Clinical trials: Sedation
Adverse Event
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature.
- Trial name
- NCT05321160
- Testing
- Esketamine, Sevoflurane
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Healthy
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Healthy Volunteers
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Trial name
- NCT00321360
- Testing
- Propofol, Patient maintained sedation
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sonia Allam
Deep Sedation, Non-invasive Ventilation Support
Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Molar Tooth Extraction Under Deep Sedation
In patients with high levels of fear and anxiety, it is recommended to perform dental procedures under sedation or general anesthesia depending on the nature of the procedure.
- Conditions
- Deep Sedation, Non-invasive Ventilation Support, Nasal Airway, Nasal CPAP Mask
- Trial name
- NCT06436638
- Testing
- Non-invasive ventilation support equipment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gözde Nur Erkan
Colonoscopy
Can Simple and Inexpensive Techniques Enhance Patient Comfort
This research study compares two methods of performing colonoscopy without sedation. The standard method is to insert the colonoscope without adding any water to the colon, and when colonic spasms occur during the examination…
- Trial name
- NCT00747084
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stress, Pain
Evaluation of the Surgical Pleth Index During Spinal and General Anesthesia
The Surgical Pleth index (SPI) has been introduced as a non invasive tool to "measure" stress and pain during surgery. Preliminary studies were performed in patients under general anaesthesia with propofol and remifentanil.
- Trial name
- NCT00789438
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University Hospital Schleswig-Holstein
Mechanical Ventilation Complication
Reduce Pediatric Sedation to Reduce Mechanical Ventilation Complication in ICU
Mechanical ventilation is a common procedure used in pediatric intensive care units (ICU). Its use requires almost always the establishment of a sedation.
- Trial name
- PEDIASED (NCT02040168)
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Sedation; Aged; Hemodynamics
A Comparision of Midazolam-dexmedetomidine With Dexmedetomidine Alone for Hemodynamic Stability and Quality of Sedation in Elderly Patients Under Spinal Anesthesia
The purpose of this study is to compare midazolam-dexmedetomidine with dexmedetomidine alone for hemodynamic stability and quality of sedation in elderly patients under spinal anesthesia.
- Trial name
- NCT01979653
- Testing
- dexmedetomidine alone or dexmedetomidine + midazolam
- Where
- South Korea
- Sponsor
- Severance Hospital
Brain Injury
Combining Observational and Physiologic Sedation Assessment Tools
When a physiologic tool to measure the patient's hypnotic state is added to current practice tools is there a decrease in the amount of drug the patient receives.
- Trial name
- COST (NCT00538369)
- Testing
- Ramsay Scale, Bispectral index monitor
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Duke University
Medically Assisted Procreation (MAP), Oocyte Retrieval
Monocentric Randomised Controlled Trial to Assess Whether Virtual Reality Reduces the Use of Hypnotic Agents During IVF/ICSI Oocyte Retrieval
Over the last few years, audiovisual distraction devices using animation, films and 3D immersion have been developed, with the aim to provide patients with a relaxing experience that disconnects them from the operating…
- Trial name
- REVAHPOVO (NCT07190729)
- Testing
- Propofol sedation + Audiovisual distraction, Propofol sedation
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Recall Phenomenon
Introducing a New EEG Based Index for Monitoring Recall Under Sedation
This is a single centre prospective observational study that will investigate a new EEG based index in recognizing recall of anesthesia in sedated patients. Awareness under general anesthesia is a dreadful complication.
- Trial name
- NCT03835156
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypertension
The Effects of Dexmedetomidine to Postoperative Awakening and Extubation-related Changes in Blood Pressure
The postoperative removal of intubation tube induces a noticeable sympathic response and increase of blood pressure. The risk of complications is especially elevated with the patients having cardiac surgery.
- Trial name
- NCT01871129
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Tampere University Hospital
Acute Ischemic Stroke, Endovascular Thrombectomy
Effects of Post-Operative Sedation for Endovascular Thrombectomy
Studies from our lab indicated that long-term sedation is protective in mice with midbrain infarct. To assess whether post-operative sedation has protective effects on clinical outcomes in patients with ischemic stroke undergoing…
- Trial name
- POSET (NCT04517383)
- Testing
- post-operative sedation, routine recovery
- Where
- China
- Volunteers
- 1,286 people
- Sponsor
- RenJi Hospital
Severe Pneumonia
The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia
This study collected data from patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings.
- Trial name
- ICU (NCT06514781)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Xiangya Hospital of Central South University
Atrial Fibrillation (Paroxysmal)
Safety and Efficacy of Conscious Sedation Versus General Anesthesia in Pulsed-Field Ablation for Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to compare the safety and efficacy of conscious sedation and general anesthesia in patients with paroxysmal atrial fibrillation undergoing their first pulsed-field ablation (PFA) procedure.
- Trial name
- SEDATE-PFA (NCT07541339)
- Testing
- conscious sedation, General Anesthesia (control group)
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Anzhen Hospital
Hypoxemia
Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery
Dentists use sedation to help patients accept difficult procedures and to relieve anxiety. During sedation, the well-being of the patient is monitored by the dental team.
- Trial name
- NCT01949012
- Testing
- Capnography
- Where
- Ireland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University College Cork
Endoscopy
Clinical Trial of Oral Midazolam in Pediatric Endoscopy
The objective of our study was to compare the safety and efficacy of oral midazolam during pediatric endoscopy.
- Trial name
- NCT00636428
- Testing
- Midazolam
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University
Microcirculation
Comparison Between Dexmedetomidine and Propofol for Patients in the Intensive Care Unit After Abdominal Surgery
This is a single-blind randomized clinical trial. Patients undergoing abdominal surgery will be enrolled and randomly divided into two groups: dexmedetomidine group and propofol group.
- Trial name
- NCT02874768
- Testing
- Dexmedetomidine, Propofol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Sedation, Intubation
Dexmedetomidine Versus Propofol for Sedation During Awake Endotracheal Intubation
The purpose of this study is to compare the sedation effect of dexmedetomidine and propofol when they are both combined with midazolam and remifentanil during awake endotracheal intubation.
- Trial name
- NCT04753515
- Testing
- dexmedetomidine combined with midazolam and remifentanil., propofol combined with midazolam and remifentanil.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Awake Craniotomy for Brain Tumour Surgery
Patient-controlled Versus Anesthesiologist-controlled Propofol-remifentanil in Awake Craniotomy
Awake craniotomy for removal of brain tumour is performed because the tumour may be located close to areas of the brain that control specific functions such as movement or speech.
- Trial name
- NCT00992940
- Testing
- Patient-Controlled Sedation/Analgesia, Anesthetist-Controlled Sedation/Analgesia
- Where
- Canada
- Sponsor
- University Health Network, Toronto
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