Parkinson's Disease (PD)NCT07606547
Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease
A study testing exspiratory muscle strength training in people with Parkinson's Disease (PD) and Dysphagia, run by University Hospital Muenster at 1 site in Germany.
Trial summary
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Parkinson's Disease (PD), Dysphagia
- What is being tested?
- exspiratory muscle strength training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteGermany
- Study dates
- Jun 2026to May 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- diagnosis of Parkinson's disease,
- PD-related dysphagia as objectively diagnosed with FEES
Who cannot join
- severe dementia, not able to give consent
- dysphagia related to other diagnoses
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site, 1 recruiting
- Recruiting
University Hospital Münster, Department of Neurology
Münster, 48149
Sonja Suntrup-Krueger, Prof. Dr. med., +4925183-46811, sonja.suntrup-krueger@ukmuenster.de
About this study
Official title: Biomechanical Effects of Expiratory Muscle Strength Training (EMST®) on Swallowing Function in Parkinson's Disease - a Prospective High-resolution Manometry Study
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients. A combination of fiberoptic endoscopic evaluation of swallowing (FEES) and pharyngeal high-resolution manometry (HRM) will be employed to comprehensively evaluate the neuromuscular changes in swallowing.
- Conditions
- Parkinson's Disease (PD), Dysphagia
- Being tested
- exspiratory muscle strength training
- Keywords
- Dysphagia, Expiratory muscle strength training, Parkinson's Disease, High-resolution pharyngeal manometry
- Medical subject headings
- Parkinson Disease, Deglutition Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
exspiratory muscle strength trainingDevice
Also called EMST
5 sets of 5 breaths with EMST per day, 5 days a week for 1 month
| Study group | Role | What they receive |
|---|---|---|
| EMST treatment | Experimental | daily EMST training on 5 days a week for 1 month Receives: Device: exspiratory muscle strength training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effect on swallowing biomechanics in pharyngeal high-resolution manometry as assessed by measurement of e.g. Pharyngeal contractile Integral (PhcI)
metrics of pharyngeal contraction and upper esophageal sphinkter opening in high-resolution pharyngeal manometry
Measured: 1 month and 3 months
Secondary outcomes (1)
Pharyngeal swallowing safety and efficiency as assessed with fiberoptic endoscopic evaluation of swallowing (FEES) applying DIGEST-FEES scoring
Assessment of Swallowing safety and efficiency with DIGEST-FEES (Dynamic Imaging Grade of Swallowing Toxicity - FEES), Range 0 (best) - 4 (worst)
Measured: 1 month and 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2026
- Study startJun 2026 (estimated)
- Primary completionMay 2028 (estimated)
- Study completionMay 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson's Disease (PD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Muenster
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Sonja Suntrup-Krueger, Prof. Dr. med., Study chair, University Hospital Münster, Department of Neurology, Albert-Schweitzer-Campus 1, A1, 48149 Münster, Germany
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07606547
- Sponsor's protocol ID
- 2025-447-f-S
- Status last verified
- May 2026
- First submitted
- 6 May 2026
- Last updated
- 3 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Biomechanical Effects of Expiratory Muscle Strength Training (EMST®) on Swallowing Function in Parkinson's Disease - a Prospective High-resolution Manometry Study
- ClinicalTrials.gov ID
- NCT07606547
- Acronym / sponsor ID
- 2025-447-f-S
- Conditions
- Parkinson's Disease (PD), Dysphagia
- Keywords
- Dysphagia, Expiratory muscle strength training, Parkinson's Disease, High-resolution pharyngeal manometry
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University Hospital MuensterUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- May 2028 (estimated)
- Study completion
- May 2028 (estimated)
- First posted
- 26 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients. A combination of fiberoptic endoscopic evaluation of swallowing (FEES) and pharyngeal high-resolution manometry (HRM) will be employed to comprehensively evaluate the neuromuscular changes in swallowing.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| EMST treatment | Experimental | Device: exspiratory muscle strength trainingdaily EMST training on 5 days a week for 1 month |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- diagnosis of Parkinson's disease,
- PD-related dysphagia as objectively diagnosed with FEES
Key exclusion criteria (2 listed)
- severe dementia, not able to give consent
- dysphagia related to other diagnoses
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| exspiratory muscle strength trainingAlso: EMST5 sets of 5 breaths with EMST per day, 5 days a week for 1 month | Device | EMST treatment |
Primary outcome
Effect on swallowing biomechanics in pharyngeal high-resolution manometry as assessed by measurement of e.g. Pharyngeal contractile Integral (PhcI)
Time frame: 1 month and 3 months
metrics of pharyngeal contraction and upper esophageal sphinkter opening in high-resolution pharyngeal manometry
1 secondary outcome
Pharyngeal swallowing safety and efficiency as assessed with fiberoptic endoscopic evaluation of swallowing (FEES) applying DIGEST-FEES scoring
Time frame: 1 month and 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sonja Suntrup-Krueger, Prof. Dr. med. study chair
University Hospital Münster, Department of Neurology, Albert-Schweitzer-Campus 1, A1, 48149 Münster, Germany
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing exspiratory muscle strength training in people with Parkinson's Disease (PD) and Dysphagia, run by University Hospital Muenster at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sonja Suntrup-Krueger, Prof. Dr. med. (+49251-83-46811, sonja.suntrup-krueger@ukmuenster.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effect on swallowing biomechanics in pharyngeal high-resolution manometry as assessed by measurement of e.g. Pharyngeal contractile Integral (PhcI) (time frame: 1 month and 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2026.