Healthy VolunteerEMOBBNCT07623746
Neural Mechanisms of Emotion-behaviour Interactions
A study testing Functional Magnetic Resonance Imaging (fMRI) in people with Healthy Volunteer, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteer
- What is being tested?
- Functional Magnetic Resonance Imaging (fMRI)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteFrance
- Study dates
- 1 Dec 2026to 10 Dec 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
- being able to use both hands
Show all 9Show fewer
- BMI between 18.5 and 30
- give written informed consen
- for women: contraception;
Who cannot join
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
- MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant)
Bron, 69500
Jacqueline SCHOLL, PhD, 4 81 10 65 00 ext. + 33, jacqueline.scholl@inserm.fr
Jacqueline SCHOLL, PhD
About this study
Official title: Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
- Conditions
- Healthy Volunteer
- Being tested
- Functional Magnetic Resonance Imaging (fMRI)
- Keywords
- FMRI, Emotions, Cognition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Functional Magnetic Resonance Imaging (fMRI)Other
Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
| Study group | Role | What they receive |
|---|---|---|
| Task 1: self-organization under threat | Experimental | Not described Receives: Other: Functional Magnetic Resonance Imaging (fMRI) |
| Task 2: self-organization and learning | Experimental | Not described Receives: Other: Functional Magnetic Resonance Imaging (fMRI) |
| Task 3 : self-organization and social context | Experimental | Not described Receives: Other: Functional Magnetic Resonance Imaging (fMRI) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Brain activity in regions of interest
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Measured: Day 0
Secondary outcomes (3)
Brain activity during task 1 (Self-organization under threat)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Measured: Day 0
Brain activity during task 2 (Self-organization and learning)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Measured: Day 0
Brain activity during task 3 (Self-organization and social context)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Measured: Day 0
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2026
- Study start1 Dec 2026 (estimated)
- Primary completion1 Dec 2030 (estimated)
- Study completion10 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy VolunteerStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jacqueline SCHOLL, PhD, Principal investigator, Institut National de la Santé Et de la Recherche Médicale, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07623746
- Sponsor's protocol ID
- 69HCL25_1123
- Other IDs
- 2025-A02658-41
- Acronym
- EMOBB
- Status last verified
- Oct 2026
- First submitted
- 20 May 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
- ClinicalTrials.gov ID
- NCT07623746
- Acronym / sponsor ID
- EMOBB / 69HCL25_1123
- Conditions
- Healthy Volunteer
- Keywords
- FMRI, Emotions, Cognition
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 1 Dec 2026 (estimated)
- Primary completion
- 1 Dec 2030 (estimated)
- Study completion
- 10 Dec 2030 (estimated)
- First posted
- 3 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Task 1: self-organization under threat | Experimental | Other: Functional Magnetic Resonance Imaging (fMRI) |
| Task 2: self-organization and learning | Experimental | Other: Functional Magnetic Resonance Imaging (fMRI) |
| Task 3 : self-organization and social context | Experimental | Other: Functional Magnetic Resonance Imaging (fMRI) |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (9 listed)
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
Key exclusion criteria (6 listed)
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Functional Magnetic Resonance Imaging (fMRI)Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions. | Other | Task 1: self-organization under threat, Task 2: self-organization and learning, Task 3 : self-organization and social context |
Primary outcome
Brain activity in regions of interest
Time frame: Day 0
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
3 secondary outcomes
Brain activity during task 1 (Self-organization under threat)
Time frame: Day 0
Brain activity during task 2 (Self-organization and learning)
Time frame: Day 0
Brain activity during task 3 (Self-organization and social context)
Time frame: Day 0
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Healthy Volunteer
Not yet recruitingPhase 1
Comparison of Pharmacokinetic/Pharmacodynamic Characteristics and Safety of GZR101-80 Injection With Separately Injected, Simultaneous Doses of GZR33 Injection and Insulin Aspart
Healthy Participants
Active, not recruitingPhase 2
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
Arterial Stiffness, White Matter Lesions
Enrolling by invitationObservational study
Screening for Hematology Branch Protocols
Hematologic Disease and Disorders, Donors
Active, not recruitingPhase 1
A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283
Asthma
RecruitingPhase 4
Testing Healthy Participants for Drowsiness After Single Dosing of Two Different Doses of Muscle Relaxer
Healthy Participants
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jacqueline SCHOLL, PhD principal investigator
Institut National de la Santé Et de la Recherche Médicale, France
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Functional Magnetic Resonance Imaging (fMRI) in people with Healthy Volunteer, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jacqueline SCHOLL, PhD (+ 33 ext. 4 81 10 65 00, jacqueline.scholl@inserm.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brain activity in regions of interest (time frame: Day 0). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.