Shock StateCRIPINCT07555041
Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients
An observational study of Shock State and Hemodynamics Instability, run by Hospices Civils de Lyon at 2 sites in France.
Trial summary
Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients. CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Shock State, Hemodynamics Instability, Microcirculation
- What is being tested?
- Microcirculation monitoring
- How many people
- 267 participants
- Where
- 2 sitesFrance
- Study dates
- 29 Apr 2026to 29 Sep 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients admitted to a University Hospital, either to a medical or surgical intensive care unit.
Who may be able to join
- Adult patient.
- Admission within the previous 24 hours, or within 24 hours of the onset of a hemodynamic instability criterion (requirement for vasopressors or fluid resuscitation).
- Absence of patient objection.
Who cannot join
- Legal guardianship, curatorship, or judicial protection.
- No social security coverage.
- Morphological abnormalities preventing CRT and IP measurements.
Trial locations and contacts
2 sites in 1 country.
France2 sites
Service de Réanimation cardio-vasculaire et thoracique, Hôpital Cardiologique louis Pradel, Hospices Civils de Lyon
Bron, 69500
Service de Médecine Intensive-Réanimation, Hôpital Édouard Herriot, Hospices Civils de Lyon
Lyon, 69003
About this study
Official title: Correlation Between Capillary Refilling tIme and Perfusion Index in Critically Ill Patients
Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.
CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.
Read more
Although CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.
The perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.
Because PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.
- Conditions
- Shock State, Hemodynamics Instability, Microcirculation, Monitoring
- Being tested
- Microcirculation monitoring
- Keywords
- Capillary refill time, Perfusion index, Microcirculation, Intensive care
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Microcirculation monitoringOther
Also called Capillary refill time (CRT) measurements
Microcirculation monitoring by Capillary Refill Time (CRT) measurements
Microcirculation monitoringOther
Also called Perfusion index (PI) measurements
Microcirculation monitoring by Perfusion Index (PI) measurements
What is being measured
The primary outcome is the main question the study is designed to answer.
Perfusion index (PI) threshold associated with abnormal capillary refill time (CRT)
The primary endpoint will be the PI threshold associated with abnormal CRT (> 3 seconds).
CRT is measured in seconds and PI in arbitrary units. These parameters will be measured simultaneously on each patient.
Measurements will be performed at the inclusion of each patient.
Measured: At the inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Apr 2026
- Study start29 Apr 2026
- Primary completion29 Sep 2026
- Study completion29 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Shock StateStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 267 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07555041
- Sponsor's protocol ID
- 69HCL26_0232
- Acronym
- CRIPI
- Status last verified
- Oct 2026
- First submitted
- 21 Apr 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation Between Capillary Refilling tIme and Perfusion Index in Critically Ill Patients
- ClinicalTrials.gov ID
- NCT07555041
- Acronym / sponsor ID
- CRIPI / 69HCL26_0232
- Conditions
- Shock State, Hemodynamics Instability, Microcirculation, Monitoring
- Keywords
- Capillary refill time, Perfusion index, Microcirculation, Intensive care
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 267 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 29 Apr 2026 (actual)
- Primary completion
- 29 Sep 2026 (actual)
- Study completion
- 29 Sep 2026 (actual)
- First posted
- 28 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.
CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.
Although CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.
The perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.
Because PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients admitted to a University Hospital, either to a medical or surgical intensive care unit.
Key inclusion criteria (3 listed)
- Adult patient.
- Admission within the previous 24 hours, or within 24 hours of the onset of a hemodynamic instability criterion (requirement for vasopressors or fluid resuscitation).
- Absence of patient objection.
Key exclusion criteria (3 listed)
- Legal guardianship, curatorship, or judicial protection.
- No social security coverage.
- Morphological abnormalities preventing CRT and IP measurements.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Microcirculation monitoringAlso: Capillary refill time (CRT) measurementsMicrocirculation monitoring by Capillary Refill Time (CRT) measurements | Other | – |
| Microcirculation monitoringAlso: Perfusion index (PI) measurementsMicrocirculation monitoring by Perfusion Index (PI) measurements | Other | – |
Primary outcome
Perfusion index (PI) threshold associated with abnormal capillary refill time (CRT)
Time frame: At the inclusion
The primary endpoint will be the PI threshold associated with abnormal CRT (> 3 seconds). CRT is measured in seconds and PI in arbitrary units. These parameters will be measured simultaneously on each patient. Measurements will be performed at the inclusion of each patient.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Shock State and Hemodynamics Instability, run by Hospices Civils de Lyon at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Perfusion index (PI) threshold associated with abnormal capillary refill time (CRT) (time frame: At the inclusion). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026; AzTrials last refreshed its copy on 28 Oct 2026.