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PARKINSON DISEASE (Disorder)NCT07555847

Effect of Kinesiotaping on Tremor in People With Parkinson's Disease

A study testing Therapeutic Kinesiotaping and Home Exercise Program in people with PARKINSON DISEASE (Disorder) and Tremor, run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this clinical trial is to learn whether adding kinesiotaping to a strengthening and stretching home-exercise program can reduce hand tremor and improve hand function in people with Parkinson's disease. Read more about this study

Who is it for?
Ages 18 to 80 years
What is being tested?
Therapeutic Kinesiotaping and Home Exercise Program
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
45 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 Mar 2025to 1 Jan 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Diagnosis of idiopathic Parkinson's disease
  • Hoehn and Yahr stage 1-4
  • Presence of hand tremor
  • Mini-Mental State Examination (MMSE) score ≥ 23
  • Stable medical treatment for at least 3 months prior to enrollment and no planned changes during the study period
  • Age between 18 and 80 years
  • Ability to understand and provide written informed consent

Who cannot join

  • Diagnosis of essential tremor or tremor due to causes other than Parkinson's disease
  • Advanced motor impairment (severe bradykinesia or dyskinesia)
  • History of allergic reaction to kinesiotaping materials
  • Presence of other neurological disorders causing tremor (e.g., ALS, multiple sclerosis, cerebellar disorders)
  • Severe psychiatric disorders (e.g., major depression, psychosis, severe anxiety)

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital

    Istanbul, Uskudar, 34668

Other trials in Turkey (Türkiye)

About this study

Official title: Effect of Kinesiotaping on Hand Tremor in Patients With Parkinson's Disease: A Randomized Controlled Trial

The goal of this clinical trial is to learn whether adding kinesiotaping to a strengthening and stretching home-exercise program can reduce hand tremor and improve hand function in people with Parkinson's disease. The study will also examine how true kinesiotaping compares with sham (placebo) taping and with exercise alone in improving tremor frequency, grip strength, fine motor skills, motor symptoms, daily living activities, and quality of life.

Adults aged 18-80 with Parkinson's disease and hand tremor will be randomly assigned to one of three groups:

Read more

Kinesiotaping + Exercise Group: Participants will receive therapeutic kinesiotaping applied to the forearm extensor muscles and wrist for 4 weeks (twice weekly), in addition to a home program of strengthening and stretching exercises.

Sham Taping + Exercise Group: Participants will receive a placebo taping without tension that does not target specific muscles, along with the same exercise program.

Exercise-Only Group: Participants will complete the same home-exercise program without any taping.

Researchers will compare the three groups to see whether kinesiotaping provides additional benefits beyond exercise and whether it performs better than sham taping. Tremor frequency will be measured using an Apple Watch device, and hand strength, dexterity, motor symptoms, and quality of life will be assessed using validated clinical scales.

Read the detailed description

Resting tremor is one of the main motor symptoms in Parkinson's disease and can significantly limit daily activities, fine motor skills, and upper-extremity function. This clinical trial is designed to evaluate whether adding therapeutic kinesiotaping to a home-based exercise program can reduce hand tremor and improve hand function. The study also aims to compare the effectiveness of true kinesiotaping with sham (placebo) taping and to determine whether either method provides additional benefit beyond exercise alone.

This randomized, controlled, three-arm clinical trial will include participants aged 18 to 80 years who have been diagnosed with Parkinson's disease and experience hand tremor. Participants will be randomly assigned to one of three groups: (1) Kinesiotaping + Exercise, (2) Sham Taping + Exercise, or (3) Exercise Only. All participants will receive a standardized home-exercise program that includes strengthening and stretching exercises targeting forearm muscles. The exercise program will be performed once daily for four weeks.

