Clinical trials: Assisted Reproductive Technology
Reproductive Performance Following Ovarian Transplantation
Transplantation of Frozen Thawed Ovarian Tissue High Reproductive Performance
Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive.
- Trial name
- NCT02659592
- Testing
- transplantation of ovarian tissue
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
COVID-19
Retrospective Study of COVID-19 on Reproductive Function
This multi-center, retrospective cohort study aimed to determine which factors are associated with ongoing pregnancy rates in infertile patients received ART treatments during the current outbreak of COVID-19 infection.Couples…
- Trial name
- NCT05685966
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Jinling Hospital, China
Assisted Reproductive Technology
Family Foundations for Individuals Pregnant Via ART
The purpose of this study is to help expectant mothers build a coparenting bond and improve communication with a support person (co-caregiver).
- Trial name
- NCT06770972
- Testing
- Family Foundations
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Polycystic Ovary Syndrome
A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation
This is a Phase IV, prospective, observational, single arm, multicenter trial to identify the population at high risk of overstimulation associated with signs and symptoms of PCOS and examines the utility of 12.5 international…
- Trial name
- ARTIST (NCT02607293)
- Testing
- Gonal-f®, Long GnRH agonist, GnRH antagonist
- Where
- Germany
- Volunteers
- 1,064 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
IVF Outcomes, Stress Levels
Virtual Reality Use in Assisted Reproductive Technology
The study will examine the effect of exposure to virtual reality on stress levels and pregnancy rates, in infertile women undergoing in vitro fertilization embryo transfer
- Trial name
- NCT04394962
- Testing
- Virtual reality
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Dr cliff Librach
to Evaluate Letrozole as a Modality for Minimal Ovarian Stimulation in ICSI Cycles .
Letrozole in Assisted Reproductive Technology
Infertility in not a health problem and that infertile couples are not really ill. However, this narrow interpretation of the problem is refuted by the world community.
- Trial name
- NCT02429999
- Testing
- Letrezole plus FSH, Standard protocol for induction of ovulation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Infertility
A Retrospective Study in Chinese Good Prognosis Patients Undergoing Assisted Reproductive Technology (ART) Treatment
This is a multicenter retrospective study in good prognosis Chinese patients. Data will be collected from infertile women who underwent first in vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI) using a…
- Trial name
- FASSION (NCT02889380)
- Testing
- No Intervention
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
No Condition
Comparison of Clinical Outcomes Between IVM and Minimal Stimulation IVF in Patients With PCOS
Polycystic ovarian syndrome (PCOS) is most common endocrinologic disease in women of reproductive age with incidence of 6.6 ~ 8%.
- Trial name
- NCT03134482
- Testing
- IVM, Minimal stimulation IVF
- Where
- 2 sites in South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHA University
Infertility
The Role of Progesterone and PIF for Successful Implantation and On-going Pregnancy in Assisted Reproductive Technology
The aim of this study is to achieve a more profound understanding of the endocrine alteration in luteal progesterone level after gonadotrophin stimulated IVF/ICSI cycles and to explore the optimal progesterone level needed for…
- Trial name
- NCT02129998
- Testing
- IVF/ICSI treatment
- Where
- Denmark
- Volunteers
- 873 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
Infertility
CONSORT Randomized Controlled Trial in Assisted Reproductive Technology
The overall objective of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered GONAL f® according to the 'Consistency in recombinant follicle stimulating hormone [r-FSH]…
- Trial name
- NCT00829244
- Testing
- GONAL f® prefilled pen
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Sperm Selection for Infertility Treatment (SSA)
Infertility is considered a disease by the World Health Organization and it is increasing worldwide affecting more than 70 million couples. About 50% of the cases are due to male inability to fertilize the oocyte.
- Trial name
- SSA (NCT02867111)
- Testing
- Sperm Selection Assay, Attractant Substance, ICSI
- Where
- 2 sites in Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Córdoba
Infertility, Female, Endometriosis
Predicting Endometrial Receptivity for Optimal Reproductive Management
The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for…
- Trial name
- PERFORM (NCT04107129)
- Testing
- Endometrial Biopsy, Euploid embryo transfer, Blood sample
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Thyroid Diseases
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these…
- Trial name
- NCT04943146
- Testing
- Prednisone 10 MG+aspirin 100MG
- Where
- 2 sites in China
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fertility Disorders, Assisted Reproductive Technology
The Clinical Cohort Study of Reproductive Health
The study will conduct a multicenter prospective clinical cohort study to collect comprehensive health information and essential specimens from pre-pregnancy to postpartum offspring development.
- Conditions
- Fertility Disorders, Assisted Reproductive Technology, Offspring Health
- Trial name
- NCT05164029
- Testing
- Completion questionnaires/providing biological samples
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
ART
Effect of Vitamin D on Outcome of Assisted Reproductive Technology(ART);
Vitamin D has many biological functions. Vitamin D receptors are widely distributed in the male and female reproductive system. Animal experiments have shown that vitamin D deficiency can affect hormone synthesis and gamete…
- Trial name
- ART (NCT03804294)
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Peking University Third Hospital
Sterility, Infertility
Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology
This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.
- Trial name
- NCT03177122
- Testing
- Myo-inositol
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
MACS Technique Efficacy
Application of MACS and Time-lapse Technology in Good-prognosis Patients
The MACS technique (magnetic-activated cell sorting) is based on the usage of microbeads, magnetic particles with a diameter of 35 nanometers joined to the compound annexin V.
- Trial name
- NCT01908569
- Testing
- MACS, NO MACS
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Vida Recoletas Sevilla
Female Infertility
Hormone Evaluation in Artificial Reproductive Technology
The aim is to be able to predict the hormonal response according to gonadotropin receptor genotype and hormone type used for treatment of women undergoing in vitro fertilization or egg donation.
- Trial name
- HEART (NCT03737253)
- Testing
- Follitropin alpha, Menotropin
- Where
- 2 sites in Poland, Sweden
- Volunteers
- 810 people
- Sponsor
- Lund University