Sciatic NerveNCT07525895
Effect of Sciatic Nerve Mobilization on Lower Extremity Pain Perception
A study testing Sciatic Nerve Mobilization in people with Sciatic Nerve and Lower Extremity Pain, run by Fenerbahce University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Sciatic Nerve, Lower Extremity Pain
- What is being tested?
- Sciatic Nerve Mobilization
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Mar 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged 18 to 30 years
- Being a student at Fenerbahçe University
- No history of major trauma or surgery in the lower extremity within the last 6 months
- Voluntarily agreeing to participate in the study and signing the informed consent form
Who cannot join
- History of neurological disease
- History of lower extremity peripheral nerve injury
- Having undergone lower extremity surgery within the last 6 months
- Regular use of analgesic or muscle relaxant medications
- Pregnancy
- Presence of any systemic disease that may interfere with the assessment or intervention procedures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Fenerbahçe University
Istanbul, Ataşehir, 34758
About this study
Official title: The Effect of Sciatic Nerve Mobilization on Pain Perception in Lower Extremity Peripheral Nerves
This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group.
Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded.
Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.
Read the detailed description
This randomized controlled pilot study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial nerve and the common peroneal nerve, in healthy university students. The study will be conducted at Fenerbahçe University.
A total of 34 participants will be included. Eligible participants will be students aged 18 to 30 years at Fenerbahçe University who voluntarily agree to participate and meet the study eligibility criteria. Participants will be randomly assigned to an intervention group or a control group.
Pain perception will be assessed using pressure pain threshold measurements obtained with a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves. Measurements will be performed before and after the study procedure using the same protocol for all participants.
Participants in the intervention group will receive a standardized sliding-type sciatic nerve mobilization protocol performed in the supine position. The mobilization includes coordinated movements of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion to create a sliding effect on the sciatic nerve. The control group will not receive any intervention.
- Conditions
- Sciatic Nerve, Lower Extremity Pain
- Being tested
- Sciatic Nerve Mobilization
- Keywords
- Sciatic nerve mobilization, Pressure pain threshold, Neurodynamic mobilization, Peripheral nerve mechanosensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sciatic Nerve MobilizationOther
A standardized sliding-type sciatic nerve mobilization will be applied in the supine position. The technique includes coordinated hip flexion, knee extension, and ankle dorsiflexion/plantarflexion movements to produce a sliding effect on the sciatic nerve.
| Study group | Role | What they receive |
|---|---|---|
| Sciatic Nerve Mobilization Group | Experimental | Participants in this group will receive a standardized sliding-type sciatic nerve mobilization. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the intervention. Receives: Other: Sciatic Nerve Mobilization |
| Control Group | No intervention | Participants in this group will receive no intervention. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the study procedure. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pressure Pain Threshold of the Tibial Nerve
Pressure pain threshold of the tibial nerve will be assessed using a pressure algometer at a standardized anatomical point in the popliteal fossa. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Measured: Before intervention and immediately after intervention
Pressure Pain Threshold of the Common Peroneal Nerve
Pressure pain threshold of the common peroneal nerve will be assessed using a pressure algometer at a standardized anatomical point around the fibular head/neck region. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Measured: Before intervention and immediately after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start20 Mar 2026
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sciatic NerveStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to one of two parallel groups: an intervention group receiving sciatic nerve mobilization or a control group receiving no intervention. Pressure pain threshold measurements of the tibial and common peroneal nerves will be obtained before and after the study procedure in both groups.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 34 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Fenerbahce University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sümeyye Akçay, Fenerbahce University
- Investigators
- Sümeyye Akçay, Asst. Prof., Principal investigator, Fenerbahçe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07525895
- Sponsor's protocol ID
- FenerbahceUniver
- Status last verified
- Jul 2026
- First submitted
- 6 Apr 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared because the study involves a small sample from a single university population, and data sharing could increase the risk of participant identification.
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Sciatic Nerve Mobilization on Pain Perception in Lower Extremity Peripheral Nerves
- ClinicalTrials.gov ID
- NCT07525895
- Acronym / sponsor ID
- FenerbahceUniver
- Conditions
- Sciatic Nerve, Lower Extremity Pain
- Keywords
- Sciatic nerve mobilization, Pressure pain threshold, Neurodynamic mobilization, Peripheral nerve mechanosensitivity
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 34 participants (estimated)
- Lead sponsor
- Fenerbahce UniversityUniversity, hospital or other
- Study start
- 20 Mar 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group.
Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded.
Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.
Detailed description
This randomized controlled pilot study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial nerve and the common peroneal nerve, in healthy university students. The study will be conducted at Fenerbahçe University.
A total of 34 participants will be included. Eligible participants will be students aged 18 to 30 years at Fenerbahçe University who voluntarily agree to participate and meet the study eligibility criteria. Participants will be randomly assigned to an intervention group or a control group.
Pain perception will be assessed using pressure pain threshold measurements obtained with a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves. Measurements will be performed before and after the study procedure using the same protocol for all participants.
Participants in the intervention group will receive a standardized sliding-type sciatic nerve mobilization protocol performed in the supine position. The mobilization includes coordinated movements of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion to create a sliding effect on the sciatic nerve. The control group will not receive any intervention.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to one of two parallel groups: an intervention group receiving sciatic nerve mobilization or a control group receiving no intervention. Pressure pain threshold measurements of the tibial and common peroneal nerves will be obtained before and after the study procedure in both groups.
| Arm | Type | Receives |
|---|---|---|
| Sciatic Nerve Mobilization Group | Experimental | Other: Sciatic Nerve MobilizationParticipants in this group will receive a standardized sliding-type sciatic nerve mobilization. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the intervention. |
| Control Group | No intervention | –Participants in this group will receive no intervention. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the study procedure. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Aged 18 to 30 years
- Being a student at Fenerbahçe University
- No history of major trauma or surgery in the lower extremity within the last 6 months
- Voluntarily agreeing to participate in the study and signing the informed consent form
Key exclusion criteria (6 listed)
- History of neurological disease
- History of lower extremity peripheral nerve injury
- Having undergone lower extremity surgery within the last 6 months
- Regular use of analgesic or muscle relaxant medications
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sciatic Nerve MobilizationA standardized sliding-type sciatic nerve mobilization will be applied in the supine position. The technique includes coordinated hip flexion, knee extension, and ankle dorsiflexion/plantarflexion movements to produce a sliding effect on the sciatic nerve. | Other | Sciatic Nerve Mobilization Group |
Primary outcome
Pressure Pain Threshold of the Tibial Nerve
Time frame: Before intervention and immediately after intervention
Pressure pain threshold of the tibial nerve will be assessed using a pressure algometer at a standardized anatomical point in the popliteal fossa. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Pressure Pain Threshold of the Common Peroneal Nerve
Time frame: Before intervention and immediately after intervention
Pressure pain threshold of the common peroneal nerve will be assessed using a pressure algometer at a standardized anatomical point around the fibular head/neck region. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared because the study involves a small sample from a single university population, and data sharing could increase the risk of participant identification.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sümeyye Akçay, Asst. Prof. principal investigator
Fenerbahçe University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sciatic Nerve Mobilization in people with Sciatic Nerve and Lower Extremity Pain, run by Fenerbahce University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pressure Pain Threshold of the Tibial Nerve (time frame: Before intervention and immediately after intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.