KeratoconusNCT07599020
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
A study testing Corvis Machine in people with Keratoconus and Intraocular Pressure, run by Tanta University.
Trial summary
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT. Read more about this study
- Who is it for?
- Ages 19 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Keratoconus, Intraocular Pressure
- What is being tested?
- Corvis Machine
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1 participants
- Where
- No sites listed yet
- Study dates
- 10 Jul 2026to 10 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients who will corneal cross linking for mild degree of keratoconus, age between 19 and 35 years old
Who cannot join
- Corneal scarring.
- Previous corneal infections.
- Minimum corneal thickness at the thinnest location less than 400 µm.
- History of uveitis or ocular allergy.
- Pre-existing glaucoma.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
Read the detailed description
This study will be prospective study. 50 Patients will be included who will undergo corneal cross linking from the out-patient clinic of Tanta University hospital between December 2025 and December 2026 will be included in the study .
Patient with age 19 till 35 years old will be included
Patient with Corneal scarring, Previous corneal infections, Minimum corneal thickness at the thinnest location less than 400 µm, History of uveitis or ocular allergy and Pre-existing glaucoma will be excluded from the study
All patient will undergo full ophthalmological examination. including best corrected visual acuity, degree of myopia , average kertometry and intraocular pressure will be measured before and after cross linkage with three different techniques including Shiotz tonometry, appalanation tonometry and CORVIS machine
- Conditions
- Keratoconus, Intraocular Pressure
- Being tested
- Corvis Machine
- Medical subject headings
- Keratoconus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Corvis MachineDevice
Measuring the intraocular pressure
| Study group | Role | What they receive |
|---|---|---|
| Measuring the intraocular pressure after cross linking | Other | Measuring the intraocular pressure by using different techniques after corneal cross linking Receives: Device: Corvis Machine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intraocular pressure will be measured by using Corvis CT before cross linking and one month after cross linking
Recording the intraocular pressure
Measured: Through the end of the study in approximately one year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 May 2026
- Study start10 Jul 2026 (estimated)
- Primary completion12 Dec 2026 (estimated)
- Study completion10 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for KeratoconusStudies of the same condition, open and under way.
- More trials run by Tanta UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 1 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dina Tadros, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07599020
- Sponsor's protocol ID
- 36264PR131099/12/25
- Status last verified
- May 2026
- First submitted
- 17 Jan 2026
- Last updated
- 20 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The statistical analysis results will be shared through the manuscript
Study at a glance
From the registry record, last updated by the sponsor on 20 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
- ClinicalTrials.gov ID
- NCT07599020
- Acronym / sponsor ID
- 36264PR131099/12/25
- Conditions
- Keratoconus, Intraocular Pressure
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 1 participants (estimated)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 10 Jul 2026 (estimated)
- Primary completion
- 12 Dec 2026 (estimated)
- Study completion
- 10 Feb 2027 (estimated)
- First posted
- 20 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
Detailed description
This study will be prospective study. 50 Patients will be included who will undergo corneal cross linking from the out-patient clinic of Tanta University hospital between December 2025 and December 2026 will be included in the study .
Patient with age 19 till 35 years old will be included
Patient with Corneal scarring, Previous corneal infections, Minimum corneal thickness at the thinnest location less than 400 µm, History of uveitis or ocular allergy and Pre-existing glaucoma will be excluded from the study
All patient will undergo full ophthalmological examination. including best corrected visual acuity, degree of myopia , average kertometry and intraocular pressure will be measured before and after cross linkage with three different techniques including Shiotz tonometry, appalanation tonometry and CORVIS machine
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Measuring the intraocular pressure after cross linking | Other | Device: Corvis MachineMeasuring the intraocular pressure by using different techniques after corneal cross linking |
Who may qualify
- Ages
- 19 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Patients who will corneal cross linking for mild degree of keratoconus, age between 19 and 35 years old
Key exclusion criteria (5 listed)
- Corneal scarring.
- Previous corneal infections.
- Minimum corneal thickness at the thinnest location less than 400 µm.
- History of uveitis or ocular allergy.
- Pre-existing glaucoma.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Corvis MachineMeasuring the intraocular pressure | Device | Measuring the intraocular pressure after cross linking |
Primary outcome
Intraocular pressure will be measured by using Corvis CT before cross linking and one month after cross linking
Time frame: Through the end of the study in approximately one year
Recording the intraocular pressure
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 May 2026.
- Individual participant dataSharing planned: Yes. The statistical analysis results will be shared through the manuscript
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Corvis Machine in people with Keratoconus and Intraocular Pressure, run by Tanta University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tamer Ibrahim, Ass professor of ophthalmology (+201001243049, dinasabry71@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intraocular pressure will be measured by using Corvis CT before cross linking and one month after cross linking (time frame: Through the end of the study in approximately one year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 May 2026; AzTrials last refreshed its copy on 8 Nov 2026.