Clinical trials: Aphasia, Broca
Stroke, Aphasia
Effects of rTMS Based on Brain Activation During Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of high or low-frequency repetitive transcranial magnetic stimulation based on brain activation with functional near infrared spectroscopy in poststroke…
- Trial name
- NCT02556385
- Testing
- High frequency rTMS, Low frequency rTMS
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Bundang Hospital
Aphasia
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
We hypothesize patients who have difficulty with word recall (naming pictures) due to a stroke will experience greater benefit in word recall after receiving a combination of transcranial direct current stimulation (tDCS) and…
- Trial name
- NCT02226796
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada
Alzheimer's Disease, Primary Progressive Non-fluent Aphasia
A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease
The purpose of this study is to determine safety, tolerability, and pharmacokinetics/dynamics of a ketogenic dietary supplement containing medium chain triglycerides (MCTs) in patients with Alzheimer disease (AD).
- Conditions
- Alzheimer's Disease, Primary Progressive Non-fluent Aphasia, Frontotemporal Dementia (FTD)
- Trial name
- MINT-01 (NCT02912936)
- Testing
- Ketogenic medium chain triglyceride drink (MCT drink)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Broca's Aphasia
Virtual Reality Based Sensorimotor Speech Therapy
The purpose of this study is to determine whether VR based language rehabilitation scenario based on the core premises of ILAT has a beneficial effect on the linguistic performance (faster retrieval of the target lexicon and…
- Trial name
- NCT02928822
- Testing
- VR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Universitat Pompeu Fabra
Aphasia, Non-fluent Aphasia
Combining tDCS and CILT in Non-fluent Aphasia
The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current…
- Conditions
- Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
- Trial name
- NCT05561400
- Testing
- tDCS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Logopenic Variant Primary Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
rTMS as a Treatment for PPA
Primary progressive aphasia (PPA) includes three variants. Two such variants, the non-fluent/agrammatic variant (nfvPPA) and the logopenic variant (lvPPA), are characterized by progressive word-finding difficulties and effortful…
- Trial name
- NCT03406429
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Aphasia, Broca
Effects of PACE Technique in Patients With Aphasia
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language.
- Trial name
- NCT07521098
- Testing
- experimental, control group conventional therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Stroke, Aphasia, Non-fluent
Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- REMAP (NCT04102228)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Aphasia, Aphasia Following Cerebral Infarction
Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)
The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired…
- Conditions
- Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired, Aphasia, Rehabilitation
- Trial name
- NCT07036406
- Testing
- Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Teachers College, Columbia University
Primary Progressive Aphasia, Semantic Dementia
Primary Progressive Aphasia Multicomponent Language Treatment Study
The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language.
- Conditions
- Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia
- Trial name
- NCT06649084
- Testing
- Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Texas at Austin
Primary Progressive Aphasia(PPA), Semantic Dementia
Intervention for Communication Quality of Life in Primary Progressive Aphasia
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and…
- Conditions
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive
- Trial name
- Multi-PA (NCT07219680)
- Testing
- Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Maya Henry
Non Fluent Aphasia in Subacute Stroke
Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
- Trial name
- NCT01850836
- Testing
- repetitive transcranial magnetic stimulation
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aphasia, Stroke
Modeling Treated Recovery From Aphasia
Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain.
- Conditions
- Aphasia, Stroke, Stroke, Ischemic, Aphasia, Broca
- Trial name
- NCT03416738
- Testing
- Semantically focused treatment, Phonologically focused treatment
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of South Carolina
Aphasia, Stroke
Galantamine Treatment for Nonfluent Aphasia in Stroke Patients
Cognitive impairment after stroke is common and has a major effect on morbidity and quality of life. Acetylcholinesterase inhibitors have demonstrated benefit in vascular dementia, but efficacy in treating more circumscribed…
- Trial name
- NCT01129479
- Testing
- Galantamine
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Progressive Aphasia, Frontotemporal Dementia
Communication Bridge Speech Therapy Research Study
This is a study on Internet-based video-practice speech and language therapy for persons with primary progressive aphasia (PPA), behavioral-variant frontotemporal dementia (bvFTD), or related conditions.
- Trial name
- CB (NCT02439853)
- Testing
- Monthly Check-in Session
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Chicago
Primary Progressive Nonfluent Aphasia
A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia
This study is a pilot trial evaluating the safety and immunogenicity of AADvac1 in patients with the non-fluent variant of Primary Progressive Aphasia.
- Trial name
- AIDA (NCT03174886)
- Testing
- AADvac1 40 µg, AADvac1 160 µg
- Where
- 3 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Axon Neuroscience SE
Aphasia Non Fluent, Stroke
Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia
The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA).
- Conditions
- Aphasia Non Fluent, Stroke, Aphasia
- Trial name
- MSE (NCT06829420)
- Testing
- Mirror speech entrainment, Traditional speech entrainment: auditory-only, Traditional speech entrainment: auditory-visual
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital