PRFT-PRFNCT07506252
Influence of Hydration Status on the Yield of Injectable Platelet-Rich Fibrin
A study testing Hydration following a drinking protocol in people with PRF and Behavior Change Interventions, run by Medical University of Graz at 1 site in Austria.
Trial summary
Due to the current lack of evidence regarding the influence of fluid intake on the amount of leukocyte- and platelet-rich fibrin fraction present in blood samples, this study aims to investigate the positive influence of this factor on the body's own matrix. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- PRF, Behavior Change Interventions, Implant Dentistry
- What is being tested?
- Hydration following a drinking protocol
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteAustria
- Study dates
- 12 Dec 2022to 19 May 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy adults
Who cannot join
- coagulation disorders
- anticoagulant medication
- pregnancy
- acute infections
- systemic diseases with the potential to affect wound healing or blood composition
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Influence of the Drinking Amount on the Autologous Blood in the Centrifuge Contained Fibrin Matrix - Platelet-rich Fibrin A Randomized Controlled Pilot Study
Due to the current lack of evidence regarding the influence of fluid intake on the amount of leukocyte- and platelet-rich fibrin fraction present in blood samples, this study aims to investigate the positive influence of this factor on the body's own matrix.
Platelet-rich fibrin, a fibrin-rich autologous matrix obtained from autologous blood via centrifugation, contains not only fibrin but also important growth factors and a large number of white blood cells, all of which make a significant contribution to tissue regeneration. The obtained fibrin matrix can be used as a membrane, as a clot (A-PRF), or as a liquid (i-PRF) to positively influence the healing process.
The novelty of this work lies in shifting the focus from purely technical centrifugation parameters to a patient-centered, easily modifiable biological variable. Hydration status represents a low-cost, non-invasive, and immediately applicable strategy to optimize autologous blood concentrates. These findings are directly relevant to clinicians seeking to enhance the predictability and efficiency of PRF-based regenerative procedures in implant dentistry.
- Conditions
- PRF, Behavior Change Interventions, Implant Dentistry
- Being tested
- Hydration following a drinking protocol
- Keywords
- PRF, Hydration, implant dentistry, regenerative dentistry
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hydration following a drinking protocolBehavioural
Participants followed a drinking protocol the day before the measurement to reach euhydration
| Study group | Role | What they receive |
|---|---|---|
| Hydration | Experimental | Drinking protocol to reach euhydration Receives: Behavioral: Hydration following a drinking protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
PRF-Volume
Volume (ml) of i-PRF obtained from each 10 ml blood sample with low speed centrifugation
Measured: 3 visits, 3 weeks
Secondary outcomes (2)
PRF yield and height
Correlation of PRF yield in ml and height in cm
Measured: 3 visits, 3 weeks
PRF yield and weight
Correlation of PRF yield in ml and weight in kg
Measured: 3 visits, 3 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Apr 2026
- Study start12 Dec 2022
- Primary completion19 May 2023
- Study completion19 May 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for PRFStudies of the same condition, open and under way.
- More trials run by Medical University of GrazThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Sequential
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medical University of Graz
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07506252
- Sponsor's protocol ID
- 34-508 ex 21/22
- Acronym
- T-PRF
- Status last verified
- Mar 2026
- First submitted
- 17 Mar 2026
- Last updated
- 1 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Data will be shared upon reasonable request. Data sheets containing anonymized measurements, sorted by outcome variable, can be shared. To request this, please contact us via email and explain your reason for wanting the data. The data will be shared personally; no public link will be provided.
Publications
Verboket RD, Anbar B, Sohling N, Kontradowitz K, Marzi I, Ghanaati S, Henrich D. Changes in platelet-rich fibrin composition after trauma and surgical intervention. Platelets. 2020 Nov 16;31(8):1069-1079. doi: 10.1080/09537104.2020.1714575. Epub 2020 Jan 23.
PubMed 31971046Hauser F, Gaydarov N, Badoud I, Vazquez L, Bernard JP, Ammann P. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study. Implant Dent. 2013 Jun;22(3):295-303. doi: 10.1097/ID.0b013e3182906eb3.
PubMed 23644909
Study at a glance
From the registry record, last updated by the sponsor on 1 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of the Drinking Amount on the Autologous Blood in the Centrifuge Contained Fibrin Matrix - Platelet-rich Fibrin A Randomized Controlled Pilot Study
- ClinicalTrials.gov ID
- NCT07506252
- Acronym / sponsor ID
- T-PRF / 34-508 ex 21/22
- Conditions
- PRF, Behavior Change Interventions, Implant Dentistry
- Keywords
- PRF, Hydration, implant dentistry, regenerative dentistry
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Medical University of GrazUniversity, hospital or other
- Study start
- 12 Dec 2022 (actual)
- Primary completion
- 19 May 2023 (actual)
- Study completion
- 19 May 2023 (actual)
- First posted
- 1 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Due to the current lack of evidence regarding the influence of fluid intake on the amount of leukocyte- and platelet-rich fibrin fraction present in blood samples, this study aims to investigate the positive influence of this factor on the body's own matrix.
Platelet-rich fibrin, a fibrin-rich autologous matrix obtained from autologous blood via centrifugation, contains not only fibrin but also important growth factors and a large number of white blood cells, all of which make a significant contribution to tissue regeneration. The obtained fibrin matrix can be used as a membrane, as a clot (A-PRF), or as a liquid (i-PRF) to positively influence the healing process.
The novelty of this work lies in shifting the focus from purely technical centrifugation parameters to a patient-centered, easily modifiable biological variable. Hydration status represents a low-cost, non-invasive, and immediately applicable strategy to optimize autologous blood concentrates. These findings are directly relevant to clinicians seeking to enhance the predictability and efficiency of PRF-based regenerative procedures in implant dentistry.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Hydration | Experimental | Behavioral: Hydration following a drinking protocolDrinking protocol to reach euhydration |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Healthy adults
Key exclusion criteria (5 listed)
- coagulation disorders
- anticoagulant medication
- pregnancy
- acute infections
- systemic diseases with the potential to affect wound healing or blood composition
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hydration following a drinking protocolParticipants followed a drinking protocol the day before the measurement to reach euhydration | Behavioural | Hydration |
Primary outcome
PRF-Volume
Time frame: 3 visits, 3 weeks
Volume (ml) of i-PRF obtained from each 10 ml blood sample with low speed centrifugation
2 secondary outcomes
PRF yield and height
Time frame: 3 visits, 3 weeks
PRF yield and weight
Time frame: 3 visits, 3 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Apr 2026.
- Background: PubMed 31971046Verboket RD, Anbar B, Sohling N, Kontradowitz K, Marzi I, Ghanaati S, Henrich D. Changes in platelet-rich fibrin composition after trauma and surgical intervention. Platelets. 2020 Nov 16;31(8):1069-1079. doi: 10.1080/09537104.2020.1714575. Epub 2020 Jan 23.
- Background: PubMed 23644909Hauser F, Gaydarov N, Badoud I, Vazquez L, Bernard JP, Ammann P. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study. Implant Dent. 2013 Jun;22(3):295-303. doi: 10.1097/ID.0b013e3182906eb3.
- Individual participant dataSharing planned: Undecided. Data will be shared upon reasonable request. Data sheets containing anonymized measurements, sorted by outcome variable, can be shared. To request this, please contact us via email and explain your reason for wanting the data. The data will be shared personally; no public link will be provided.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hydration following a drinking protocol in people with PRF and Behavior Change Interventions, run by Medical University of Graz at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
PRF-Volume (time frame: 3 visits, 3 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07506252, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Apr 2026.