LightNCT07517484
Light and Anesthesia
A study testing eye mask in people with Light and Anesthesia, run by Peking University People's Hospital at 1 site in China.
Trial summary
The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include: Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure… Read more about this study
- Who is it for?
- Ages 18 to 64 years
- Conditions the study is for
- Light, Anesthesia, Sedation
- What is being tested?
- eye mask
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 siteChina
- Study dates
- 3 Oct 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 64 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- a. Age between 18 and 65 years, regardless of gender;
- b. ASA physical status I-II;
- c. 18.5 ≤ BMI ≤ 28;
- d. Signed written informed consent.
Who cannot join
- a. Blindness or history of photosensitivity disorders;
- b. Patients requiring medication for sleep, or with a history of sleep disorders;
- c. Presence of neurological diseases;
- d. Pregnancy;
- e. Severe hepatic or renal dysfunction;
- f. History of anesthetic drug abuse or alcohol abuse;
- g. History of adverse anesthesia events (difficult airway, allergy to anesthetic agents).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Peking University People's Hospital
Beijing, 100044
Xiaoyan Li, 18810599681, 2411110461@bjmu.edu.cn
About this study
Official title: Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia
The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include:
Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia.
The following data will be recorded for all patients:
Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time
- Conditions
- Light, Anesthesia, Sedation
- Being tested
- eye mask
- Keywords
- light, anesthesia, sedation depth
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
eye maskDevice
Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.
| Study group | Role | What they receive |
|---|---|---|
| the light-shielded group | Experimental | Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia. Receives: Device: eye mask |
| the non-light-shielded group | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
The dose of sedative medications
The dose of sedative medications required during the induction period in patients
Measured: Perioperative
Secondary outcomes (3)
Induction time of anesthesia
Induction time of anesthesia
Measured: Perioperative
total dose of sedative medications
total dose of sedative medications required to maintain a certain range of anesthetic depth during surgery
Measured: during surgery
emergence time
emergence time after drug discontinuation
Measured: Perioperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start3 Oct 2025
- Primary completion30 Jun 2026 (estimated)
- Study completion30 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for LightStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Peking University People's Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yi Feng, MD, Peking University People's Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07517484
- Sponsor's protocol ID
- 2025-h018
- Status last verified
- Mar 2026
- First submitted
- 26 Mar 2026
- Last updated
- 29 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: To protect patient privacy and ensure the security of clinical data, the individual participant data (IPD) collected in this study will be used only for scientific analysis and publication related to this trial. No public disclosure, sharing, or uploading to public repositories is planned. Therefore, IPD will not be made available.
Publications
Boatright JH, Rubim NM, Iuvone PM. Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis Neurosci. 1994 Sep-Oct;11(5):1003-12. doi: 10.1017/s095252380000393x.
PubMed 7947393Szolnoki J, Polaner DM, Eckle T. Diurnal variations in recovery times after general anaesthesia in children. Br J Anaesth. 2018 Oct;121(4):776-786. doi: 10.1016/j.bja.2018.06.027. Epub 2018 Aug 10.
PubMed 30236240Shen JH, Ye M, Chen Q, Chen Y, Zhao HL, Khan A, Yi B, Ning JL, Lu KZ, Gu JT. Effects of circadian rhythm on Narcotrend index and target-controlled infusion concentration of propofol anesthesia. BMC Anesthesiol. 2021 Sep 6;21(1):215. doi: 10.1186/s12871-021-01445-z.
PubMed 34488646Wang D, Huang Y, Wang X, Chen X, Li J, Zhang S, Wu J, Liu D, Ma D, Mei W. Circadian differences in emergence from volatile anaesthesia in mice: involvement of the locus coeruleus noradrenergic system. Br J Anaesth. 2020 Oct;125(4):548-559. doi: 10.1016/j.bja.2020.07.012. Epub 2020 Aug 15.
PubMed 32807382Shao Y, Li Y, Wang N, Xue Y, Wang T, Qiu F, Lu Y, Lan D, Wu H. Effect of daily light exposure on sleep in polar regions: A meta-analysis. J Sleep Res. 2024 Oct;33(5):e14144. doi: 10.1111/jsr.14144. Epub 2024 Jan 22.
