Multiple SclerosisMSNCT07558252
The Effect of Acupressure on Multiple Sclerosis Patients
A study testing Acupressure in people with Multiple Sclerosis, run by Hasan Kalyoncu University at 1 site in Turkey (Türkiye).
Trial summary
There are studies in the literature evaluating the effects of acupressure application in MS patients. In a study; it was shown that acupressure application reduced pain and fatigue. In a study; acupressure was found to reduce fatigue and depression scores. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Acupressure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 90 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2025to 1 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- At least 6 months of confirmed MS diagnosis
- With RRMS
- Aged 18 years or older
- With a pain score of VAS≥3
- Not having used pain medication in the last 8 hours prior to the acupressure session
- With a Fatigue Severity Scale score of 4 or higher
Show all 20Show fewer
- Without a diagnosis of cancer
- Without diabetes
- No neurological disease other than MS
- Not receiving any other complementary treatment
- Non-smoker
- Literate and able to communicate
- No deformity or lesion in the areas where acupressure will be applied
- No mental problems that could prevent cooperation with the acupressure application
- Not taking sedative medication
- With stable vital signs
- Without heart disease
- Not pregnant
- Residing in Şanlıurfa
- Patients who are willing to participate in the study
Who cannot join
- Patients who did not attend at least 4 sessions
- Patients who wish to withdraw from the study
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Hospital of Harran University
Sanliurfa, Şanlıurfa, 63000
About this study
Official title: The Effect of Acupressure on Pain, Fatigue, Sleep, and Quality of Life in Multiple Sclerosis Patients
There are studies in the literature evaluating the effects of acupressure application in MS patients. In a study; it was shown that acupressure application reduced pain and fatigue. In a study; acupressure was found to reduce fatigue and depression scores. In a study; acupressure was found to improve the patient's physical and cognitive functions and quality of life. In a study; acupressure was found to have positive effects on reducing fatigue in MS patients. In a study acupressure application was found to have significant effects in reducing fatigue. There are no studies evaluating the combined effects of acupressure on fatigue, pain, sleep quality, and quality of life parameters in MS patients. This study is planned to determine the effects of acupressure on fatigue, pain, sleep quality, and quality of life in MS patients.
- Conditions
- Multiple Sclerosis
- Being tested
- Acupressure
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AcupressureOther
examining pain, fatigue, sleep, and quality of life
| Study group | Role | What they receive |
|---|---|---|
| intervention | Experimental | intervention Receives: Other: Acupressure |
| sham | Sham comparator | Plasebo Receives: Other: Acupressure |
| Control | No intervention | Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fatigue Severity Scale (FSS)
The FSS is a 9-item scale used to assess the impact of fatigue on daily activities. Each item is rated on a 7-point Likert scale ranging from 1 to 7. The total score is the average of the 9 items. Scores range from 1 to 7, where higher scores indicate greater fatigue severity (worse outcome).
Measured: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Secondary outcomes (3)
Visual Analog Scale (VAS) for Pain
The Visual Analog Scale (VAS) is used to measure the intensity of pain. It consists of a 10-cm horizontal line where 0 indicates "no pain" and 10 indicates "unbearable pain." Participants mark the point that represents their current pain level. Higher scores represent increased pain intensity (worse outcome).
Measured: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Pittsburgh Sleep Quality Index (PSQI)
The PSQI is used to evaluate sleep quality over the past month. It consists of 19 individual items generating seven component scores. The total score ranges from 0 to 21. A higher total score indicates poorer sleep quality (worse outcome).
Measured: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Multiple Sclerosis Quality of Life-54 (MSQOL-54)
The MSQOL-54 is a multidimensional health-related quality of life measure. It provides two main summary scores: Physical Health and Mental Health. Scores for each subscale are transformed to a 0-100 scale. For these subscales, higher scores indicate a better quality of life (better outcome).
Measured: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Apr 2026
- Study start1 Mar 2025
- Primary completion1 Nov 2025
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hasan Kalyoncu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mustafa Karaağaç, Hasan Kalyoncu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07558252
- Sponsor's protocol ID
- 2025/016
- Other IDs
- Non
- Acronym
- MS
- Status last verified
- Apr 2026
- First submitted
- 7 Apr 2026
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Acupressure on Pain, Fatigue, Sleep, and Quality of Life in Multiple Sclerosis Patients
- ClinicalTrials.gov ID
- NCT07558252
- Acronym / sponsor ID
- MS / 2025/016
- Conditions
- Multiple Sclerosis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- Hasan Kalyoncu UniversityUniversity, hospital or other
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 1 Nov 2025 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 30 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There are studies in the literature evaluating the effects of acupressure application in MS patients. In a study; it was shown that acupressure application reduced pain and fatigue. In a study; acupressure was found to reduce fatigue and depression scores. In a study; acupressure was found to improve the patient's physical and cognitive functions and quality of life. In a study; acupressure was found to have positive effects on reducing fatigue in MS patients. In a study acupressure application was found to have significant effects in reducing fatigue. There are no studies evaluating the combined effects of acupressure on fatigue, pain, sleep quality, and quality of life parameters in MS patients. This study is planned to determine the effects of acupressure on fatigue, pain, sleep quality, and quality of life in MS patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| intervention | Experimental | Other: Acupressureintervention |
| sham | Sham comparator | Other: AcupressurePlasebo |
| Control | No intervention | –Control |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (20 listed)
- At least 6 months of confirmed MS diagnosis
- With RRMS
- Aged 18 years or older
- With a pain score of VAS≥3
- Not having used pain medication in the last 8 hours prior to the acupressure session
Key exclusion criteria (2 listed)
- Patients who did not attend at least 4 sessions
- Patients who wish to withdraw from the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acupressureexamining pain, fatigue, sleep, and quality of life | Other | intervention, sham |
Primary outcome
Fatigue Severity Scale (FSS)
Time frame: Baseline, at the end of the 3rd week, and at the end of the 6th week.
The FSS is a 9-item scale used to assess the impact of fatigue on daily activities. Each item is rated on a 7-point Likert scale ranging from 1 to 7. The total score is the average of the 9 items. Scores range from 1 to 7, where higher scores indicate greater fatigue severity (worse outcome).
3 secondary outcomes
Visual Analog Scale (VAS) for Pain
Time frame: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Pittsburgh Sleep Quality Index (PSQI)
Time frame: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Multiple Sclerosis Quality of Life-54 (MSQOL-54)
Time frame: Baseline, at the end of the 3rd week, and at the end of the 6th week.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupressure in people with Multiple Sclerosis, run by Hasan Kalyoncu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 20 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fatigue Severity Scale (FSS) (time frame: Baseline, at the end of the 3rd week, and at the end of the 6th week.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.