Cardiorespiratory ArrestSIM-CPR NursesNCT07623447
Impact of Realistic Simulation Training on Nurses' Cardiopulmonary Resuscitation Performance
A study testing CPR training for nurses with the use of electrical therapy in people with Cardiorespiratory Arrest, run by Instituto de Cardiologia do Rio Grande do Sul at 1 site in Brazil.
Trial summary
Introduction: Cardiopulmonary arrest is one of the most prevalent cardiovascular emergencies worldwide, associated with high morbidity and mortality. In Brazil, approximately 14 million people have some form of cardiovascular disease, accounting for around 400,000 deaths per year, which corresponds to 30% of all… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Cardiorespiratory Arrest
- What is being tested?
- CPR training for nurses with the use of electrical therapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 134 participants
- Where
- 1 siteBrazil
- Study dates
- 18 Mar 2026to 20 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Nurses with more than one year of professional experience,
Who cannot join
- Nurses who are instructors of ACLS, PALS, or BLS, Nurses who have already participated in any of these trainings.
Trial locations and contacts
1 site in 1 country.
Brazil1 site
Instituto de Cardiologia do RS
Porto Alegre, Rio Grande do Sul, 90040371
About this study
Official title: Impact of Training Nurses Through Realistic Simulation for Performing Cardiopulmonary Resuscitation With Emphasis on Electrical Therapy: Randomized Clinical Trial
Introduction: Cardiopulmonary arrest is one of the most prevalent cardiovascular emergencies worldwide, associated with high morbidity and mortality. In Brazil, approximately 14 million people have some form of cardiovascular disease, accounting for around 400,000 deaths per year, which corresponds to 30% of all deaths recorded in the country.
Cardiovascular diseases were responsible for more than 198,000 deaths among Brazilians in 2020 and represent the main underlying causes of cardiac arrest. Therefore, early recognition of cardiac arrest can lead to improved outcomes and better patient prognosis. Given this scenario, the need to train healthcare professionals in the appropriate management of cardiac arrest-as well as to educate the general population-is evident.
Read more
In this context, Resolution No. 704/2022 of the Federal Council of Nursing (COFEN) regulates and authorizes nurses to manage cardiac arrest and perform electrical therapy, including defibrillation, in the absence of a physician, provided they are properly trained.
This study proposes a randomized clinical trial to evaluate the impact of training nurses through realistic simulation for the management of cardiac arrest with a shockable rhythm.
Objective: To evaluate the impact of training nurses using realistic simulation to perform cardiopulmonary resuscitation (CPR), with an emphasis on electrical therapy.
Methods: This is a randomized clinical trial.
Expected Results: This study is expected to expand and enhance nurses' knowledge and skills, enabling them to perform defibrillation in cases of cardiac arrest due to shockable rhythms in their work environments, thereby promoting higher quality care and improving patient outcomes.
Read the detailed description
Cardiopulmonary arrest (CPA) represents one of the most prevalent cardiovascular emergencies worldwide and is associated with high morbidity and mortality. In Brazil, approximately 14 million individuals have some form of cardiovascular disease (CVD), accounting for nearly 400,000 deaths annually, which corresponds to about 30% of all deaths recorded in the country.
According to the Brazilian Society of Cardiology, CVDs were responsible for more than 198,000 deaths in 2020 and constitute the primary underlying causes of CPA. Early recognition of CPA is therefore critical, as it is directly associated with improved outcomes and better patient prognosis.
CPA may present with four cardiac rhythms: asystole, pulseless electrical activity (PEA), ventricular fibrillation (VF), and pulseless ventricular tachycardia (pVT). Among these, only VF and pVT are shockable rhythms. In adult patients with sudden cardiac arrest due to VF or pVT, the heart exhibits disorganized electrical activity that is ineffective in maintaining perfusion to vital organs. In such cases, survival rates are significantly higher when immediate chest compressions and early defibrillation are performed.
Defibrillation is defined as the delivery of a controlled electrical shock aimed at terminating an abnormal cardiac rhythm, particularly life-threatening arrhythmias. During defibrillation, an electrical current induces simultaneous depolarization of myocardial cells. Although this intervention does not directly restore effective cardiac output, it creates the conditions necessary for the resumption of organized electrical activity. If myocardial viability is preserved, pacemaker cells may regain control of cardiac rhythm, resulting in the return of spontaneous circulation (ROSC).
