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AthleteNCT07546513

Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels

A study testing Cistanche deserticola and Standardized anaerobic training program in people with Athlete and Elite Athlete, run by Beijing Sport University at 1 site in China.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study is a double-blind, randomized, placebo-controlled trial designed to examine whether 8 weeks of Cistanche deserticola supplementation, when combined with a standardized anaerobic training program, can improve anaerobic exercise performance, recovery, and selected body composition outcomes in young adult men… Read more about this study

Who is it for?
Ages 18 to 25 years, men onlyHealthy volunteers can take part
Conditions the study is for
Athlete, Elite Athlete, Sport Performance
What is being tested?
Cistanche deserticola and Standardized anaerobic training program
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
56 participants
Where
1 siteChina
Study dates
25 Jun 2026to 15 Sep 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 25 years
  • Men only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Male, aged 18 to 25 years
  • Body mass index (BMI) between 18.5 and 25.0 kg/m²
  • Able and willing to provide written informed consent
  • Willing to comply with study procedures, supplementation, training, and assessments
  • Belonging to one of the following athletic training strata:
  • High-level elite stratum: Chinese National Level-1 Athlete standard in sprint-related events, regular training in past 12 months and active during study
  • Amateur stratum: regular exercise-training background in past 12 months without National Level-1 status

Who cannot join

  • Use of steroids or ergogenic supplements during study
  • Known cardiovascular, metabolic, musculoskeletal, or other conditions making participation unsafe or affecting outcomes
  • Current use of medications affecting muscle growth, recovery, hormones, or high-intensity performance
  • Current injury or limitation preventing safe participation
  • Known allergy or intolerance to supplement/placebo ingredients
  • Participation in another clinical trial or structured intervention during study period
  • Inability or unwillingness to comply with protocol
  • Any other condition deemed unsuitable by investigators

Trial locations and contacts

1 site in 1 country.

China1 site
  • Wuhan Sport University

    Wuhan, Hubei, 430000

Other trials in China

About this study

Official title: Effects of Cistanche Supplementation on Anaerobic Exercise Performance and Recovery in Men With Different Athletic Training Levels: A Double-Blind, Randomized, Placebo-Controlled Trial

This study is a double-blind, randomized, placebo-controlled trial designed to examine whether 8 weeks of Cistanche deserticola supplementation, when combined with a standardized anaerobic training program, can improve anaerobic exercise performance, recovery, and selected body composition outcomes in young adult men with different athletic training levels.

Participants will be assigned to receive either Cistanche deserticola extract or a matched placebo while completing the same supervised anaerobic training program. The study will assess changes in anaerobic performance, including Wingate test outcomes and jump performance, as well as recovery-related indicators such as blood lactate, creatine kinase, malondialdehyde, testosterone, cortisol, and the testosterone-to-cortisol ratio. Body composition outcomes, including body fat percentage and skeletal muscle mass, will also be evaluated.

The purpose of this study is to determine whether Cistanche deserticola supplementation provides additional benefits beyond training alone, and whether these effects differ between highly trained and recreationally trained participants.

Being tested
Cistanche deserticola, Matched placebo paste, Standardized anaerobic training program
Keywords
Cistanche, anaerobic performance, exercise recovery, explosive power, lactate, muscle damage, body composition, randomized controlled trial

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Cistanche deserticolaDietary supplement

    Participants receive Cistanche deserticola extract paste at a dose of 5 g/day for 8 weeks. The supplement is administered in two sachets per day, one after breakfast and one after lunch. The product is derived from Cistanche deserticola Y.C. Ma cultivated in Inner Mongolia and consists primarily of phenylethanoid glycosides. Batch-specific quality-control documentation is provided by the supplier to ensure consistency.

  • Matched placebo pasteDietary supplement

    Participants receive a matched placebo for 8 weeks. The placebo is administered in two sachets per day, one after breakfast and one after lunch, following the same schedule as the experimental supplement. It contains maltodextrin, microcrystalline cellulose, caramel coloring, and a food-grade bittering agent, and is matched to the active supplement in appearance, weight, texture, and taste.

  • Standardized anaerobic training programBehavioural

    All participants complete the same supervised standardized anaerobic training program 3 times per week for 8 consecutive weeks. Each session lasts approximately 50 to 65 minutes and includes a dynamic warm-up, repeated sprint training, explosive/strength-support exercises, short-bout high-intensity interval training, and a cool-down. Training load is progressively increased across the intervention period, and attendance as well as session rating of perceived exertion are recorded throughout the study.