PubMed 38253963Ishizawa M, Uchiumi T, Takahata M, Yamaki M, Sato T. Effects of pre-bedtime blue-light exposure on ratio of deep sleep in healthy young men. Sleep Med. 2021 Aug;84:303-307. doi: 10.1016/j.sleep.2021.05.046. Epub 2021 Jun 8.
PubMed 34217920Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017 Mar 15;173:94-106. doi: 10.1016/j.lfs.2017.02.008. Epub 2017 Feb 16.
PubMed 28214594Barger LK, Sullivan JP, Lockley SW, Czeisler CA. Exposure to Short Wavelength-Enriched White Light and Exercise Improves Alertness and Performance in Operational NASA Flight Controllers Working Overnight Shifts. J Occup Environ Med. 2021 Feb 1;63(2):111-118. doi: 10.1097/JOM.0000000000002054.
PubMed 33065729Daurat A, Foret J, Benoit O, Mauco G. Bright light during nighttime: effects on the circadian regulation of alertness and performance. Biol Signals Recept. 2000 Nov-Dec;9(6):309-18. doi: 10.1159/000014654.
PubMed 11025337Dollish HK, Tsyglakova M, McClung CA. Circadian rhythms and mood disorders: Time to see the light. Neuron. 2024 Jan 3;112(1):25-40. doi: 10.1016/j.neuron.2023.09.023. Epub 2023 Oct 18.
PubMed 37858331LeGates TA, Fernandez DC, Hattar S. Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 2014 Jul;15(7):443-54. doi: 10.1038/nrn3743. Epub 2014 Jun 11.
PubMed 24917305Ramsey DJ, Ramsey KM, Vavvas DG. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov;28(5-6):406-21. doi: 10.3109/08820538.2013.825294. Epub 2013 Sep 6.
PubMed 24010846Jensen EW, Litvan H, Struys M, Martinez Vazquez P. Pitfalls and challenges when assessing the depth of hypnosis during general anaesthesia by clinical signs and electronic indices. Acta Anaesthesiol Scand. 2004 Nov;48(10):1260-7. doi: 10.1111/j.1399-6576.2004.00521.x.
PubMed 15504186Sear JW. Practical treatment recommendations for the safe use of anaesthetics. Drugs. 1992 Jan;43(1):54-68. doi: 10.2165/00003495-199243010-00006.
PubMed 1372860Shepherd J, Jones J, Frampton G, Bryant J, Baxter L, Cooper K. Clinical effectiveness and cost-effectiveness of depth of anaesthesia monitoring (E-Entropy, Bispectral Index and Narcotrend): a systematic review and economic evaluation. Health Technol Assess. 2013 Aug;17(34):1-264. doi: 10.3310/hta17340.
PubMed 23962378
Study at a glance
From the registry record, last updated by the sponsor on 29 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia
- ClinicalTrials.gov ID
- NCT07517484
- Acronym / sponsor ID
- 2025-h018
- Conditions
- Light, Anesthesia, Sedation
- Keywords
- light, anesthesia, sedation depth
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Peking University People's HospitalUniversity, hospital or other
- Study start
- 3 Oct 2025 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 30 Jun 2026 (estimated)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include:
Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia.
The following data will be recorded for all patients:
Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| the light-shielded group | Experimental | Device: eye maskPatients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia. |
| the non-light-shielded group | No intervention | – |
Who may qualify
- Ages
- 18 to 64 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- a. Age between 18 and 65 years, regardless of gender;
- b. ASA physical status I-II;
- c. 18.5 ≤ BMI ≤ 28;
- d. Signed written informed consent.
Key exclusion criteria (7 listed)
- a. Blindness or history of photosensitivity disorders;
- b. Patients requiring medication for sleep, or with a history of sleep disorders;
- c. Presence of neurological diseases;
- d. Pregnancy;
- e. Severe hepatic or renal dysfunction;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| eye maskPatients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia. | Device | the light-shielded group |
Primary outcome
The dose of sedative medications
Time frame: Perioperative
The dose of sedative medications required during the induction period in patients
3 secondary outcomes
Induction time of anesthesia
Time frame: Perioperative
total dose of sedative medications
Time frame: during surgery
emergence time
Time frame: Perioperative
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 May 2026.
