Aging and Cognitive HealthNCT07639203
PotenziaMente: A Digital Executive Function Training Intervention for Healthy Aging in the Elderly Population
A study testing Remote Cognitive Training and Supervised In-Person Cognitive Training in people with Aging and Cognitive Health and Healty, run by Università degli Studi di Trento at 1 site in Italy.
Trial summary
The study, entitled "PotenziaMente: Cognitive Training in Aging," is a clinical trial designed to evaluate the effectiveness of an individualized tablet-based cognitive training program targeting executive functions (e.g., planning, cognitive flexibility, and problem solving) in healthy older adults. Read more about this study
- Who is it for?
- Ages 65 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging and Cognitive Health, Healty
- What is being tested?
- Remote Cognitive Training and Supervised In-Person Cognitive Training
- Type of treatment
- Pill or oral medicine, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteItaly
- Study dates
- 17 Sep 2024to Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 75 years
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Cognitively healthy adults aged 65 to 75 years. Montreal Cognitive Assessment (MoCA) equivalent score ≥ 1, according to Italian normative values.
Who cannot join
- History of current or previous neurological or neuropsychiatric disorders.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Italy1 site, 1 recruiting
- Recruiting
Centro Interdipartimentale Mente/Cervello - CIMeC
Rovereto, Trento, 38068
Beatrice Feder, 0039 0464808159, beatrice.feder@unitn.it
About this study
The study, entitled "PotenziaMente: Cognitive Training in Aging," is a clinical trial designed to evaluate the effectiveness of an individualized tablet-based cognitive training program targeting executive functions (e.g., planning, cognitive flexibility, and problem solving) in healthy older adults. Executive functions are higher-order cognitive processes that support adaptive functioning in daily life and influence other cognitive domains, such as memory. The primary aim of the study is to enhance cognitive performance, specifically executive functioning, in neurologically healthy adults aged 65 to 75 years. A secondary aim is to compare the effects of two different delivery modalities of the same cognitive training program: home-based self-administration via tablet versus supervised tablet-based training in the presence of a trained researcher. Participants will undergo cognitive assessments at baseline (pre-training), immediately after the intervention (post-training), and at a 3-month follow-up.
This is a randomized parallel-group interventional clinical trial without masking. Participants are randomly assigned to one of two groups: a home-based cognitive training condition, in which they perform an individualized tablet-based cognitive training program targeting executive functions independently at home via a tablet application without direct supervision, or a supervised cognitive training condition, in which they perform the same individualized tablet-based cognitive training under the supervision of a trained researcher in a controlled environment. The intervention consists of two sessions per week, 1 hour per session, for 4 consecutive weeks, delivered via tablet-based exercises. The study uses a parallel assignment model with a prospective design and a primary purpose of treatment (cognitive enhancement and prevention of cognitive decline).
The primary outcome is the change in executive functioning from baseline to post-intervention, assessed using standardized neuropsychological tests. Secondary outcomes include between-group differences (home-based vs. supervised) in executive functioning, changes in global cognitive functioning from baseline to post-intervention, and maintenance of cognitive effects at the 3-month follow-up.
- Conditions
- Aging and Cognitive Health, Healty
- Being tested
- Remote Cognitive Training, Supervised In-Person Cognitive Training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Remote Cognitive TrainingBehavioural
A 4-week tablet-based cognitive training intervention targeting executive functions in healthy older adults. Participants complete 2 individualized training sessions per week (1 hour each), delivered remotely via email and performed independently at home using a tablet. The intervention focuses on enhancing executive functioning, including planning, cognitive flexibility, and problem solving, with the aim of improving overall cognitive performance in daily life.
Supervised In-Person Cognitive TrainingBehavioural
A 4-week tablet-based cognitive training intervention targeting executive functions in healthy older adults. Participants complete 2 individual training sessions per week (1 hour each), delivered in person under the supervision of a trained researcher in a controlled environment. The intervention focuses on enhancing executive functioning, including planning, cognitive flexibility, and problem solving, with the aim of improving overall cognitive performance in daily life.
| Study group | Role | What they receive |
|---|---|---|
| Remote Cognitive Training | Experimental | A group of participants randomly assigned to a remote tablet-based cognitive training intervention through individualized training sessions aimed at improving cognitive performance. Receives: Behavioral: Remote Cognitive Training |
| Supervised In-Person Cognitive Training | Active comparator | A group of participants randomly assigned to an in-person supervised tablet-based cognitive training intervention consisting of individualized training sessions aimed at improving cognitive performance. Receives: Behavioral: Supervised In-Person Cognitive Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Tower of London Test (Bruni et al. 2020)
Accuracy and timing
Measured: 0-4 months
Frontal Assessment Battery (Apollonio et al., 2005)
Minimum value: 0; Maximum value: 18; Higher scores indicate better executive functioning.
