Muscle StrengthBFRT-ARMNCT07462520
Effects of Blood Flow Restriction vs. High-Load Resistance Training on Arm Strength
A study testing Low Load Blood Flow Restriction Training and High Load Resistance Training in people with Muscle Strength and Resistance Training, run by Gazi University at 1 site in Turkey (Türkiye).
Trial summary
This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in healthy young adults. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Strength, Resistance Training, Blood Flow Restriction
- What is being tested?
- Low Load Blood Flow Restriction Training and High Load Resistance Training
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Feb 2024to 1 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy individuals between the ages of 18 and 40
- Individuals not taking any dietary supplements
- Individuals not taking a substance containing anabolic ingredients
- Individuals subjected to a resistance training program for at least 6 months
- Individuals not performing aerobic training for more than 30 minutes per day
- Individuals training with a personal trainer
Who cannot join
- Individuals with a skeletal muscle injury in the last 6 months
- Individuals who have undergone a surgical operation
- Individuals with chronic high blood pressure and cardiovascular disease
- Individuals who miss three consecutive training sessions
- Individuals with chronic cardiovascular disease
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Blood Flow Restriction Resistance Exercise on Arm Muscle Strength and Isokinetic Contraction Parameters
This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in healthy young adults. Participants were prospectively assigned to either a low-load BFRT group or a high-load resistance training group for a 7-week intervention period. Muscle strength and isokinetic peak torque were assessed before and after the intervention. The primary objective was to determine whether low-load BFRT produces comparable improvements in muscle strength and isokinetic performance to high-load resistance training.
Read the detailed description
his interventional study was designed to compare the effects of low-load blood flow restriction resistance training (LL-BFRT) and high-load resistance training (HL-RT) on arm muscle strength and isokinetic contraction parameters in healthy individuals.
A total of 22 healthy young adults were prospectively assigned to either a low-load BFRT group or a high-load resistance training group. The intervention lasted 7 weeks. The low-load BFRT group performed resistance exercises at 30% of one-repetition maximum (1RM) combined with individualized blood flow restriction pressure, while the high-load group trained at 70% of 1RM without blood flow restriction.
Primary outcome measures included isokinetic peak torque values of the elbow flexors and extensors. Secondary outcomes included muscle strength assessments. All participants completed pre-intervention and post-intervention evaluations.
The study aimed to determine whether low-load BFRT can induce strength and performance adaptations comparable to traditional high-load resistance training, offering an alternative training strategy when high mechanical loads are not desirable.
- Conditions
- Muscle Strength, Resistance Training, Blood Flow Restriction
- Being tested
- Low Load Blood Flow Restriction Training, High Load Resistance Training
- Keywords
- Blood flow restriction, Resistance exercise, Isokinetic contraction, Muscle strength, Peak Torque
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low Load Blood Flow Restriction TrainingProcedure or surgery
Low-load resistance training performed at 30% of one-repetition maximum with individualized blood flow restriction pressure.
High Load Resistance TrainingProcedure or surgery
Traditional resistance training performed at 70% of one-repetition maximum without blood flow restriction.
| Study group | Role | What they receive |
|---|---|---|
| Low-Load Blood Flow Restriction Training(LL-BFRT) | Experimental | Participants performed resistance exercises at 30% of one-repetition maximum combined with individualized blood flow restriction pressure for 7 weeks. Receives: Procedure: Low Load Blood Flow Restriction Training |
| High-Load Resistance Training(HL-RT) | Active comparator | Participants performed resistance exercises at 70% of one-repetition maximum without blood flow restriction for 7 weeks. Receives: Procedure: High Load Resistance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Arm Muscle Strength
Isokinetic peak torque of elbow flexor and extensor muscles measured using an isokinetic dynamometer.
Measured: Baseline and after 7 weeks of training
Secondary outcomes (1)
Isokinetic Contraction Parameters
Isokinetic peak torque (Nm) of elbow flexor and extensor muscles measured using an isokinetic dynamometer.
Measured: Baseline and after 7 weeks of training
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start5 Feb 2024
- Primary completion25 Mar 2024
- Study completion1 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle StrengthStudies of the same condition, open and under way.
- More trials run by Gazi UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were prospectively assigned to one of two parallel groups: a low-load blood flow restriction training group or a high-load resistance training group. Both groups completed a 7-week intervention, and outcomes were assessed pre- and post-intervention.
- Masking
- None (open label)
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gazi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hüsnü Kocaman, Gazi University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07462520
- Sponsor's protocol ID
- E-77082166-302.08.01-506408
- Acronym
- BFRT-ARM
- Status last verified
- Mar 2026
- First submitted
- 5 Mar 2026
- Last updated
- 12 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Kocaman H, Aydos L. The effect of blood flow restriction resistance exercise on arm muscle strength and isokinetic contraction parameters. BMC Sports Sci Med Rehabil. 2026 Mar 26;18(1):202. doi: 10.1186/s13102-026-01658-0.
