Acute Decompensated Heart FailureNCT07572955
A Study Of Acute Decompensated Heart Failure
A study testing Lung Ultrasound in people with Acute Decompensated Heart Failure, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Decompensated Heart Failure
- What is being tested?
- Lung Ultrasound
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 500 participants
- Where
- 1 siteUnited States
- Study dates
- 26 Aug 2026to Jun 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Subjects ≥18 years of age
- Admitted to St. Mary's Hospital Cardiology Progressive Care Unit (Cardiology 1-5 teams)
- Admission diagnosis of either:
- Acute systolic heart failure
- Acute on chronic systolic heart failure
- Acute diastolic heart failure
Show all 11Show fewer
- Acute on chronic diastolic heart failure
- Acute right heart failure
- Acute on chronic right heart failure
- Failure heart biventricular
- Able to provide informed consent and willing to undergo daily lung ultrasound examinations during their hospitalization.
Who cannot join
- Subjects <18 years of age
- Unable to provide informed consent.
- Unwilling to undergo daily lung ultrasound examinations.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Andy Dang, 507-255-7752, dang.phong@mayo.edu
Jared Bird, MD
About this study
Official title: HF-FOCUS: Serial Lung Ultrasound And Peripheral Venous Pressure Monitoring To Enhance The Care Of Hospitalized Patients With Acute Decompensated Heart Failure
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. A 1-day reduction in hospital length of stay in unblinded subjects receiving daily HF-FOCUS examinations compared to a blinded standard of care arm.
- Conditions
- Acute Decompensated Heart Failure
- Being tested
- Lung Ultrasound
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lung UltrasoundDiagnostic test
Patients will undergo lung ultrasound assessments at hospital admission, daily throughout admission, and at hospital discharge.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Active comparator | Patients undergoing daily lung ultrasound with the results reported to the provider care teams on admission and each morning Receives: Diagnostic Test: Lung Ultrasound |
| Group 2 | Experimental | Patients undergoing daily lung ultrasound but the results will be blinded to the provider care teams Receives: Diagnostic Test: Lung Ultrasound |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of days in the hospital
The number of days a patient is in the hospital will be determined by the day of admission and day of discharge. The day of discharge will be defined as when the consultant physician states that the patient is medically ready for discharge from the hospital.
Measured: Baseline
Secondary outcomes (5)
Number of re-hospitalized patients
Number of patients re-hospitalized will be determined by the number of patients admitted to the hospital post discharge
Measured: Baseline
Number of deaths
Number of deaths will be determined by number of patient deaths due to any cause
Measured: Baseline
Change in effective diuresis
Diuresis will be measured from a urine sample and calculated by total diuresis in liters/admission weight in kilograms
Measured: Baseline, up to 90 Days
Change in diuretic dosing
Diuretic dosing will be measured in mg
Measured: Baseline, up to 90 Days
Change in Lung Congestion
Lung congestion will be measured using a lung ultrasound and measured as a percentage
Measured: Baseline, up to 90 Days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 May 2026
- Study start26 Aug 2026
- Primary completionJun 2028 (estimated)
- Study completionJun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Decompensated Heart FailureStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jared G. Bird, Mayo Clinic
- Investigators
- Jared Bird, MD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07572955
- Sponsor's protocol ID
- 26-000119
- Status last verified
- Sep 2026
- First submitted
- 1 May 2026
- Last updated
- 8 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- HF-FOCUS: Serial Lung Ultrasound And Peripheral Venous Pressure Monitoring To Enhance The Care Of Hospitalized Patients With Acute Decompensated Heart Failure
- ClinicalTrials.gov ID
- NCT07572955
- Acronym / sponsor ID
- 26-000119
- Conditions
- Acute Decompensated Heart Failure
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 26 Aug 2026 (actual)
- Primary completion
- Jun 2028 (estimated)
- Study completion
- Jun 2028 (estimated)
- First posted
- 7 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. A 1-day reduction in hospital length of stay in unblinded subjects receiving daily HF-FOCUS examinations compared to a blinded standard of care arm.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Active comparator | Diagnostic Test: Lung UltrasoundPatients undergoing daily lung ultrasound with the results reported to the provider care teams on admission and each morning |
| Group 2 | Experimental | Diagnostic Test: Lung UltrasoundPatients undergoing daily lung ultrasound but the results will be blinded to the provider care teams |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (11 listed)
- Subjects ≥18 years of age
- Admitted to St. Mary's Hospital Cardiology Progressive Care Unit (Cardiology 1-5 teams)
- Admission diagnosis of either:
- Able to provide informed consent and willing to undergo daily lung ultrasound examinations during their hospitalization.
Key exclusion criteria (3 listed)
- Subjects <18 years of age
- Unable to provide informed consent.
- Unwilling to undergo daily lung ultrasound examinations.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lung UltrasoundPatients will undergo lung ultrasound assessments at hospital admission, daily throughout admission, and at hospital discharge. | Diagnostic test | Group 1, Group 2 |
Primary outcome
Number of days in the hospital
Time frame: Baseline
The number of days a patient is in the hospital will be determined by the day of admission and day of discharge. The day of discharge will be defined as when the consultant physician states that the patient is medically ready for discharge from the hospital.
5 secondary outcomes
Number of re-hospitalized patients
Time frame: Baseline
Number of deaths
Time frame: Baseline
Change in effective diuresis
Time frame: Baseline, up to 90 Days
Change in diuretic dosing
Time frame: Baseline, up to 90 Days
Change in Lung Congestion
Time frame: Baseline, up to 90 Days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Acute Decompensated Heart Failure
Recruiting
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure
Recruiting
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Acute Decompensated Heart Failure
Recruiting
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
RecruitingObservational study
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock
Cardiogenic Shock, Acute Myocardial Infarction
RecruitingPhase 3
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Heart Failure, Acute Heart Failure
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jared Bird, MD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Lung Ultrasound in people with Acute Decompensated Heart Failure, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Andy Dang (507-255-7752, dang.phong@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of days in the hospital (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026.