PainNCT07505992
Acupressure for Pain, Injection Fear, and Satisfaction in Intramuscular Injection Patients
A study testing acupressure in people with Pain and Satisfaction, run by Istanbul University - Cerrahpasa at 1 site in Cyprus.
Trial summary
Background: Intramuscular (IM) injection-related pain and anxiety continue to be common problems in nursing practice. Non-pharmacological interventions such as acupressure are increasingly recognized for their potential to reduce procedure-related discomfort and enhance patient satisfaction. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Pain, Satisfaction, Fear
- What is being tested?
- acupressure
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteCyprus
- Study dates
- 15 Nov 2024to 20 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Were aged 18 years or older,
- Possessed sufficient physical and cognitive abilities to assess pain using the VAS,
- Had the ability to read and comprehend study instructions,
- Were newly prescribed IM Diclofenac Sodium (without prior doses),
- Had a body mass index within the normal or obese range ac- cording to WHO classification,
- Had no scars, wounds,
Who cannot join
- Patients who had taken any analgesic medications on the day of injection were excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Acupressure Therapy on Pain, Injection Fear, and Post-Injection Satisfaction in Patients Undergoing Intramuscular Injection: A Randomized Controlled Trial
Background: Intramuscular (IM) injection-related pain and anxiety continue to be common problems in nursing practice. Non-pharmacological interventions such as acupressure are increasingly recognized for their potential to reduce procedure-related discomfort and enhance patient satisfaction.
Aim: This study is planned to evaluate the effects of acupressure therapy on pain, injection-related fear, and post-injection satisfaction among patients receiving IM injections.
Methods: This study is designed as a randomized controlled trial to be conducted with 68 patients presenting to the emergency department and requiring IM diclofenac sodium injection. Participants will be randomly assigned to either an intervention group (n = 34), which will receive acupressure at the GB30 (Huantiao) point prior to injection, or a control group (n = 34), which will receive standard care. Data will be collected using the Visual Analog Scale, Injection Fear Scale, and Post-Injection Satisfaction Scale.
Read the detailed description
Intramuscular (IM) injections are among the most frequently performed parenteral medication administration methods by nurses worldwide, with billions of injections administered each year ( World Health Organization [WHO]). Despite their widespread use, IM injections continue to represent a significant source of pain, fear, and discomfort for patients. Injection-related pain is not limited to transient physical discomfort; it may also contribute to the development of injection fear, anxiety, and avoidance of future medical procedures. Pain is a universal human experience; however, its perception and expression vary across individuals. Furthermore, preinjection anxiety and fear significantly influence the pain experience. The act of needle penetration itself may trigger anxiety and, in some cases, lead to persistent fear of future injections. This fear can result in patients delaying or refusing injections, potentially compromising treat- ment adherence and recovery. Injection fear may lead individuals to avoid healthcare services, reduce adherence to prescribed treatments, and cause delays in care processes. These consequences are in direct conflict with the fundamental principles of patient-centered and evidence-based nursing care. Furthermore, pain and fear experienced during injections can negatively affect patient satisfaction, thereby reducing the perceived quality of care. Therefore, nurses are expected to apply evidence-based, patient-centered interventions during medication administration to reduce pain and improve patient outcomes. Several techniques have been recommended in the literature to minimize pain associated with IM injections, including correct injection site selection, appropriate patient positioning, slow drug administration, use of the Z-track technique, air- lock technique, distraction strategies, and complementary therapies. However, current evidence predominantly addresses pain intensity, while injection-related fear and postinjection satisfaction, which are key indicators of patient experience, remain under explored. Acupressure is a noninvasive technique that involves apply- ing pressure to specific points on the body using the fingers to alleviate or prevent pain. It is a low-cost and easily applicable complementary intervention that has been shown to be effective in pain management across various clinical contexts. In acupressure therapy, it is assumed that vital energy, referred to as Chi , flows throughout the body along energy channels known as meridians, which are named according to internal organs. Pressure applied to specific points along these meridians is believed to reduce tension and muscle stiffness in various parts of the body, enhance endorphin release, and modulate pain trans- mission pathways, thereby decreasing pain perception. However, there is a notable lack of studies comprehensively examining the effects of acupressure therapy on IM injection-related pain, injection fear, and postinjection satisfaction. The American Society for Pain Management Nursing emphasizes the importance of tailored, effective interventions for pain, anxiety, and fear management before, during, and after invasive procedures to enhance patient satisfaction. In this context, acupressure therapy represents a promising intervention for reducing pain perception during IM injections, alleviating injection-related fear, and ultimately enhancing postinjection satisfaction. To the best of our knowledge, no randomized con- trolled study has simultaneously examined the effects of acupressure on pain, injection-related fear, and postinjection satisfaction in patients receiving IM injections. Although various techniques have been explored to manage IM injection-related discomfort, the number of studies evaluating the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction remains limited. Addressing this gap is critically important to support nurses in delivering evidence-based, holistic, and patient-centered care during IM injection practices. Therefore, this randomized controlled study was conducted to comprehensively evaluate the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction in patients undergoing IM injections.
