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Muscle PowerAPTE-OANCT07522398

Acute Power Training Effects in Older Adults

A study testing Power Training at Different Fatigue Levels in people with Muscle Power and Functional Performance, run by Hasselt University at 1 site in Belgium.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility. Read more about this study

Who is it for?
Ages 65 to 85 yearsHealthy volunteers can take part
What is being tested?
Power Training at Different Fatigue Levels
Could I receive a placebo?
No, everyone receives an active treatment
How many people
42 participants
Where
1 siteBelgium
Study dates
20 Apr 2026to Jan 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 65 to 85 years
  • All sexes
  • Healthy volunteers accepted
  • Older adult

Who may be able to join

  • Participants must:
  • Be 65 to 85 years old.
  • Be able to live independently and perform everyday activities without help.
  • Not have regularly done resistance or strength training in the past year.
  • Be able to understand study instructions and communicate in the study language.
  • Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.

Who cannot join

  • Participants will not be eligible if they have any of the following:
  • Unstable heart disease, neurological disease, acute infection, or fever.
  • Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.
  • Use of whey protein, casein, or amino acid supplements in the month before the study.
  • Acute or chronic injuries to the legs or lower body muscles.
  • Any injury or condition that prevents safe leg extension exercises.
Show all 9Show fewer
  • Recent lower-limb joint replacement (less than 6 months ago).
  • Dependence on walking aids.
  • Current participation in another interventional trial.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Max Riesbeck, Master of Science contact

+32 11 26 84 93

max.riesbeck@uhasselt.be

Evelien Van Roie, PhD contact

+3211269062

evelien.vanroie@uhasselt.be

Belgium1 site, 1 recruiting
  • REVAL - Faculty of Rehabilitation Sciences

    Diepenbeek, Flanders, 3590

    Faculteit Revalidatiewetenschappen, +32(0)11 26 93 11, reval.rws@uhasselt.be

    Recruiting

Other trials in Belgium

About this study

Official title: Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults

The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.

The main questions the study aims to answer are:

Read more
  • How does the level of fatigue during power training acutely affect strength, movement, and muscle function?
  • How does it affect recovery, muscle soreness, and how hard the exercise feels?

Researchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.

Participants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.

During the study, participants will:

  • Perform power training on a pneumatic leg press machine
  • Complete strength and mobility tests before and after exercise
  • Provide small blood samples to measure body responses to exercise
  • Rate how hard the exercise feels
  • Report muscle soreness for up to two days after exercise

The results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.

Being tested
Power Training at Different Fatigue Levels
Keywords
Power Training, Older Adults, Aging, Muscle Power, Velocity Loss, Resistance Training, Neuromuscular Function, Functional Performance, Physiological Responses, Exercise Fatigue

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Power Training at Different Fatigue LevelsBehavioural

    Also called Power Training at Different Velocity Loss Thresholds, Power Training at Different Velocity-Based Training Doses

    Participants perform supervised power-training exercise on a pneumatic leg press. Each participant completes three exercise sessions, each separated by approximately one week. In each session, participants perform 4 sets of leg press exercise under different fatigue conditions:

    1. Exercise sets are terminated when movement velocity decreases by 10%. B) Exercise sets are terminated when movement velocity decreases by 30%. C) Exercise sets are terminated at 10% velocity loss, with total work matched to the 30% condition.
Study groups in NCT07522398
Study groupRoleWhat they receive
Low-Fatigue Power Training (10% velocity loss)ExperimentalParticipants perform a single supervised session of power training on a pneumatic leg press, consisting of 4 sets. During the exercise, movement speed is continuously monitored. In this arm, the exercise set will be stopped when movement speed decreases by 10% compared with the fastest repetition, which corresponds to a low level of fatigue (small amount of repetitions).
Receives: Behavioral: Power Training at Different Fatigue Levels
Moderate Fatigue Power Training (30% velocity loss)ExperimentalParticipants perform a single supervised session of power training on a pneumatic leg press, consisting of 4 sets. During the exercise, movement speed is continuously monitored. In this arm, the exercise set will be stopped when movement speed decreases by 30% compared with the fastest repetition, which corresponds to a moderate level of fatigue (more repetitions, performed closer to muscle failure).
Receives: Behavioral: Power Training at Different Fatigue Levels
Cluster-Set Power Training (10% Velocity Loss)ExperimentalParticipants perform a single supervised session of power training on a pneumatic leg press. In this arm, the exercise is organized into 4 cluster sets. A cluster set consists of small groups of repetitions separated by short rest periods within the set. Participants will perform clusters of 3-4 repetitions with 20 seconds of rest between clusters. During the exercise, movement speed is continuously monitored. Each cluster will be performed within the range of 10% velocity loss compared with the fastest repetition, which corresponds to a low level of fatigue. Clusters will continue until the total number of repetitions matches the training volume (amount of total repetitions) reached in the 30% velocity loss condition. This design allows participants to complete a similar total training volume as in the moderate fatigue condition, while maintaining lower fatigue, enabling researchers to separate the effects of exercise volume from the effects of fatigue.
Receives: Behavioral: Power Training at Different Fatigue Levels

