Multiple SclerosisNCT07462338
Validity and Reliability of Timed Up and Go Test in Dual-Task Conditions for Multiple Sclerosis Patients
An observational study of Multiple Sclerosis and Reliability and Validity, run by Sanko University at 1 site in Turkey (Türkiye).
Trial summary
his study aims to examine the validity and reliability of the Timed Up and Go (TUG) test in patients with Multiple Sclerosis (MS) under dual-task conditions, where participants perform both a motor and a cognitive task at the same time. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Multiple Sclerosis, Reliability and Validity, Dual Task
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Feb 2026to 1 Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: multiple sclerosis
Who may be able to join
- Diagnosed with Multiple Sclerosis (MS).
- Age 18 years or older.
- EDSS score low to moderate (able to walk without assistive devices).
- Willing to provide informed consent.
- Able to perform Timed Up and Go (TUG) test.
Who cannot join
- Severe cognitive impairment preventing understanding of instructions.
- Recent MS relapse (within the past 30 days).
- Use of walking aids that interfere with TUG test performance.
- Other neurological or musculoskeletal conditions affecting walking or balance.
- Any condition that makes participation unsafe, according to the investigato
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Validity and Reliability of Timed Up and Go Test in Dual-Task Conditions in Patients With Multiple Sclerosis
his study aims to examine the validity and reliability of the Timed Up and Go (TUG) test in patients with Multiple Sclerosis (MS) under dual-task conditions, where participants perform both a motor and a cognitive task at the same time. MS affects movement, balance, and cognitive functions, which can lead to difficulties in walking and increased risk of falls.
In this study, volunteers with MS will be asked to perform the TUG test in different conditions:
Read more
Single-task TUG: walking, standing up, and sitting down without additional tasks.
Cognitive dual-task TUG: performing TUG while doing a cognitive task, such as counting backwards or word generation.
Motor dual-task TUG: performing TUG while carrying a small object on a tray.
Participants' demographic and clinical information will be recorded, and tests will be repeated to evaluate the reliability of the measurements. The results will help determine if the TUG test can reliably assess both motor and cognitive performance in MS patients.
The study is observational, and no experimental treatment will be given. Participation involves only performing tests and answering questions, taking approximately 25-30 minutes per session. All collected data will be kept confidential.
Read the detailed description
This study investigates the validity and reliability of the Timed Up and Go (TUG) test under dual-task conditions in patients with Multiple Sclerosis (MS). MS is a chronic neurological disease that affects motor and cognitive functions, often leading to walking difficulties, balance problems, and increased risk of falls.
Volunteers with MS will be recruited from the Neurological Rehabilitation Unit at SANKO University. Eligible participants will perform the TUG test in three conditions:
Single-task TUG: normal TUG without additional tasks.
Cognitive dual-task TUG (kSKYT): performing TUG while counting backwards in threes or generating words starting with a specific letter.
Motor dual-task TUG (mSKYT): performing TUG while carrying a small ball on a tray.
Participants' demographic and clinical data, including age, sex, height, weight, MS duration, EDSS score, and history of falls, will be recorded. TUG tests will be conducted by two physiotherapists and repeated after one week to assess test-retest reliability and inter-rater reliability.
Convergent validity will be evaluated by comparing dual-task TUG results with single-task TUG, 25-step walking test, Mini-BESTest, and a dual-task questionnaire. Known-groups validity will be assessed by comparing results between MS patients who have fallen and those who have not.
All data will be coded and stored confidentially. The study is observational, with no experimental interventions, and each assessment session will take approximately 25-30 minutes.
