Muscle FatigueNCT07457398
Effects of Gastrocnemius Fatigue on Muscle Elasticity and Jumping
A study testing Isometric Plantar Flexion Fatigue Protocol in people with Muscle Fatigue and Muscle Elasticity, run by University of Beykent at 1 site in Turkey (Türkiye).
Trial summary
This study investigates the acute and 24-hour recovery effects of localized muscle fatigue on the viscoelastic properties of the medial gastrocnemius (MG) muscle and vertical jump performance. Read more about this study
- Who is it for?
- Ages 18 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Fatigue, Muscle Elasticity, Athletic Performance
- What is being tested?
- Isometric Plantar Flexion Fatigue Protocol
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2026to 24 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy volunteers aged between 18 and 25.
- Physical activity level categorized as sedentary or recreationally active according to IPAQ.
- Willingness to follow the supine isometric fatigue protocol and attend follow-up measurements.
- Sedentary or recreationally active (IPAQ scores).
Who cannot join
- History of lower extremity musculoskeletal injuries or surgeries within the last 6 months.
- Any diagnosed neurological, metabolic, or cardiovascular diseases.
- Regular use of medications or supplements that may affect muscle tone or recovery (e.g., muscle relaxants, high-dose antioxidants).
- Recent history of intensive strength training for the lower limbs.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Effects of Gastrocnemius Muscle Fatigue on Muscle Elastic Properties and Jump Performance
This study investigates the acute and 24-hour recovery effects of localized muscle fatigue on the viscoelastic properties of the medial gastrocnemius (MG) muscle and vertical jump performance. The research aims to quantify the changes in muscle stiffness, tone, and elasticity immediately after a standardized fatigue protocol and to monitor the recovery of these parameters 24 hours later. Additionally, the study evaluates the impact of fatigue on explosive power, measured by countermovement jump (CMJ) height, across these time points.
Read the detailed description
Participants undergo a structured experimental procedure to evaluate the changes across three time points:
Baseline Assessment: Passive muscle tone (Hz), stiffness (N/m), and elasticity (logarithmic decrement) of the medial gastrocnemius (MG) are measured using the MyotonPRO device. Initial vertical jump height is determined through countermovement jump (CMJ) tests.
Fatigue Protocol \& Acute Assessment: Participants perform standardized standing calf raises until task failure. Immediately following the protocol, MG myotonometric properties and CMJ performance are re-measured to determine the acute fatigue-induced changes.
24-Hour Follow-up: Participants return to the laboratory exactly 24 hours later. All measurements (MyotonPRO and CMJ) are repeated to assess the return to baseline levels and the recovery status of the muscle-tendon unit.
The statistical analysis focuses on the differences between baseline, post-fatigue, and 24-hour recovery measurements.
- Conditions
- Muscle Fatigue, Muscle Elasticity, Athletic Performance
- Being tested
- Isometric Plantar Flexion Fatigue Protocol
- Keywords
- Muscle Fatigue, Muscle Myotonometric Properties, Countermovement Jump
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isometric Plantar Flexion Fatigue ProtocolDevice
Participants undergo a localized isometric fatigue protocol in a supine position with their feet placed against a solid wall. They perform maximal isometric plantar flexion pushing against the wall. The protocol continues until the participant reports a score of 8 or higher (indicating 'very strong' to 'maximal' exertion) on the Borg CR-10 Scale. Task failure is also confirmed by the inability to maintain the required isometric pressure or foot position despite verbal encouragement. This ensures a standardized level of subjective and objective muscle fatigue across all participants.
| Study group | Role | What they receive |
|---|---|---|
| Gastrocnemius Fatigue Group | Experimental | Participants in this arm undergo a standardized localized muscle fatigue protocol for the plantar flexors. This involves performing repetitive standing calf raises at a constant tempo of 60 beats per minute until task failure. Muscle myotonometric properties (tone, stiffness, elasticity) and vertical jump performance (CMJ) are measured at baseline, immediately post-fatigue, and 24 hours later to evaluate acute changes and recovery. Receives: Device: Isometric Plantar Flexion Fatigue Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Stiffness of the Medial and Lateral Gastrocnemius
Evaluation of the intrinsic mechanical stiffness of the medial (MG) and lateral (LG) gastrocnemius muscles using myotonometry. Higher values indicate greater stiffness. Measured in Newtons per meter (N/m).
Measured: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Secondary outcomes (3)
Vertical Jump Performance (Jump Height)
Assessment of explosive power using the Countermovement Jump (CMJ) height measured on a digital force platform. Measured in centimeters (cm).
Measured: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Countermovement Jump Phase Durations (Braking and Eccentric)
Temporal analysis of the jumping strategy, specifically the duration of the eccentric and braking phases. Measured in milliseconds (ms).
Measured: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Dynamic Balance Performance (Y-Balance Test)
Measurement of dynamic postural control in three directions (Anterior, Posteromedial, Posterolateral). Reach distances are normalized to leg length. Measured in percentage of leg length (%LL).
Measured: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Mar 2026
- Study start15 Jan 2026
- Primary completion15 Feb 2026
- Study completion24 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- A single-group, repeated measures design where all participants undergo a fatigue protocol, with measurements taken at three time points: baseline, immediately post-fatigue, and 24 hours later.
- Masking
- None (open label)
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Beykent
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yasemin Şahbaz, University of Beykent
- Investigators
- Ali İlez, PhD Can, Principal investigator, VU University of AmsterdamNergiz Batur, PhD Can, Principal investigator, Galata University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07457398
- Sponsor's protocol ID
- UBeykent-17
- Status last verified
- May 2026
- First submitted
- 25 Feb 2026
- Last updated
- 22 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly available to protect participant privacy. However, de-identified aggregate data and study protocols may be shared upon reasonable request to the corresponding author.
