Low Back PainNCT07556926
High-intensity Laser Therapy and Mulligan Mobilization for Patients With Chronic Nonspecific Low Back Pain
A study testing High-intensity laser therapy and Mulligan mobilization and Mulligan Mobilization in people with Low Back Pain, run by Anas Radi Hassan Alashram at 1 site in Jordan.
Trial summary
The goal of this clinical trial is to evaluate whether combining high-intensity laser therapy with Mulligan mobilization techniques can effectively treat chronic non-specific low back pain in adult patients aged 18-60 years, including both males and females. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Low Back Pain
- What is being tested?
- High-intensity laser therapy and Mulligan mobilization and Mulligan Mobilization
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteJordan
- Study dates
- 30 Apr 2026to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Male and female participants aged 18-60 years
- Diagnosis of chronic non-specific low back pain (pain persisting for ≥3 months)
- Pain localized between the lower costal margins and gluteal folds, with or without referred pain
- Baseline pain intensity of ≥3 on the Numeric Pain Rating Scale (NPRS)
- Ability to understand and follow instructions and provide informed consent
- Not currently receiving other forms of physiotherapy or structured treatment for low back pain during the study period
Who cannot join
- Specific spinal pathology (e.g., fracture, tumor, infection, inflammatory diseases such as ankylosing spondylitis)
- History of spinal surgery
- Neurological deficits or signs of nerve root compression (e.g., severe radiculopathy)
- Pregnancy
- Severe osteoporosis or other contraindications to manual therapy
- Contraindications to high-intensity laser therapy (e.g., malignancy in the treatment area, photosensitivity disorders)
- Current use of medications that significantly affect pain perception (e.g., high-dose opioids)
- Participation in another clinical trial within the last 3 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Jordan1 site
Middle East University
Amman
Anas Radi Alashram, PhD, 00962788088509, anasalashram@gmail.com
Anas Radi Alashram, PhD, anasalashram@gmail.com
About this study
Official title: Effects of Combined High-intensity Laser Therapy and Mulligan Mobilization on Patients With Chronic Nonspecific Low Back Pain: A Pilot Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether combining high-intensity laser therapy with Mulligan mobilization techniques can effectively treat chronic non-specific low back pain in adult patients aged 18-60 years, including both males and females.
The main questions it aims to answer are:
Read more
Does the combined intervention reduce pain intensity more effectively than standard or single-modality treatment? Does the combined intervention improve functional disability and lumbar range of motion?
Researchers will compare high-intensity laser therapy combined with Mulligan mobilization to [control group: Mulligan alone] to determine whether the combined approach produces superior clinical outcomes.
Participants will:
Receive high-intensity laser therapy according to a standardized treatment protocol Undergo Mulligan mobilization techniques administered by a trained therapist Attend multiple treatment sessions over a defined intervention period Complete assessments of pain intensity, functional disability, and lumbar range of motion before and after treatment
Read the detailed description
Chronic non-specific low back pain is a prevalent musculoskeletal condition associated with pain, reduced functional capacity, and decreased quality of life. Conservative management often includes manual therapy and physical modalities; however, the optimal combination of these approaches remains unclear.
High-intensity laser therapy (HILT) has been proposed to provide analgesic and anti-inflammatory effects and to promote tissue healing. Mulligan mobilization techniques, particularly sustained natural apophyseal glides (SNAGs), are commonly used to restore pain-free movement and improve spinal function. While both interventions have shown individual benefits, evidence regarding their combined effect is limited.
This pilot randomized controlled trial aims to explore the feasibility and preliminary clinical effectiveness of combining HILT with Mulligan mobilization in adults with chronic non-specific low back pain. The study will evaluate changes in pain intensity, functional disability, and lumbar range of motion following the intervention period.
Participants will be randomly allocated to intervention groups, and outcomes will be assessed at baseline and post-intervention using standardized clinical measures. Findings from this pilot study will help inform the design of larger trials and clarify whether a multimodal approach incorporating HILT and Mulligan techniques offers added clinical value in this population.
