Knee OsteoarthritisNCT07484594
Integrated Trunk Stabilization With Osteoarthritis Rehabilitation in Knee-Spine Syndrome
A study testing Trunk Stabilization exercises with conventional Rehab and Conventional Rehabilitation in people with Knee Osteoarthritis, run by Riphah International University at 2 sites in Pakistan.
Trial summary
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis Read more about this study
- Who is it for?
- Ages 40 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Trunk Stabilization exercises with conventional Rehab and Conventional Rehabilitation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 2 sitesPakistan
- Study dates
- 11 May 2026to 15 Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 40-60 years
- Both Genders
- Bilateral Knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system
- Kellgren \& Lawrence grade 2 and 3 with complaint of pain, crepitations, stiffness and bony enlargement
- History of backpain for the past 3 months with no complaint of radiating pain
- Able to walk independently/unaided
Who cannot join
- Kellgren \& Lawrence grade 4
- Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the previous 6 months.
- History of lower limb or lumbar trauma/surgery, presence of fracture or deformity, or planned surgery within the study period
- Lumbar pathologies, for example, spondylolisthesis, ankylosing spondylitis, or any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease or impairment except lumbar spondylosis
- BMI>30
- Presence of infection, cauda equina syndrome, or meningitis
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan2 sites, 2 recruiting
- Recruiting
Bahria Active Hospital
Islamabad, AL, 44000
Suman Sheraz, PhD, 03335646361, suman.sheraz@riphah.edu.pk
Imran Amjad, MSPT, 03324390125, imran.amjad@riphah.edu.pk
- Not yet recruiting
Bahria Active
Rawalpindi
Suman Sheraz, PhD, 03335646361 ext. 03335646361, suman.sheraz@riphah.edu.pk
Imran Amjad, PhD, 03324390125, imran.amjad@riphah.edu.pk
About this study
Official title: Integrating Trunk Stabilization Exercises With Conventional Rehabilitation Protocol for Osteoarthritis in Patients With Knee-Spine Syndrome
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis
Read the detailed description
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation protocols for patients with knee-spine syndrome. It seeks to determine whether improving trunk stability can positively influence knee joint mechanics, leading to a reduction in knee pain and improvements in physical function, mobility, and overall functional performance in individuals with knee osteoarthritis. The findings may support a more comprehensive rehabilitation approach addressing both spinal and knee involvement in osteoarthritis management.
- Conditions
- Knee Osteoarthritis
- Being tested
- Trunk Stabilization exercises with conventional Rehab, Conventional Rehabilitation
- Keywords
- Knee Osteoarthritis, Knee-Spine Syndrome, Trunk Exercise
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Trunk Stabilization exercises with conventional RehabOther
The protocol for will be followed for 6 weeks, where individuals will perform trunk stabilization exercises with conventional rehabilitation for knee osteoarthritis.
Conventional RehabilitationOther
The protocol for will be followed for 6 weeks, where conventional rehabilitation for knee osteoarthritis will be implemented.
| Study group | Role | What they receive |
|---|---|---|
| Trunk Stabilization exercises with conventional Rehab | Experimental | The intervention will include the conventional knee osteoarthritis rehabilitation protocol comprising mobilization, stretching, and strengthening exercises, along with the following trunk stabilization exercises performed for 6 repetition followed by 30 second rest :
1. Prone extension
2. Back bridge
3. Unilateral back bridge
4. Sideways step-up
5. Bird dog Receives: Other: Trunk Stabilization exercises with conventional Rehab |
| Conventional Rehabilitation | Other | The conventional rehabilitation protocol for knee osteoarthritis included Maitland's mobilization performed at a rate of 2-3 oscillations per second for 2 minutes, followed by stretching exercises held for 30 seconds across three sets. Muscle strengthening exercises were also incorporated, consisting of 10 repetitions with a 15-second hold, performed over four sets. Receives: Other: Conventional Rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analogue Scale
The Visual Analog Scale (VAS) is a simple and reliable tool for assessing pain intensity on a continuous visual scale. The extreme limits of pain are represented by the straight line's ends, where 0 indicates no pain, and 10 indicates the worst pain a person has ever felt.
Measured: 6 weeks
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
It is widely used in the evaluation of knee osteoarthritis to assess activities of daily living, functional mobility, gait, general health, and quality of life. It has 24 items divided into 3 subscales: pain (5 items), stiffness (2 items), and physical function (17 items). The scores range from 0 to 4 for each subscale. The score ranges from 0 to 96, where zero indicates no pain, stiffness, and functional limitation. Higher scores indicate worse pain, stiffness, and functional limitation.
Measured: 6 weeks
Secondary outcomes (4)
Range Of motion (ROM)
A Goniometer is used to measure active and passive ROM for knee flexion and extension while the patient lies supine
Measured: 6 weeks
Time-Up-and-Go (TUG)
This test is a widely used assessment of functional mobility, particularly in patients with knee osteoarthritis. The test measures the total time it takes for a patient to stand up from a chair, walk 3 meters at a comfortable pace, turn around, walk back to the chair, and sit down. A shorter time indicates better functional performance
Measured: 6 weeks
Oswestry Disability Index (ODI)
It is a questionnaire that gives a subjective percentage score of level of function/disability in activities of daily living of patients with low back pain. It contains 10 items, each scored from 0 to 5, with the total score converted to a percentage ranging from 0% to 100%. Higher percentages indicate greater disability, i.e., worse outcomes, while lower percentages indicate less disability/better outcomes.
