Muscle StrengthNCT07425288
Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training in Sedentary Women
A study testing Unilateral Isokinetic Training and Unilateral Single-Leg Squat Training in people with Muscle Strength and Proprioception, run by Cagatay Muslum Gokdogan at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and… Read more about this study
- Who is it for?
- Ages 18 to 35 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Strength, Proprioception
- What is being tested?
- Unilateral Isokinetic Training and Unilateral Single-Leg Squat Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 47 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Nov 2023to 22 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- female gender,
- no lower extremity problems in the last 6 months,
- not actively participating in sports
Who cannot join
- history of orthopedic surgery within the last 2 years,
- ongoing lower extremity pain, systemic disease that could prevent exercise,
- a neurological problems.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Gazi University, Faculty of Health Sciences
Ankara, Ankara, 06560
About this study
Official title: Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training on Strength, Proprioception, and Muscle Thickness in Sedentary Women: A Randomized Controlled Trial
This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and untrained lower extremities.
Participants will be randomly assigned to one of the training groups. The intervention will be applied to one lower limb only. Strength, proprioception, and muscle thickness will be assessed before and after the intervention period. The primary objective is to evaluate whether unilateral training induces cross-education effects in the contralateral limb.
The findings of this study may contribute to rehabilitation strategies by clarifying the potential benefits of unilateral exercise programs for improving neuromuscular performance and muscle morphology in sedentary individuals.
- Conditions
- Muscle Strength, Proprioception
- Being tested
- Unilateral Isokinetic Training, Unilateral Single-Leg Squat Training
- Keywords
- contralateral training, isokinetic training, single-leg squat, proprioception.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Unilateral Isokinetic TrainingBehavioural
Unilateral isokinetic strength training will be applied to one lower extremity using an isokinetic dynamometer. The training program will be performed according to the study protocol. The contralateral limb will not receive any direct intervention.
Unilateral Single-Leg Squat TrainingBehavioural
Participants will perform unilateral single-leg squat exercises on one lower extremity according to the study protocol. The opposite limb will not receive any direct training.
| Study group | Role | What they receive |
|---|---|---|
| Unilateral Isokinetic Training | Experimental | Participants in this group will receive unilateral isokinetic strength training applied to one lower extremity only. The contralateral limb will not receive any direct intervention. Receives: Behavioral: Unilateral Isokinetic Training |
| Unilateral Single-Leg Squat Training | Experimental | Participants in this group will perform unilateral single-leg squat training on one lower extremity only. The opposite limb will not receive any direct training. Receives: Behavioral: Unilateral Single-Leg Squat Training |
| Control Group | No intervention | Participants in this group will not receive any exercise or training intervention during the study period and will continue their usual daily activities. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Strength
Muscle strength of the lower extremities will be assessed using isokinetic dynamometry to evaluate peak torque values in both the trained and contralateral limbs.
Measured: Baseline and after 6 weeks of intervention
Secondary outcomes (2)
Proprioception
Lower extremity proprioception will be evaluated using joint position sense assessment to determine proprioceptive accuracy in both limbs.
Measured: Baseline and after 6 weeks of intervention
Muscle Thickness
Muscle thickness of selected thigh muscles will be measured using ultrasonography to assess morphological adaptations following unilateral training.
Measured: Baseline and after 6 weeks of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2026
- Study start15 Nov 2023
- Primary completion10 Apr 2024
- Study completion22 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle StrengthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to one of three parallel groups. Two experimental groups will receive unilateral exercise interventions, consisting of unilateral isokinetic training or unilateral single-leg squat training. A third group will serve as a control group and will not receive any intervention. Participants will remain in their assigned groups throughout the study period.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 47 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cagatay Muslum Gokdogan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Cagatay Muslum Gokdogan, Harran University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07425288
- Sponsor's protocol ID
- 13.11.2023-E.795767
- Other IDs
- 13.11.2023-E.795767
- Status last verified
- Feb 2026
- First submitted
- 13 Feb 2026
- Last updated
- 20 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training on Strength, Proprioception, and Muscle Thickness in Sedentary Women: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07425288
- Acronym / sponsor ID
- 13.11.2023-E.795767
- Conditions
- Muscle Strength, Proprioception
- Keywords
- contralateral training, isokinetic training, single-leg squat, proprioception.
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 47 participants (actual)
- Lead sponsor
- Cagatay Muslum GokdoganUniversity, hospital or other
- Study start
- 15 Nov 2023 (actual)
- Primary completion
- 10 Apr 2024 (actual)
- Study completion
- 22 May 2024 (actual)
- First posted
- 20 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and untrained lower extremities.
Participants will be randomly assigned to one of the training groups. The intervention will be applied to one lower limb only. Strength, proprioception, and muscle thickness will be assessed before and after the intervention period. The primary objective is to evaluate whether unilateral training induces cross-education effects in the contralateral limb.
The findings of this study may contribute to rehabilitation strategies by clarifying the potential benefits of unilateral exercise programs for improving neuromuscular performance and muscle morphology in sedentary individuals.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Participants will be randomly assigned to one of three parallel groups. Two experimental groups will receive unilateral exercise interventions, consisting of unilateral isokinetic training or unilateral single-leg squat training. A third group will serve as a control group and will not receive any intervention. Participants will remain in their assigned groups throughout the study period.
| Arm | Type | Receives |
|---|---|---|
| Unilateral Isokinetic Training | Experimental | Behavioral: Unilateral Isokinetic TrainingParticipants in this group will receive unilateral isokinetic strength training applied to one lower extremity only. The contralateral limb will not receive any direct intervention. |
| Unilateral Single-Leg Squat Training | Experimental | Behavioral: Unilateral Single-Leg Squat TrainingParticipants in this group will perform unilateral single-leg squat training on one lower extremity only. The opposite limb will not receive any direct training. |
| Control Group | No intervention | –Participants in this group will not receive any exercise or training intervention during the study period and will continue their usual daily activities. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- female gender,
- no lower extremity problems in the last 6 months,
- not actively participating in sports
Key exclusion criteria (3 listed)
- history of orthopedic surgery within the last 2 years,
- ongoing lower extremity pain, systemic disease that could prevent exercise,
- a neurological problems.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Unilateral Isokinetic TrainingUnilateral isokinetic strength training will be applied to one lower extremity using an isokinetic dynamometer. The training program will be performed according to the study protocol. The contralateral limb will not receive any direct intervention. | Behavioural | Unilateral Isokinetic Training |
| Unilateral Single-Leg Squat TrainingParticipants will perform unilateral single-leg squat exercises on one lower extremity according to the study protocol. The opposite limb will not receive any direct training. | Behavioural | Unilateral Single-Leg Squat Training |
Primary outcome
Muscle Strength
Time frame: Baseline and after 6 weeks of intervention
Muscle strength of the lower extremities will be assessed using isokinetic dynamometry to evaluate peak torque values in both the trained and contralateral limbs.
2 secondary outcomes
Proprioception
Time frame: Baseline and after 6 weeks of intervention
Muscle Thickness
Time frame: Baseline and after 6 weeks of intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Unilateral Isokinetic Training and Unilateral Single-Leg Squat Training in people with Muscle Strength and Proprioception, run by Cagatay Muslum Gokdogan at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Strength (time frame: Baseline and after 6 weeks of intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.