In the kinesiotaping group, therapeutic taping will be applied to the forearm extensor muscles and wrist using functional taping techniques with appropriate tension and directional application. This approach aims to enhance proprioceptive input, improve muscle activation, and reduce tremor amplitude. In the sham taping group, tape will be applied without therapeutic tension and without following muscle-fiber orientation, providing a placebo intervention. The control group will receive the exercise program only, without any taping.

Tremor severity and frequency will be assessed using accelerometer data from an Apple Watch worn on the affected wrist. Grip strength will be measured with a Jamar dynamometer, and hand dexterity will be evaluated using the Nine Hole Peg Test. Motor symptoms will be assessed with the MDS-UPDRS Part 3, and quality of life will be evaluated using the Parkinson's Disease Questionnaire (PDQ-39). Outcomes will be measured at baseline (T0), at the end of the 4-week intervention (T1), and two weeks after the end of treatment (T2).

The primary objective of this study is to determine whether kinesiotaping provides additional benefit in reducing hand tremor compared with exercise alone. Secondary objectives include evaluating improvements in hand function, changes in grip strength, changes in motor symptoms, and improvements in quality-of-life measures. Kinesiotaping is expected to support tremor control by enhancing proprioceptive feedback. The sham taping group is included to control for placebo effects and to distinguish the specific therapeutic contribution of true kinesiotaping.

This study aims to provide clinical evidence on the usefulness of kinesiotaping as an adjunct to exercise for managing tremor in individuals with Parkinson's disease. The three-arm design will allow clear comparison between true taping, sham taping, and exercise alone, helping to identify the unique effects of kinesiotaping.

Being tested
Therapeutic Kinesiotaping, Sham Taping, Home Exercise Program
Keywords
Kinesiotaping, Kinesiologic taping, Parkinson tremor, Hand tremor, Upper extremity tremor, Forearm extensor taping, Sham taping, Exercise therapy, Home exercise program, MDS-UPDRS, PDQ-39, Nine Hole Peg Test, Grip strength, Apple Watch, tremor measurement
Medical subject headings
Parkinson Disease, Tremor

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Therapeutic KinesiotapingOther

    Kinesiotaping applied to forearm extensor muscles with therapeutic tension and direction, twice weekly for 4 weeks

  • Sham TapingOther

    Placebo taping applied without therapeutic tension and without muscle alignment, twice weekly for 4 weeks

  • Home Exercise ProgramBehavioural

    Daily strengthening and stretching exercises targeting forearm muscles, performed for 4 weeks.

Study groups in NCT07555847
Study groupRoleWhat they receive
Kinesiotaping + ExerciseExperimentalParticipants receive therapeutic kinesiotaping applied to the forearm extensor muscles and wrist twice weekly for 4 weeks, in addition to a daily home-based strengthening and stretching exercise program.
Receives: Other: Therapeutic Kinesiotaping; Behavioral: Home Exercise Program
Sham Taping + ExerciseSham comparatorParticipants receive sham taping without therapeutic tension and without following muscle-fiber orientation, applied twice weekly for 4 weeks, along with the same daily home-based exercise program
Receives: Other: Sham Taping; Behavioral: Home Exercise Program
Exercise OnlyActive comparatorParticipants complete the standardized daily home-based strengthening and stretching exercise program for 4 weeks, with no taping applied
Receives: Behavioral: Home Exercise Program

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Tremor Frequency (Hz)

    Change in dominant tremor frequency measured using Apple Watch sensors (accelerometer and gyroscope) during a standardized 60-second recording period. Lower frequency values indicate improvement in tremor severity.

