AKI - Acute Kidney InjuryCIILOSNCT07586059
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
An observational study of AKI - Acute Kidney Injury and Critical Illness, run by Karolinska Institutet.
Trial summary
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- AKI - Acute Kidney Injury, Critical Illness
- What is being tested?
- continuous renal replacement therapy
- Type of treatment
- Medical device
- How many people
- 500,000 participants
- Where
- No sites listed yet
- Study dates
- 1 Nov 2026to 31 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: All adult critically ill patients in Swedish ICUs from 2010-2023, with- and without the need of CRRT forms this cohort. Within the cohort, a nested case-control type of study can be performed. Two groups: Group 1: Patients with CRRT initiation time less than 30 hours (early CRRT) Group 2: Patients with CRRT initiation time 30 hours or more (late CRRT)
Who may be able to join
- Patients with critical illness
- Admitted to Swedish ICUs from 2010-2023
- Adult (18 years or older)
Who cannot join
- Patients under 18 years of age
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: CIILOS - Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).
Read the detailed description
This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS).
The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients.
CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.
- Conditions
- AKI - Acute Kidney Injury, Critical Illness
- Being tested
- continuous renal replacement therapy
- Keywords
- AKI, CRRT, CKRT, Critical Illness, Intensive care
- Medical subject headings
- Acute Kidney Injury, Critical Illness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
continuous renal replacement therapyDevice
We are evaluting early vs late initiation of CRRT
What is being measured
The primary outcome is the main question the study is designed to answer.
Intensive care unit (ICU) length of stay (LOS) measured in hours
Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)
Measured: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)
Secondary outcomes (2)
Mortality
Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality
Measured: ONE-YEAR Mortality post admission
Mechanical ventilation
Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours
Measured: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 May 2026
- Study start1 Nov 2026 (estimated)
- Primary completion31 Dec 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AKI - Acute Kidney InjuryStudies of the same condition, open and under way.
- More trials run by Karolinska InstitutetThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 500,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Karolinska Institutet
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Max Bell, Karolinska Institutet
- Investigators
- Max Bell, MD, PhD, Principal investigator, Karolinska University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07586059
- Sponsor's protocol ID
- CIILOS
- Acronym
- CIILOS
- Status last verified
- Sep 2026
- First submitted
- 18 Dec 2025
- Last updated
- 18 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Swedish law prohibits IPD sharing using extracted quality register data, when this has not been stated in the primary ethics application. However, other researchers can theoretically apply for data extraction from the Swedish Intensive Care Register.
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- CIILOS - Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
- ClinicalTrials.gov ID
- NCT07586059
- Acronym / sponsor ID
- CIILOS / CIILOS
- Conditions
- AKI - Acute Kidney Injury, Critical Illness
- Keywords
- AKI, CRRT, CKRT, Critical Illness, Intensive care
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 500,000 participants (estimated)
- Lead sponsor
- Karolinska InstitutetUniversity, hospital or other
- Study start
- 1 Nov 2026 (estimated)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 14 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).
Detailed description
This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS).
The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients.
CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- All adult critically ill patients in Swedish ICUs from 2010-2023, with- and without the need of CRRT forms this cohort. Within the cohort, a nested case-control type of study can be performed. Two groups: Group 1: Patients with CRRT initiation time less than 30 hours (early CRRT) Group 2: Patients with CRRT initiation time 30 hours or more (late CRRT)
Key inclusion criteria (3 listed)
- Patients with critical illness
- Admitted to Swedish ICUs from 2010-2023
- Adult (18 years or older)
Key exclusion criteria (1 listed)
- Patients under 18 years of age
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| continuous renal replacement therapyWe are evaluting early vs late initiation of CRRT | Device | – |
Primary outcome
Intensive care unit (ICU) length of stay (LOS) measured in hours
Time frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)
Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)
2 secondary outcomes
Mortality
Time frame: ONE-YEAR Mortality post admission
Mechanical ventilation
Time frame: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2026.
- Individual participant dataSharing planned: No. Swedish law prohibits IPD sharing using extracted quality register data, when this has not been stated in the primary ethics application. However, other researchers can theoretically apply for data extraction from the Swedish Intensive Care Register.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Max Bell, MD, PhD principal investigator
Karolinska University Hospital
Questions about this trial
What is this clinical trial studying?
An observational study of AKI - Acute Kidney Injury and Critical Illness, run by Karolinska Institutet.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Max Bell, MD, PhD (+46708278533, max.bell@regionstockholm.se), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intensive care unit (ICU) length of stay (LOS) measured in hours (time frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2026.