Nocturnal EnuresisNCT07508111
Causes and Types of Nocturnal Enuresis in Children
An observational study of Nocturnal Enuresis and Nocturnal Enuresis in Children, run by Assiut University.
Trial summary
Nocturnal enuresis, commonly known as bedwetting, is a frequent condition that affects many children and can have a significant impact on their self-esteem, social life, and family stress. Read more about this study
- Who is it for?
- Ages 5 to 18 years
- Conditions the study is for
- Nocturnal Enuresis, Nocturnal Enuresis in Children, Primary Nocturnal Enuresis
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- May 2026to Jun 2027
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 18 years
- All sexes
- Child, Adult
Study population: The study population consists of male and female children aged 5 years and older who present with nocturnal enuresis at the pediatric outpatient clinics of Assiut University Children's Hospital in Assiut, Egypt. For the purpose of this study, nocturnal enuresis is defined as involuntary voiding during sleep occurring at least twice a week for a duration of at least three months. The target population includes patients presenting with both primary and secondary enuresis, as well as mono-symptomatic and poly-symptomatic forms. Children with known neurological disorders (such as epilepsy or cerebral palsy), diabetes mellitus, acute urinary tract infections requiring immediate treatment, or structural anomalies of the urinary system requiring immediate surgery are excluded from this population.
Who may be able to join
- Male and female children aged above 5 years.
- Presenting with nocturnal enuresis, defined as involuntary voiding during sleep for ≥2 nights/week for ≥3 months.
- Parents or caregivers providing informed consent, including child assent where applicable.
Who cannot join
- Children with known neurological disorders, such as epilepsy or cerebral palsy.
- Presence of an acute urinary tract infection (indicated by a positive urine culture requiring treatment).
- Children diagnosed with diabetes mellitus.
- Structural anomalies of the urinary system requiring immediate surgery, such as severe hypospadias.
- Families unwilling to participate or complete follow-up data collection.
About this study
Official title: A Descriptive Study on the Causes and Types of Nocturnal Enuresis Among Children Attending Assiut University Children's Hospital
Nocturnal enuresis, commonly known as bedwetting, is a frequent condition that affects many children and can have a significant impact on their self-esteem, social life, and family stress. The causes of bedwetting can vary widely, ranging from deep sleep patterns and excess nighttime urine production to underlying medical conditions like constipation, urinary tract infections, or enlarged tonsils and adenoids (which can affect breathing during sleep).The main goal of this descriptive study is to understand the different types and the underlying causes of bedwetting among children attending the pediatric outpatient clinics at Assiut University Children's Hospital. By identifying these specific causes in the local population, healthcare providers can offer better, more targeted treatments and help reduce the stigma surrounding this condition.
During a single clinic visit, researchers will collect information through a structured interview with the parents and the child. The study involves a routine physical examination, including checking weight, height, and looking for physical signs of constipation or enlarged tonsils. Participants will also undergo standard tests to help pinpoint any medical causes, such as a urine test (urinalysis and culture), a basic ultrasound of the abdomen and pelvis, and potentially plain X-rays if issues like severe constipation or airway blockages are suspected.
The study aims to include at least 80 male and female children aged 5 years and older who have been experiencing bedwetting at least twice a week for three months or more.
Read the detailed description
This research is a descriptive, cross-sectional study conducted at the pediatric outpatient clinics of Assiut University Hospital. It assesses a single cohort of children presenting with nocturnal enuresis at a specific point in time to determine the prevalence, types, and associated causes of their condition, without longitudinal follow-up or comparison against a pre-defined control group.
Data collection utilizes a structured checklist derived from clinical guidelines, administered by the principal investigator during a single clinic visit for each subject. The assessment includes the following components:
- Comprehensive History Taking: A semi-structured interview will classify the enuresis as primary or secondary, and mono-symptomatic or poly-symptomatic. The history will systematically evaluate potential contributing factors, including constipation (utilizing the Bristol Stool Scale and Rome IV criteria), history of urinary tract infections (UTIs), symptoms of adenotonsillar hypertrophy (e.g., mouth breathing, snoring, observed sleep apnea), dietary habits (caffeine and fluid intake patterns), current medications, and family history.
- Physical Examination: Subjects will undergo a targeted physical examination, including anthropometric measurements (weight, height, BMI percentiles). An oral examination will grade tonsil and adenoid size using the Brodsky scale. Further screening includes an abdominal examination for fecal loading or palpable masses, a genitourinary inspection, and screening for spinal malformations (e.g., inspecting the sacral area for dimples or hair tufts indicative of spina bifida occulta).
- Routine Investigations: All participants will undergo same-day routine laboratory and imaging investigations, including urinalysis, urine culture and sensitivity, and an abdominal/pelvic ultrasound.
- Conditional/Advanced Investigations: Depending on clinical indications and the presence of "red flags," additional diagnostics may be ordered. These include plain X-rays (KUB for constipation/stones or lateral neck X-rays for adenoidal-nasopharyngeal ratio), MRI of the spine or brain for suspected neurological anomalies, urodynamics for suspected bladder dysfunction or outlet obstruction, and polysomnography for suspected obstructive sleep apnea.
- Conditions
- Nocturnal Enuresis, Nocturnal Enuresis in Children, Primary Nocturnal Enuresis, Secondary Nocturnal Enuresis, Monosymptomatic Enuresis Nocturna, Polysymptomatic Enuresis
- Keywords
- Nocturnal Enuresis, Bedwetting, Urinary Incontinence, Pediatrics, Primary Enuresis, Secondary Enuresis, Monosymptomatic Enuresis
- Medical subject headings
- Nocturnal Enuresis, Urinary Incontinence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Children with Nocturnal Enuresis | Male and female children over 5 years of age presenting with nocturnal enuresis (involuntary voiding during sleep ≥2 nights/week for ≥3 months) at the pediatric outpatient clinics at Assiut University Hospital. This observational cohort will be evaluated via clinical history, physical examination, and routine laboratory and imaging investigations. The purpose is to determine the prevalence, types (primary vs. secondary, mono vs. polysymptomatic), and associated causes (e.g., constipation, UTI, adenotonsillar hypertrophy, malformations) of their condition. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percentage of Participants with Identified Medical Causes for Nocturnal Enuresis
The proportion of enrolled children diagnosed with underlying medical conditions contributing to nocturnal enuresis. This is determined through structured clinical history, physical examinations, and diagnostic investigations. Specific underlying factors evaluated include constipation (assessed using the Bristol Stool Scale and Rome IV criteria) , urinary tract infections (confirmed via urine culture) , and adenotonsillar hypertrophy (assessed using the Brodsky scale). The outcome will be reported as the percentage of the study cohort presenting with one or more of these identified medical conditions.
Measured: Up to 7 days from the initial clinic visit
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study startMay 2026 (estimated)
- Primary completionMay 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nocturnal EnuresisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mira Mounir Jawarji, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07508111
- Sponsor's protocol ID
- Nocturnal Enuresis Causes
- Status last verified
- Mar 2026
- First submitted
- 27 Mar 2026
- Last updated
- 2 Apr 2026
- Results posted
- No