Elective Egg FreezingDAEEFNCT07543445
Decision Aid for Elective Egg Freezing
A study testing elective egg freezing decision aid in people with Elective Egg Freezing and Oocyte Cryopreservation, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
The goal of this clinical trial is to evaluate whether a culturally tailored decision aid can improve decision-making and clinical outcomes for Taiwanese women considering elective egg freezing. Read more about this study
- Who is it for?
- Ages 20 years and older, women only
- Conditions the study is for
- Elective Egg Freezing, Oocyte Cryopreservation, Decision Aid
- What is being tested?
- elective egg freezing decision aid
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteTaiwan
- Study dates
- 13 Apr 2026to 31 Dec 2031
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Women aged 20 years or older.
- Currently considering elective egg freezing (EEF).
- Able to communicate and read Chinese fluently.
- Have access to the internet and a mobile device (smartphone, tablet, or computer) to complete online questionnaires.
Who cannot join
- Individuals who have previously completed oocyte cryopreservation.
- Women undergoing fertility preservation due to malignancy (i.e., breast cancer).
- Postmenopausal women.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site
National Taiwan University Hospital
Taipei, Taiwan, 100
Jou-Chien Liao, Doctor, +886987877611, ruth5056@gmail.com
About this study
Official title: Knowledge, Decision-making, and Oocyte Cryopreservation Outcomes in Taiwanese Women Considering Elective Egg Freezing: a Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether a culturally tailored decision aid can improve decision-making and clinical outcomes for Taiwanese women considering elective egg freezing.
The main questions it aims to answer are:
Read more
Does the decision aid improve women's knowledge about elective egg freezing and help clarify their personal values? Does the decision aid reduce decision regret and psychological distress after making a decision about egg freezing?
Researchers will compare women who use the decision aid with those who receive standard counseling to see if the tool improves knowledge, reduces distress and regret, and leads to better clinical outcomes (such as completing egg freezing or achieving a higher number of frozen oocytes).
Participants will:
- Complete questionnaires assessing their baseline knowledge, attitudes, and values regarding egg freezing
- Receive either the decision aid or standard counseling
- Complete follow-up questionnaires to assess knowledge, distress, and decision regret
- Have their clinical outcomes recorded, including whether they undergo egg freezing and the number of oocytes retrieved and frozen
- Conditions
- Elective Egg Freezing, Oocyte Cryopreservation, Decision Aid, Egg Freezing, Shared Decision Making, Assisted Reproductive Technology
- Being tested
- elective egg freezing decision aid
- Keywords
- elective egg freezing, planned oocyte cryopreservation, fertility preservation, decision aid, shared decision making, assisted reproductive technology, randomized controlled trial
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
elective egg freezing decision aidOther
The EEF decision aid used in this study is an evidence-based educational tool designed to support shared decision making. Its primary function is to provide clear, balanced, and structured information to help women make decisions that align with their personal values and reproductive goals.
| Study group | Role | What they receive |
|---|---|---|
| Decision Aid | Experimental | Not described Receives: Other: elective egg freezing decision aid |
| Control | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Decision Regret Scale
The Decision Regret Scale (DRS) is a 5-item validated questionnaire used to assess distress or remorse after a healthcare decision. Each item is scored on a 5-point Likert scale. Scores are transformed to a 0-100 scale, with higher scores indicating greater decision regret (worse outcome).
Measured: 6 months, 24 months
Secondary outcomes (6)
Knowledge score regarding elective egg freezing
Knowledge regarding elective egg freezing will be assessed using a self-developed questionnaire consisting of multiple-choice items covering fertility decline, success rates, risks, and procedural aspects. Each correct answer is awarded 1 point. Scores are transformed to a 0-100 scale, with higher scores indicating greater knowledge (better outcome).
Measured: baseline, 6 months, 24 months
Decisional conflict scale
The Decisional Conflict Scale (DCS) is a 16-item validated instrument measuring personal perceptions of uncertainty in choosing options, modifiable factors contributing to uncertainty, and perceived effective decision-making. Each item is scored on a 5-point Likert scale. Scores are converted to a 0-100 scale, with higher scores indicating greater decisional conflict (worse outcome).
Measured: baseline, 6 months, 24 months
Depression anxiety stress scale
The Depression Anxiety Stress Scales-21 (DASS-21) is a 21-item validated questionnaire assessing symptoms of depression, anxiety, and stress across three subscales. Each item is scored from 0 to 3. Subscale scores range from 0 to 21 (or 0-42 after standard multiplication), with higher scores indicating greater psychological distress (worse outcome).
Measured: baseline, 6 months, 24 months
Elective egg freezing treatment completion rate
Treatment completion is defined as participants who undergo at least one completed oocyte retrieval cycle for elective egg freezing following enrollment. The completion rate will be calculated as the proportion of participants who complete treatment out of all enrolled participants.
Measured: From enrollment to the end of intervention at 2 years.
