Glycaemic ResponseNCT07609004
Influence of Tea Consumption on Human Glycemic Response
A study testing Tea Type #1, Tea Type #2 and Standardized meal in people with Glycaemic Response, run by National University of Singapore at 1 site in Singapore.
Trial summary
The specific aim of this study is to evaluate the postprandial metabolic responses of individuals to tea varieties when consumed individually or together with a standardized meal. Read more about this study
- Who is it for?
- Ages 21 to 60 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Glycaemic Response
- What is being tested?
- Tea Type #1, Tea Type #2 and Standardized meal
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteSingapore
- Study dates
- 25 Mar 2026to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 60 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male
- Chinese ethnicity
- Ages 21-60 years old (inclusive)
- Healthy
- Weigh at least 50kg
- Must be English-literate and able to give informed consent in English
- Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
Who cannot join
- Female
- A current smoker, or has smoked in the past 2 years
- Fasting glucose >= 7 mmol/L
- History of type 1/type 2 diabetes
- Regular use of medication that may affect glucose metabolism (e.g., steroids)
- Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
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- History of food allergies to test products (milk tea) i.e. milk allergies, or lactose intolerance
- History of food allergies to any of the ready made meals (such as soy, peanuts, eggs, shellfish etc)
- Have donated blood of more than 500 mL within 8 weeks of study enrolment
- Any other conditions, which, in the opinion of the Investigator would make the subject unsuitable for inclusion or could interfere with the subject participating in or completing the study
Trial locations and contacts
1 site in 1 country.
Singapore1 site
National University of Singapore, Department of Food Science & Technology
Singapore
About this study
The specific aim of this study is to evaluate the postprandial metabolic responses of individuals to tea varieties when consumed individually or together with a standardized meal.
Read the detailed description
This study aims to investigate the effects of tea and food consumption on postprandial metabolic responses, specifically focusing on blood glucose (glycemia) and blood lipid levels. The primary objective is to generate scientifically grounded insights that can inform consumer education and product communication regarding the metabolic impacts of tea and food intake. The study will recruit healthy male volunteers of Chinese ethnicity, aged 21 to 60 years inclusive. Eligible participants will be required to attend seven study visits: (1) an initial screening session, (2) a 2-hour Oral Glucose Tolerance Test (OGTT), and (3-7) five 3-hour intervention sessions.
During the screening, participants will undergo body composition measurement, and a blood draw to confirm eligibility. Participants will also be provided with standardized dinner meals to be consumed the day before each subsequent visits as their last meal of the day before an overnight fast. In the OGTT session, participants will fast overnight. They will be cannulated and consume a glucose beverage; blood samples will be collected at seven timepoints over two hours to analyze for glucose, insulin, lipids, and other metabolic biomarkers. Each of the five intervention sessions will also require overnight fasting. Participants will consume either: one of two tea beverages, each tea beverage with a standardized meal, or the meal alone. Participants will be cannulated and blood will be drawn at nine timepoints over three hours per session. They will also complete satiety questionnaires at each timepoint. Blood samples will be analyzed for glucose, insulin, lipid panel, hormones, and other metabolic biomarkers to evaluate the postprandial effects of the interventions.
The findings are expected to clarify whether tea modulates postprandial glycemic and lipid responses compared to typical intake conditions. Results may support evidence-based communication about tea's metabolic effects and inform future product development and consumer guidance.
- Conditions
- Glycaemic Response
- Being tested
- Tea Type #1, Tea Type #2, Standardized meal
- Keywords
- tea, glucose, insulin, OGTT
- Medical subject headings
- Insulin Resistance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tea Type #1Dietary supplement
This is a specific tea variety #1 that will be consumed by participants. It contains milk, a small amount of sugar, and will be served cold with ice.
Tea Type #2Dietary supplement
This is a specific tea variety #1 that will be consumed by participants. It contains milk, a small amount of sugar, and will be served cold with ice.
Standardized mealDietary supplement
This is a ready to eat meal that can be purchased off the shelves in local stores. The same meal is used for several study arms to serve as a standardization on the nutritional content consumed.
| Study group | Role | What they receive |
|---|---|---|
| Tea Type #1 | Experimental | In this intervention, participants will be cannulated and required to consume a specific tea beverage #1. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. Receives: Dietary Supplement: Tea Type #1 |
| Tea Type #2 | Experimental | In this intervention, participants will be cannulated and required to consume a specific tea beverage #2. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. Receives: Dietary Supplement: Tea Type #2 |
| Tea Type #1 + Standardized Meal | Experimental | In this intervention, participants will be cannulated and required to consume a specific tea beverage #1 and a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. Receives: Dietary Supplement: Tea Type #1; Dietary Supplement: Standardized meal |
| Tea Type #2 + Standardized Meal | Experimental | In this intervention, participants will be cannulated and required to consume a specific tea beverage #2 and a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. Receives: Dietary Supplement: Tea Type #2; Dietary Supplement: Standardized meal |
| Standardized Meal | Experimental | In this intervention, participants will be cannulated and required to consume a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. Receives: Dietary Supplement: Standardized meal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in laboratory analysis of blood glucose and insulin measurements at 9 timepoints over 3 hours for each session
Measured: Approximately 16 weeks from enrolment to the end of study
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 May 2026
- Study start25 Mar 2026
- Primary completionDec 2026 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Glycaemic ResponseStudies of the same condition, open and under way.