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Maximum Voluntary Contraction (MVC)

    Maximum voluntary contraction (MVC) will be assessed to determine the maximum force-generating capacity of the leg extensors using an isokinetic dynamometer (Humac Norm). Simultaneously, muscle activity will be recorded using surface electromyography (EMG; Delsys EMG system).

    Primary outcome metric: Peak torque (Nm) obtained from three maximal isometric trials recorded on the dynamometer, combined with EMG amplitude (µV) to quantify muscle activation. Interpretation: Higher torque values indicate greater knee extensor strength. EMG amplitude reflects the level of muscle activation during maximal voluntary effort.

    Interpretation: Higher force values indicate greater leg muscle strength. EMG values indicate the level of muscle activation during the maximal effort.

    Measured: Measurements will be taken before exercise (baseline), 5 minutes after each training session, and 24 hours after each session.

Secondary outcomes (15)
  1. Rate of Torque Development (RTD)

    Rate of torque development (RTD) will be assessed to determine how quickly participants can generate torque with their leg extensors. This will be measured using an isokinetic dynamometer (Humac Norm), which records joint torque, alongside surface electromyography (EMG; Delsys EMG system), which measures muscle activation. This parameter provides insight into neuromuscular responses to different levels of power training-induced fatigue.

    Metric: Peak rate of torque development (Nm/s) calculated from three maximal trials, together with EMG amplitude (µV). RTD will be calculated as the slope of the torque-time curve over a specified time interval (e.g., 0-100ms, 100-200 ms).

    Measured: Measurements will be taken before exercise (baseline), 5 minutes after each training session, and 24 hours after each session.

  2. Muscle Activity

    Muscle activity will be assessed by recording the electrical signals of the leg muscles during the leg press exercise using surface electromyography (sEMG; Delsys EMG system). This method enables quantification of muscle activation and fatigue-related changes in neuromuscular function.

    Surface electrodes will be placed on three key thigh muscles: the vastus lateralis, vastus medialis, and biceps femoris.

    Metric: EMG amplitude (µV), derived from the recorded electrical signals, representing the level of muscle activation during exercise.

    Measured: Measurements will be taken before exercise (baseline), during exercise session (mean value across the full session), 5 minutes post exercise, and 24 hours post exercise (3 exercise sessions, 1 week apart)

  3. Strength Training Data: Mean Movement Velocity

    Mean concentric movement velocity (meter per second (m/s)) recorded during each leg press (exercise) repetition using the Keiser A400 Leg Press.

    Measured: During each exercise session (mean values across the full session) (3 Sessions ; ~1 week apart)

  4. Strength Training Data: Power

    Mean mechanical power (Watts (W)) produced during each leg press repetition recorded by the Keiser A400 Leg Press.

    Measured: During each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart)

  5. Strength Training Data: Total Number of Repetitions

    Total number of repetitions (count) completed during each exercise session on the leg press.

    Measured: During each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart)

  6. Muscle Oxygenation

    Muscle oxygenation will be assessed to determine oxygen availability in the thigh muscle (vastus lateralis) during and after exercise using near-infrared spectroscopy (NIRS). In addition, a vascular occlusion test will be performed to evaluate muscle oxygen extraction and the recovery kinetics of oxygenation following transient blood flow restriction.

    Metric: Muscle oxygen saturation (%; e.g., SmO₂), as well as reoxygenation rate and amplitude following occlusion.

    Measured: Baseline (pre-exercise), continuously during each exercise session, 5 minutes post-exercise, and 24 hours post-exercise (for each of the 3 sessions, 1 week apart)

  7. Blood Lactate

    Small blood sample will be taken to measure lactate, in millimoles per liter analysed through standard laboratory tests, including Enzyme-Linked Immunosorbent Assay (ELISA).

