Orthodontic Treatment AccelerationPBMT-CANNCT07597304
Photobiomodulation Therapy (PBMT) for Accelerating Maxillary Canine Movement Using Two Wavelengths (650 nm and 976 nm): A Split-Mouth Randomized Controlled Clinical Trial
A study testing 650 nm Photobiomodulation Therapy and 976 nm Photobiomodulation Therapy in people with Orthodontic Treatment Acceleration and Photobiomodulation Therapy, run by Kufa University at 1 site in Iraq.
Trial summary
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Orthodontic Treatment Acceleration, Photobiomodulation Therapy
- What is being tested?
- 650 nm Photobiomodulation Therapy and 976 nm Photobiomodulation Therapy
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteIraq
- Study dates
- 5 May 2025to 20 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- good oral hygiene and the absence of any medications affecting bone metabolism.
Who cannot join
- systemic diseases, periodontal pathology, a history of previous orthodontic treatment, or the use of antibiotics or anti-inflammatory drugs during the study.[
Trial locations and contacts
1 site in 1 country.
Iraq1 site
Orthodontic Clinic, College of Dentistry, University of Kufa
Najaf, Najaf Governorate, 54001
About this study
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.
Read the detailed description
Photobiomodulation therapy (PBMT) has been proposed as a non-invasive adjunctive method to accelerate orthodontic tooth movement and reduce overall treatment duration. This split-mouth randomized clinical trial aims to evaluate and compare the effectiveness of two different laser wavelengths (650 nm and 976 nm) on the acceleration of maxillary canine movement during orthodontic treatment.
Participants requiring bilateral maxillary first premolar extraction and canine retraction as part of their orthodontic treatment will be included. Each patient will serve as their own control using a split-mouth design. One side will receive PBMT application during canine retraction, while the contralateral side will act as the control or receive an alternative wavelength according to the randomization protocol.
Orthodontic canine movement will be performed using standardized orthodontic mechanics under controlled force application. The primary outcome measure will be the rate of maxillary canine movement assessed at regular intervals. Secondary outcomes will include total treatment duration required for space closure and the influence of patient-related factors such as age and gender on treatment outcomes.
The study will compare the clinical effectiveness of 650 nm and 976 nm wavelengths in accelerating orthodontic tooth movement. Statistical analyses including paired t-tests, independent t-tests, and correlation analyses will be used to evaluate differences between groups and assess associations between demographic variables and treatment response.
The findings of this study may provide clinically relevant evidence regarding the effectiveness of PBMT in reducing orthodontic treatment time and improving treatment efficiency.
- Being tested
- 650 nm Photobiomodulation Therapy, 976 nm Photobiomodulation Therapy
- Keywords
- Photobiomodulation Therapy Low-Level Laser Therapy Orthodontics Canine Retraction Orthodontic Tooth Movement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
650 nm Photobiomodulation TherapyDevice
Application of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.
976 nm Photobiomodulation TherapyDevice
Application of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.
| Study group | Role | What they receive |
|---|---|---|
| 650 nm PBMT | Experimental | Participants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction. Receives: Device: 650 nm Photobiomodulation Therapy |
| 976 nm PBMT | Experimental | Participants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction. Receives: Device: 976 nm Photobiomodulation Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of Maxillary Canine Movement
Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths.
Measured: 6 months
Secondary outcomes (2)
Correlation Between Age and Rate of Canine Retraction
Assessment of the correlation between patient age (years) and rate of maxillary canine retraction measured in millimeters per month using digital caliper measurements on study models.
Measured: 6 months
Difference in Rate of Canine Retraction Between Sexes
Comparison of the rate of maxillary canine retraction (mm/month) between male and female participants measured using digital caliper measurements on study models.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 May 2026
- Study start5 May 2025
- Primary completion6 Mar 2026
- Study completion20 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Orthodontic Treatment AccelerationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study uses a split-mouth randomized clinical trial design in which each participant serves as their own control. Maxillary canine retraction will be performed bilaterally following premolar extraction. Different photobiomodulation therapy wavelengths (650 nm and 976 nm) will be applied according to the randomization protocol during orthodontic canine movement.
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Kufa University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Almustafa Alhumadi, Kufa University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07597304
- Sponsor's protocol ID
- PBMT-CANINE-2026
- Other IDs
- KU-IRB-2026-1-2
- Acronym
- PBMT-CAN
- Status last verified
- May 2026
- First submitted
- 12 May 2026
- Last updated
- 19 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared in order to protect participant confidentiality and privacy.
Publications
Alhumadi A. Gender-related response to different wavelength low-level laser therapy in orthodontic mandibular canine movement: a split-mouth study. Endodontics Today. 2026;24:58-66. doi:10.36377/ET-0159.
Al-Kufi HM, Alhumadi A, Huthiafa SM. A comparative evaluation of postoperative re-pigmentation following gingival depigmentation using a 940-nm diode laser and abrasion method: a split-mouth study. Lasers in Dental Science. 2024;8(1):3. doi:10.1007/s41547-023-00208-y.
Zheng J, Yang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021 Jun 28;21(1):324. doi: 10.1186/s12903-021-01684-z.
