Clinical trials: Keratoconus
Keratoconus
Familial Analysis of Keratoconus Risk
The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC. It's a familial, epidemiological, prospective, single-center study.
- Trial name
- AFRIK (NCT02812563)
- Testing
- genetic
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Keratoconus
Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
The purpose of this study is to determine whether corneal collagen crosslinking is effective in the treatment of progressive keratoconus.
- Trial name
- CXL-RCT (NCT01604135)
- Testing
- Corneal Collagen Crosslinking
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Sahlgrenska University Hospital
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Keratoconus, Corneal Ectasia
Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).
Compare different corneal parameters and visual outcome of corneal collagen cross-linking (CXL) with conventional versus accelerated ultraviolet-A irradiation using riboflavin with hydroxypropyl methylcellulose.
- Trial name
- CXL (NCT02883478)
- Testing
- UV-X 1000 (3 mW/cm²), UV-X 2000 (9 mW/cm²), riboflavin with hydroxypropyl methylcellulose
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Keratoconus
Biomechanical Properties of Keratoconic Eyes
In keratoconus (KC) corneal thinning and protrusion can cause myopia and irregular astigmatism, affecting vision. The biomechanical properties of the cornea is maintained by an intricate collagen network, which is responsible for…
- Trial name
- NCT02476149
- Testing
- Corneal Cross-linking
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Plymouth
Keratoconus
Initial Correction Keratoconus
Keratoconus is a non-inflammatory, progressive disease in which corneal irregularity increases. As the condition develops, more advanced forms of optical correction are needed to improve vision for patients.
- Trial name
- NCT04918316
- Testing
- Corneal gas permeable lens
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois at Chicago
Myopia, Keratoconus
Assessment of Corneal Biomechanical Properties Using Corvis ST and ECD Following LASIK, PRK, CXL, Veriflex IOL and Implantable Collamer Lens
To evaluate corneal biomechanical changes using the Corvis ST and ECD in patients who have under-gone LASIK, PRK, corneal cross-linking (CXL), Veriflex IOL and ICL.
- Conditions
- Myopia, Keratoconus, Refractive Surgery
- Trial name
- NCT06818461
- Testing
- Corvis St Before and after lasik, PRK, CXL, Veriflex IOL and ICL
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Keratoconus
Collagen Cross-linking in Keratoconus
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus.
- Trial name
- NCT03760432
- Testing
- Laser Custom Corneal Collagen Cross-Linking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Fruste Keratoconus, Risk of Ectasia
Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia
This study is being performed to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) in strengthening and optimizing the biomechanical and biochemical stability of the cornea in patients…
- Trial name
- NCT01726283
- Testing
- Corneal Cross-Linking, Riboflavin
- Where
- 8 sites in United States
- Volunteers
- 22 people
- Sponsor
- Cxlusa
Progressive Keratoconus
Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus
This study attempts to compare Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF) in a series of keratoconic eyes before and after Corneal collagen cross-linking (CXL).
- Trial name
- NCT01411384
- Testing
- Corneal collagen cross-linking, Ocular Response Analyzer (ORA)
- Volunteers
- 80 people
- Sponsor
- Democritus University of Thrace
Keratoconus
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
Multi-center, parallel-group, placebo-controlled trial designed to assess the safety and efficacy of twice-daily topically administered GLK-221 Ophthalmic Solution in subjects with keratoconus.
- Trial name
- NCT07400952
- Testing
- GLK-221 Ophthalmic Solution
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Glaukos Corporation
Keratoconus
Correlation Between Eye Rubbing and Keratoconus Severity in a Treatment-naive Keratoconic Population
determination if, within a keratoconic population, strong eye rubbing was correlated with visual acuity, spherical equivalent value, biomicroscopic signs, corneal pachymetry, keratometry, and tomography classification…
- Trial name
- FROTT EYES (NCT02883881)
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Keratoconus
The Possible Role of Thyroxine in Keratoconus Development
Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Hormonal imbalances may be associated with KC as it affects the corneal metabolism.
- Trial name
- NCT03637673
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Keratoconus, Cornea Disease
Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
The cornea plays a fundamental role in vision, being a complex tissue essential for ocular health. In ophthalmological practice, there are situations such as corneal crosslinking, where damage to the corneal epithelium occurs.
- Conditions
- Keratoconus, Cornea Disease, Eye Diseases, Wound Heal
- Trial name
- NCT06601101
- Testing
- Insulin
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Keratoconus, Ectasia
Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs
This study will determine the efficacy of collagen cross linking for progressive keratoconus and ectasia after lasik. It will try and determine which is a more effective treatment: collagen cross linking alone or collagen cross…
- Trial name
- NCT01081561
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Yaron S. Rabinowitz M.D.
Keratoconus
Management of Patients With Keratoconus With Intacs
Purpose To evaluate long-term follow up of Intacs microthin prescription inserts (Addition Technology Inc, Fremont, Calif) for the management of keratoconus. Design A long-term (five years) retrospective, follow-up study
- Trial name
- NCT00384501
- Testing
- Intacs
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital of Crete
Keratoconus
Treatment of Keratoconus With Advanced Corneal Crosslinking
The purpose of this study was to determine whether mechanical compression of the cornea during corneal crosslinking for keratoconus using a sutured rigid contact lens can improve the optical outcomes of the treatment.
- Trial name
- NCT02425150
- Testing
- Corneal reshaping/crosslinking (CRXL), Corneal Crosslinking (CXL)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
Keratoconus, Pellucid Marginal Degeneration
T-Cat Laser & Cross-linking for Keratoconus
The purpose of this study is to determine whether excimer laser corneal surface ablation (T-Cat) can be safely combined with simultaneous corneal collagen cross-linking treatment to produce an improved and stable corneal profile…
- Trial name
- T-Cat (NCT00777322)
- Testing
- Excimer laser ablation, and collagen cross-linking
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust