Exercise RecoveryANTI-RBENCT07472244
Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?
A study testing Intervention in people with Exercise Recovery, run by University of Bath at 1 site in United Kingdom.
Trial summary
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise Recovery
- What is being tested?
- Intervention
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 52 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 Sep 2025to 28 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18 - 45 years of age
- BMI 18.5 - 29.9 kg/m2
- Able to perform 20-minutes of bench stepping exercise
- Capable and willing to provide consent (oral and written)
Who cannot join
- Familiarised with bench stepping exercise procedures
- Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
- Participants exhibiting any alteration in clinical inflammation parameters due to other cause
- Participants currently being prescribed any anti-inflammatory medications
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
University of Bath
Bath
Max Davis, 07950449960, md959@bath.ac.uk
About this study
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise
. However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
- Conditions
- Exercise Recovery
- Being tested
- Control, Intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ControlDietary supplement
Identical maltodextrin tablet. Appearance and weight matched
InterventionDietary supplement
1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | Vitamin C and Non-steroidal anti-inflammatory drug Receives: Dietary Supplement: Intervention |
| Control | Placebo comparator | Identical Placebo Receives: Dietary Supplement: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Function
Jump height calculated through flight time
Measured: Baseline and post exercise (2 hours, 1 day, 7 day)
Secondary outcomes (4)
Muscle Function
Peak power quantified using a Keiser Leg Press
Measured: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Peak force quantified using a Keiser Leg Press
Measured: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Peak velocity quantified using a Keiser Leg Press
Measured: Baseline and post exercise (2 hours, 1 day, 7 day)
Creatine Kinase
Plasma Creatine Kinase
Measured: Baseline and immediately, 1-h (hour)-, 2-h-, 24-h-,and 48-hours-post-exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Mar 2026
- Study start1 Sep 2025
- Primary completion28 Feb 2027 (estimated)
- Study completion28 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise RecoveryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The proposed study is a randomised, double blind, placebo controlled, parallel-group study
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 52 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Bath
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Max Davis, University of Bath
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07472244
- Sponsor's protocol ID
- 11104-14846
- Acronym
- ANTI-RBE
- Status last verified
- Feb 2026
- First submitted
- 4 Mar 2026
- Last updated
- 16 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 16 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?
- ClinicalTrials.gov ID
- NCT07472244
- Acronym / sponsor ID
- ANTI-RBE / 11104-14846
- Conditions
- Exercise Recovery
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 52 participants (estimated)
- Lead sponsor
- University of BathUniversity, hospital or other
- Study start
- 1 Sep 2025 (actual)
- Primary completion
- 28 Feb 2027 (estimated)
- Study completion
- 28 Feb 2027 (estimated)
- First posted
- 16 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise
. However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- The proposed study is a randomised, double blind, placebo controlled, parallel-group study
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Dietary Supplement: InterventionVitamin C and Non-steroidal anti-inflammatory drug |
| Control | Placebo comparator | Dietary Supplement: ControlIdentical Placebo |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- 18 - 45 years of age
- BMI 18.5 - 29.9 kg/m2
- Able to perform 20-minutes of bench stepping exercise
- Capable and willing to provide consent (oral and written)
Key exclusion criteria (4 listed)
- Familiarised with bench stepping exercise procedures
- Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
- Participants exhibiting any alteration in clinical inflammation parameters due to other cause
- Participants currently being prescribed any anti-inflammatory medications
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ControlIdentical maltodextrin tablet. Appearance and weight matched | Dietary supplement | Control |
| Intervention1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h | Dietary supplement | Intervention |
Primary outcome
Muscle Function
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Jump height calculated through flight time
4 secondary outcomes
Muscle Function
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Muscle Function
Time frame: Baseline and post exercise (2 hours, 1 day, 7 day)
Creatine Kinase
Time frame: Baseline and immediately, 1-h (hour)-, 2-h-, 24-h-,and 48-hours-post-exercise
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Mar 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intervention in people with Exercise Recovery, run by University of Bath at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Function (time frame: Baseline and post exercise (2 hours, 1 day, 7 day)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Mar 2026.