- More trials run by National University of SingaporeThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National University of Singapore
- Sponsor type
- University, hospital or other
- Collaborators
- Tea Explorer Pte. Ltd.
- Responsible party
- Principal investigator, Mei Hui Liu, National University of Singapore
- Investigators
- Mei Hui Liu, PhD, Principal investigator, National University of Singapore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07609004
- Sponsor's protocol ID
- NUS-IRB-2025-906
- Status last verified
- Feb 2026
- First submitted
- 19 Feb 2026
- Last updated
- 27 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Tea Consumption on Human Glycemic Response
- ClinicalTrials.gov ID
- NCT07609004
- Acronym / sponsor ID
- NUS-IRB-2025-906
- Conditions
- Glycaemic Response
- Keywords
- tea, glucose, insulin, OGTT
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- National University of SingaporeUniversity, hospital or other
- Collaborators
- Tea Explorer Pte. Ltd.
- Study start
- 25 Mar 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 27 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The specific aim of this study is to evaluate the postprandial metabolic responses of individuals to tea varieties when consumed individually or together with a standardized meal.
Detailed description
This study aims to investigate the effects of tea and food consumption on postprandial metabolic responses, specifically focusing on blood glucose (glycemia) and blood lipid levels. The primary objective is to generate scientifically grounded insights that can inform consumer education and product communication regarding the metabolic impacts of tea and food intake. The study will recruit healthy male volunteers of Chinese ethnicity, aged 21 to 60 years inclusive. Eligible participants will be required to attend seven study visits: (1) an initial screening session, (2) a 2-hour Oral Glucose Tolerance Test (OGTT), and (3-7) five 3-hour intervention sessions.
During the screening, participants will undergo body composition measurement, and a blood draw to confirm eligibility. Participants will also be provided with standardized dinner meals to be consumed the day before each subsequent visits as their last meal of the day before an overnight fast. In the OGTT session, participants will fast overnight. They will be cannulated and consume a glucose beverage; blood samples will be collected at seven timepoints over two hours to analyze for glucose, insulin, lipids, and other metabolic biomarkers. Each of the five intervention sessions will also require overnight fasting. Participants will consume either: one of two tea beverages, each tea beverage with a standardized meal, or the meal alone. Participants will be cannulated and blood will be drawn at nine timepoints over three hours per session. They will also complete satiety questionnaires at each timepoint. Blood samples will be analyzed for glucose, insulin, lipid panel, hormones, and other metabolic biomarkers to evaluate the postprandial effects of the interventions.
The findings are expected to clarify whether tea modulates postprandial glycemic and lipid responses compared to typical intake conditions. Results may support evidence-based communication about tea's metabolic effects and inform future product development and consumer guidance.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| Tea Type #1 | Experimental | Dietary Supplement: Tea Type #1In this intervention, participants will be cannulated and required to consume a specific tea beverage #1. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. |
| Tea Type #2 | Experimental | Dietary Supplement: Tea Type #2In this intervention, participants will be cannulated and required to consume a specific tea beverage #2. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. |
| Tea Type #1 + Standardized Meal | Experimental | Dietary Supplement: Tea Type #1, Dietary Supplement: Standardized mealIn this intervention, participants will be cannulated and required to consume a specific tea beverage #1 and a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. |
| Tea Type #2 + Standardized Meal | Experimental | Dietary Supplement: Tea Type #2, Dietary Supplement: Standardized mealIn this intervention, participants will be cannulated and required to consume a specific tea beverage #2 and a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. |
| Standardized Meal | Experimental | Dietary Supplement: Standardized mealIn this intervention, participants will be cannulated and required to consume a standardized meal. Blood will be drawn through the cannula at 9 different timepoints (0, 15, 30, 45, 60, 90, 120, 150, 180 min) to test for glucose, insulin, lipids, and other metabolic biomarkers. |
Who may qualify
- Ages
- 21 to 60 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Male
- Chinese ethnicity
- Ages 21-60 years old (inclusive)
- Healthy
- Weigh at least 50kg
Key exclusion criteria (10 listed)
- Female
- A current smoker, or has smoked in the past 2 years
- Fasting glucose >= 7 mmol/L
- History of type 1/type 2 diabetes
- Regular use of medication that may affect glucose metabolism (e.g., steroids)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tea Type #1This is a specific tea variety #1 that will be consumed by participants. It contains milk, a small amount of sugar, and will be served cold with ice. | Dietary supplement | Tea Type #1, Tea Type #1 + Standardized Meal |
| Tea Type #2This is a specific tea variety #1 that will be consumed by participants. It contains milk, a small amount of sugar, and will be served cold with ice. | Dietary supplement | Tea Type #2, Tea Type #2 + Standardized Meal |
| Standardized mealThis is a ready to eat meal that can be purchased off the shelves in local stores. The same meal is used for several study arms to serve as a standardization on the nutritional content consumed. | Dietary supplement | Standardized Meal, Tea Type #1 + Standardized Meal, Tea Type #2 + Standardized Meal |
Primary outcome
Changes in laboratory analysis of blood glucose and insulin measurements at 9 timepoints over 3 hours for each session
Time frame: Approximately 16 weeks from enrolment to the end of study
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mei Hui Liu, PhD principal investigator
National University of Singapore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tea Type #1, Tea Type #2 and Standardized meal in people with Glycaemic Response, run by National University of Singapore at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in laboratory analysis of blood glucose and insulin measurements at 9 timepoints over 3 hours for each session (time frame: Approximately 16 weeks from enrolment to the end of study). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.