- Conditions
- Low Back Pain
- Being tested
- High-intensity laser therapy and Mulligan mobilization, Mulligan Mobilization
- Medical subject headings
- Low Back Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-intensity laser therapy and Mulligan mobilizationDevice
Combined high-intensity laser therapy and Mulligan mobilization
Mulligan MobilizationOther
Mulligan Mobilization alone
| Study group | Role | What they receive |
|---|---|---|
| Mulligan Mobilization | Active comparator | Mulligan Mobilization alone Receives: Other: Mulligan Mobilization |
| High-intensity laser therapy and Mulligan mobilization | Experimental | Combined high-intensity laser therapy and Mulligan mobilization Receives: Device: High-intensity laser therapy and Mulligan mobilization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale (NPRS)
The Numeric Pain Rating Scale (NPRS) is a self-reported measure used to assess pain intensity. It typically consists of an 11-point scale ranging from 0 to 10, where 0 indicates "no pain" and 10 represents "the worst imaginable pain." Participants are asked to select the number that best reflects their current level of pain, or their average pain over a specified period.
The NPRS is widely used in clinical and research settings due to its simplicity, reliability, and validity in measuring pain intensity in individuals with musculoskeletal conditions, including chronic low back pain. Changes in NPRS scores over time are used to evaluate the effectiveness of therapeutic interventions, with a reduction of approximately 2 points often considered clinically meaningful.
Measured: Change from baseline NPRS at 4-week
Secondary outcomes (2)
Oswestry Disability Index (ODI)
The Oswestry Disability Index (ODI) is a validated self-reported questionnaire used to assess functional disability related to low back pain. It consists of 10 sections evaluating different aspects of daily living, including pain intensity, personal care, lifting, walking, sitting, standing, sleeping, social life, traveling, and employment/homemaking.
Each section is scored on a 6-point scale (0-5), with higher scores indicating greater disability. The total score is calculated by summing the section scores and converting them into a percentage, where 0% represents no disability and 100% represents maximum disability.
The ODI is widely used in both clinical practice and research due to its reliability, validity, and sensitivity to change in patients with low back pain. It is commonly used to monitor patient progress and evaluate the effectiveness of interventions over time.
Measured: Change from baseline ODI at 4-week
Lumbar Flexion Range of Motion (ROM)
Lumbar Flexion Range of Motion (ROM) refers to the degree of forward bending movement of the lumbar spine. It is commonly measured in degrees using instruments such as a goniometer, inclinometer, or dual inclinometer technique.
During assessment, the participant is typically asked to bend forward as far as possible from a standing position while keeping the knees straight. The angle of movement is then recorded in degrees, reflecting the flexibility and mobility of the lumbar spine.
Lumbar flexion ROM is an important clinical outcome in patients with low back pain, as reduced flexion is often associated with pain, stiffness, and functional limitations. Improvements in lumbar flexion degree following intervention indicate enhanced spinal mobility and functional capacity.
Measured: Change from baseline Lumbar Flexion Range of Motion (ROM) at 4-week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Apr 2026
- Study start30 Apr 2026 (estimated)
- Primary completion30 May 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Low Back PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Anas Radi Hassan Alashram
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Anas Radi Hassan Alashram, Middle East University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07556926
- Sponsor's protocol ID
- ADAD/1199
- Status last verified
- Apr 2026
- First submitted
- 19 Apr 2026
- Last updated
- 29 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Combined High-intensity Laser Therapy and Mulligan Mobilization on Patients With Chronic Nonspecific Low Back Pain: A Pilot Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07556926
- Acronym / sponsor ID
- ADAD/1199
- Conditions
- Low Back Pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Anas Radi Hassan AlashramUniversity, hospital or other
- Study start
- 30 Apr 2026 (estimated)
- Primary completion
- 30 May 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 29 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate whether combining high-intensity laser therapy with Mulligan mobilization techniques can effectively treat chronic non-specific low back pain in adult patients aged 18-60 years, including both males and females.
The main questions it aims to answer are:
Does the combined intervention reduce pain intensity more effectively than standard or single-modality treatment? Does the combined intervention improve functional disability and lumbar range of motion?
Researchers will compare high-intensity laser therapy combined with Mulligan mobilization to [control group: Mulligan alone] to determine whether the combined approach produces superior clinical outcomes.