Study groups in NCT07546513
Study groupRoleWhat they receive
Cistanche Supplementation + Standardized Anaerobic TrainingExperimentalParticipants in this arm receive Cistanche deserticola extract paste (5 g/day) for 8 weeks while completing the same supervised standardized anaerobic training program as the control arm. The training program is performed 3 times per week and includes repeated sprint training, explosive/strength-support exercises, and short-bout high-intensity interval training.
Receives: Dietary Supplement: Cistanche deserticola; Behavioral: Standardized anaerobic training program
Placebo + Standardized Anaerobic TrainingActive comparatorParticipants in this arm receive a matched placebo for 8 weeks while completing the same supervised standardized anaerobic training program as the experimental arm. The placebo is matched in appearance, weight, texture, and taste. The training program is performed 3 times per week and includes repeated sprint training, explosive/strength-support exercises, and short-bout high-intensity interval training.
Receives: Dietary Supplement: Matched placebo paste; Behavioral: Standardized anaerobic training program

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Peak power during the 30-second Wingate Anaerobic Test

    Peak power (W) measured during a 30-second Wingate Anaerobic Test performed on a Monark 894E cycle ergometer. The test is conducted under standardized conditions, and the primary analysis will evaluate the change from baseline to post-intervention and the between-group difference in change after 8 weeks of intervention.

    Measured: Baseline (week 0) and post-intervention (week 8)

  2. Squat jump height

    Squat jump (SJ) height in centimeters, assessed under standardized testing conditions as a measure of lower-limb explosive performance. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  3. Countermovement jump

    Countermovement jump (CMJ) height in centimeters, assessed under standardized testing conditions as a measure of lower-limb explosive performance. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

Secondary outcomes (10)
  1. Average power during the 30-second Wingate Anaerobic Test

    Average power (W) measured during the 30-second Wingate Anaerobic Test. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  2. Minimum power during the 30-second Wingate Anaerobic Test

    Measured: Baseline (week 0) and post-intervention (week 8)

  3. Power drop during the 30-second Wingate Anaerobic Test

    Power drop (%) calculated from the 30-second Wingate Anaerobic Test as an index of fatigue during maximal anaerobic effort. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  4. Post-exercise blood lactate response

    Capillary blood lactate concentration (mmol/L) measured immediately after the Wingate Anaerobic Test and at 3 minutes of recovery as indices of acute metabolic stress and recovery. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  5. Serum creatine kinase concentration

    Measured: Baseline (week 0) and post-intervention (week 8)

  6. Serum malondialdehyde concentration

    Serum malondialdehyde (MDA, nmol/mL) measured as a biomarker related to oxidative stress. Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  7. Serum testosterone concentration

    Fasting serum testosterone concentration (ng/mL) measured from venous blood samples collected under standardized morning conditions.

    Measured: Baseline (week 0) and post-intervention (week 8)

  8. Body fat percentage

    Body fat percentage measured using bioelectrical impedance analysis (InBody 770). Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  9. Skeletal muscle mass

    Skeletal muscle mass (kg) measured using bioelectrical impedance analysis (InBody 770). Analyses will assess change from baseline to post-intervention and between-group differences in change.

    Measured: Baseline (week 0) and post-intervention (week 8)

  10. Serum cortisol concentration

    Fasting serum cortisol concentration (μg/dL) measured from venous blood samples collected under standardized morning conditions.

    Measured: Baseline (week 0) and post-intervention (week 8)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Apr 2026
  2. Study start25 Jun 2026
  3. Primary completion1 Sep 2026
  4. Study completion15 Sep 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Health services research
Allocation
Randomised
Intervention model
Parallel groups
Model description
Model Description
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
56 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07546513
Sponsor's protocol ID
2025161
Status last verified
Jun 2026
First submitted
13 Apr 2026
Last updated
21 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided: The investigators have not yet decided whether individual participant data will be shared. Any future sharing of de-identified data will depend on participant consent, institutional requirements, ethics approval, and data governance considerations.

Publications

  • Bassett DR Jr. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1396. doi: 10.1249/01.MSS.0000078923.96621.1D. No abstract available.

    PubMed 12900695
  • Metter EJ, Talbot LA, Schrager M, Conwit R. Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002 Oct;57(10):B359-65. doi: 10.1093/gerona/57.10.b359.

