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Panic DisorderNCT07439224

Qigong and Multicomponent Exercise in Panic Disorder

A study testing Exercise Training in people with Panic Disorder and Panic Disorder (With or Without Agoraphobia), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Panic disorder is a psychiatric disease characterized by recurrent panic attacks that occur in expected or unexpected situations and create feelings of intense fear, restlessness and discomfort. Read more about this study

Who is it for?
Ages 18 to 65 years
What is being tested?
Exercise Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 Dec 2024to 30 Sep 2028
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Being between the ages of 18-65
  • Being diagnosed with "panic disorder" by a psychiatrist
  • Not having another psychiatric illness
  • Wanting to participate in the research voluntarily and signing the informed consent
  • Not having a history of communication or neuromusculoskeletal disease that would not allow the application of evaluation and treatment methods

Who cannot join

  • Having a vision and/or hearing problem that would prevent participation in the study
  • History of neurological, cardiopulmonary and musculoskeletal system disease that would negatively affect participation in evaluation and treatment

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Turkey (Türkiye)1 site, 1 recruiting
  • Dokuz Eylul University

    Izmir

    Dokuz Eylul University Faculty of Physical Therapy, +902324124901, fiziktedavi@deu.edu.tr

    Recruiting

Other trials in Turkey (Türkiye)

About this study

Official title: Investigation of the Effects of Qigong Exercise Training and Multicomponent Exercise Training on Physical and Mental Health in People With Panic Disorder

Panic disorder is a psychiatric disease characterized by recurrent panic attacks that occur in expected or unexpected situations and create feelings of intense fear, restlessness and discomfort. Panic disorder often has a chronic course, its frequency and severity can be irregular, various physical, mental, and behavioral symptoms can develop, and the quality of life of individuals can decrease significantly. Evidence-based psychotherapy and pharmacotherapy are effective in reducing the symptoms of panic disorder and managing the disorder. However, both of these treatment methods have certain limitations, and approximately one-third of patients do not respond to therapy or the response is not sufficiently effective. Delaying treatment of the disease results in a poor prognosis and more established symptoms. Exercise can be viewed as a low-cost, supportive treatment for relieving symptoms with comparable efficacy to medication and other psychological interventions. Although exercise is recommended for patients with anxiety-panic disorder, there remains uncertainty about whether its effects are sustainable, the type and intensity of exercise required for effective treatment, and thus the effects of qigong and multicomponent exercise on multiple health outcomes in panic disorder. The aim of this study is to examine the effects of Qigong exercise training and multicomponent exercise training on anxiety-panic, balance, mobility, walking, functional strength, physical activity, sleep quality, fatigue, chronic musculoskeletal pain, quality of life and cognition.

Being tested
Exercise Training
Keywords
Anxiety disorders, Baduanjin, Exercise training, Physical health, Mental health, Multicomponent exercise, Panic disorder, Qigong, Mind-body exercises
Medical subject headings
Panic Disorder, Disease, Motor Activity, Anxiety Disorders, Psychological Well-Being

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT07439224
Study groupRoleWhat they receive
Qigong-Baduanjin Exercise Training GroupExperimentalIn our study, the Qigong exercise training group will receive Baduanjin training via online platform for 8 weeks, 2 days a week, 1 hour a day, under the supervision of a physiotherapist. Each lesson will consist of 10 minutes of warm-up, 40 minutes of Qigong Baduanjin exercises, and 10 minutes of cool-down. First, the participants will be taught isometric and isotonic segmental movement sequences in the upper and lower extremities, then they will be taught to combine breathing techniques, and then they will be taught to focus their attention on movement, breathing, and Qi (life force). In addition, the patients will be asked to exercise at home unsupervised for 1 day a week and keep an exercise diary. According to the participant's compliance and problems, examinations will be made in weekly check-ups and the exercise diary recorded by the patients will be checked, and thus exercise progressions will be ensured. The sessions will be carried out in groups and supervised.
Receives: Other: Exercise Training
Multicomponent Exercise (resistance, balance, endurance and cognitive-motor skills) Training GroupExperimentalParticipants in this group will receive multicomponent exercise training via online platform, 2 times a week, 1 hour per day, for 8 weeks. In addition, patients will be asked to exercise at home unsupervised for 1 day a week and keep an exercise diary. Participant's compliance and problems will be examined during weekly check-ups, and exercise progressions will be provided by increasing the intensity according to the participant's compliance. Sessions will be performed and supervised in groups. The multicomponent exercise intervention will consist of a combined training program with three components (resistance training with "elastic resistance band", balance training, endurance and training to develop cognitive-motor skills (dual task)). Each session will have a 3-part structure (warm-up, main exercise and cool-down) to increase the level of difficulty and commitment, and progress will be monitored throughout the 8-week multicomponent treatment.
Receives: Other: Exercise Training
Wait List - Control GroupNo interventionParticipants in this group will only be monitored during the study, they will continue their normal treatments, in addition to their usual medical care, if they have a sports or exercise program, they will be asked to continue but not to start a new program, and they will be informed about healthy lifestyle recommendations (regular physical activity-exercise, nutrition, sleep, etc.). In this group with a waiting list structure, individuals who have completed the study follow-up period will be offered exercise program options and will be included in the training programs if they want to participate in exercise training, but the data of these participants will not be included in the analyses of this study.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. DSM-5 Panic Disorder Severity Scale