Participants will:
Receive high-intensity laser therapy according to a standardized treatment protocol Undergo Mulligan mobilization techniques administered by a trained therapist Attend multiple treatment sessions over a defined intervention period Complete assessments of pain intensity, functional disability, and lumbar range of motion before and after treatment
Detailed description
Chronic non-specific low back pain is a prevalent musculoskeletal condition associated with pain, reduced functional capacity, and decreased quality of life. Conservative management often includes manual therapy and physical modalities; however, the optimal combination of these approaches remains unclear.
High-intensity laser therapy (HILT) has been proposed to provide analgesic and anti-inflammatory effects and to promote tissue healing. Mulligan mobilization techniques, particularly sustained natural apophyseal glides (SNAGs), are commonly used to restore pain-free movement and improve spinal function. While both interventions have shown individual benefits, evidence regarding their combined effect is limited.
This pilot randomized controlled trial aims to explore the feasibility and preliminary clinical effectiveness of combining HILT with Mulligan mobilization in adults with chronic non-specific low back pain. The study will evaluate changes in pain intensity, functional disability, and lumbar range of motion following the intervention period.
Participants will be randomly allocated to intervention groups, and outcomes will be assessed at baseline and post-intervention using standardized clinical measures. Findings from this pilot study will help inform the design of larger trials and clarify whether a multimodal approach incorporating HILT and Mulligan techniques offers added clinical value in this population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Mulligan Mobilization | Active comparator | Other: Mulligan MobilizationMulligan Mobilization alone |
| High-intensity laser therapy and Mulligan mobilization | Experimental | Device: High-intensity laser therapy and Mulligan mobilizationCombined high-intensity laser therapy and Mulligan mobilization |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male and female participants aged 18-60 years
- Diagnosis of chronic non-specific low back pain (pain persisting for ≥3 months)
- Pain localized between the lower costal margins and gluteal folds, with or without referred pain
- Baseline pain intensity of ≥3 on the Numeric Pain Rating Scale (NPRS)
- Ability to understand and follow instructions and provide informed consent
Key exclusion criteria (8 listed)
- Specific spinal pathology (e.g., fracture, tumor, infection, inflammatory diseases such as ankylosing spondylitis)
- History of spinal surgery
- Neurological deficits or signs of nerve root compression (e.g., severe radiculopathy)
- Pregnancy
- Severe osteoporosis or other contraindications to manual therapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-intensity laser therapy and Mulligan mobilizationCombined high-intensity laser therapy and Mulligan mobilization | Device | High-intensity laser therapy and Mulligan mobilization |
| Mulligan MobilizationMulligan Mobilization alone | Other | Mulligan Mobilization |
Primary outcome
Numeric Pain Rating Scale (NPRS)
Time frame: Change from baseline NPRS at 4-week
The Numeric Pain Rating Scale (NPRS) is a self-reported measure used to assess pain intensity. It typically consists of an 11-point scale ranging from 0 to 10, where 0 indicates "no pain" and 10 represents "the worst imaginable pain." Participants are asked to select the number that best reflects their current level of pain, or their average pain over a specified period. The NPRS is widely used in clinical and research settings due to its simplicity, reliability, and validity in measuring pain intensity in individuals with musculoskeletal conditions, including chronic low back pain. Changes in NPRS scores over time are used to evaluate the effectiveness of therapeutic interventions, with a reduction of approximately 2 points often considered clinically meaningful.
2 secondary outcomes
Oswestry Disability Index (ODI)
Time frame: Change from baseline ODI at 4-week
Lumbar Flexion Range of Motion (ROM)
Time frame: Change from baseline Lumbar Flexion Range of Motion (ROM) at 4-week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: No
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Effect of Lumbar Stabilization Exercises With and Without YTWL (Scapular Stabilization Exercises) on Reducing Chronic Low Back Pain and Related Disability. A Randomized Clinical Trial,
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Enrolling by invitation
Effects of 3-dimensional Versus Dynamic Myofascial Release Techniques With Lumbar Mobilization and Exercise Therapy Program in Chronic Non-specific Low Back Pain.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-intensity laser therapy and Mulligan mobilization and Mulligan Mobilization in people with Low Back Pain, run by Anas Radi Hassan Alashram at 1 site in Jordan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Jordan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Anas Radi Alashram, PhD (00962788088509, anasalashram@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (NPRS) (time frame: Change from baseline NPRS at 4-week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026; AzTrials last refreshed its copy on 7 Nov 2026.