Alveolar Bone LossTUBERO-IMPLANTNCT07460076
Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone
A study testing Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft in people with Alveolar Bone Loss and Esthetic Zone Implant Rehabilitation, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
Trial summary
Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alveolar Bone Loss, Esthetic Zone Implant Rehabilitation
- What is being tested?
- Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 1 siteVietnam
- Study dates
- 1 Jan 2026to Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older
- Patients requiring single implant placement in the maxillary esthetic zone
- Indication for immediate implant placement following tooth extraction
- Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft
- Adequate oral hygiene and ability to maintain postoperative care
- Willingness to participate in the study and provide informed consent
Who cannot join
- Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases
- History of radiotherapy in the head and neck region
- Active periodontal disease or untreated oral infection
- Heavy smoking (more than 10 cigarettes per day)
- Pregnancy or lactation
- Severe parafunctional habits
- Insufficient bone volume preventing implant placement with the planned protocol
- Patients unable to attend follow-up visits
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Vietnam1 site, 1 recruiting
- Recruiting
University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh, 700000
Duy Anh Tran, DDS, +84 868324216, tranduyanhump17@gmail.com
About this study
Official title: Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series
Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.
This prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.
Read the detailed description
Immediate implant placement has become a widely accepted treatment modality in the esthetic zone. However, the presence of buccal bone defects following tooth extraction may negatively affect peri-implant tissue stability and esthetic outcomes. Autogenous bone graft harvested from the maxillary tuberosity has been proposed as a reliable grafting material due to its corticocancellous structure and high osteogenic potential.
This prospective interventional case series aims to evaluate the effectiveness of autogenous maxillary tuberosity graft used in conjunction with immediate implant placement in the esthetic zone. Patients requiring extraction and implant placement in the maxillary esthetic region will be treated with immediate implant placement and augmentation using a two-layer autogenous graft harvested from the maxillary tuberosity, consisting of cortical bone and connective tissue.
Clinical and radiographic outcomes will be assessed during follow-up. Buccal bone thickness will be evaluated using cone-beam computed tomography (CBCT). Facial soft tissue thickness will be measured clinically. Esthetic outcomes will be assessed using the pink esthetic score (PES) following definitive prosthetic restoration.
The results of this study are expected to provide clinical evidence regarding the effectiveness of maxillary tuberosity autogenous grafts for improving peri-implant tissue stability and esthetic outcomes in immediate implant placement.
- Being tested
- Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft
- Keywords
- Immediate Implant Placement, Maxillary Tuberosity Graft, Autogenous Bone Graft, Dental Implant, Pink Esthetic Score
- Medical subject headings
- Alveolar Bone Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate Implant Placement With Maxillary Tuberosity Autogenous GraftProcedure or surgery
Immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity. The graft is used to reconstruct the buccal bone plate and improve peri-implant tissue stability and esthetic outcomes.
| Study group | Role | What they receive |
|---|---|---|
| Immediate Implant With Maxillary Tuberosity Graft | Experimental | Patients receiving immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity to reconstruct the buccal bone plate. Receives: Procedure: Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Buccal Bone Thickness
Buccal bone thickness around the implant measured on cone-beam computed tomography (CBCT) in the mid-facial aspect of the implant site.
Measured: 6 months after implant placement
Secondary outcomes (1)
Facial Soft Tissue Thickness
Facial peri-implant soft tissue thickness measured clinically at the mid-facial aspect of the implant site.
Measured: 6 months after implant placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start1 Jan 2026
- Primary completionOct 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone LossStudies of the same condition, open and under way.
- More trials run by University of Medicine and Pharmacy at Ho Chi Minh CityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Single-arm prospective case series evaluating immediate implant placement with autogenous maxillary tuberosity graft in the esthetic zone.
- Masking
- None (open label)
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tran Duy Anh, University of Medicine and Pharmacy at Ho Chi Minh City
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07460076
- Sponsor's protocol ID
- MT-BLOCK-GRAFT-IMPLANT
- Acronym
- TUBERO-IMPLANT
- Status last verified
- Mar 2026
- First submitted
- 4 Mar 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series
- ClinicalTrials.gov ID
- NCT07460076
- Acronym / sponsor ID
- TUBERO-IMPLANT / MT-BLOCK-GRAFT-IMPLANT
- Keywords
- Immediate Implant Placement, Maxillary Tuberosity Graft, Autogenous Bone Graft, Dental Implant, Pink Esthetic Score
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- University of Medicine and Pharmacy at Ho Chi Minh CityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.
This prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.
Detailed description
Immediate implant placement has become a widely accepted treatment modality in the esthetic zone. However, the presence of buccal bone defects following tooth extraction may negatively affect peri-implant tissue stability and esthetic outcomes. Autogenous bone graft harvested from the maxillary tuberosity has been proposed as a reliable grafting material due to its corticocancellous structure and high osteogenic potential.
This prospective interventional case series aims to evaluate the effectiveness of autogenous maxillary tuberosity graft used in conjunction with immediate implant placement in the esthetic zone. Patients requiring extraction and implant placement in the maxillary esthetic region will be treated with immediate implant placement and augmentation using a two-layer autogenous graft harvested from the maxillary tuberosity, consisting of cortical bone and connective tissue.
Clinical and radiographic outcomes will be assessed during follow-up. Buccal bone thickness will be evaluated using cone-beam computed tomography (CBCT). Facial soft tissue thickness will be measured clinically. Esthetic outcomes will be assessed using the pink esthetic score (PES) following definitive prosthetic restoration.
The results of this study are expected to provide clinical evidence regarding the effectiveness of maxillary tuberosity autogenous grafts for improving peri-implant tissue stability and esthetic outcomes in immediate implant placement.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Single-arm prospective case series evaluating immediate implant placement with autogenous maxillary tuberosity graft in the esthetic zone.
| Arm | Type | Receives |
|---|---|---|
| Immediate Implant With Maxillary Tuberosity Graft | Experimental | Procedure: Immediate Implant Placement With Maxillary Tuberosity Autogenous GraftPatients receiving immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity to reconstruct the buccal bone plate. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adults aged 18 years or older
- Patients requiring single implant placement in the maxillary esthetic zone
- Indication for immediate implant placement following tooth extraction
- Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft
- Adequate oral hygiene and ability to maintain postoperative care
Key exclusion criteria (8 listed)
- Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases
- History of radiotherapy in the head and neck region
- Active periodontal disease or untreated oral infection
- Heavy smoking (more than 10 cigarettes per day)
- Pregnancy or lactation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate Implant Placement With Maxillary Tuberosity Autogenous GraftImmediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity. The graft is used to reconstruct the buccal bone plate and improve peri-implant tissue stability and esthetic outcomes. | Procedure or surgery | Immediate Implant With Maxillary Tuberosity Graft |
Primary outcome
Buccal Bone Thickness
Time frame: 6 months after implant placement
Buccal bone thickness around the implant measured on cone-beam computed tomography (CBCT) in the mid-facial aspect of the implant site.
1 secondary outcome
Facial Soft Tissue Thickness
Time frame: 6 months after implant placement
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft in people with Alveolar Bone Loss and Esthetic Zone Implant Rehabilitation, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Duy Anh Tran, DDS (+84 868324216, tranduyanhump17@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Buccal Bone Thickness (time frame: 6 months after implant placement). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.