Parkinson DiseaseNCT07442370
The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients
A study testing Conventional Exercise and Functional Turning Exercises in people with Parkinson Disease and Parkinsonism, run by Uskudar University at 1 site in Turkey (Türkiye).
Trial summary
Turning is a frequent cause of falls in people with Parkinson's disease, but it is rarely trained specifically in conventional exercise programs. This randomized controlled trial examines whether adding functional turning exercises to a conventional exercise program improves fall risk, gait speed, and balance in… Read more about this study
- Who is it for?
- Ages 50 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Parkinson Disease, Parkinsonism
- What is being tested?
- Conventional Exercise and Functional Turning Exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2026to 30 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Individuals with a clinical diagnosis of idiopathic Parkinson's disease (Hoehn \& Yahr stages 1-2)
- Individuals aged 50-70 years
- Mini Mental State Test score ≥ 24
- Individuals whose medical treatment has been stable in the last 6 weeks
- Individuals with stable vital signs
- Individuals who volunteer to participate in the study and understand the purpose and process of the study, and who have signed a written informed consent form
Who cannot join
- Advanced Parkinson's disease (H\&Y 3-5)
- Severe orthopedic problems
- Vestibular system disorders
- History of serious falls in the last 6 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients: A Randomized Controlled Study
Turning is a frequent cause of falls in people with Parkinson's disease, but it is rarely trained specifically in conventional exercise programs. This randomized controlled trial examines whether adding functional turning exercises to a conventional exercise program improves fall risk, gait speed, and balance in patients with early-stage Parkinson's disease. Fifty patients are randomly assigned to conventional exercise or to conventional exercise plus functional turning exercises. Both groups exercise three times per week for 12 weeks with similar session duration. Outcomes are assessed before and after the intervention.
Read the detailed description
Patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1-2, aged 50-70 years) are recruited from the physiotherapy and rehabilitation clinic of a medical center in Istanbul. Participants are allocated to two groups (25 per group) by drawing lots from an opaque bag containing 50 slips. The control group receives a conventional program of stretching, strengthening, balance, and gait exercises. The experimental group receives the same conventional program at a reduced dose together with 18-20 minutes of functional turning exercises, so that total session duration is similar in both groups (approximately 45-50 minutes). All sessions are delivered individually by a physiotherapist, three times per week for 12 weeks (36 sessions). The Timed Up and Go test, the 10-Meter Walk Test, and the Berg Balance Scale are administered at baseline and two days after the end of the intervention, in the "on" medication state; each test is performed three times and the mean is used. Outcome assessment is not blinded
- Conditions
- Parkinson Disease, Parkinsonism
- Being tested
- Conventional Exercise, Functional Turning Exercises
- Keywords
- turning, exercise
- Medical subject headings
- Parkinson Disease, Parkinsonian Disorders, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional ExerciseOther
Stretching (pectorals, trunk rotators, hip flexors, hamstrings, quadriceps, gastrocnemius-soleus; 2 x 20-30 s per muscle group), strengthening (sit-to-stand, mini-squat, standing hip abduction and extension, knee extension, heel raises, trunk extensors; 2 x 10-12 repetitions, with dumbbell resistance increased every two weeks), balance training (weight shifting, reaching, semi-tandem and tandem stance, multidirectional stepping), and gait training (overground walking with emphasis on step length and arm swing, start-stop practice, obstacle crossing, directional changes). In the experimental arm the same exercises are performed with fewer sets and repetitions and shorter balance and gait practice
Functional Turning ExercisesOther
Structured program of about 18-20 minutes per session: (1) seated trunk rotation while reaching with a ball to targets on both sides, 3 x 10 repetitions per direction; (2) seated resisted trunk rotation with an exercise ball against an elastic band, 2 x 10 repetitions per direction; (3) standing object transfer from front to a target behind the body with trunk rotation, 3 x 10 repetitions; (4) figure-of-eight walking around two points about 2 m apart, 3 laps; (5) trunk rotation in single-leg stance, 3 x 30 s; (6) trunk rotation with a ball in tandem stance, 3 x 30 s; (7) sit-to-stand, 90-degree turn on verbal command, return and sit, 3 x 10 repetitions. Elastic band resistance is increased every two weeks (red, green, blue, black).
| Study group | Role | What they receive |
|---|---|---|
| Conventional Exercise Group | Active comparator | Conventional exercise program (stretching, strengthening, balance, and gait exercises), 3 sessions per week for 12 weeks, approximately 45-50 minutes per session. Receives: Other: Conventional Exercise |
| Functional Turning Exercise Group | Experimental | Conventional exercise program at a reduced dose plus a functional turning exercise program, 3 sessions per week for 12 weeks, approximately 45-50 minutes per session. Receives: Other: Conventional Exercise; Other: Functional Turning Exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Timed Up and Go Test
This outcome measure will be used to assess functional mobility using a virtual reality-based adaptation of the Timed Up and Go test. Test completion time will be automatically recorded by the system. Validity and reliability will be examined through comparison with the conventional Timed Up and Go test and repeated measurements.