    Measured: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

Secondary outcomes (7)
  1. Hand Grip Strength (kg)

    Measured using a Jamar hand dynamometer. Higher values indicate better muscle strength.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  2. Pinch Strength (kg)

    Measured using a Jamar pinch meter. Higher values indicate better finger strength.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  3. Fahn-Tolosa-Marin Tremor Rating Scale Score

    Clinician-rated scale assessing tremor severity. Scores range from 0 to 144, with higher scores indicating more severe tremor.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  4. Nine-Hole Peg Test

    Measures fine motor dexterity and hand coordination. Shorter completion time indicates better performance.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  5. MDS-UPDRS Part III Score

    Clinician-rated motor examination assessing severity of Parkinsonian motor symptoms. Scores range from 0 to 132, with higher scores indicating worse motor impairment.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  6. Parkinson's Disease Questionnaire-39 (PDQ-39) Score

    Patient-reported quality of life measure. Scores range from 0 to 100, with higher scores indicating worse quality of life.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

  7. Barthel Index Score

    Measures independence in activities of daily living. Scores range from 0 to 100, with higher scores indicating greater independence.

    Measured: Time Frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted29 Apr 2026
  2. Study start1 Mar 2025
  3. Primary completion1 Nov 2025
  4. Study completion1 Jan 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Three-arm parallel design comparing kinesiotaping plus exercise, sham taping plus exercise, and exercise alone in individuals with Parkinson's disease and hand tremor.
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
45 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07555847
Sponsor's protocol ID
PD-KT-RCT-2025
Status last verified
Apr 2026
First submitted
14 Apr 2026
Last updated
29 Apr 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data (IPD) will not be shared due to patient privacy concerns, institutional policies, and the lack of a predefined data-sharing infrastructure for this single-center academic study.

Publications

  • Giray E, Karali-Bingul D, Akyuz G. The Effectiveness of Kinesiotaping, Sham Taping or Exercises Only in Lateral Epicondylitis Treatment: A Randomized Controlled Study. PM R. 2019 Jul;11(7):681-693. doi: 10.1002/pmrj.12067. Epub 2019 Mar 28.

    PubMed 30609278
  • Dai H, Lin H, Lueth TC. Quantitative assessment of parkinsonian bradykinesia based on an inertial measurement unit. Biomed Eng Online. 2015 Jul 12;14:68. doi: 10.1186/s12938-015-0067-8.

    PubMed 26164814
  • Shahien M, Elaraby A, Gamal M, Abdelazim E, Abdelazeem B, Ghaith HS, Negida A. Physical therapy interventions for the management of hand tremors in patients with Parkinson's disease: a systematic review. Neurol Sci. 2023 Feb;44(2):461-470. doi: 10.1007/s10072-022-06420-1. Epub 2022 Oct 7.

    PubMed 36205810
  • Mahadevan N, Demanuele C, Zhang H, Volfson D, Ho B, Erb MK, Patel S. Development of digital biomarkers for resting tremor and bradykinesia using a wrist-worn wearable device. NPJ Digit Med. 2020 Jan 15;3:5. doi: 10.1038/s41746-019-0217-7. eCollection 2020.

    PubMed 31970290
  • Bravi R, Quarta E, Cohen EJ, Gottard A, Minciacchi D. A little elastic for a better performance: kinesiotaping of the motor effector modulates neural mechanisms for rhythmic movements. Front Syst Neurosci. 2014 Sep 25;8:181. doi: 10.3389/fnsys.2014.00181. eCollection 2014.

    PubMed 25309355
  • Capecci M, Serpicelli C, Fiorentini L, Censi G, Ferretti M, Orni C, Renzi R, Provinciali L, Ceravolo MG. Postural rehabilitation and Kinesio taping for axial postural disorders in Parkinson's disease. Arch Phys Med Rehabil. 2014 Jun;95(6):1067-75. doi: 10.1016/j.apmr.2014.01.020. Epub 2014 Feb 5.

    PubMed 24508531

Questions about this trial

What is this clinical trial studying?

A study testing Therapeutic Kinesiotaping and Home Exercise Program in people with PARKINSON DISEASE (Disorder) and Tremor, run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Tremor Frequency (Hz) (time frame: Baseline (Day 0), End of treatment (Week 4), and Follow-up (Week 8; 4 weeks after treatment completion)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07555847, which also lists 6 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.

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