PubMed 34182967Wazwaz F, Seehra J, Carpenter GH, Papageorgiou SN, Cobourne MT. Duration of canine retraction with fixed appliances: A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2023 Feb;163(2):154-172. doi: 10.1016/j.ajodo.2022.08.009. Epub 2022 Dec 1.
PubMed 36464569
Study at a glance
From the registry record, last updated by the sponsor on 19 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Photobiomodulation Therapy (PBMT) for Accelerating Maxillary Canine Movement Using Two Wavelengths (650 nm and 976 nm): A Split-Mouth Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07597304
- Acronym / sponsor ID
- PBMT-CAN / PBMT-CANINE-2026
- Keywords
- Photobiomodulation Therapy Low-Level Laser Therapy Orthodontics Canine Retraction Orthodontic Tooth Movement
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Kufa UniversityUniversity, hospital or other
- Study start
- 5 May 2025 (actual)
- Primary completion
- 6 Mar 2026 (actual)
- Study completion
- 20 Mar 2026 (actual)
- First posted
- 19 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.
Detailed description
Photobiomodulation therapy (PBMT) has been proposed as a non-invasive adjunctive method to accelerate orthodontic tooth movement and reduce overall treatment duration. This split-mouth randomized clinical trial aims to evaluate and compare the effectiveness of two different laser wavelengths (650 nm and 976 nm) on the acceleration of maxillary canine movement during orthodontic treatment.
Participants requiring bilateral maxillary first premolar extraction and canine retraction as part of their orthodontic treatment will be included. Each patient will serve as their own control using a split-mouth design. One side will receive PBMT application during canine retraction, while the contralateral side will act as the control or receive an alternative wavelength according to the randomization protocol.
Orthodontic canine movement will be performed using standardized orthodontic mechanics under controlled force application. The primary outcome measure will be the rate of maxillary canine movement assessed at regular intervals. Secondary outcomes will include total treatment duration required for space closure and the influence of patient-related factors such as age and gender on treatment outcomes.
The study will compare the clinical effectiveness of 650 nm and 976 nm wavelengths in accelerating orthodontic tooth movement. Statistical analyses including paired t-tests, independent t-tests, and correlation analyses will be used to evaluate differences between groups and assess associations between demographic variables and treatment response.
The findings of this study may provide clinically relevant evidence regarding the effectiveness of PBMT in reducing orthodontic treatment time and improving treatment efficiency.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This study uses a split-mouth randomized clinical trial design in which each participant serves as their own control. Maxillary canine retraction will be performed bilaterally following premolar extraction. Different photobiomodulation therapy wavelengths (650 nm and 976 nm) will be applied according to the randomization protocol during orthodontic canine movement.
| Arm | Type | Receives |
|---|---|---|
| 650 nm PBMT | Experimental | Device: 650 nm Photobiomodulation TherapyParticipants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction. |
| 976 nm PBMT | Experimental | Device: 976 nm Photobiomodulation TherapyParticipants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- good oral hygiene and the absence of any medications affecting bone metabolism.
Key exclusion criteria (1 listed)
- systemic diseases, periodontal pathology, a history of previous orthodontic treatment, or the use of antibiotics or anti-inflammatory drugs during the study.[
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 650 nm Photobiomodulation TherapyApplication of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement. | Device | 650 nm PBMT |
| 976 nm Photobiomodulation TherapyApplication of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement. | Device | 976 nm PBMT |
Primary outcome
Rate of Maxillary Canine Movement
Time frame: 6 months
Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths.
2 secondary outcomes
Correlation Between Age and Rate of Canine Retraction
Time frame: 6 months
Difference in Rate of Canine Retraction Between Sexes
Time frame: 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 May 2026.
- BackgroundAlhumadi A. Gender-related response to different wavelength low-level laser therapy in orthodontic mandibular canine movement: a split-mouth study. Endodontics Today. 2026;24:58-66. doi:10.36377/ET-0159.
- BackgroundAl-Kufi HM, Alhumadi A, Huthiafa SM. A comparative evaluation of postoperative re-pigmentation following gingival depigmentation using a 940-nm diode laser and abrasion method: a split-mouth study. Lasers in Dental Science. 2024;8(1):3. doi:10.1007/s41547-023-00208-y.
- Background: PubMed 34182967Zheng J, Yang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021 Jun 28;21(1):324. doi: 10.1186/s12903-021-01684-z.
- Background: PubMed 36464569Wazwaz F, Seehra J, Carpenter GH, Papageorgiou SN, Cobourne MT. Duration of canine retraction with fixed appliances: A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2023 Feb;163(2):154-172. doi: 10.1016/j.ajodo.2022.08.009. Epub 2022 Dec 1.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared in order to protect participant confidentiality and privacy.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 650 nm Photobiomodulation Therapy and 976 nm Photobiomodulation Therapy in people with Orthodontic Treatment Acceleration and Photobiomodulation Therapy, run by Kufa University at 1 site in Iraq.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Iraq. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of Maxillary Canine Movement (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07597304, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 May 2026.