outcomes (7)
  1. Difference in test meal liking between taste intensity conditions

    Difference in test meal liking (VAS) between the three (high-, low- and ideal) umami taste intensities.

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

  2. Absolute difference in umami taste intensity ratings of the ad libitum test meal between taste intensity conditions

    Difference in absolute taste intensity ratings of the ad libitum test meal between the three (high-, low- and ideal) umami taste intensities. This will be rated after each lunch meal on a visual analogue scale (VAS).

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

  3. Relative difference in umami taste intensity ratings of the ad libitum test meal between taste intensity conditions

    Relative taste intensity ratings based on ranking. Participants will be asked to rank the three meals based on umami taste intensity after the 3rd lunch meal. Ranking will be used, with anchors "least intense" to "most intense".

    Measured: Test session 4 (week 4)

  4. Difference in water consumption during the ad libitum test meal between taste intensity conditions

    Difference in water consumption in volume (grams) from the ad libitum test meal between the three (high-, low- and ideal) umami taste intensities

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

  5. Difference in reported appetite and fullness ratings between the three conditions

    Before and after the ad libitum test meals, appetite and fullness ratings of participants will be assessed on a Visual Analogue Scale (VAS). Differences of these rating between umami taste intensity conditions (low-, high- and ideal umami taste intensity) will be assessed. VAS 0-100 will be used, with anchors "Not at all" to "Extremely".

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

  6. Difference in test meal liking between taste intensity conditions

    Difference in test meal liking (VAS) between the three (high-, low- and ideal) umami taste intensities. VAS 0-100 will be used, with anchors "Not tasty at all" to "Extremely tasty".

    Measured: Test session 2, 3 and 4 (week 2, 3 and 4)

  7. Habitual taste exposure

    Habitual taste exposure will be measured with a food frequency questionnaire (tasteFFQ) specifically designed to assess relative food intake based on taste cluster. Individual optimum umami intensity will be compared to habitual dietary taste exposure to the salt, umami and fat taste cluster, as well as to the intake of umami tasting food items.

    Participants will fill in the tasteFFQ directly after the first (hedonic mapping session) visit. The tasteFFQ inquires average daily food intake, measured with a reference period of the previous four weeks.

    Measured: Participants will fill in the TasteFFQ directly after the first visit (hedonic mapping). The TasteFFQ captures average daily food intake over the previous four weeks (so food intake prior to study enrollment).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted19 Feb 2026
  2. Study start15 Sep 2025
  3. Primary completion21 Oct 2025
  4. Study completion21 Oct 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Crossover
Model description
Complete block randomized cross-over design
Masking
Single blind
Who is masked
Participant
Enrolment
47 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07421466
Sponsor's protocol ID
NL51747.081.14 OptUmami Study
Acronym
OptUmami
Status last verified
Dec 2025
First submitted
3 Dec 2025
Last updated
19 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Individual study participant data will be shared after anonymization upon study publication in an open data repository (e.g. DANS or Yoda).

Publications

  • Masic U, Yeomans MR. Umami flavor enhances appetite but also increases satiety. Am J Clin Nutr. 2014 Aug;100(2):532-8. doi: 10.3945/ajcn.113.080929. Epub 2014 Jun 18.

    PubMed 24944058
  • Sorensen LB, Moller P, Flint A, Martens M, Raben A. Effect of sensory perception of foods on appetite and food intake: a review of studies on humans. Int J Obes Relat Metab Disord. 2003 Oct;27(10):1152-66. doi: 10.1038/sj.ijo.0802391.

    PubMed 14513063
  • Bolhuis DP, Lakemond CM, de Wijk RA, Luning PA, de Graaf C. Effect of salt intensity on ad libitum intake of tomato soup similar in palatability and on salt preference after consumption. Chem Senses. 2010 Nov;35(9):789-99. doi: 10.1093/chemse/bjq077. Epub 2010 Aug 12.

    PubMed 20705808
  • Bolhuis DP, Lakemond CM, de Wijk RA, Luning PA, Graaf Cd. Both longer oral sensory exposure to and higher intensity of saltiness decrease ad libitum food intake in healthy normal-weight men. J Nutr. 2011 Dec;141(12):2242-8. doi: 10.3945/jn.111.143867. Epub 2011 Nov 2.

    PubMed 22049294
  • Bolhuis DP, Lakemond CM, de Wijk RA, Luning PA, de Graaf C. Effect of salt intensity in soup on ad libitum intake and on subsequent food choice. Appetite. 2012 Feb;58(1):48-55. doi: 10.1016/j.appet.2011.09.001. Epub 2011 Sep 29.

    PubMed 21986190
  • Masic U, Yeomans MR. Monosodium glutamate delivered in a protein-rich soup improves subsequent energy compensation. J Nutr Sci. 2014 Aug 13;3:e15. doi: 10.1017/jns.2014.15. eCollection 2014.

    PubMed 25191607
  • Forde, C. G. (2016). Flavor perception and satiation. In Flavor (pp. 251-276). Woodhead Publishing

  • Jayasena DD, Kang T, Wijayasekara KN, Jo C. Innovative Application of Cold Plasma Technology in Meat and Its Products. Food Sci Anim Resour. 2023 Nov;43(6):1087-1110. doi: 10.5851/kosfa.2023.e31. Epub 2023 Nov 1.

    PubMed 37969327

Questions about this trial

What is this clinical trial studying?

A study testing Hedonic mapping and Ad libitum risotto test meal in people with Taste Sensitivity and Umami Taste Perception, run by Wageningen University at 1 site in Netherlands.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 19 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Difference in food intake from ad libitum test meal between taste intensity conditions (time frame: Test session 2, 3 and 4 (week 2, 3 and 4)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07421466, which also lists 8 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Feb 2026.

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