- Conditions
- Multiple Sclerosis, Reliability and Validity, Dual Task
- Keywords
- multiple sclerosis, reliability and validity, dual task
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Multiple Sclerosis Patients Observed for Dual-Task TUG Test | This cohort includes volunteers diagnosed with Multiple Sclerosis (MS) who will participate in observational assessments of functional mobility using the Timed Up and Go (TUG) test under single-task and dual-task conditions. No experimental interventions will be applied. Participants will perform cognitive and motor dual-tasks simultaneously with the TUG test to evaluate walking, balance, and functional mobility. Demographic and clinical data, including age, sex, MS duration, EDSS score, and fall history, will be recorded. The cohort will be assessed by trained physiotherapists to determine test-retest and inter-rater reliability, as well as validity of the dual-task TUG test. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sit-to-Stand and Walk Test (SKYT)
SKYT is a test that assesses an individual's functional mobility, balance, and walking performance, including sitting, standing up, walking, turning, and sitting back down. The participant is asked to walk 3 metres and
Measured: 1 week
Dual-task SKYT tests
Dual-task SKYT tests will consist of three different dual-task SKYT tests: two cognitive dual-task SKYT tests (cSKYT) and one motor dual-task SKYT test (mSKYT). The cognitive task parameters of the cSKYT will be numerical processing
Measured: one weeks
The 25-step walk test (S25AYT)
This is a standardised test used to assess walking speed and functional mobility in MS patients, performed by walking a distance of 7.62 metres as quickly and safely as possible. The test has been reported to have high rel
Measured: one weeks
Dual-task questionnaire
The questionnaire was originally developed to assess individuals with neurological injury or disease and is used to evaluate the frequency of difficulties experienced in daily activities involving dual tasks. The questionnaire consists of 10 items, and each question is rated on a 5-point scale (0 = 'never' to 4 = 'very often' or N/A = 'not applicable'). The resulting score is the average score per question (questionnaire score = total questionnaire score/10). Its validity and reliability in the Turkish MS population have been demonstrated.
Measured: one weeks
Mini-BESTest
A test frequently used in neurological disease populations that assesses the dynamic components of balance control. Participants are asked to perform various balance tasks (e.g., postural responses, sensorimotor strategies, dynamic walking). Studies conducted in MS patients have demonstrated that the Mini-BESTest has high reliability and validity in the Turkish neurological population, including MS.
Measured: one weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start15 Feb 2026
- Primary completion15 Mar 2026 (estimated)
- Study completion1 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sanko University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hakan Polat, Sanko University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07462338
- Sponsor's protocol ID
- hakanpolat16
- Status last verified
- Mar 2026
- First submitted
- 4 Mar 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Validity and Reliability of Timed Up and Go Test in Dual-Task Conditions in Patients With Multiple Sclerosis
- ClinicalTrials.gov ID
- NCT07462338
- Acronym / sponsor ID
- hakanpolat16
- Conditions
- Multiple Sclerosis, Reliability and Validity, Dual Task
- Keywords
- multiple sclerosis, reliability and validity, dual task
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Sanko UniversityUniversity, hospital or other
- Study start
- 15 Feb 2026 (actual)
- Primary completion
- 15 Mar 2026 (estimated)
- Study completion
- 1 Apr 2026 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
his study aims to examine the validity and reliability of the Timed Up and Go (TUG) test in patients with Multiple Sclerosis (MS) under dual-task conditions, where participants perform both a motor and a cognitive task at the same time. MS affects movement, balance, and cognitive functions, which can lead to difficulties in walking and increased risk of falls.
In this study, volunteers with MS will be asked to perform the TUG test in different conditions:
Single-task TUG: walking, standing up, and sitting down without additional tasks.
Cognitive dual-task TUG: performing TUG while doing a cognitive task, such as counting backwards or word generation.
Motor dual-task TUG: performing TUG while carrying a small object on a tray.
Participants' demographic and clinical information will be recorded, and tests will be repeated to evaluate the reliability of the measurements. The results will help determine if the TUG test can reliably assess both motor and cognitive performance in MS patients.
The study is observational, and no experimental treatment will be given. Participation involves only performing tests and answering questions, taking approximately 25-30 minutes per session. All collected data will be kept confidential.
Detailed description
This study investigates the validity and reliability of the Timed Up and Go (TUG) test under dual-task conditions in patients with Multiple Sclerosis (MS). MS is a chronic neurological disease that affects motor and cognitive functions, often leading to walking difficulties, balance problems, and increased risk of falls.