Publications
Sahbaz Y, Ilez A, Batur N. Asynchronous recovery of medial and lateral gastrocnemius mechanical properties and jump performance following localized plantar flexor fatigue. BMC Sports Sci Med Rehabil. 2026 May 28;18(1):341. doi: 10.1186/s13102-026-01774-x.
PubMed 42210407
Study at a glance
From the registry record, last updated by the sponsor on 22 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Gastrocnemius Muscle Fatigue on Muscle Elastic Properties and Jump Performance
- ClinicalTrials.gov ID
- NCT07457398
- Acronym / sponsor ID
- UBeykent-17
- Conditions
- Muscle Fatigue, Muscle Elasticity, Athletic Performance
- Keywords
- Muscle Fatigue, Muscle Myotonometric Properties, Countermovement Jump
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- University of BeykentUniversity, hospital or other
- Study start
- 15 Jan 2026 (actual)
- Primary completion
- 15 Feb 2026 (actual)
- Study completion
- 24 Feb 2026 (actual)
- First posted
- 9 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the acute and 24-hour recovery effects of localized muscle fatigue on the viscoelastic properties of the medial gastrocnemius (MG) muscle and vertical jump performance. The research aims to quantify the changes in muscle stiffness, tone, and elasticity immediately after a standardized fatigue protocol and to monitor the recovery of these parameters 24 hours later. Additionally, the study evaluates the impact of fatigue on explosive power, measured by countermovement jump (CMJ) height, across these time points.
Detailed description
Participants undergo a structured experimental procedure to evaluate the changes across three time points:
Baseline Assessment: Passive muscle tone (Hz), stiffness (N/m), and elasticity (logarithmic decrement) of the medial gastrocnemius (MG) are measured using the MyotonPRO device. Initial vertical jump height is determined through countermovement jump (CMJ) tests.
Fatigue Protocol \& Acute Assessment: Participants perform standardized standing calf raises until task failure. Immediately following the protocol, MG myotonometric properties and CMJ performance are re-measured to determine the acute fatigue-induced changes.
24-Hour Follow-up: Participants return to the laboratory exactly 24 hours later. All measurements (MyotonPRO and CMJ) are repeated to assess the return to baseline levels and the recovery status of the muscle-tendon unit.
The statistical analysis focuses on the differences between baseline, post-fatigue, and 24-hour recovery measurements.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- A single-group, repeated measures design where all participants undergo a fatigue protocol, with measurements taken at three time points: baseline, immediately post-fatigue, and 24 hours later.
| Arm | Type | Receives |
|---|---|---|
| Gastrocnemius Fatigue Group | Experimental | Device: Isometric Plantar Flexion Fatigue ProtocolParticipants in this arm undergo a standardized localized muscle fatigue protocol for the plantar flexors. This involves performing repetitive standing calf raises at a constant tempo of 60 beats per minute until task failure. Muscle myotonometric properties (tone, stiffness, elasticity) and vertical jump performance (CMJ) are measured at baseline, immediately post-fatigue, and 24 hours later to evaluate acute changes and recovery. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Healthy volunteers aged between 18 and 25.
- Physical activity level categorized as sedentary or recreationally active according to IPAQ.
- Willingness to follow the supine isometric fatigue protocol and attend follow-up measurements.
- Sedentary or recreationally active (IPAQ scores).
Key exclusion criteria (4 listed)
- History of lower extremity musculoskeletal injuries or surgeries within the last 6 months.
- Any diagnosed neurological, metabolic, or cardiovascular diseases.
- Regular use of medications or supplements that may affect muscle tone or recovery (e.g., muscle relaxants, high-dose antioxidants).
- Recent history of intensive strength training for the lower limbs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isometric Plantar Flexion Fatigue ProtocolParticipants undergo a localized isometric fatigue protocol in a supine position with their feet placed against a solid wall. They perform maximal isometric plantar flexion pushing against the wall. The protocol continues until the participant reports a score of 8 or higher (indicating 'very strong' to 'maximal' exertion) on the Borg CR-10 Scale. Task failure is also confirmed by the inability to maintain the required isometric pressure or foot position despite verbal encouragement. This ensures a standardized level of subjective and objective muscle fatigue across all participants. | Device | Gastrocnemius Fatigue Group |
Primary outcome
Muscle Stiffness of the Medial and Lateral Gastrocnemius
Time frame: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Evaluation of the intrinsic mechanical stiffness of the medial (MG) and lateral (LG) gastrocnemius muscles using myotonometry. Higher values indicate greater stiffness. Measured in Newtons per meter (N/m).
3 secondary outcomes
Vertical Jump Performance (Jump Height)
Time frame: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Countermovement Jump Phase Durations (Braking and Eccentric)
Time frame: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Dynamic Balance Performance (Y-Balance Test)
Time frame: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 May 2026.
- Derived from this study: PubMed 42210407Sahbaz Y, Ilez A, Batur N. Asynchronous recovery of medial and lateral gastrocnemius mechanical properties and jump performance following localized plantar flexor fatigue. BMC Sports Sci Med Rehabil. 2026 May 28;18(1):341. doi: 10.1186/s13102-026-01774-x.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly available to protect participant privacy. However, de-identified aggregate data and study protocols may be shared upon reasonable request to the corresponding author.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ali İlez, PhD Can principal investigator
VU University of Amsterdam
Nergiz Batur, PhD Can principal investigator
Galata University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isometric Plantar Flexion Fatigue Protocol in people with Muscle Fatigue and Muscle Elasticity, run by University of Beykent at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Stiffness of the Medial and Lateral Gastrocnemius (time frame: Baseline, immediately post-fatigue (Post-0), and 24 hours post-fatigue (Post-24h)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07457398, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 May 2026.