Measured: 0-4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jun 2026
- Study start17 Sep 2024
- Primary completion30 Jun 2026 (estimated)
- Study completionSep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aging and Cognitive HealthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Università degli Studi di Trento
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Costanza Papagno, Università degli Studi di Trento
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07639203
- Sponsor's protocol ID
- Protocollo 2024-053
- Status last verified
- May 2026
- First submitted
- 5 Jun 2026
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- PotenziaMente: A Digital Executive Function Training Intervention for Healthy Aging in the Elderly Population
- ClinicalTrials.gov ID
- NCT07639203
- Acronym / sponsor ID
- Protocollo 2024-053
- Conditions
- Aging and Cognitive Health, Healty
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Università degli Studi di TrentoUniversity, hospital or other
- Study start
- 17 Sep 2024 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- Sep 2026 (estimated)
- First posted
- 10 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study, entitled "PotenziaMente: Cognitive Training in Aging," is a clinical trial designed to evaluate the effectiveness of an individualized tablet-based cognitive training program targeting executive functions (e.g., planning, cognitive flexibility, and problem solving) in healthy older adults. Executive functions are higher-order cognitive processes that support adaptive functioning in daily life and influence other cognitive domains, such as memory. The primary aim of the study is to enhance cognitive performance, specifically executive functioning, in neurologically healthy adults aged 65 to 75 years. A secondary aim is to compare the effects of two different delivery modalities of the same cognitive training program: home-based self-administration via tablet versus supervised tablet-based training in the presence of a trained researcher. Participants will undergo cognitive assessments at baseline (pre-training), immediately after the intervention (post-training), and at a 3-month follow-up.
This is a randomized parallel-group interventional clinical trial without masking. Participants are randomly assigned to one of two groups: a home-based cognitive training condition, in which they perform an individualized tablet-based cognitive training program targeting executive functions independently at home via a tablet application without direct supervision, or a supervised cognitive training condition, in which they perform the same individualized tablet-based cognitive training under the supervision of a trained researcher in a controlled environment. The intervention consists of two sessions per week, 1 hour per session, for 4 consecutive weeks, delivered via tablet-based exercises. The study uses a parallel assignment model with a prospective design and a primary purpose of treatment (cognitive enhancement and prevention of cognitive decline).
The primary outcome is the change in executive functioning from baseline to post-intervention, assessed using standardized neuropsychological tests. Secondary outcomes include between-group differences (home-based vs. supervised) in executive functioning, changes in global cognitive functioning from baseline to post-intervention, and maintenance of cognitive effects at the 3-month follow-up.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Remote Cognitive Training | Experimental | Behavioral: Remote Cognitive TrainingA group of participants randomly assigned to a remote tablet-based cognitive training intervention through individualized training sessions aimed at improving cognitive performance. |
| Supervised In-Person Cognitive Training | Active comparator | Behavioral: Supervised In-Person Cognitive TrainingA group of participants randomly assigned to an in-person supervised tablet-based cognitive training intervention consisting of individualized training sessions aimed at improving cognitive performance. |
Who may qualify
- Ages
- 65 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (1 listed)
- Cognitively healthy adults aged 65 to 75 years. Montreal Cognitive Assessment (MoCA) equivalent score ≥ 1, according to Italian normative values.
Key exclusion criteria (1 listed)
- History of current or previous neurological or neuropsychiatric disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Remote Cognitive TrainingA 4-week tablet-based cognitive training intervention targeting executive functions in healthy older adults. Participants complete 2 individualized training sessions per week (1 hour each), delivered remotely via email and performed independently at home using a tablet. The intervention focuses on enhancing executive functioning, including planning, cognitive flexibility, and problem solving, with the aim of improving overall cognitive performance in daily life. | Behavioural | Remote Cognitive Training |
| Supervised In-Person Cognitive TrainingA 4-week tablet-based cognitive training intervention targeting executive functions in healthy older adults. Participants complete 2 individual training sessions per week (1 hour each), delivered in person under the supervision of a trained researcher in a controlled environment. The intervention focuses on enhancing executive functioning, including planning, cognitive flexibility, and problem solving, with the aim of improving overall cognitive performance in daily life. | Behavioural | Supervised In-Person Cognitive Training |
Primary outcome
The Tower of London Test (Bruni et al. 2020)
Time frame: 0-4 months
Accuracy and timing
Frontal Assessment Battery (Apollonio et al., 2005)
Time frame: 0-4 months
Minimum value: 0; Maximum value: 18; Higher scores indicate better executive functioning.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Remote Cognitive Training and Supervised In-Person Cognitive Training in people with Aging and Cognitive Health and Healty, run by Università degli Studi di Trento at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Beatrice Feder (0039 0464808159, beatrice.feder@unitn.it), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Tower of London Test (Bruni et al. 2020) (time frame: 0-4 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.