Measured: Baseline and after 12 weeks of intervention
Secondary outcomes (2)
10-Meter Walk Test (gait speed)
Gait speed in m/s at normal, comfortable pace over the central 10 m of a 14 m walkway. Mean of three trials. Higher values indicate better performance.
Measured: Baseline and after 12 weeks of intervention
Berg Balance Scale (BBS)
14-item scale of functional balance; total score 0-56. Higher scores indicate better balance. Mean of three administrations, rounded to the nearest whole number.
Measured: Baseline and after 12 weeks of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Mar 2026
- Study start1 Mar 2026
- Primary completion30 Aug 2026
- Study completion30 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Uskudar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Doç.Dr.Ömer Şevgin, Uskudar University
- Investigators
- Kübra UZUN, Study chair, Uskudar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07442370
- Sponsor's protocol ID
- Uskudar91
- Status last verified
- Oct 2026
- First submitted
- 25 Feb 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be deposited in a public repository; de-identified data are available from the corresponding author on reasonable request.
Publications
Bellows S. Physiotherapy and Exercise in Parkinson's Disease. Neurol Clin. 2025 May;43(2):427-443. doi: 10.1016/j.ncl.2024.12.014. Epub 2025 Jan 24.
PubMed 40185529Zhang J, Wu M, Hou X, Song W, Li J, Teng L, Li X, Yu D, Pan J, Zhu L. Unconventional exercises for motor function in Parkinson's disease: an umbrella review of meta-analyses. Age Ageing. 2025 Mar 3;54(3):afaf062. doi: 10.1093/ageing/afaf062.
PubMed 40125629Jansen JA, Buurke TJ, van de Venis L, Weerdesteyn V, Keijsers N, Nonnekes J. Narrow-based gait in people with Parkinson's disease: Its mechanisms explored. J Parkinsons Dis. 2025 Mar;15(2):329-337. doi: 10.1177/1877718X241313333. Epub 2025 Feb 2.
PubMed 39973508Uzun K, Bugday B, Aydin S, Sevgin O. Effects of Structured Functional Turning Practice Within a Time-Matched Exercise Program on Functional Mobility, Gait Speed, and Balance in Early-Stage Parkinson's Disease: A Randomized Controlled Trial. J Clin Med. 2026 Oct 16;15(20):8044. doi: 10.3390/jcm15208044.
PubMed 42941559
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT07442370
- Acronym / sponsor ID
- Uskudar91
- Conditions
- Parkinson Disease, Parkinsonism
- Keywords
- turning, exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Uskudar UniversityUniversity, hospital or other
- Study start
- 1 Mar 2026 (actual)
- Primary completion
- 30 Aug 2026 (actual)
- Study completion
- 30 Aug 2026 (actual)
- First posted
- 2 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Turning is a frequent cause of falls in people with Parkinson's disease, but it is rarely trained specifically in conventional exercise programs. This randomized controlled trial examines whether adding functional turning exercises to a conventional exercise program improves fall risk, gait speed, and balance in patients with early-stage Parkinson's disease. Fifty patients are randomly assigned to conventional exercise or to conventional exercise plus functional turning exercises. Both groups exercise three times per week for 12 weeks with similar session duration. Outcomes are assessed before and after the intervention.
