Procedural AnxietyNCT07518953
Effect of Music on Pain and Anxiety During Nail Biopsies
A study testing Music intervention and Local anesthesia injections in people with Procedural Anxiety and Pain, run by Weill Medical College of Cornell University at 1 site in United States.
Trial summary
This study is looking at whether listening to music during a nail biopsy can reduce pain and anxiety. Patients scheduled for a nail biopsy at the Weill Cornell Medicine dermatology clinic will be randomly assigned to either listen to a calming instrumental/classical music playlist during their procedure or receive… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Procedural Anxiety, Pain
- What is being tested?
- Music intervention and Local anesthesia injections
- Type of treatment
- Injection or infusion, Surgery or procedure, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Jun 2026to Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male or female ≥18 years of age
- Scheduled to undergo nail biopsy at the Weill Cornell Medicine dermatology clinic
- Able to provide informed consent
- Able to read and understand English
Who cannot join
- Significant hearing impairment that would prevent ability to hear the music intervention
- Cognitive impairment that would prevent completion of study questionnaires
- Unable or unwilling to provide informed consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Weill Cornell Medicine Department of Dermatology
New York, New York, 10021
Shari R Lipner, MD, PhD, shl9032@med.cornell.edu
Rebecca Zhang, BS, rez4002@med.cornell.edu
About this study
This study is looking at whether listening to music during a nail biopsy can reduce pain and anxiety. Patients scheduled for a nail biopsy at the Weill Cornell Medicine dermatology clinic will be randomly assigned to either listen to a calming instrumental/classical music playlist during their procedure or receive standard care without music. After the procedure, participants will complete short questionnaires rating their pain, anxiety, and overall satisfaction. The goal is to determine whether a simple, low-cost music intervention can improve the experience of patients undergoing nail biopsies.
- Conditions
- Procedural Anxiety, Pain
- Being tested
- Music intervention, Local anesthesia injections
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Music interventionBehavioural
A standardized playlist of instrumental, classical, and relaxing music delivered to participants beginning 2-3 minutes before local anesthesia administration and continuing throughout the nail biopsy procedure. The music is intended to reduce procedural pain and anxiety as an adjunct to standard care.
Local anesthesia injectionsProcedure or surgery
Local anesthesia injections
| Study group | Role | What they receive |
|---|---|---|
| Music Intervention | Experimental | Participants listen to a standardized instrumental/classical/relaxing music playlist beginning 2-3 minutes before local anesthesia and continuing throughout the nail biopsy procedure. Receives: Behavioral: Music intervention; Procedure: Local anesthesia injections |
| Standard care/ control | Other | Participants receive standard care during nail biopsy without any music intervention. No music is played during local anesthesia administration or the procedure. Receives: Procedure: Local anesthesia injections |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean pain intensity measured by Visual Analog Scale
Total scores range from 0-10 with 10 meaning worst pain imaginable
Measured: Immediately after the nail biopsy procedure
Secondary outcomes (6)
Mean anxiety score measured by short-form State-Trait Anxiety Inventory
Total scores range from 20 - 80 with scores higher than 34 - 36 indicating anxiety
Measured: Immediately after the nail biopsy procedure
Perceived helpfulness of music intervention (music group only) measured by single-item Likert scale
Likert scale ranges from 1 (not helpful at all) to 5 (extremely helpful).
Measured: Immediately after the nail biopsy procedure
Patient satisfaction score measured by single-item Likert scale rating overall experience
1=very dissatisfied to 5=very satisfied
Measured: Immediately after the nail biopsy procedure
Willingness to undergo future nail biopsy procedures measured by single-item yes/no question
Measured: Immediately after the nail biopsy procedure
Number of participants with adverse events related to the procedure
Measured: immediately after the nail biopsy procedure
Number of participants with adverse events related to the music intervention
Measured: Immediately after nail biopsy procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2026
- Study start18 Jun 2026
- Primary completionJan 2027 (estimated)
- Study completionJan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Procedural AnxietyStudies of the same condition, open and under way.
- More trials run by Weill Medical College of Cornell UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two parallel arms: music intervention group and standard care control group, randomized 1:1.
