Carpal Tunnel Syndrome (CTS)NCT07573878
Combined Effects of Neurodynamics With PNF on Pain and ROM in Patients With CTS.
A study testing Neurodynamic and PNF and Baseline Treatment in people with Carpal Tunnel Syndrome (CTS), run by Riphah International University at 1 site in Pakistan.
Trial summary
The goal of this clinical trial is to determine the combined effects of neurodynamics with proprioceptive neuromuscular facilitation technique on reducing pain and improving range of motion in patients with carpal tunnel syndrome. Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS)
- What is being tested?
- Neurodynamic and PNF and Baseline Treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jan 2025to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed cases of carpal tunnel syndrome.
- Patients having positive Tinel's test and Phalen's test.
- Symptoms persisted for at least 4 weeks.
- Availability and motivation of patients to participate in a 2-week program.
Who cannot join
- Patient with contraindications to rehabilitation treatment.
- Patients with a history of previous upper limb surgery.
- Patient received steroid injection or have any systemic disease that can influence condition.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Bahawal Victoria Hospital
Chak Eighty-seven -Twelve Left, Punjab Province, 63100
About this study
Official title: Combined Effects of Neurodynamics With Proprioceptive Neuromuscular Facilitation Technique on Pain and Range of Motion in Patient With Carpal Tunnel Syndrome.
The goal of this clinical trial is to determine the combined effects of neurodynamics with proprioceptive neuromuscular facilitation technique on reducing pain and improving range of motion in patients with carpal tunnel syndrome. This study evaluates whether neurodynamics combined with PNF is an effective approach in treating CTS compared to baseline treatment, as both techniques are well known for their individual effects. This treatment is given for 2 weeks, 5 days per week with 10 repetitions for each exercise.
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Being tested
- Neurodynamic and PNF, Baseline Treatment
- Keywords
- Carpal tunnel syndrome, Median nerve, Neurodynamic, PNF, Range of motion
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neurodynamic and PNFOther
Also called Neurodynamic, Proprioceptive Neuromuscular Facilitation technique
These 2 exercises were provided in 10 repetitions for 2 weeks (duration), 5 days per week (frequency).
- PNF techniques used in carpal tunnel treatment includes
- Rhythmic Initiation
- Agonistic Reversals. ii) For Neurodynamic (1) Distal nerve tension technique :Hand was placed in six different positions each position maintained for 7 second and have 5 repetitions for each step this is done in median nerve tension technique (2) nerve slide
Baseline TreatmentOther
Also called medication, wrist splint, Ultrasound therapy, Cold therapy
They were provided with common conservative physical therapy treatment for 2 weeks, 5 days per week, following carpal tunnel syndrome.
These treatments included use of a wrist splint, especially at night, along with 10-15 min of cold and ultrasound therapy. Medications like NSAIDs were given for 5 days.
| Study group | Role | What they receive |
|---|---|---|
| Neurodynamic with PNF | Experimental | PNF technique include Rhythmic Initiation along with agonistic reversals. Neurodynamics includes the distal nerve tension technique along with nerve sliding. Receives: Other: Neurodynamic and PNF |
| Baseline treatment | Active comparator | Wrist splint along with ultrasound therapy, cold therapy, and medication like NSAIDs. Receives: Other: Baseline Treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quick DASH Questionnaire
Changes from Baseline Quick DASH questionnaire (Quick Disabilities of the Arm, Shoulder, and Hand) is a concise version of the DASH questionnaire. It consists of 11 items, with each item scored from 1 (no difficulty) to 5 (unable to perform), assessing daily activities, pain, and social functioning, along with optional modules for work or sports/performing arts. The total score ranges from 0 to 100, where 0 indicates no disability and 100 indicates the most severe disability.
Score Ranges:
0-20: Minimal disability 21-40: Mild to moderate disability 41-60: Moderate to severe disability 61-100: Extreme disability The score is calculated by summing responses, dividing by the number of items (n), subtracting 1, and multiplying by 25.
Measured: 2nd week
Visual Analog Scale
The Visual Analog Scale (VAS) is a frequently utilized tool in clinical and research settings to measure subjective experiences like pain. It was first developed in 1921 by psychologists Mary H.S. Hayes and Donald G. Paterson as a "graphic rating" method for subjective assessments, later adopted and adapted for measuring pain and clinical symptoms in the 1960s. It consists of a 10 cm line where patients spot their pain intensity, from 0 "no pain" at one end to 10 "unbearable pain" at the other.