- Conditions
- Pain, Satisfaction, Fear
- Being tested
- acupressure
- Medical subject headings
- Pain, Personal Satisfaction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
acupressureOther
Acupressure was applied to the GB30 point, which is anatomically located at the junction of the lateral one- third and medial two-thirds of the distance between the greater trochanter of the femur and the sacral hiatus. Pressure was applied using the thumb at an intensity sufficient to produce slight skin blanching without causing pain, consistent with previously published acupressure protocols. The pressure was applied continuously for 1 minute immediately prior to the IM injection. To ensure consistency and standardization, all acupressure applications were performed by the same researcher following a predefined protocol. Participants in the control group received routine IM injection care without acupressure intervention.
| Study group | Role | What they receive |
|---|---|---|
| acupressure group | Experimental | acupressure Receives: Other: acupressure |
| Control group | No intervention | Standard injection procedure was performed. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analog Scale
There is a significant difference in visual analog scale pain scores between patients in the acupressure group and those in the control group. 1 represents the lowest level of pain, and 10 represents the highest level of pain. As the number increases, the intensity of the pain also increases.
Measured: 1 day
Fear Scale
There is a significant difference in injection fear scale scores between patients in the acupressure group and those in the control group. The scale is calculated based on the average item score. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of fear increases.
Measured: 1 day
postinjection satisfaction scale
There is a significant difference in postinjection satisfaction scale scores between patients in the acupressure group and those in the control group. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of satisfaction increases. The Post-Injection Satisfaction Scale consists of 9 items.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Apr 2026
- Study start15 Nov 2024
- Primary completion20 Feb 2025
- Study completion20 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PainStudies of the same condition, open and under way.
- More trials run by Istanbul University - CerrahpasaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul University - Cerrahpasa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Seda CEVHEROĞLU, Istanbul University - Cerrahpasa
- Investigators
- Seda C Cevheroglu, Assit. Prof, Study director, Eastern Mediterranean University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07505992
- Sponsor's protocol ID
- Doğu Akdeniz Üniversitesi
- Status last verified
- Apr 2026
- First submitted
- 24 Mar 2026
- Last updated
- 7 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Acupressure Therapy on Pain, Injection Fear, and Post-Injection Satisfaction in Patients Undergoing Intramuscular Injection: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07505992
- Acronym / sponsor ID
- Doğu Akdeniz Üniversitesi
- Conditions
- Pain, Satisfaction, Fear
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Istanbul University - CerrahpasaUniversity, hospital or other
- Study start
- 15 Nov 2024 (actual)
- Primary completion
- 20 Feb 2025 (actual)
- Study completion
- 20 Feb 2025 (actual)
- First posted
- 1 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background: Intramuscular (IM) injection-related pain and anxiety continue to be common problems in nursing practice. Non-pharmacological interventions such as acupressure are increasingly recognized for their potential to reduce procedure-related discomfort and enhance patient satisfaction.
Aim: This study is planned to evaluate the effects of acupressure therapy on pain, injection-related fear, and post-injection satisfaction among patients receiving IM injections.
Methods: This study is designed as a randomized controlled trial to be conducted with 68 patients presenting to the emergency department and requiring IM diclofenac sodium injection. Participants will be randomly assigned to either an intervention group (n = 34), which will receive acupressure at the GB30 (Huantiao) point prior to injection, or a control group (n = 34), which will receive standard care. Data will be collected using the Visual Analog Scale, Injection Fear Scale, and Post-Injection Satisfaction Scale.
