Aphasia, BrocaNCT07521098
Effects of PACE Technique in Patients With Aphasia
A study testing experimental in people with Aphasia, Broca, run by Riphah International University at 1 site in Pakistan.
Trial summary
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language. It can manifest in various forms, such as difficulties with speaking, writing, reading, and comprehension, which severely impair daily functioning and quality of… Read more about this study
- Who is it for?
- Ages 45 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Aphasia, Broca
- What is being tested?
- experimental
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 sitePakistan
- Study dates
- 18 Mar 2025to 29 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age: Patients from age 45-65 years will be included in the study
- Both gender male and female will be included in the study.
- Diagnosed Adults with aphasia will be included in the study.
- Severity level: Mild to moderate will be included in the study
- Only non-fluent type of Aphasia will be included in the study
Who cannot join
- Adult with any co-morbid condition will be excluded from study.
Trial locations and contacts
1 site in 1 country.
About this study
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language. It can manifest in various forms, such as difficulties with speaking, writing, reading, and comprehension, which severely impair daily functioning and quality of life. For adults with aphasia, regaining communication skills is often a critical aspect of rehabilitation, demanding a combination of therapeutic strategies.
The Promoting Aphasics' Communicative Effectiveness (PACE) technique is a widely recognized approach to improve communication in individuals with aphasia. Developed in the late 20th century, the PACE technique focuses on naturalistic communication, encouraging patients to utilize any available communicative means verbal or non-verbal to convey messages effectively. By simulating real-world conversational scenarios in therapy, PACE aims to enhance both expressive and receptive communication skills, thereby facilitating better interaction in social contexts. This approach is especially beneficial for individuals with severe expressive language impairments, as it emphasizes the overall success of communication rather than linguistic accuracy.
A descriptive experimental research design was followed in the present study to explore the effect of PACE technique in adults with Aphasia. The study will be conducted at DHQ Faisalabad. The Duration of study is relied on 16 sessions. Three sessions will be conducted per week and the duration of a session is about forty minutes. Sample size (N=16) (Control group =8, Experimental group=8). Patients who were identified with mile to moderate level of Aphasia are age of 45 to 65 years old. Group A will be an experimental group (who will receive both Conventional and Promoting Aphasic Communicative Effectiveness technique). Group B will be a controlled group (who will receive just Conventional Therapy). A randomized Clinical trial will employ to collect data from participants approach at DHQ Faisalabad.
Read the detailed description
This approach is especially beneficial for individuals with severe expressive language impairments, as it emphasizes the overall success of communication rather than linguistic accuracy. A descriptive experimental research design was followed in the present study to explore the effect of PACE technique in adults with Aphasia. The study will be conducted at DHQ Faisalabad. Sample size (N=16) (Control group =8, Experimental group=8). Patients who were identified with mild to moderate level of Aphasia are age of 45 to 65 years old. Group A will be an experimental group (who will receive both Conventional and Promoting Aphasic Communicative Effectiveness technique). Group B will be a controlled group (who will receive just Conventional Therapy). A randomized Clinical trial will employ to collect data from participants approach at DHQ Faisalabad.
- Conditions
- Aphasia, Broca
- Being tested
- experimental, control group conventional therapy
- Medical subject headings
- Aphasia, Broca
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
experimentalBehavioural
Promoting Aphasics' Communicative Effectiveness (PACE) is a functional approach to aphasia intervention that emphasizes natural, interactive communication between the clinician and the individual with aphasia. Unlike traditional therapy, which often focuses on accuracy, PACE encourages any form of communication-verbal or non-verbal-such as gestures, drawing, writing, or using augmentative devices. The therapy is conducted in a conversational setting, where both participants exchange new information, ensuring the person with aphasia takes an active role in communication. By reducing pressure and promoting alternative communication strategies, PACE enhances confidence, encourages spontaneous language use, and helps individuals regain functional communication skills in real-life situations
control group conventional therapyOther
Control Arm (Standard Therapy or No Treatment) Participants receive either traditional speech therapy (e.g., structured drills, naming tasks) or no treatment for comparison.
| Study group | Role | What they receive |
|---|---|---|
| pace therapy | Experimental | In a clinical trial or intervention study, the number of arms refers to the different groups that receive specific types of treatment or intervention. Each "arm" represents a distinct study condition. Here are common types of arms in PACE (Promoting Aphasics' Communicative Effectiveness) intervention studies:
1. Experimental Arm (PACE Intervention) Participants receive PACE therapy, which encourages multimodal communication (speech, gestures, writing, drawing, etc.) in a conversational setting.