Number of oocytes cryopreserved per participant
The total number of mature oocytes (metaphase II oocytes) successfully retrieved and cryopreserved per participant during the study period will be recorded. If participants undergo multiple cycles, the cumulative number of oocytes cryopreserved will be reported.
Measured: From enrollment to the end of intervention at 2 years.
Ovarian stimulation cycle cancellation rate
Cycle cancellation is defined as initiation of ovarian stimulation without proceeding to oocyte retrieval. The cancellation rate will be calculated as the proportion of initiated cycles that are canceled prior to oocyte retrieval.
Measured: From enrollment to the end of intervention at 2 years.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Apr 2026
- Study start13 Apr 2026 (estimated)
- Primary completion31 Jul 2029 (estimated)
- Study completion31 Dec 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Elective Egg FreezingStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07543445
- Sponsor's protocol ID
- 202601216RINA
- Acronym
- DAEEF
- Status last verified
- Apr 2026
- First submitted
- 9 Apr 2026
- Last updated
- 21 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: De-identified individual participant data (IPD) will not be made publicly available due to the sensitive nature of the data, which includes personal reproductive decision-making, psychological assessments, and qualitative responses that may carry a risk of re-identification.
Study at a glance
From the registry record, last updated by the sponsor on 21 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Knowledge, Decision-making, and Oocyte Cryopreservation Outcomes in Taiwanese Women Considering Elective Egg Freezing: a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07543445
- Acronym / sponsor ID
- DAEEF / 202601216RINA
- Conditions
- Elective Egg Freezing, Oocyte Cryopreservation, Decision Aid, Egg Freezing, Shared Decision Making, Assisted Reproductive Technology
- Keywords
- elective egg freezing, planned oocyte cryopreservation, fertility preservation, decision aid, shared decision making, assisted reproductive technology, randomized controlled trial
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 13 Apr 2026 (estimated)
- Primary completion
- 31 Jul 2029 (estimated)
- Study completion
- 31 Dec 2031 (estimated)
- First posted
- 21 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate whether a culturally tailored decision aid can improve decision-making and clinical outcomes for Taiwanese women considering elective egg freezing.
The main questions it aims to answer are:
Does the decision aid improve women's knowledge about elective egg freezing and help clarify their personal values? Does the decision aid reduce decision regret and psychological distress after making a decision about egg freezing?
Researchers will compare women who use the decision aid with those who receive standard counseling to see if the tool improves knowledge, reduces distress and regret, and leads to better clinical outcomes (such as completing egg freezing or achieving a higher number of frozen oocytes).
Participants will:
- Complete questionnaires assessing their baseline knowledge, attitudes, and values regarding egg freezing
- Receive either the decision aid or standard counseling
- Complete follow-up questionnaires to assess knowledge, distress, and decision regret
- Have their clinical outcomes recorded, including whether they undergo egg freezing and the number of oocytes retrieved and frozen
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Decision Aid | Experimental | Other: elective egg freezing decision aid |
| Control | No intervention | – |
Who may qualify
- Ages
- 20 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Women aged 20 years or older.
- Currently considering elective egg freezing (EEF).
- Able to communicate and read Chinese fluently.
- Have access to the internet and a mobile device (smartphone, tablet, or computer) to complete online questionnaires.
Key exclusion criteria (3 listed)
- Individuals who have previously completed oocyte cryopreservation.
- Women undergoing fertility preservation due to malignancy (i.e., breast cancer).
- Postmenopausal women.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| elective egg freezing decision aidThe EEF decision aid used in this study is an evidence-based educational tool designed to support shared decision making. Its primary function is to provide clear, balanced, and structured information to help women make decisions that align with their personal values and reproductive goals. | Other | Decision Aid |
Primary outcome
Decision Regret Scale
Time frame: 6 months, 24 months
The Decision Regret Scale (DRS) is a 5-item validated questionnaire used to assess distress or remorse after a healthcare decision. Each item is scored on a 5-point Likert scale. Scores are transformed to a 0-100 scale, with higher scores indicating greater decision regret (worse outcome).
6 secondary outcomes
Knowledge score regarding elective egg freezing
Time frame: baseline, 6 months, 24 months
Decisional conflict scale
Time frame: baseline, 6 months, 24 months
Depression anxiety stress scale
Time frame: baseline, 6 months, 24 months
Elective egg freezing treatment completion rate
Time frame: From enrollment to the end of intervention at 2 years.
Number of oocytes cryopreserved per participant
Time frame: From enrollment to the end of intervention at 2 years.
Ovarian stimulation cycle cancellation rate
Time frame: From enrollment to the end of intervention at 2 years.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Apr 2026.
- Individual participant dataSharing planned: No. De-identified individual participant data (IPD) will not be made publicly available due to the sensitive nature of the data, which includes personal reproductive decision-making, psychological assessments, and qualitative responses that may carry a risk of re-identification.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing elective egg freezing decision aid in people with Elective Egg Freezing and Oocyte Cryopreservation, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jou-Chien Liao, Doctor (+886 987877611, ruth5056@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Decision Regret Scale (time frame: 6 months, 24 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Apr 2026.