Measured: 6 weeks
Flexicurve (Lumbar Range of motion)
Flexicurve is a flexible plastic-coated metal ruler molded to the lumbar spine's sagittal contour (typically T12 to S1) to non-invasively measure lordosis angle via traced perpendicular heights, serving as a radiation-free alternative to X-rays
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2026
- Study start11 May 2026
- Primary completion15 Sep 2026 (estimated)
- Study completion15 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Suman Sheraz, PhD, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07484594
- Sponsor's protocol ID
- Tooba Rauf
- Status last verified
- Jul 2026
- First submitted
- 16 Mar 2026
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Integrating Trunk Stabilization Exercises With Conventional Rehabilitation Protocol for Osteoarthritis in Patients With Knee-Spine Syndrome
- ClinicalTrials.gov ID
- NCT07484594
- Acronym / sponsor ID
- Tooba Rauf
- Conditions
- Knee Osteoarthritis
- Keywords
- Knee Osteoarthritis, Knee-Spine Syndrome, Trunk Exercise
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 11 May 2026 (actual)
- Primary completion
- 15 Sep 2026 (estimated)
- Study completion
- 15 Oct 2026 (estimated)
- First posted
- 20 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis
Detailed description
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation protocols for patients with knee-spine syndrome. It seeks to determine whether improving trunk stability can positively influence knee joint mechanics, leading to a reduction in knee pain and improvements in physical function, mobility, and overall functional performance in individuals with knee osteoarthritis. The findings may support a more comprehensive rehabilitation approach addressing both spinal and knee involvement in osteoarthritis management.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Trunk Stabilization exercises with conventional Rehab | Experimental | Other: Trunk Stabilization exercises with conventional RehabThe intervention will include the conventional knee osteoarthritis rehabilitation protocol comprising mobilization, stretching, and strengthening exercises, along with the following trunk stabilization exercises performed for 6 repetition followed by 30 second rest : 1. Prone extension 2. Back bridge 3. Unilateral back bridge 4. Sideways step-up 5. Bird dog |
| Conventional Rehabilitation | Other | Other: Conventional RehabilitationThe conventional rehabilitation protocol for knee osteoarthritis included Maitland's mobilization performed at a rate of 2-3 oscillations per second for 2 minutes, followed by stretching exercises held for 30 seconds across three sets. Muscle strengthening exercises were also incorporated, consisting of 10 repetitions with a 15-second hold, performed over four sets. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Age 40-60 years
- Both Genders
- Bilateral Knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system
- Kellgren \& Lawrence grade 2 and 3 with complaint of pain, crepitations, stiffness and bony enlargement
- History of backpain for the past 3 months with no complaint of radiating pain
Key exclusion criteria (6 listed)
- Kellgren \& Lawrence grade 4
- Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the previous 6 months.
- History of lower limb or lumbar trauma/surgery, presence of fracture or deformity, or planned surgery within the study period
- Lumbar pathologies, for example, spondylolisthesis, ankylosing spondylitis, or any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease or impairment except lumbar spondylosis
- BMI>30
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Trunk Stabilization exercises with conventional RehabThe protocol for will be followed for 6 weeks, where individuals will perform trunk stabilization exercises with conventional rehabilitation for knee osteoarthritis. | Other | Trunk Stabilization exercises with conventional Rehab |
| Conventional RehabilitationThe protocol for will be followed for 6 weeks, where conventional rehabilitation for knee osteoarthritis will be implemented. | Other | Conventional Rehabilitation |
Primary outcome
Visual Analogue Scale
Time frame: 6 weeks
The Visual Analog Scale (VAS) is a simple and reliable tool for assessing pain intensity on a continuous visual scale. The extreme limits of pain are represented by the straight line's ends, where 0 indicates no pain, and 10 indicates the worst pain a person has ever felt.
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
Time frame: 6 weeks
It is widely used in the evaluation of knee osteoarthritis to assess activities of daily living, functional mobility, gait, general health, and quality of life. It has 24 items divided into 3 subscales: pain (5 items), stiffness (2 items), and physical function (17 items). The scores range from 0 to 4 for each subscale. The score ranges from 0 to 96, where zero indicates no pain, stiffness, and functional limitation. Higher scores indicate worse pain, stiffness, and functional limitation.
4 secondary outcomes
Range Of motion (ROM)
Time frame: 6 weeks
Time-Up-and-Go (TUG)
Time frame: 6 weeks
Oswestry Disability Index (ODI)
Time frame: 6 weeks
Flexicurve (Lumbar Range of motion)
Time frame: 6 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Knee Osteoarthritis
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Single vs Triple Hyaluronic Acid in Knee Osteoarthritis
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The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Suman Sheraz, PhD principal investigator
Riphah International University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Trunk Stabilization exercises with conventional Rehab and Conventional Rehabilitation in people with Knee Osteoarthritis, run by Riphah International University at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Suman Sheraz, PhD (03335646361 ext. 03335646361, suman.sheraz@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analogue Scale (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.