    PubMed 12242311
  • Foster C, Florhaug JA, Franklin J, Gottschall L, Hrovatin LA, Parker S, Doleshal P, Dodge C. A new approach to monitoring exercise training. J Strength Cond Res. 2001 Feb;15(1):109-15.

    PubMed 11708692
  • Bobbert MF, Gerritsen KG, Litjens MC, Van Soest AJ. Why is countermovement jump height greater than squat jump height? Med Sci Sports Exerc. 1996 Nov;28(11):1402-12. doi: 10.1097/00005768-199611000-00009.

    PubMed 8933491
  • Thomas S, Reading J, Shephard RJ. Revision of the Physical Activity Readiness Questionnaire (PAR-Q). Can J Sport Sci. 1992 Dec;17(4):338-45.

    PubMed 1330274
  • Adlercreutz H, Harkonen M, Kuoppasalmi K, Naveri H, Huhtaniemi I, Tikkanen H, Remes K, Dessypris A, Karvonen J. Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int J Sports Med. 1986 Jun;7 Suppl 1:27-8. doi: 10.1055/s-2008-1025798. No abstract available.

    PubMed 3744643
  • Oliver JL, Ramachandran AK, Singh U, Ramirez-Campillo R, Lloyd RS. The Effects of Strength, Plyometric and Combined Training on Strength, Power and Speed Characteristics in High-Level, Highly Trained Male Youth Soccer Players: A Systematic Review and Meta-Analysis. Sports Med. 2024 Mar;54(3):623-643. doi: 10.1007/s40279-023-01944-8. Epub 2023 Oct 28.

    PubMed 37897637
  • Aslam S, Habyarimana JD, Bin SY. Neuromuscular adaptations to resistance training in elite versus recreational athletes. Front Physiol. 2025 Jun 9;16:1598149. doi: 10.3389/fphys.2025.1598149. eCollection 2025.

    PubMed 40551899
  • Gabbett TJ, Oetter E. From Tissue to System: What Constitutes an Appropriate Response to Loading? Sports Med. 2025 Jan;55(1):17-35. doi: 10.1007/s40279-024-02126-w. Epub 2024 Nov 11.

    PubMed 39527327
  • Guo L, Xu P, Li Z, Li Y, Li J, Li S, Lin N, Xu Y. Cistanche total glycoside capsule promotes sperm maturation and fertility by activating the NELL2 Lumicrine pathway in a male reproductive impairment model. J Ethnopharmacol. 2025 Sep 25;353(Pt A):120289. doi: 10.1016/j.jep.2025.120289. Epub 2025 Jul 12.

    PubMed 40659143
  • Jiao X, Liu X, Cao Q, Deng Z. Plant-based supplements in enhancing exercise performance and recovery. Front Nutr. 2025 Nov 24;12:1699642. doi: 10.3389/fnut.2025.1699642. eCollection 2025.

    PubMed 41368183
  • Naderi A, Rothschild JA, Santos HO, Hamidvand A, Koozehchian MS, Ghazzagh A, Berjisian E, Podlogar T. Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review. Sports Med. 2025 Jul;55(7):1559-1577. doi: 10.1007/s40279-025-02213-6. Epub 2025 Apr 12.

    PubMed 40221559
  • Tao B, Lian W, Min R, Zhang X, Chen L, Hao S, Li Z, Ma C, Zhang H, Liu C. Effects of Cistanche deserticola Y.C. Ma Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial. Nutrients. 2025 Sep 16;17(18):2965. doi: 10.3390/nu17182965.

    PubMed 41010491
  • Tao J, Zhong X, Lin H, Lai Y, Jian Z, Tao A, Jiang G. The potential, challenges, and prospects of polysaccharides from the genus Cistanche as therapeutic agents for aging-related diseases: A review. Int J Biol Macromol. 2025 Jun;312:144144. doi: 10.1016/j.ijbiomac.2025.144144. Epub 2025 May 11.

    PubMed 40360111
  • Varillas-Delgado D. Nutritional Intervention and Ergogenic Aids in Sport Performance and Recovery. Nutrients. 2025 Aug 29;17(17):2806. doi: 10.3390/nu17172806.

    PubMed 40944195

Questions about this trial

What is this clinical trial studying?

A study testing Cistanche deserticola and Standardized anaerobic training program in people with Athlete and Elite Athlete, run by Beijing Sport University at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Peak power during the 30-second Wingate Anaerobic Test (time frame: Baseline (week 0) and post-intervention (week 8)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07546513, which also lists 15 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.

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