The focus is on functional communication rather than perfect speech production. Receives: Behavioral: experimental |
| control group conventional therapy | Active comparator | 2. Control Arm (Standard Therapy or No Treatment) Participants receive either traditional speech therapy (e.g., structured drills, naming tasks) or no treatment for comparison. Receives: Other: control group conventional therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mississippi Aphasia Screening Test
The Mississippi Aphasia Screening Test (MAST) is a brief and efficient tool designed to assess language abilities in individuals with aphasia, particularly those who have experienced a stroke or brain injury. It is a standardized screening test that evaluates various aspects of language function, including expressive and receptive abilities. The MAST consists of simple tasks such as naming, repetition, following commands, and verbal fluency, allowing clinicians to quickly identify language impairments. It is widely used due to its reliability, ease of administration, and effectiveness in detecting aphasia in both clinical and research setting
Measured: 6 to 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2026
- Study start18 Mar 2025
- Primary completion20 Jun 2025
- Study completion29 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Aphasia, BrocaStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mehwish Ikhlaque, MS, Principal investigator, Riphah International University, Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07521098
- Sponsor's protocol ID
- rec/rcr&ahs/24/0682
- Status last verified
- Apr 2026
- First submitted
- 2 Apr 2026
- Last updated
- 9 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Filipska-Blejder K, Zielinska J, Zielinski M, Wisniewski A, Slusarz R. How Does Aphasia Affect Quality of Life? Preliminary Reports. J Clin Med. 2023 Dec 14;12(24):7687. doi: 10.3390/jcm12247687.
PubMed 38137755Haakana M, Kurhila S, Lilja N, Savijärvi M. Kuka, mitä, häh? Korjausaloitteet suomalaisessa arkikeskustelussa [Other-initiation of repair in Finnish everyday conversation]. Virittäjä. 2024;120(2)
Study at a glance
From the registry record, last updated by the sponsor on 9 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of PACE Technique in Patients With Aphasia
- ClinicalTrials.gov ID
- NCT07521098
- Acronym / sponsor ID
- rec/rcr&ahs/24/0682
- Conditions
- Aphasia, Broca
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 18 Mar 2025 (actual)
- Primary completion
- 20 Jun 2025 (actual)
- Study completion
- 29 Jun 2025 (actual)
- First posted
- 9 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language. It can manifest in various forms, such as difficulties with speaking, writing, reading, and comprehension, which severely impair daily functioning and quality of life. For adults with aphasia, regaining communication skills is often a critical aspect of rehabilitation, demanding a combination of therapeutic strategies.
The Promoting Aphasics' Communicative Effectiveness (PACE) technique is a widely recognized approach to improve communication in individuals with aphasia. Developed in the late 20th century, the PACE technique focuses on naturalistic communication, encouraging patients to utilize any available communicative means verbal or non-verbal to convey messages effectively. By simulating real-world conversational scenarios in therapy, PACE aims to enhance both expressive and receptive communication skills, thereby facilitating better interaction in social contexts. This approach is especially beneficial for individuals with severe expressive language impairments, as it emphasizes the overall success of communication rather than linguistic accuracy.
A descriptive experimental research design was followed in the present study to explore the effect of PACE technique in adults with Aphasia. The study will be conducted at DHQ Faisalabad. The Duration of study is relied on 16 sessions. Three sessions will be conducted per week and the duration of a session is about forty minutes. Sample size (N=16) (Control group =8, Experimental group=8). Patients who were identified with mile to moderate level of Aphasia are age of 45 to 65 years old. Group A will be an experimental group (who will receive both Conventional and Promoting Aphasic Communicative Effectiveness technique). Group B will be a controlled group (who will receive just Conventional Therapy). A randomized Clinical trial will employ to collect data from participants approach at DHQ Faisalabad.