    Panic levels will be evaluated with the DSM-5 Panic Disorder Severity Scale. It provides a five-point Likert-type rating (0=never, 1=sometimes, 2=half of the time, 3=most of the time, 4=all of the time). Scores obtained from the scale items determine the severity of panic disorder. The total score for the scale ranges from 0 to 40, with higher scores indicating more severe panic disorder symptoms.

    Measured: change from baseline to 8 weeks

  2. State-Trait Anxiety Inventory

    State and trait anxiety levels will be assessed with the State-Trait Anxiety Inventory. The State-Trait Anxiety Inventory is a psychological inventory consisting of 40 self-report items on a 4-point Likert scale. The STAI measures two types of anxiety separately in two forms (STAI-S; STAI-T)-state anxiety and trait anxiety. The scale has 20 state-domain and 20 trait-domain questions. A score of 1 indicates that the situation described in the question does not reflect their personality at all; a score of 4 indicates that the situation described in the question reflects their personality completely. Each form is scored between 20 and 80, with higher scores positively correlated with higher anxiety levels, while lower scores indicate lower anxiety levels. The cutoff score for this scale is 44, with scores of 45 and above indicating higher anxiety levels.

    Measured: change from baseline to 8 weeks

Secondary outcomes (12)
  1. Mini-Balance Assessment Systems Test

    The Mini-Balance Assessment Systems Test will be used for clinical balance assessment.

    Measured: change from baseline to 8 weeks

  2. Functional Walking Assessment

    Functional Walking Assessment will be used to assess postural stability and balance during various walking tasks.

    Measured: change from baseline to 8 weeks

  3. Activity-Specific Balance Confidence Scale

    Activity-Specific Balance Confidence Scale will be used to evaluate functional balance-mobility-walking performance. For each question, the score ranges from 0% (no confidence) to 100% (full confidence). The values across all activities are summed and the average calculated. Measurement results range from 0% to 100%, with a higher average score indicating higher confidence. A score above 80% on this scale indicates that the balance is reliable.

    Measured: change from baseline to 8 weeks

  4. 5-Repetition Sit-to-Stand Test

    The 5-Repetition Sit-to-Stand Test will be used to measure overall stability and functional lower extremity muscle strength.

    Measured: change from baseline to 8 weeks

  5. Sedentary Behavior Questionnaire

    The Sedentary Behavior Questionnaire is a questionnaire developed to assess the time spent performing 11 sedentary behaviors on a typical weekday and weekend day. The questionnaire has nine response options: "Never," "15 minutes or less," "30 minutes," "1 hour," "2 hours," "3 hours," "4 hours," "5 hours," and "6 hours or more." Before scoring, the time spent on each behavior is converted to hours (for example, a 15-minute response is recorded as 0.25 hours). For a total score, the behavioral durations in hours are summed separately for weekdays and weekends. To obtain the average sedentary behavior duration for weekdays and weekends, the total time spent during the week is multiplied by 5, and the total time spent on weekends is multiplied by 2. When calculating the total time spent on sedentary behavior during the weekdays and weekends, scores higher than 24 hours/day are reduced to 24 hours/day and recorded.