- Background: PubMed 7947393Boatright JH, Rubim NM, Iuvone PM. Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis Neurosci. 1994 Sep-Oct;11(5):1003-12. doi: 10.1017/s095252380000393x.
- Background: PubMed 30236240Szolnoki J, Polaner DM, Eckle T. Diurnal variations in recovery times after general anaesthesia in children. Br J Anaesth. 2018 Oct;121(4):776-786. doi: 10.1016/j.bja.2018.06.027. Epub 2018 Aug 10.
- Background: PubMed 34488646Shen JH, Ye M, Chen Q, Chen Y, Zhao HL, Khan A, Yi B, Ning JL, Lu KZ, Gu JT. Effects of circadian rhythm on Narcotrend index and target-controlled infusion concentration of propofol anesthesia. BMC Anesthesiol. 2021 Sep 6;21(1):215. doi: 10.1186/s12871-021-01445-z.
- Background: PubMed 32807382Wang D, Huang Y, Wang X, Chen X, Li J, Zhang S, Wu J, Liu D, Ma D, Mei W. Circadian differences in emergence from volatile anaesthesia in mice: involvement of the locus coeruleus noradrenergic system. Br J Anaesth. 2020 Oct;125(4):548-559. doi: 10.1016/j.bja.2020.07.012. Epub 2020 Aug 15.
- Background: PubMed 38253963Shao Y, Li Y, Wang N, Xue Y, Wang T, Qiu F, Lu Y, Lan D, Wu H. Effect of daily light exposure on sleep in polar regions: A meta-analysis. J Sleep Res. 2024 Oct;33(5):e14144. doi: 10.1111/jsr.14144. Epub 2024 Jan 22.
- Background: PubMed 34217920Ishizawa M, Uchiumi T, Takahata M, Yamaki M, Sato T. Effects of pre-bedtime blue-light exposure on ratio of deep sleep in healthy young men. Sleep Med. 2021 Aug;84:303-307. doi: 10.1016/j.sleep.2021.05.046. Epub 2021 Jun 8.
- Background: PubMed 28214594Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017 Mar 15;173:94-106. doi: 10.1016/j.lfs.2017.02.008. Epub 2017 Feb 16.
- Background: PubMed 33065729Barger LK, Sullivan JP, Lockley SW, Czeisler CA. Exposure to Short Wavelength-Enriched White Light and Exercise Improves Alertness and Performance in Operational NASA Flight Controllers Working Overnight Shifts. J Occup Environ Med. 2021 Feb 1;63(2):111-118. doi: 10.1097/JOM.0000000000002054.
- Background: PubMed 11025337Daurat A, Foret J, Benoit O, Mauco G. Bright light during nighttime: effects on the circadian regulation of alertness and performance. Biol Signals Recept. 2000 Nov-Dec;9(6):309-18. doi: 10.1159/000014654.
- Background: PubMed 37858331Dollish HK, Tsyglakova M, McClung CA. Circadian rhythms and mood disorders: Time to see the light. Neuron. 2024 Jan 3;112(1):25-40. doi: 10.1016/j.neuron.2023.09.023. Epub 2023 Oct 18.
- Background: PubMed 24917305LeGates TA, Fernandez DC, Hattar S. Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 2014 Jul;15(7):443-54. doi: 10.1038/nrn3743. Epub 2014 Jun 11.
- Background: PubMed 24010846Ramsey DJ, Ramsey KM, Vavvas DG. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov;28(5-6):406-21. doi: 10.3109/08820538.2013.825294. Epub 2013 Sep 6.
- Individual participant dataSharing planned: No. To protect patient privacy and ensure the security of clinical data, the individual participant data (IPD) collected in this study will be used only for scientific analysis and publication related to this trial. No public disclosure, sharing, or uploading to public repositories is planned. Therefore, IPD will not be made available.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing eye mask in people with Light and Anesthesia, run by Peking University People's Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yi Feng, Ph.D (010-88325590, doctor_yifeng@sina.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The dose of sedative medications (time frame: Perioperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07517484, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 May 2026.