The energy dose delivered during defibrillation depends on the type of defibrillator used. Biphasic defibrillators, currently the most widely used devices, typically deliver initial shocks ranging from 120 to 200 joules, with the possibility of escalation according to manufacturer recommendations. In contrast, monophasic defibrillators generally require a fixed dose of 360 joules. A monophasic waveform delivers current in a single direction, whereas a biphasic waveform alternates the direction of current flow, a phenomenon known as polarity reversal, which improves defibrillation efficiency.
Evidence consistently demonstrates that early defibrillation is a key determinant of survival in cardiac arrest. The probability of successful defibrillation decreases rapidly over time, with each minute of untreated cardiac arrest resulting in a 7-10% reduction in the likelihood of ROSC. When cardiopulmonary resuscitation (CPR) is initiated promptly, this decline becomes more gradual, averaging 3-4% per minute. Early CPR can double or even triple survival rates in cases of witnessed sudden cardiac arrest. Furthermore, VF tends to deteriorate into asystole within minutes, reinforcing that immediate defibrillation is the definitive treatment for shockable rhythms.
Large-scale studies have demonstrated a strong association between shorter time to defibrillation and improved survival to hospital discharge. In one study involving over 12,000 participants, 4,546 presented with VF. A reduced interval between rhythm recognition and defibrillation was significantly associated with increased survival rates. When defibrillation was performed immediately after rhythm identification, return of spontaneous circulation occurred in nearly all cases. However, after 60 seconds, success rates declined to approximately 80-90%. Survival was 74% among patients who received defibrillation within the first three minutes after collapse, compared to only 49% among those who received defibrillation after this period.
Although undergraduate curricula in healthcare fields, particularly medicine and nursing, include training in cardiac arrest management, this type of care remains a significant challenge for many professionals. This highlights the need for more effective educational strategies aimed at improving knowledge retention, technical skills, and clinical performance in emergency situations.
- Conditions
- Cardiorespiratory Arrest
- Being tested
- CPR training for nurses with the use of electrical therapy
- Keywords
- cardiorespiratory arrest, Nursing training, Simulation, defibrillation
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CPR training for nurses with the use of electrical therapyBehavioural
Theoretical-Practical Training: the Intervention group will receive a theoretical-practical class using realistic simulation addressing the following topics: electrocardiography; knowledge of cardiorespiratory arrest rhythms: pulseless ventricular tachycardia, ventricular fibrillation, asystole, pulseless electrical activity; identification of shockable and non-shockable rhythms; use of the defibrillator and its functionalities; and advanced life support with an emphasis on cardiorespiratory arrest management. The activity will last one hour.
| Study group | Role | What they receive |
|---|---|---|
| Theoretical-Practical Training | Experimental | Theoretical-Practical Training: The intervention group will participate in a one-hour theoretical-practical session based on realistic simulation. The training will cover the following topics: electrocardiography; recognition of cardiac arrest rhythms, including pulseless ventricular tachycardia (pVT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA); identification of shockable and non-shockable rhythms; operation and key functionalities of the defibrillator; and advanced life support, with an emphasis on cardiac arrest management. Receives: Behavioral: CPR training for nurses with the use of electrical therapy |
| Control group: the group will receive an explanatory leaflet with the algorithm for cardiorespirator | Placebo comparator | This group of nurses will receive an explanatory leaflet outlining the role of nurses in cardiopulmonary arrest (CPA), including the use of electrical therapy, specifically defibrillation. The leaflet will also include the algorithm describing the sequence of actions for cardiopulmonary resuscitation (CPR). Receives: Behavioral: CPR training for nurses with the use of electrical therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Primary outcome
Description: Measure the impact of realistic simulation-mediated training for nurses facing a CPA situation with a shockable rhythm.
Measured: Four hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2026
- Study start18 Mar 2026
- Primary completion20 Dec 2026 (estimated)
- Study completion20 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiorespiratory ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The Randomized Clinical Trial will include nurses with more than one year of experience who agree to participate in the study by signing the Informed Consent Form (Appendix 2). Professionals will be invited by email or WhatsApp message, sent directly to the professional and to the healthcare institutions, and also by invitation sent by the Regional Nursing Council (COREN/RS). To preserve the anonymity of participants in the evaluation test, each will be assigned a number, preceded by the letter "E," as a codename. Participants will be randomized using an electronic randomization system (random.org) and divided into two groups: Control Group (n=30) and Intervention Group (n=30). Professionals who agree to participate in the study will be blinded to the intended intervention.