    Measured: change from baseline to 8 weeks

  6. Baecke Habitual Physical Activity Questionnaire

    The Baecke Habitual Physical Activity Questionnaire will assess participant's habitual physical activities over the last 12 months. This questionnaire consists of 16 questions regarding three main areas of individual physical activity in the last 12 months: occupational (items 1-8), sports (items 9-12), and recreational (items 13-16). Scores for each area range from 1 to 5; higher scores indicate higher physical activity.

    Measured: change from baseline to 8 weeks

  7. Exercise Benefits/Barriers Scale

    The Exercise Benefits/Barriers Scale will be used to measure the perceived benefits of exercise and the perceived barriers to exercise. Each participant will be asked to rate perceived benefits and perceived barriers on a 4-point Likert scale ("Strongly Agree," "Agree," "Disagree," and "Strongly Disagree"). Possible scores on the benefits scale range from 29 to 116, with higher scores indicating greater perceived benefits. Possible scores on the barriers scale range from 14 to 56, with higher scores indicating greater perceived barriers. The total score ranges from 43 to 172. The higher the score, the more positively perceived physical activity benefits are relative to physical activity barriers.

    Measured: change from baseline to 8 weeks

  8. Montreal Cognitive Assessment Scale

    Cognitive functions will be assessed with the Montreal Cognitive Assessment Scale. The scale, which can be administered quickly, presents the individual with eight different cognitive tasks. Developed to assess mild cognitive impairments, this scale assesses various cognitive abilities, including executive functions, visual-spatial skills, memory, language, attention and concentration, abstract thinking, calculation, and orientation. The maximum score possible from the test battery is 30, but scores of 21 or higher are considered normal.

    Measured: change from baseline to 8 weeks

  9. Pittsburgh Sleep Quality Index

    Sleep quality will be evaluated with the Pittsburgh Sleep Quality Index. The index is a 19-item self-report measure that assesses sleep quality and disturbances over the past month. The 19 individual items form a score of seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping pills, and daytime dysfunction. Each component is rated on a 0-3 scale. The sum of the seven components provides the total scale score. The sum of the seven component scores ranges from 0 to 21; higher scores represent poorer subjective sleep quality.

    Measured: change from baseline to 8 weeks

  10. Modified Fatigue Impact Scale

    The Modified Fatigue Impact Scale will be used to evaluate the participant's fatigue status in the last month. The scale consists of 21 questions assessing the physical, cognitive, and social effects of fatigue. Each item is scored from 0 (no problem) to 4 (maximum problem). Higher scores indicate increased fatigue exposure, and lower scores indicate a lower degree of fatigue.

    Measured: change from baseline to 8 weeks

  11. Nordic Musculoskeletal Questionnaire

    The Nordic Musculoskeletal Questionnaire will be used to measure musculoskeletal pain. This survey consists of three main sections. The first section addresses any distress (such as pain, aching, discomfort, or numbness) experienced by the participant over the past 12 months. The second section asks the same question, but it addresses any distress experienced by the participant over the past 7 days. The final section addresses any injuries caused by distress experienced over the past 12 months. Data collected in each section relates to different anatomical areas: neck, shoulders, back, elbows, hands/wrists, waist, hips/thighs, knees, and feet/ankles. The survey primarily inquires about the presence of pain in nine body areas. Responses are recorded as binary options ("yes" or "no"). If the participant answers "yes," the relevant subquestions are discussed.

    Measured: change from baseline to 8 weeks

  12. Short Form-36

    Quality of life will be assessed with Short Form-36. The SF-36 questionnaire measures health status by considering physical functioning and exercise, emotional and physical role functioning, overall mental health, social role functioning, bodily pain, and general health. The 36 items in the scale give it its name. This scale consists of eight subscales. It includes subparameters for pain, physical and social functioning, fatigue, health perception, emotional state, emotional problems, and limitations due to physical problems. The scale considers the last four weeks. Questions are scored from 0 to 100.

    Measured: change from baseline to 8 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Feb 2026
  2. Study start1 Dec 2024
  3. Primary completion30 Jan 2028 (estimated)
  4. Study completion30 Sep 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
60 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07439224
Sponsor's protocol ID
9029-GOA
Status last verified
Aug 2026
First submitted
18 Aug 2025
Last updated
25 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Questions about this trial

What is this clinical trial studying?

A study testing Exercise Training in people with Panic Disorder and Panic Disorder (With or Without Agoraphobia), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 25 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

DSM-5 Panic Disorder Severity Scale (time frame: change from baseline to 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2026.

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