Detailed description
This approach is especially beneficial for individuals with severe expressive language impairments, as it emphasizes the overall success of communication rather than linguistic accuracy. A descriptive experimental research design was followed in the present study to explore the effect of PACE technique in adults with Aphasia. The study will be conducted at DHQ Faisalabad. Sample size (N=16) (Control group =8, Experimental group=8). Patients who were identified with mild to moderate level of Aphasia are age of 45 to 65 years old. Group A will be an experimental group (who will receive both Conventional and Promoting Aphasic Communicative Effectiveness technique). Group B will be a controlled group (who will receive just Conventional Therapy). A randomized Clinical trial will employ to collect data from participants approach at DHQ Faisalabad.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| pace therapy | Experimental | Behavioral: experimentalIn a clinical trial or intervention study, the number of arms refers to the different groups that receive specific types of treatment or intervention. Each "arm" represents a distinct study condition. Here are common types of arms in PACE (Promoting Aphasics' Communicative Effectiveness) intervention studies: 1. Experimental Arm (PACE Intervention) Participants receive PACE therapy, which encourages multimodal communication (speech, gestures, writing, drawing, etc.) in a conversational setting. The focus is on functional communication rather than perfect speech production. |
| control group conventional therapy | Active comparator | Other: control group conventional therapy2. Control Arm (Standard Therapy or No Treatment) Participants receive either traditional speech therapy (e.g., structured drills, naming tasks) or no treatment for comparison. |
Who may qualify
- Ages
- 45 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age: Patients from age 45-65 years will be included in the study
Key exclusion criteria (1 listed)
- Adult with any co-morbid condition will be excluded from study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| experimentalPromoting Aphasics' Communicative Effectiveness (PACE) is a functional approach to aphasia intervention that emphasizes natural, interactive communication between the clinician and the individual with aphasia. Unlike traditional therapy, which often focuses on accuracy, PACE encourages any form of communication-verbal or non-verbal-such as gestures, drawing, writing, or using augmentative devices. The therapy is conducted in a conversational setting, where both participants exchange new information, ensuring the person with aphasia takes an active role in communication. By reducing pressure and promoting alternative communication strategies, PACE enhances confidence, encourages spontaneous language use, and helps individuals regain functional communication skills in real-life situations | Behavioural | pace therapy |
| control group conventional therapyControl Arm (Standard Therapy or No Treatment) Participants receive either traditional speech therapy (e.g., structured drills, naming tasks) or no treatment for comparison. | Other | control group conventional therapy |
Primary outcome
Mississippi Aphasia Screening Test
Time frame: 6 to 8 weeks
The Mississippi Aphasia Screening Test (MAST) is a brief and efficient tool designed to assess language abilities in individuals with aphasia, particularly those who have experienced a stroke or brain injury. It is a standardized screening test that evaluates various aspects of language function, including expressive and receptive abilities. The MAST consists of simple tasks such as naming, repetition, following commands, and verbal fluency, allowing clinicians to quickly identify language impairments. It is widely used due to its reliability, ease of administration, and effectiveness in detecting aphasia in both clinical and research setting
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Apr 2026.
- Background: PubMed 38137755Filipska-Blejder K, Zielinska J, Zielinski M, Wisniewski A, Slusarz R. How Does Aphasia Affect Quality of Life? Preliminary Reports. J Clin Med. 2023 Dec 14;12(24):7687. doi: 10.3390/jcm12247687.
- BackgroundHaakana M, Kurhila S, Lilja N, Savijärvi M. Kuka, mitä, häh? Korjausaloitteet suomalaisessa arkikeskustelussa [Other-initiation of repair in Finnish everyday conversation]. Virittäjä. 2024;120(2)
- Individual participant dataSharing planned: No
Related trials for Aphasia, Broca
Not yet recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia (BG-Aphasia-01)
Expressive Aphasia, Aphasia Following Cerebral Infarction
Recruiting
Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation
Stroke Rehabilitation, Aphasia, Broca
Recruiting
Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
Aphasia Non Fluent, Stroke
Active, not recruiting
Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia
Aphasia Non Fluent, Stroke
Not yet recruiting
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Non-fluent Aphasia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mehwish Ikhlaque, MS principal investigator
Riphah International University, Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing experimental in people with Aphasia, Broca, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mississippi Aphasia Screening Test (time frame: 6 to 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07521098, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Apr 2026.