- Masking
- None (open label)
- Enrolment
- 134 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Instituto de Cardiologia do Rio Grande do Sul
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07623447
- Sponsor's protocol ID
- 6121/24
- Acronym
- SIM-CPR Nurses
- Status last verified
- Mar 2026
- First submitted
- 17 Jul 2025
- Last updated
- 3 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Training Nurses Through Realistic Simulation for Performing Cardiopulmonary Resuscitation With Emphasis on Electrical Therapy: Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07623447
- Acronym / sponsor ID
- SIM-CPR Nurses / 6121/24
- Conditions
- Cardiorespiratory Arrest
- Keywords
- cardiorespiratory arrest, Nursing training, Simulation, defibrillation
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 134 participants (estimated)
- Lead sponsor
- Instituto de Cardiologia do Rio Grande do SulUniversity, hospital or other
- Study start
- 18 Mar 2026 (actual)
- Primary completion
- 20 Dec 2026 (estimated)
- Study completion
- 20 Mar 2027 (estimated)
- First posted
- 3 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Introduction: Cardiopulmonary arrest is one of the most prevalent cardiovascular emergencies worldwide, associated with high morbidity and mortality. In Brazil, approximately 14 million people have some form of cardiovascular disease, accounting for around 400,000 deaths per year, which corresponds to 30% of all deaths recorded in the country.
Cardiovascular diseases were responsible for more than 198,000 deaths among Brazilians in 2020 and represent the main underlying causes of cardiac arrest. Therefore, early recognition of cardiac arrest can lead to improved outcomes and better patient prognosis. Given this scenario, the need to train healthcare professionals in the appropriate management of cardiac arrest-as well as to educate the general population-is evident.
In this context, Resolution No. 704/2022 of the Federal Council of Nursing (COFEN) regulates and authorizes nurses to manage cardiac arrest and perform electrical therapy, including defibrillation, in the absence of a physician, provided they are properly trained.
This study proposes a randomized clinical trial to evaluate the impact of training nurses through realistic simulation for the management of cardiac arrest with a shockable rhythm.
Objective: To evaluate the impact of training nurses using realistic simulation to perform cardiopulmonary resuscitation (CPR), with an emphasis on electrical therapy.
Methods: This is a randomized clinical trial.
Expected Results: This study is expected to expand and enhance nurses' knowledge and skills, enabling them to perform defibrillation in cases of cardiac arrest due to shockable rhythms in their work environments, thereby promoting higher quality care and improving patient outcomes.
Detailed description
Cardiopulmonary arrest (CPA) represents one of the most prevalent cardiovascular emergencies worldwide and is associated with high morbidity and mortality. In Brazil, approximately 14 million individuals have some form of cardiovascular disease (CVD), accounting for nearly 400,000 deaths annually, which corresponds to about 30% of all deaths recorded in the country.
According to the Brazilian Society of Cardiology, CVDs were responsible for more than 198,000 deaths in 2020 and constitute the primary underlying causes of CPA. Early recognition of CPA is therefore critical, as it is directly associated with improved outcomes and better patient prognosis.
CPA may present with four cardiac rhythms: asystole, pulseless electrical activity (PEA), ventricular fibrillation (VF), and pulseless ventricular tachycardia (pVT). Among these, only VF and pVT are shockable rhythms. In adult patients with sudden cardiac arrest due to VF or pVT, the heart exhibits disorganized electrical activity that is ineffective in maintaining perfusion to vital organs. In such cases, survival rates are significantly higher when immediate chest compressions and early defibrillation are performed.
Defibrillation is defined as the delivery of a controlled electrical shock aimed at terminating an abnormal cardiac rhythm, particularly life-threatening arrhythmias. During defibrillation, an electrical current induces simultaneous depolarization of myocardial cells. Although this intervention does not directly restore effective cardiac output, it creates the conditions necessary for the resumption of organized electrical activity. If myocardial viability is preserved, pacemaker cells may regain control of cardiac rhythm, resulting in the return of spontaneous circulation (ROSC).
The energy dose delivered during defibrillation depends on the type of defibrillator used. Biphasic defibrillators, currently the most widely used devices, typically deliver initial shocks ranging from 120 to 200 joules, with the possibility of escalation according to manufacturer recommendations. In contrast, monophasic defibrillators generally require a fixed dose of 360 joules. A monophasic waveform delivers current in a single direction, whereas a biphasic waveform alternates the direction of current flow, a phenomenon known as polarity reversal, which improves defibrillation efficiency.
