StrokeNCT07494890
Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment
A study testing Resisted walking in people with Stroke, run by University of Cincinnati at 1 site in United States.
Trial summary
Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence. The goal of this cross-sectional study is to determine the measurement properties of a novel biomechanical cost of walking measure in chronic stroke capable of pinpointing… Read more about this study
- Who is it for?
- Ages 30 to 80 years
- Conditions the study is for
- Stroke
- What is being tested?
- Resisted walking
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteUnited States
- Study dates
- 25 Jun 2026to 1 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 30-80 years at the time of consent
- Hemiparesis from ischemic and/or hemorrhagic strokes
- Most recent stroke for which participant sought treatment, at least 3 months prior to study consent
- Walking speed <1.0 m/s on the 10-meter walk test
- Able to walk 10m over ground with assistive devices as needed
- Able to walk at least 5 minutes continuously on the treadmill ≥ 0.1 mile per hour
- No contraindications to exercise according to ACSM guidelines
- Able to communicate with investigators, follow a 2-step command and correctly answer consent comprehension questions
Who cannot join
- Hospitalization for cardiac or pulmonary disease within past 3 months
- Implanted pacemaker or defibrillator
- Severe lower limb hypertonia (Ashworth >2)
- Foot drop or lower limb joint instability without adequate stabilizing device
- Clinically significant neurologic disorder other than stroke
- Other significant medical condition likely to jeopardize safety (e.g. joint contracture, gait limited by pain)
- Pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Cincinnati - Digital Futures
Cincinnati, Ohio, 45206
Christina Garrity, DPT, (513) 558-7499, garritca@mail.uc.edu
About this study
Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence. The goal of this cross-sectional study is to determine the measurement properties of a novel biomechanical cost of walking measure in chronic stroke capable of pinpointing the origins of movement inefficiencies. This research aims to:
- determine the convergent validity of biomechanical cost of walking with functional measures in relation to metabolic cost of walking,
- determine the reliability of biomechanical cost of walking in relation to metabolic cost of walking,
- determine the responsiveness of biomechanical cost of walking in relation to metabolic cost of walking.
Individuals with walking impairment from stroke will complete three 5-minute comfortable speed treadmill walking trials. The 3rd walking trial will be against resistance to increase cost of walking. This single session study will compare the metric properties of biomechanical cost of walking in relation to metabolic cost of walking.
- Conditions
- Stroke
- Being tested
- Resisted walking
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resisted walkingBehavioural
Comfortable speed treadmill walking with resisted forward progression.
| Study group | Role | What they receive |
|---|---|---|
| Treadmill walking with and without resistance | Experimental | Not described Receives: Behavioral: Resisted walking |
What is being measured
The primary outcome is the main question the study is designed to answer.
Constituent Lower Extremity Work
Energy expenditure calculated using biomechanical variables such as force and limb motion
Measured: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.
Metabolic Cost of Walking
Energy expenditure calculated using oxygen consumption and carbon dioxide production
Measured: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2026
- Study start25 Jun 2026
- Primary completion1 Mar 2027 (estimated)
- Study completion1 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by University of CincinnatiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 18 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Cincinnati
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Christina Garrity, University of Cincinnati
- Investigators
- Christina Garrity, DPT, Principal investigator, University of Cincinnati
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07494890
- Sponsor's protocol ID
- 2024-0863-03
- Status last verified
- Mar 2026
- First submitted
- 20 Mar 2026
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment
- ClinicalTrials.gov ID
- NCT07494890
- Acronym / sponsor ID
- 2024-0863-03
- Conditions
- Stroke
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 18 participants (estimated)
- Lead sponsor
- University of CincinnatiUniversity, hospital or other
- Study start
- 25 Jun 2026 (actual)
- Primary completion
- 1 Mar 2027 (estimated)
- Study completion
- 1 Mar 2027 (estimated)
- First posted
- 27 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence. The goal of this cross-sectional study is to determine the measurement properties of a novel biomechanical cost of walking measure in chronic stroke capable of pinpointing the origins of movement inefficiencies. This research aims to:
- determine the convergent validity of biomechanical cost of walking with functional measures in relation to metabolic cost of walking,
- determine the reliability of biomechanical cost of walking in relation to metabolic cost of walking,
- determine the responsiveness of biomechanical cost of walking in relation to metabolic cost of walking.
Individuals with walking impairment from stroke will complete three 5-minute comfortable speed treadmill walking trials. The 3rd walking trial will be against resistance to increase cost of walking. This single session study will compare the metric properties of biomechanical cost of walking in relation to metabolic cost of walking.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Treadmill walking with and without resistance | Experimental | Behavioral: Resisted walking |
Who may qualify
- Ages
- 30 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age 30-80 years at the time of consent
- Hemiparesis from ischemic and/or hemorrhagic strokes
- Most recent stroke for which participant sought treatment, at least 3 months prior to study consent
- Walking speed <1.0 m/s on the 10-meter walk test
- Able to walk 10m over ground with assistive devices as needed
Key exclusion criteria (7 listed)
- Hospitalization for cardiac or pulmonary disease within past 3 months
- Implanted pacemaker or defibrillator
- Severe lower limb hypertonia (Ashworth >2)
- Foot drop or lower limb joint instability without adequate stabilizing device
- Clinically significant neurologic disorder other than stroke
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resisted walkingComfortable speed treadmill walking with resisted forward progression. | Behavioural | Treadmill walking with and without resistance |
Primary outcome
Constituent Lower Extremity Work
Time frame: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.
Energy expenditure calculated using biomechanical variables such as force and limb motion
Metabolic Cost of Walking
Time frame: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.
Energy expenditure calculated using oxygen consumption and carbon dioxide production
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Christina Garrity, DPT principal investigator
University of Cincinnati
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resisted walking in people with Stroke, run by University of Cincinnati at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Christina Garrity, DPT ((513) 558-7499, garritca@mail.uc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Constituent Lower Extremity Work (time frame: 1st minute and 5th minute of resisted walking trial versus non-resisted walking trial.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026; AzTrials last refreshed its copy on 8 Nov 2026.