Musculoskeletal InjuryNCT07526753
Focused Shockwave (ESWT), Radial Pressure Waves (EPAT), And Electromagnetic Transduction Therapy (EMTT) For Lower Extremity Musculoskeletal Injuries
A study testing Shock wave, Radial pressure waves and Electromagnetic transduction therapy (EMTT) in people with Musculoskeletal Injury, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this study is to assess the efficacy of ESWT, EPAT, EMTT and the combination of these therapies in treating patients with lower extremity soft tissue, cartilage, and bone injuries. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Musculoskeletal Injury
- What is being tested?
- Shock wave, Radial pressure waves and Electromagnetic transduction therapy (EMTT)
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Mar 2026to Apr 2035
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Men and women > 18 with lower extremity musculoskeletal injury confirmed by physician
Who cannot join
- All devices: Patients with active cancer or who may be pregnant.
- For EMTT only, patients with shrapnel, metal in the body, pacemaker, or non-MRI compatible implantable devices.
Trial locations and contacts
1 site in 1 country.
United States1 site
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
About this study
The purpose of this study is to assess the efficacy of ESWT, EPAT, EMTT and the combination of these therapies in treating patients with lower extremity soft tissue, cartilage, and bone injuries.
- Conditions
- Musculoskeletal Injury
- Being tested
- Shock wave, Radial pressure waves, Electromagnetic transduction therapy (EMTT)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Shock waveDevice
shockwave
Radial pressure wavesDevice
Pressure waves
Electromagnetic transduction therapy (EMTT)Device
EMTT
| Study group | Role | What they receive |
|---|---|---|
| shock wave only | Experimental | Not described Receives: Device: Shock wave |
| shock wave + radial pressure wave | Experimental | Not described Receives: Device: Shock wave; Device: Radial pressure waves |
| EMTT | Experimental | EMTT Receives: Device: Electromagnetic transduction therapy (EMTT) |
| shock wave + EMTT | Experimental | Not described Receives: Device: Shock wave; Device: Electromagnetic transduction therapy (EMTT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
VAS
Measured: initial, 6weeks, 3 months, 6 months, 1 year
Secondary outcomes (1)
FAAM
Measured: baseline, 6 week, 3 month, 6 month 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start15 Mar 2026
- Primary completionApr 2035 (estimated)
- Study completionApr 2035 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Musculoskeletal InjuryStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elizabeth Bondi, Mayo Clinic
- Investigators
- Elizabeth Bondi, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07526753
- Sponsor's protocol ID
- 25-011219
- Status last verified
- Apr 2026
- First submitted
- 6 Apr 2026
- Last updated
- 18 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Focused Shockwave (ESWT), Radial Pressure Waves (EPAT), And Electromagnetic Transduction Therapy (EMTT) For Lower Extremity Musculoskeletal Injuries
- ClinicalTrials.gov ID
- NCT07526753
- Acronym / sponsor ID
- 25-011219
- Conditions
- Musculoskeletal Injury
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 15 Mar 2026 (actual)
- Primary completion
- Apr 2035 (estimated)
- Study completion
- Apr 2035 (estimated)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to assess the efficacy of ESWT, EPAT, EMTT and the combination of these therapies in treating patients with lower extremity soft tissue, cartilage, and bone injuries.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| shock wave only | Experimental | Device: Shock wave |
| shock wave + radial pressure wave | Experimental | Device: Shock wave, Device: Radial pressure waves |
| EMTT | Experimental | Device: Electromagnetic transduction therapy (EMTT)EMTT |
| shock wave + EMTT | Experimental | Device: Shock wave, Device: Electromagnetic transduction therapy (EMTT) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Men and women > 18 with lower extremity musculoskeletal injury confirmed by physician
Key exclusion criteria (2 listed)
- All devices: Patients with active cancer or who may be pregnant.
- For EMTT only, patients with shrapnel, metal in the body, pacemaker, or non-MRI compatible implantable devices.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Shock waveshockwave | Device | shock wave + EMTT, shock wave + radial pressure wave, shock wave only |
| Radial pressure wavesPressure waves | Device | shock wave + radial pressure wave |
| Electromagnetic transduction therapy (EMTT)EMTT | Device | EMTT, shock wave + EMTT |
Primary outcome
VAS
Time frame: initial, 6weeks, 3 months, 6 months, 1 year
1 secondary outcome
FAAM
Time frame: baseline, 6 week, 3 month, 6 month 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 May 2026.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Elizabeth Bondi principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Shock wave, Radial pressure waves and Electromagnetic transduction therapy (EMTT) in people with Musculoskeletal Injury, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 18 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
VAS (time frame: initial, 6weeks, 3 months, 6 months, 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 May 2026.