Evidence consistently demonstrates that early defibrillation is a key determinant of survival in cardiac arrest. The probability of successful defibrillation decreases rapidly over time, with each minute of untreated cardiac arrest resulting in a 7-10% reduction in the likelihood of ROSC. When cardiopulmonary resuscitation (CPR) is initiated promptly, this decline becomes more gradual, averaging 3-4% per minute. Early CPR can double or even triple survival rates in cases of witnessed sudden cardiac arrest. Furthermore, VF tends to deteriorate into asystole within minutes, reinforcing that immediate defibrillation is the definitive treatment for shockable rhythms.
Large-scale studies have demonstrated a strong association between shorter time to defibrillation and improved survival to hospital discharge. In one study involving over 12,000 participants, 4,546 presented with VF. A reduced interval between rhythm recognition and defibrillation was significantly associated with increased survival rates. When defibrillation was performed immediately after rhythm identification, return of spontaneous circulation occurred in nearly all cases. However, after 60 seconds, success rates declined to approximately 80-90%. Survival was 74% among patients who received defibrillation within the first three minutes after collapse, compared to only 49% among those who received defibrillation after this period.
Although undergraduate curricula in healthcare fields, particularly medicine and nursing, include training in cardiac arrest management, this type of care remains a significant challenge for many professionals. This highlights the need for more effective educational strategies aimed at improving knowledge retention, technical skills, and clinical performance in emergency situations.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- The Randomized Clinical Trial will include nurses with more than one year of experience who agree to participate in the study by signing the Informed Consent Form (Appendix 2). Professionals will be invited by email or WhatsApp message, sent directly to the professional and to the healthcare institutions, and also by invitation sent by the Regional Nursing Council (COREN/RS). To preserve the anonymity of participants in the evaluation test, each will be assigned a number, preceded by the letter "E," as a codename. Participants will be randomized using an electronic randomization system (random.org) and divided into two groups: Control Group (n=30) and Intervention Group (n=30). Professionals who agree to participate in the study will be blinded to the intended intervention.
| Arm | Type | Receives |
|---|---|---|
| Theoretical-Practical Training | Experimental | Behavioral: CPR training for nurses with the use of electrical therapyTheoretical-Practical Training: The intervention group will participate in a one-hour theoretical-practical session based on realistic simulation. The training will cover the following topics: electrocardiography; recognition of cardiac arrest rhythms, including pulseless ventricular tachycardia (pVT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA); identification of shockable and non-shockable rhythms; operation and key functionalities of the defibrillator; and advanced life support, with an emphasis on cardiac arrest management. |
| Control group: the group will receive an explanatory leaflet with the algorithm for cardiorespirator | Placebo comparator | Behavioral: CPR training for nurses with the use of electrical therapyThis group of nurses will receive an explanatory leaflet outlining the role of nurses in cardiopulmonary arrest (CPA), including the use of electrical therapy, specifically defibrillation. The leaflet will also include the algorithm describing the sequence of actions for cardiopulmonary resuscitation (CPR). |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Nurses with more than one year of professional experience,
Key exclusion criteria (1 listed)
- Nurses who are instructors of ACLS, PALS, or BLS, Nurses who have already participated in any of these trainings.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CPR training for nurses with the use of electrical therapyTheoretical-Practical Training: the Intervention group will receive a theoretical-practical class using realistic simulation addressing the following topics: electrocardiography; knowledge of cardiorespiratory arrest rhythms: pulseless ventricular tachycardia, ventricular fibrillation, asystole, pulseless electrical activity; identification of shockable and non-shockable rhythms; use of the defibrillator and its functionalities; and advanced life support with an emphasis on cardiorespiratory arrest management. The activity will last one hour. | Behavioural | Control group: the group will receive an explanatory leaflet with the algorithm for cardiorespirator, Theoretical-Practical Training |
Primary outcome
Primary outcome
Time frame: Four hours
Description: Measure the impact of realistic simulation-mediated training for nurses facing a CPA situation with a shockable rhythm.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2026.
- This systematic review examines the concept of authentic learning in health education, analyzing its impact on the development of clinical skills, critical thinking, and professional competencies. It synthesizes current evidence on teaching strategies thLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CPR training for nurses with the use of electrical therapy in people with Cardiorespiratory Arrest, run by Instituto de Cardiologia do Rio Grande do Sul at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 3 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Primary outcome (time frame: Four hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2026.