Measured: 2nd week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 May 2026
- Study start1 Jan 2025
- Primary completion1 Oct 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Arnab Altaf, ppdpt, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07573878
- Sponsor's protocol ID
- REC/RCR & AHS/24/0293
- Status last verified
- May 2026
- First submitted
- 27 Mar 2026
- Last updated
- 7 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Shabbir S, Naeem F, Aroob A. Comparative Effects of Neurodynamics With and Without Wrist Splint in patients with Carpal Tunnel Syndrome. Pakistan Journal of Medical & Health Sciences. S Shabbir, F Naeem, A Aroob Pakistan Journal of Medical and Health Sciences, 2022•academia.edu
Aditi, K., Manish, J. K., Vaibhav, A., & Yadav, N. Analysing the Effects of Neuro-dynamics in Carpal Tunnel Syndrome in Pain and Disability: A Randomized Control Trial.
Zaheer SA, Ahmed Z. Neurodynamic Techniques in the Treatment of Mild-to-Moderate Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis. J Clin Med. 2023 Jul 25;12(15):4888. doi: 10.3390/jcm12154888.
PubMed 37568290Nunez de Arenas-Arroyo S, Cavero-Redondo I, Torres-Costoso A, Reina-Gutierrez S, Alvarez-Bueno C, Martinez-Vizcaino V. Short-term Effects of Neurodynamic Techniques for Treating Carpal Tunnel Syndrome: A Systematic Review With Meta-analysis. J Orthop Sports Phys Ther. 2021 Dec;51(12):566-580. doi: 10.2519/jospt.2021.10533. Epub 2021 Nov 16.
PubMed 34784245Hamzeh H, Madi M, Alghwiri AA, Hawamdeh Z. The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial. J Hand Ther. 2021 Oct-Dec;34(4):521-530. doi: 10.1016/j.jht.2020.07.005. Epub 2020 Jul 30.
PubMed 32893098
Study at a glance
From the registry record, last updated by the sponsor on 7 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Effects of Neurodynamics With Proprioceptive Neuromuscular Facilitation Technique on Pain and Range of Motion in Patient With Carpal Tunnel Syndrome.
- ClinicalTrials.gov ID
- NCT07573878
- Acronym / sponsor ID
- REC/RCR & AHS/24/0293
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Keywords
- Carpal tunnel syndrome, Median nerve, Neurodynamic, PNF, Range of motion
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 7 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine the combined effects of neurodynamics with proprioceptive neuromuscular facilitation technique on reducing pain and improving range of motion in patients with carpal tunnel syndrome. This study evaluates whether neurodynamics combined with PNF is an effective approach in treating CTS compared to baseline treatment, as both techniques are well known for their individual effects. This treatment is given for 2 weeks, 5 days per week with 10 repetitions for each exercise.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Neurodynamic with PNF | Experimental | Other: Neurodynamic and PNFPNF technique include Rhythmic Initiation along with agonistic reversals. Neurodynamics includes the distal nerve tension technique along with nerve sliding. |
| Baseline treatment | Active comparator | Other: Baseline TreatmentWrist splint along with ultrasound therapy, cold therapy, and medication like NSAIDs. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Diagnosed cases of carpal tunnel syndrome.
- Patients having positive Tinel's test and Phalen's test.
- Symptoms persisted for at least 4 weeks.
- Availability and motivation of patients to participate in a 2-week program.
Key exclusion criteria (3 listed)
- Patient with contraindications to rehabilitation treatment.
- Patients with a history of previous upper limb surgery.
- Patient received steroid injection or have any systemic disease that can influence condition.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neurodynamic and PNFAlso: Neurodynamic, Proprioceptive Neuromuscular Facilitation techniqueThese 2 exercises were provided in 10 repetitions for 2 weeks (duration), 5 days per week (frequency). i) PNF techniques used in carpal tunnel treatment includes 1. Rhythmic Initiation 2. Agonistic Reversals. ii) For Neurodynamic (1) Distal nerve tension technique :Hand was placed in six different positions each position maintained for 7 second and have 5 repetitions for each step this is done in median nerve tension technique (2) nerve slide | Other | Neurodynamic with PNF |
| Baseline TreatmentAlso: medication, wrist splint, Ultrasound therapy, Cold therapyThey were provided with common conservative physical therapy treatment for 2 weeks, 5 days per week, following carpal tunnel syndrome. These treatments included use of a wrist splint, especially at night, along with 10-15 min of cold and ultrasound therapy. Medications like NSAIDs were given for 5 days. | Other | Baseline treatment |
Primary outcome
Quick DASH Questionnaire
Time frame: 2nd week
Changes from Baseline Quick DASH questionnaire (Quick Disabilities of the Arm, Shoulder, and Hand) is a concise version of the DASH questionnaire. It consists of 11 items, with each item scored from 1 (no difficulty) to 5 (unable to perform), assessing daily activities, pain, and social functioning, along with optional modules for work or sports/performing arts. The total score ranges from 0 to 100, where 0 indicates no disability and 100 indicates the most severe disability. Score Ranges: 0-20: Minimal disability 21-40: Mild to moderate disability 41-60: Moderate to severe disability 61-100: Extreme disability The score is calculated by summing responses, dividing by the number of items (n), subtracting 1, and multiplying by 25.