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Weill Medical College of Cornell University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Shari R Lipner, MD, PhD, Principal investigator, Weill Cornell Medicine, Department of Dermatology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07518953
- Sponsor's protocol ID
- 25-12029644
- Status last verified
- Jul 2026
- First submitted
- 1 Apr 2026
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Music on Pain and Anxiety During Nail Biopsies
- ClinicalTrials.gov ID
- NCT07518953
- Acronym / sponsor ID
- 25-12029644
- Conditions
- Procedural Anxiety, Pain
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Weill Medical College of Cornell UniversityUniversity, hospital or other
- Study start
- 18 Jun 2026 (actual)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Jan 2027 (estimated)
- First posted
- 9 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is looking at whether listening to music during a nail biopsy can reduce pain and anxiety. Patients scheduled for a nail biopsy at the Weill Cornell Medicine dermatology clinic will be randomly assigned to either listen to a calming instrumental/classical music playlist during their procedure or receive standard care without music. After the procedure, participants will complete short questionnaires rating their pain, anxiety, and overall satisfaction. The goal is to determine whether a simple, low-cost music intervention can improve the experience of patients undergoing nail biopsies.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Two parallel arms: music intervention group and standard care control group, randomized 1:1.
| Arm | Type | Receives |
|---|---|---|
| Music Intervention | Experimental | Behavioral: Music intervention, Procedure: Local anesthesia injectionsParticipants listen to a standardized instrumental/classical/relaxing music playlist beginning 2-3 minutes before local anesthesia and continuing throughout the nail biopsy procedure. |
| Standard care/ control | Other | Procedure: Local anesthesia injectionsParticipants receive standard care during nail biopsy without any music intervention. No music is played during local anesthesia administration or the procedure. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Male or female ≥18 years of age
- Scheduled to undergo nail biopsy at the Weill Cornell Medicine dermatology clinic
- Able to provide informed consent
- Able to read and understand English
Key exclusion criteria (3 listed)
- Significant hearing impairment that would prevent ability to hear the music intervention
- Cognitive impairment that would prevent completion of study questionnaires
- Unable or unwilling to provide informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Music interventionA standardized playlist of instrumental, classical, and relaxing music delivered to participants beginning 2-3 minutes before local anesthesia administration and continuing throughout the nail biopsy procedure. The music is intended to reduce procedural pain and anxiety as an adjunct to standard care. | Behavioural | Music Intervention |
| Local anesthesia injectionsLocal anesthesia injections | Procedure or surgery | Music Intervention, Standard care/ control |
Primary outcome
Mean pain intensity measured by Visual Analog Scale
Time frame: Immediately after the nail biopsy procedure
Total scores range from 0-10 with 10 meaning worst pain imaginable
6 secondary outcomes
Mean anxiety score measured by short-form State-Trait Anxiety Inventory
Time frame: Immediately after the nail biopsy procedure
Perceived helpfulness of music intervention (music group only) measured by single-item Likert scale
Time frame: Immediately after the nail biopsy procedure
Patient satisfaction score measured by single-item Likert scale rating overall experience
Time frame: Immediately after the nail biopsy procedure
Willingness to undergo future nail biopsy procedures measured by single-item yes/no question
Time frame: Immediately after the nail biopsy procedure
Number of participants with adverse events related to the procedure
Time frame: immediately after the nail biopsy procedure
Number of participants with adverse events related to the music intervention
Time frame: Immediately after nail biopsy procedure
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
- Individual participant dataSharing planned: No
Related trials for Procedural Anxiety
Not yet recruitingObservational study
Soap-and-Water Bed Bath Versus Disposable Wipe Bath in the Same ICU Patients
Critical Illness, Pain
Not yet recruiting
Virtual Reality for Pain and Anxiety During Surgical Uterine Evacuation After Early Pregnancy Loss
Early Pregnancy Loss, Procedural Pain
Not yet recruiting
Virtual Reality to Reduce Anxiety During Thoracic Epidural Placement.
Preoperative Anxiety Score
Not yet recruiting
Effect of Short-Video Distraction During Burn Dressing on Anxiety, Pain, and Fear in Children
Burn Injury, Procedural Anxiety
Not yet recruiting
Peri-procedural Weighted Blanket Use for ECT
Post-ect Agitation, Post-ictal Agitation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Shari R Lipner, MD, PhD principal investigator
Weill Cornell Medicine, Department of Dermatology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Music intervention and Local anesthesia injections in people with Procedural Anxiety and Pain, run by Weill Medical College of Cornell University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Shari R Lipner, MD, PhD ((646) 962-3376, shl9032@med.cornell.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean pain intensity measured by Visual Analog Scale (time frame: Immediately after the nail biopsy procedure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026.