Clinical trials: PARKINSON DISEASE (Disorder)
Lysosomal Storage Disorders, Gaucher Disease
Genetic Studies of Lysosomal Storage Disorders
The purpose of this study is to identify genetic, biochemical, and clinical factors that are associated with disease severity in people with Gaucher disease and other lysosomal storage disorders.
- Conditions
- Lysosomal Storage Disorders, Gaucher Disease, Parkinson Disease
- Trial name
- NCT00001215
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Parkinson's Disease, Tourette's Syndrome
Physiological Investigations of Movement Disorders
Background: Previous studies have given researchers information on how the brain controls movement, how people learn to make fine, skilled movements, and why some people have movement disorders.
- Conditions
- Parkinson's Disease, Tourette's Syndrome, Tic Disorders, Dystonia
- Trial name
- NCT01019343
- Testing
- Transcranial Direct Current Stimulation (tDCS), Eye-tracking Device, Pulsed vibrator
- Where
- United States
- Volunteers
- 1,273 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Investigating the Increased Risk of Falls in Individuals With Parkinson's Disease Treated With Deep Brain Stimulation
The purpose of this pilot study is to assess changes in thinking and movement after deep brain stimulator implantation. The study will also examine whether these changes are related to the risk of falls.
- Trial name
- NCT07725315
- Testing
- DBS as part of standard of care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
PARKINSON DISEASE (Disorder), Cell Therapy
A Phase 1 Study of NCR201 in Parkinson's Disease Patients With Prior DBS
This is a Phase 1 clinical trial to evaluate the safety and tolerability of a new cell therapy called NCR201. The study will enroll adults with moderate-to-advanced primary Parkinson's disease who have previously undergone deep…
- Conditions
- PARKINSON DISEASE (Disorder), Cell Therapy, Human Induced Pluripotent Stem Cells, Deep Brain Stimulation
- Trial name
- NCR201-2004 (NCT07896187)
- Testing
- NCR201
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Parkinson Disease, Impulse Control Disorder
STIMPulseControl Ancillary Speech Study
Speech assessment is a substudy to the STIMPulseControl study (hereinafter referred to as the main study), where audio recordings of patients voices will be recorded as part of a speech analysis in the main study, for this…
- Trial name
- NCT06561919
- Testing
- bilateral high frequency deep brain stimulation of the subthalamic neucleus combined with best medical treatment according to widely accepted expert consensus paper, best medical treatment for management of impulse control in Parkinson´s disease according to widely accepted expert consensus paper
- Where
- 13 sites in Germany, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Steffen Paschen
Gait Disorders, Neurologic, Atypical Parkinson Disease
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging
- Trial name
- NCT06906276
- Testing
- Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
PARKINSON DISEASE (Disorder), Caregiver Burden
Effect of Artificial Intelligent-based Training and Benson Relaxation Exercises on Caregiver Burden and Stress Levels in Caregivers of Patients With Parkinson's Disease
The aim of this study is to evaluate the effect of artificial intelligence-supported training and the Benson relaxation exercise on the care burden and stress levels of caregivers of people with Parkinson's disease.
- Conditions
- PARKINSON DISEASE (Disorder), Caregiver Burden, Caregiver Stress
- Trial name
- NCT07876830
- Testing
- artificial intelligent-based training, artificial intelligent-based Benson's relaxation exercise
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ataturk University
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
PARKINSON DISEASE (Disorder)
Oculomotor-Pupillary AI Biomarkers in Parkinson's
The goal of this prospective observational study is to investigate whether oculomotor-pupillary abnormalities detected using a novel edge-AI eye-tracking device can serve as objective and quantitative biomarkers for the early…
- Trial name
- NCT07886450
- Testing
- Edge-AI Eye-Tracking Assessment
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Parkinson Disease, Impulse Control Disorders
Bilateral Subthalamic Stimulation in PD Patients With Impulse Control Disorders - STIMPulseControl
The focus of the study is on patients Parkinson's disease showing as well behavioral disorders that can be described as pathological and are summarized under the term impulse control disorder (ICD).
- Trial name
- NCT06498349
- Testing
- bilateral high frequency deep brainstimulation of the subthalamic nucleus combined with best medical treatment, best medical treatment (BMT): Adjustment of the dopaminergic medication and non-dopaminergic therapy customized for each patient according to the latest published Consensus Group Recommendations
- Where
- 13 sites in Germany, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- University of Kiel
REM Behavior Disorder, Parkinson Disease
Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease
This study aims to assess the levels of phosphorylated alpha-synuclein (P-SYN) in patients with Parkinson's disease and REM Behavior Disorder using a minimally invasive skin punch biopsy.
- Trial name
- Syn-Q (NCT06621602)
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- CND Life Sciences
PARKINSON DISEASE (Disorder), Parkinson's Disease (PD)
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle…
- Trial name
- NCT07226284
- Testing
- Vagal nerve stimulation, No intervention
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke, PARKINSON DISEASE (Disorder)
Objective Longitudinal Monitoring of Postural Stability and Gait During Neurorehabilitation: Clinical Application of Instrumented Posturography and Three-Dimensional Motion Analysis
Nowadays, stroke is one of the most common leading causes of death in many countries. As the number of stroke patients is increasing, even in younger age groups, there is an increasing need to improve their rehabilitation.
- Conditions
- Stroke, PARKINSON DISEASE (Disorder), Multiple Sclerosis
- Trial name
- NCT07411664
- Testing
- Stroke posturo/3D group, Parkinson posturo/3D group, Multiple sclerosis posturo/3D group
- Where
- Hungary
- Volunteers
- 151 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
PARKINSON DISEASE (Disorder)
Effectiveness of a Home-Based Exercise Program Supported by Self-Management Education in People With Parkinson Disease
This randomized, assessor-blinded clinical trial evaluates whether a structured self-management education and home exercise program improves balance, walking capacity, fall-related concerns, upper-extremity dexterity, and quality…
- Trial name
- NCT07817862
- Testing
- Self-Management Education and Home Exercise Program, Parkinson Disease Educational Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University
Healthy Subjects, Schizophrenia
Studies of Frontal Lobe Brain Functioning in Schizophrenia
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers.
- Conditions
- Healthy Subjects, Schizophrenia, Parkinson Disease
- Trial name
- NCT00001258
- Testing
- Oxygen-15 Water
- Where
- United States
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Mental Health (NIMH)
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)