Visual Analog Scale
Time frame: 2nd week
The Visual Analog Scale (VAS) is a frequently utilized tool in clinical and research settings to measure subjective experiences like pain. It was first developed in 1921 by psychologists Mary H.S. Hayes and Donald G. Paterson as a "graphic rating" method for subjective assessments, later adopted and adapted for measuring pain and clinical symptoms in the 1960s. It consists of a 10 cm line where patients spot their pain intensity, from 0 "no pain" at one end to 10 "unbearable pain" at the other.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 May 2026.
- BackgroundShabbir S, Naeem F, Aroob A. Comparative Effects of Neurodynamics With and Without Wrist Splint in patients with Carpal Tunnel Syndrome. Pakistan Journal of Medical & Health Sciences. S Shabbir, F Naeem, A Aroob Pakistan Journal of Medical and Health Sciences, 2022•academia.edu
- BackgroundAditi, K., Manish, J. K., Vaibhav, A., & Yadav, N. Analysing the Effects of Neuro-dynamics in Carpal Tunnel Syndrome in Pain and Disability: A Randomized Control Trial.
- Background: PubMed 37568290Zaheer SA, Ahmed Z. Neurodynamic Techniques in the Treatment of Mild-to-Moderate Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis. J Clin Med. 2023 Jul 25;12(15):4888. doi: 10.3390/jcm12154888.
- Background: PubMed 34784245Nunez de Arenas-Arroyo S, Cavero-Redondo I, Torres-Costoso A, Reina-Gutierrez S, Alvarez-Bueno C, Martinez-Vizcaino V. Short-term Effects of Neurodynamic Techniques for Treating Carpal Tunnel Syndrome: A Systematic Review With Meta-analysis. J Orthop Sports Phys Ther. 2021 Dec;51(12):566-580. doi: 10.2519/jospt.2021.10533. Epub 2021 Nov 16.
- Background: PubMed 32893098Hamzeh H, Madi M, Alghwiri AA, Hawamdeh Z. The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial. J Hand Ther. 2021 Oct-Dec;34(4):521-530. doi: 10.1016/j.jht.2020.07.005. Epub 2020 Jul 30.
- Comparative Effects of Neurodynamics With and Without Wrist Splint in patients with Carpal Tunnel SyndromeLink provided by the sponsor.
- Effectiveness of proprioceptive neuromuscular facilitation pattern on upper extremity and scapula in patients with adhesive capsulitis: a single-centre assessor-blinded randomised controlled trial (RCT)Link provided by the sponsor.
- Comparison of Two Different Applications of Proprioceptive Neuromuscular Facilitation Techniques to Increase Upper-Extremity Muscle Strength Bezmialem Science 2021;9(2):190-197 DOI: 10.14235/bas.galenos.2020.3854Link provided by the sponsor.
- Changes in Median Nerve Excursion with Neurodynamic techniques in patients with carpal tunnel syndrome and healthy adults: influencing factors H Farghaly, H Rashed, H Elgendy, A Mohamed Egyptian Journal of Physical Therapy, 2023•ejpt.journals.ekb.egLink provided by the sponsor.
- Effect of Neurodynamic Technique on Carpal Tunnel Syndrome" Single Case Report"Link provided by the sponsor.
- Comparison of Two Different Applications of Proprioceptive Neuromuscular Facilitation Techniques to Increase Upper-Extremity Muscle Strength Bezmialem Science 2021;9(2):190-197Link provided by the sponsor.
- Individual participant dataSharing planned: No
Related trials for Carpal Tunnel Syndrome (CTS)
Not yet recruitingObservational study
Postural Control and Balance Performance in Patients With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS), Postural Assessment
Recruiting
Comparison of Wrist Splint Positions in Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS), Peripheral Neuropathies
Recruiting
Effects of Repetitive Peripheral Magnetic Stimulation(rPMS) on CTS(Carpal Tunnel Syndrome)
Carpal Tunnel Syndrome (CTS)
Recruiting
Hand Function Outcome After the Application of Transfer Energy Capacitive and Resistive on Post-burn Patients Presented With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) Post-burn
Not yet recruiting
Effect of Progressive Gamified Motor Rehabilitation After Carpal Tunnel Release
Carpal Tunnel Surgery
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Arnab Altaf, ppdpt principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neurodynamic and PNF and Baseline Treatment in people with Carpal Tunnel Syndrome (CTS), run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quick DASH Questionnaire (time frame: 2nd week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07573878, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 May 2026.