Volunteers with MS will be recruited from the Neurological Rehabilitation Unit at SANKO University. Eligible participants will perform the TUG test in three conditions:
Single-task TUG: normal TUG without additional tasks.
Cognitive dual-task TUG (kSKYT): performing TUG while counting backwards in threes or generating words starting with a specific letter.
Motor dual-task TUG (mSKYT): performing TUG while carrying a small ball on a tray.
Participants' demographic and clinical data, including age, sex, height, weight, MS duration, EDSS score, and history of falls, will be recorded. TUG tests will be conducted by two physiotherapists and repeated after one week to assess test-retest reliability and inter-rater reliability.
Convergent validity will be evaluated by comparing dual-task TUG results with single-task TUG, 25-step walking test, Mini-BESTest, and a dual-task questionnaire. Known-groups validity will be assessed by comparing results between MS patients who have fallen and those who have not.
All data will be coded and stored confidentially. The study is observational, with no experimental interventions, and each assessment session will take approximately 25-30 minutes.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Multiple Sclerosis Patients Observed for Dual-Task TUG Test | – | –This cohort includes volunteers diagnosed with Multiple Sclerosis (MS) who will participate in observational assessments of functional mobility using the Timed Up and Go (TUG) test under single-task and dual-task conditions. No experimental interventions will be applied. Participants will perform cognitive and motor dual-tasks simultaneously with the TUG test to evaluate walking, balance, and functional mobility. Demographic and clinical data, including age, sex, MS duration, EDSS score, and fall history, will be recorded. The cohort will be assessed by trained physiotherapists to determine test-retest and inter-rater reliability, as well as validity of the dual-task TUG test. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- multiple sclerosis
Key inclusion criteria (5 listed)
- Diagnosed with Multiple Sclerosis (MS).
- Age 18 years or older.
- EDSS score low to moderate (able to walk without assistive devices).
- Willing to provide informed consent.
- Able to perform Timed Up and Go (TUG) test.
Key exclusion criteria (5 listed)
- Severe cognitive impairment preventing understanding of instructions.
- Recent MS relapse (within the past 30 days).
- Use of walking aids that interfere with TUG test performance.
- Other neurological or musculoskeletal conditions affecting walking or balance.
- Any condition that makes participation unsafe, according to the investigato
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Sit-to-Stand and Walk Test (SKYT)
Time frame: 1 week
SKYT is a test that assesses an individual's functional mobility, balance, and walking performance, including sitting, standing up, walking, turning, and sitting back down. The participant is asked to walk 3 metres and
Dual-task SKYT tests
Time frame: one weeks
Dual-task SKYT tests will consist of three different dual-task SKYT tests: two cognitive dual-task SKYT tests (cSKYT) and one motor dual-task SKYT test (mSKYT). The cognitive task parameters of the cSKYT will be numerical processing
The 25-step walk test (S25AYT)
Time frame: one weeks
This is a standardised test used to assess walking speed and functional mobility in MS patients, performed by walking a distance of 7.62 metres as quickly and safely as possible. The test has been reported to have high rel
Dual-task questionnaire
Time frame: one weeks
The questionnaire was originally developed to assess individuals with neurological injury or disease and is used to evaluate the frequency of difficulties experienced in daily activities involving dual tasks. The questionnaire consists of 10 items, and each question is rated on a 5-point scale (0 = 'never' to 4 = 'very often' or N/A = 'not applicable'). The resulting score is the average score per question (questionnaire score = total questionnaire score/10). Its validity and reliability in the Turkish MS population have been demonstrated.
Mini-BESTest
Time frame: one weeks
A test frequently used in neurological disease populations that assesses the dynamic components of balance control. Participants are asked to perform various balance tasks (e.g., postural responses, sensorimotor strategies, dynamic walking). Studies conducted in MS patients have demonstrated that the Mini-BESTest has high reliability and validity in the Turkish neurological population, including MS.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Multiple Sclerosis and Reliability and Validity, run by Sanko University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sit-to-Stand and Walk Test (SKYT) (time frame: 1 week). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.