Detailed description
Intramuscular (IM) injections are among the most frequently performed parenteral medication administration methods by nurses worldwide, with billions of injections administered each year ( World Health Organization [WHO]). Despite their widespread use, IM injections continue to represent a significant source of pain, fear, and discomfort for patients. Injection-related pain is not limited to transient physical discomfort; it may also contribute to the development of injection fear, anxiety, and avoidance of future medical procedures. Pain is a universal human experience; however, its perception and expression vary across individuals. Furthermore, preinjection anxiety and fear significantly influence the pain experience. The act of needle penetration itself may trigger anxiety and, in some cases, lead to persistent fear of future injections. This fear can result in patients delaying or refusing injections, potentially compromising treat- ment adherence and recovery. Injection fear may lead individuals to avoid healthcare services, reduce adherence to prescribed treatments, and cause delays in care processes. These consequences are in direct conflict with the fundamental principles of patient-centered and evidence-based nursing care. Furthermore, pain and fear experienced during injections can negatively affect patient satisfaction, thereby reducing the perceived quality of care. Therefore, nurses are expected to apply evidence-based, patient-centered interventions during medication administration to reduce pain and improve patient outcomes. Several techniques have been recommended in the literature to minimize pain associated with IM injections, including correct injection site selection, appropriate patient positioning, slow drug administration, use of the Z-track technique, air- lock technique, distraction strategies, and complementary therapies. However, current evidence predominantly addresses pain intensity, while injection-related fear and postinjection satisfaction, which are key indicators of patient experience, remain under explored. Acupressure is a noninvasive technique that involves apply- ing pressure to specific points on the body using the fingers to alleviate or prevent pain. It is a low-cost and easily applicable complementary intervention that has been shown to be effective in pain management across various clinical contexts. In acupressure therapy, it is assumed that vital energy, referred to as Chi , flows throughout the body along energy channels known as meridians, which are named according to internal organs. Pressure applied to specific points along these meridians is believed to reduce tension and muscle stiffness in various parts of the body, enhance endorphin release, and modulate pain trans- mission pathways, thereby decreasing pain perception. However, there is a notable lack of studies comprehensively examining the effects of acupressure therapy on IM injection-related pain, injection fear, and postinjection satisfaction. The American Society for Pain Management Nursing emphasizes the importance of tailored, effective interventions for pain, anxiety, and fear management before, during, and after invasive procedures to enhance patient satisfaction. In this context, acupressure therapy represents a promising intervention for reducing pain perception during IM injections, alleviating injection-related fear, and ultimately enhancing postinjection satisfaction. To the best of our knowledge, no randomized con- trolled study has simultaneously examined the effects of acupressure on pain, injection-related fear, and postinjection satisfaction in patients receiving IM injections. Although various techniques have been explored to manage IM injection-related discomfort, the number of studies evaluating the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction remains limited. Addressing this gap is critically important to support nurses in delivering evidence-based, holistic, and patient-centered care during IM injection practices. Therefore, this randomized controlled study was conducted to comprehensively evaluate the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction in patients undergoing IM injections.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| acupressure group | Experimental | Other: acupressureacupressure |
| Control group | No intervention | –Standard injection procedure was performed. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Were aged 18 years or older,
- Possessed sufficient physical and cognitive abilities to assess pain using the VAS,
- Had the ability to read and comprehend study instructions,
- Were newly prescribed IM Diclofenac Sodium (without prior doses),
- Had a body mass index within the normal or obese range ac- cording to WHO classification,
Key exclusion criteria (1 listed)
- Patients who had taken any analgesic medications on the day of injection were excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| acupressureAcupressure was applied to the GB30 point, which is anatomically located at the junction of the lateral one- third and medial two-thirds of the distance between the greater trochanter of the femur and the sacral hiatus. Pressure was applied using the thumb at an intensity sufficient to produce slight skin blanching without causing pain, consistent with previously published acupressure protocols. The pressure was applied continuously for 1 minute immediately prior to the IM injection. To ensure consistency and standardization, all acupressure applications were performed by the same researcher following a predefined protocol. Participants in the control group received routine IM injection care without acupressure intervention. | Other | acupressure group |
Primary outcome
Visual Analog Scale
Time frame: 1 day
There is a significant difference in visual analog scale pain scores between patients in the acupressure group and those in the control group. 1 represents the lowest level of pain, and 10 represents the highest level of pain. As the number increases, the intensity of the pain also increases.
Fear Scale
Time frame: 1 day
There is a significant difference in injection fear scale scores between patients in the acupressure group and those in the control group. The scale is calculated based on the average item score. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of fear increases.
postinjection satisfaction scale
Time frame: 1 day
There is a significant difference in postinjection satisfaction scale scores between patients in the acupressure group and those in the control group. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of satisfaction increases. The Post-Injection Satisfaction Scale consists of 9 items.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Seda C Cevheroglu, Assit. Prof study director
Eastern Mediterranean University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing acupressure in people with Pain and Satisfaction, run by Istanbul University - Cerrahpasa at 1 site in Cyprus.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Cyprus. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analog Scale (time frame: 1 day). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Apr 2026.