    Measured: Measurements will be taken at baseline and immediately post exercise session (3 sessions, 1 week apart)

  8. Blood Gas

    A Small blood sample will be taken to measure blood gas levels (blood oxygen/carbon dioxide levels) using standard laboratory tests, including Enzyme-Linked Immunosorbent Assay (ELISA).

    Measured: Measurements will be taken at baseline and immediately post exercise session (3 sessions, 1 week apart).

  9. Creatine Kinase (CK)

    Small blood samples will be taken to measure creatine kinase (CK), an enzyme that increases in the blood when muscles are damaged or stressed.

    Metric: CK concentration in units per liter (U/L).

    Measured: Measurements will be taken at Baseline and 24 hours after each exercise session.

  10. Functional Performance: Five-Repetition Sit-to-Stand Test

    Five-Repetition Sit-to-Stand (5xSTS) test: Participants stand up from a chair repeatedly. An inertial measurement unit (DynaPort MoveTest, McRoberts, The Hague, NL) measures speed (meters per second (m/s)), movement duration (s) , and power (W).

    Measured: Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.

  11. Functional Performance: Counter Movement Jump

    Countermovement Jump (CMJ): Participants jump vertically from a standing position. Jump height (cm), force (Nm), and power (W) are measured using KINVENT force plates.

    Measured: Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.

  12. Functional Performance: Stair Ascent test

    Stair Ascent Test (SA): Participants climb a set of stairs while wearing an inertial measurement unit (DynaPort MoveTest, McRoberts, The Hague, NL), which measures speed (m/s), movement duration (s), distance (cm), and power (W).

    Measured: Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.

  13. Functional Performance: 30-s Sit-to-Stand Test

    30-Second Sit-to-Stand (30sSTS) Tests: Participants stand up from a chair repeatedly. An inertial measurement unit (DynaPort MoveTest, McRoberts, The Hague, NL) measures speed (m/s), movement duration (s), and power (W).

    Measured: Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.

  14. Perceived Exertion

    Perceived exertion will be assessed using the OMNI Resistance Exercise Scale (OMNI-RES). Participants will rate their level of effort after each exercise set during the leg press sessions. The scale ranges from 1 (no exertion at all) to 10 (maximum effort), with higher scores indicating greater perceived exertion.

    Measured: Assessed after each exercise set during each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart)

  15. Delayed Onset Muscle Soreness (DOMS)

    Delayed onset of muscle soreness (DOMS) will be assessed using a Visual Analog Scale (VAS). Participants will rate perceived soreness in the leg muscles on a scale from 0 (no soreness) to 10 (worst possible soreness), with higher scores indicating greater muscle soreness.

    Measured: Ratings will be collected at baseline, 24 hours after exercise, and 48 hours after exercise using a remote survey.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Apr 2026
  2. Study start20 Apr 2026
  3. Primary completionJan 2027 (estimated)
  4. Study completionJan 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Crossover
Model description
Participants will complete three exercise sessions different by fatigue and volume levels, each separated by about one week. The order of the first two sessions will be randomized. These sessions involve two different exercise conditions with different levels of fatigue. The third session will always be performed last. This session is designed to match the total amount of exercise volume performed in one of the earlier sessions for each participant individually. Because this matching depends on the amount of exercise volume completed previously, the final session must occur after the first two sessions. This study design allows researchers to compare how different levels of fatigue affect participants' responses to exercise, while also examining the effects of exercise volume independently of fatigue.
Masking
None (open label)
Enrolment
42 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07522398
Sponsor's protocol ID
B1152025000035
Other IDs
BOF25OWB22
Acronym
APTE-OA
Status last verified
Apr 2026
First submitted
25 Mar 2026
Last updated
17 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Pseudonymazed participant data, including study measurements and outcomes, along with relevant supporting documents (e.g., study protocol, statistical analysis plan). Data will be shared via a Data Transfer Agreement (DTA). Access may be provided through a secure repository such as FAIRVault.

Questions about this trial

What is this clinical trial studying?

A study testing Power Training at Different Fatigue Levels in people with Muscle Power and Functional Performance, run by Hasselt University at 1 site in Belgium.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Max Riesbeck, Master of Science (+32 11 26 84 93, max.riesbeck@uhasselt.be), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Maximum Voluntary Contraction (MVC) (time frame: Measurements will be taken before exercise (baseline), 5 minutes after each training session, and 24 hours after each session.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.

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