PubMed 41888942
Study at a glance
From the registry record, last updated by the sponsor on 12 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Blood Flow Restriction Resistance Exercise on Arm Muscle Strength and Isokinetic Contraction Parameters
- ClinicalTrials.gov ID
- NCT07462520
- Acronym / sponsor ID
- BFRT-ARM / E-77082166-302.08.01-506408
- Conditions
- Muscle Strength, Resistance Training, Blood Flow Restriction
- Keywords
- Blood flow restriction, Resistance exercise, Isokinetic contraction, Muscle strength, Peak Torque
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Gazi UniversityUniversity, hospital or other
- Study start
- 5 Feb 2024 (actual)
- Primary completion
- 25 Mar 2024 (actual)
- Study completion
- 1 Apr 2024 (actual)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in healthy young adults. Participants were prospectively assigned to either a low-load BFRT group or a high-load resistance training group for a 7-week intervention period. Muscle strength and isokinetic peak torque were assessed before and after the intervention. The primary objective was to determine whether low-load BFRT produces comparable improvements in muscle strength and isokinetic performance to high-load resistance training.
Detailed description
his interventional study was designed to compare the effects of low-load blood flow restriction resistance training (LL-BFRT) and high-load resistance training (HL-RT) on arm muscle strength and isokinetic contraction parameters in healthy individuals.
A total of 22 healthy young adults were prospectively assigned to either a low-load BFRT group or a high-load resistance training group. The intervention lasted 7 weeks. The low-load BFRT group performed resistance exercises at 30% of one-repetition maximum (1RM) combined with individualized blood flow restriction pressure, while the high-load group trained at 70% of 1RM without blood flow restriction.
Primary outcome measures included isokinetic peak torque values of the elbow flexors and extensors. Secondary outcomes included muscle strength assessments. All participants completed pre-intervention and post-intervention evaluations.
The study aimed to determine whether low-load BFRT can induce strength and performance adaptations comparable to traditional high-load resistance training, offering an alternative training strategy when high mechanical loads are not desirable.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants were prospectively assigned to one of two parallel groups: a low-load blood flow restriction training group or a high-load resistance training group. Both groups completed a 7-week intervention, and outcomes were assessed pre- and post-intervention.
| Arm | Type | Receives |
|---|---|---|
| Low-Load Blood Flow Restriction Training(LL-BFRT) | Experimental | Procedure: Low Load Blood Flow Restriction TrainingParticipants performed resistance exercises at 30% of one-repetition maximum combined with individualized blood flow restriction pressure for 7 weeks. |
| High-Load Resistance Training(HL-RT) | Active comparator | Procedure: High Load Resistance TrainingParticipants performed resistance exercises at 70% of one-repetition maximum without blood flow restriction for 7 weeks. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Healthy individuals between the ages of 18 and 40
- Individuals not taking any dietary supplements
- Individuals not taking a substance containing anabolic ingredients
- Individuals subjected to a resistance training program for at least 6 months
- Individuals not performing aerobic training for more than 30 minutes per day
Key exclusion criteria (5 listed)
- Individuals with a skeletal muscle injury in the last 6 months
- Individuals who have undergone a surgical operation
- Individuals with chronic high blood pressure and cardiovascular disease
- Individuals who miss three consecutive training sessions
- Individuals with chronic cardiovascular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low Load Blood Flow Restriction TrainingLow-load resistance training performed at 30% of one-repetition maximum with individualized blood flow restriction pressure. | Procedure or surgery | Low-Load Blood Flow Restriction Training(LL-BFRT) |
| High Load Resistance TrainingTraditional resistance training performed at 70% of one-repetition maximum without blood flow restriction. | Procedure or surgery | High-Load Resistance Training(HL-RT) |
Primary outcome
Arm Muscle Strength
Time frame: Baseline and after 7 weeks of training
Isokinetic peak torque of elbow flexor and extensor muscles measured using an isokinetic dynamometer.
1 secondary outcome
Isokinetic Contraction Parameters
Time frame: Baseline and after 7 weeks of training
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Mar 2026.
- Derived from this study: PubMed 41888942Kocaman H, Aydos L. The effect of blood flow restriction resistance exercise on arm muscle strength and isokinetic contraction parameters. BMC Sports Sci Med Rehabil. 2026 Mar 26;18(1):202. doi: 10.1186/s13102-026-01658-0.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low Load Blood Flow Restriction Training and High Load Resistance Training in people with Muscle Strength and Resistance Training, run by Gazi University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Arm Muscle Strength (time frame: Baseline and after 7 weeks of training). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07462520, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Mar 2026.