Detailed description
Patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1-2, aged 50-70 years) are recruited from the physiotherapy and rehabilitation clinic of a medical center in Istanbul. Participants are allocated to two groups (25 per group) by drawing lots from an opaque bag containing 50 slips. The control group receives a conventional program of stretching, strengthening, balance, and gait exercises. The experimental group receives the same conventional program at a reduced dose together with 18-20 minutes of functional turning exercises, so that total session duration is similar in both groups (approximately 45-50 minutes). All sessions are delivered individually by a physiotherapist, three times per week for 12 weeks (36 sessions). The Timed Up and Go test, the 10-Meter Walk Test, and the Berg Balance Scale are administered at baseline and two days after the end of the intervention, in the "on" medication state; each test is performed three times and the mean is used. Outcome assessment is not blinded
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional Exercise Group | Active comparator | Other: Conventional ExerciseConventional exercise program (stretching, strengthening, balance, and gait exercises), 3 sessions per week for 12 weeks, approximately 45-50 minutes per session. |
| Functional Turning Exercise Group | Experimental | Other: Conventional Exercise, Other: Functional Turning ExercisesConventional exercise program at a reduced dose plus a functional turning exercise program, 3 sessions per week for 12 weeks, approximately 45-50 minutes per session. |
Who may qualify
- Ages
- 50 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Individuals with a clinical diagnosis of idiopathic Parkinson's disease (Hoehn \& Yahr stages 1-2)
- Individuals aged 50-70 years
- Mini Mental State Test score ≥ 24
- Individuals whose medical treatment has been stable in the last 6 weeks
- Individuals with stable vital signs
Key exclusion criteria (4 listed)
- Advanced Parkinson's disease (H\&Y 3-5)
- Severe orthopedic problems
- Vestibular system disorders
- History of serious falls in the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional ExerciseStretching (pectorals, trunk rotators, hip flexors, hamstrings, quadriceps, gastrocnemius-soleus; 2 x 20-30 s per muscle group), strengthening (sit-to-stand, mini-squat, standing hip abduction and extension, knee extension, heel raises, trunk extensors; 2 x 10-12 repetitions, with dumbbell resistance increased every two weeks), balance training (weight shifting, reaching, semi-tandem and tandem stance, multidirectional stepping), and gait training (overground walking with emphasis on step length and arm swing, start-stop practice, obstacle crossing, directional changes). In the experimental arm the same exercises are performed with fewer sets and repetitions and shorter balance and gait practice | Other | Conventional Exercise Group, Functional Turning Exercise Group |
| Functional Turning ExercisesStructured program of about 18-20 minutes per session: (1) seated trunk rotation while reaching with a ball to targets on both sides, 3 x 10 repetitions per direction; (2) seated resisted trunk rotation with an exercise ball against an elastic band, 2 x 10 repetitions per direction; (3) standing object transfer from front to a target behind the body with trunk rotation, 3 x 10 repetitions; (4) figure-of-eight walking around two points about 2 m apart, 3 laps; (5) trunk rotation in single-leg stance, 3 x 30 s; (6) trunk rotation with a ball in tandem stance, 3 x 30 s; (7) sit-to-stand, 90-degree turn on verbal command, return and sit, 3 x 10 repetitions. Elastic band resistance is increased every two weeks (red, green, blue, black). | Other | Functional Turning Exercise Group |
Primary outcome
Timed Up and Go Test
Time frame: Baseline and after 12 weeks of intervention
This outcome measure will be used to assess functional mobility using a virtual reality-based adaptation of the Timed Up and Go test. Test completion time will be automatically recorded by the system. Validity and reliability will be examined through comparison with the conventional Timed Up and Go test and repeated measurements.
2 secondary outcomes
10-Meter Walk Test (gait speed)
Time frame: Baseline and after 12 weeks of intervention
Berg Balance Scale (BBS)
Time frame: Baseline and after 12 weeks of intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Background: PubMed 40185529Bellows S. Physiotherapy and Exercise in Parkinson's Disease. Neurol Clin. 2025 May;43(2):427-443. doi: 10.1016/j.ncl.2024.12.014. Epub 2025 Jan 24.
- Background: PubMed 40125629Zhang J, Wu M, Hou X, Song W, Li J, Teng L, Li X, Yu D, Pan J, Zhu L. Unconventional exercises for motor function in Parkinson's disease: an umbrella review of meta-analyses. Age Ageing. 2025 Mar 3;54(3):afaf062. doi: 10.1093/ageing/afaf062.
- Background: PubMed 39973508Jansen JA, Buurke TJ, van de Venis L, Weerdesteyn V, Keijsers N, Nonnekes J. Narrow-based gait in people with Parkinson's disease: Its mechanisms explored. J Parkinsons Dis. 2025 Mar;15(2):329-337. doi: 10.1177/1877718X241313333. Epub 2025 Feb 2.
- Derived from this study: PubMed 42941559Uzun K, Bugday B, Aydin S, Sevgin O. Effects of Structured Functional Turning Practice Within a Time-Matched Exercise Program on Functional Mobility, Gait Speed, and Balance in Early-Stage Parkinson's Disease: A Randomized Controlled Trial. J Clin Med. 2026 Oct 16;15(20):8044. doi: 10.3390/jcm15208044.
- Individual participant dataSharing planned: No. Individual participant data will not be deposited in a public repository; de-identified data are available from the corresponding author on reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kübra UZUN study chair
Uskudar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Exercise and Functional Turning Exercises in people with Parkinson Disease and Parkinsonism, run by Uskudar University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Timed Up and Go Test (time frame: Baseline and after 12 weeks of intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07442370, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.