Clinical trials: Aging and Cognitive Health
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Subjective Cognitive Concerns, Mild Cognitive Impairment
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched…
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- Trial name
- NCT05881239
- Testing
- AROMHA Brain Health Test
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Alzheimer Disease, Mild Cognitive Impairment
A Scalable Nutrition Adherence Intervention
Objective 1: To scale-up the nutrition adherence intervention for testing in racially diverse rural communities in North Florida. The investigators hypothesize that: 1.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Adherence
- Trial name
- NCT06121986
- Testing
- Improving Cognitive Aging through Nutrition (ICAN) Adherence Program, Improving Cognitive Aging through Nutrition, Mediterranean diet
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Florida State University
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cognitive Dysfunction, Motor Skills Disorders
Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Iraqis
This study investigates the impact of sociodemographic, psychological, and quality of life factors on dual-task performance in elderly individuals living in Iraq.
- Conditions
- Cognitive Dysfunction, Motor Skills Disorders, Aging
- Trial name
- SociQ-DT (NCT06476561)
- Testing
- - Sociodemographic Assessment - Psychological Assessment - Quality of Life Assessment - D
- Where
- Turkey (Türkiye)
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Traumatic Brain Injury, Aging
The Long-term Consequences After Traumatic Brain Injury in the Elderly
A better understanding of the injury patterns, injury severity, risk profiles, consequences and impact of Traumatic Brain Injury (TBI) in the elderly population is necessary due to the increasing incidence and prevalence of TBI…
- Conditions
- Traumatic Brain Injury, Aging, Cognitive Impairment, Quality of Life
- Trial name
- NCT04074850
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity & Overweight
Multimodal Intervention for Weight Management and Health in the Elderly Population
Aging may be accompanied by changes in body composition, muscle strength, metabolic health, and well-being. In older adults with overweight or obesity, strategies that combine physical exercise, behavioral changes, and…
- Trial name
- NCT07820774
- Testing
- Nutritional guidance focused on adopting a high-protein diet., Group Cognitive Behavioral Therapy Intervention, Resistance Training Program
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Aging
Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults
The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in adults aged 60 to 80 with stable health.
- Trial name
- NCT06068803
- Testing
- Ketone drink
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
Cognitive Decline, Cognitive Function
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
This study will evaluate the efficacy of 1MD Nutrition's MindMD supplement in improving and maintaining cognitive function and memory.
- Trial name
- NCT06523218
- Testing
- MindMD Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Aging, Alzheimer Disease
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's…
- Conditions
- Aging, Alzheimer Disease, Life Style, Healthy, Exercise
- Trial name
- LIBRA-NET (NCT06986096)
- Testing
- Aerobic-strength training and nutritional counseling, Cognitive training and stretching.
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- Slovak Academy of Sciences
Overweight (BMI > 25), Obesity & Overweight
WB-EMS Combined With Nutritional Guidance for a High-Protein Diet on Body Composition, Muscle Function, Psychological and Functional Outcomes in Older Adults With Excess Adiposity
This is a 16-week randomized controlled trial (RCT) with outcome assessor blinding. The objective is to investigate the effects of resistance training (RT) combined with whole-body neuromuscular electrical stimulation (WB-NMES)…
- Conditions
- Overweight (BMI > 25), Obesity & Overweight, Aging
- Trial name
- WB-EMS (NCT07859072)
- Testing
- Whole-Body Neuromuscular Electrical Stimulation (WB-NMES), Conventional Resistance Training, High-Protein Nutritional Guidance
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Mild Cognitive Impairment
Digital Tools to Support Healthcare Decision Making
The goal for this project is to support the cognitive components of older adults' health-management activities through development of digital assistant technology tools tailored to three exemplar healthcare management task…
- Trial name
- CREATE P3 (NCT07485725)
- Testing
- Project 3, Phase 2: Clinical Trial
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease, Aging
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau…
- Conditions
- Alzheimer Disease, Aging, Lifestyle Factors, Cognitive Impairment
- Trial name
- LIBRA REMIND (NCT07042087)
- Testing
- Mindfulness Yoga, Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern, Cognitive Training
- Where
- Czechia
- Volunteers
- 48 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Aging, Physical Activity in Adults
Health Effects of Taekwondo Training for Elderly Over the Age of 60 Years
This randomized controlled trial investigates the effects of a 10-week Taekwondo (TKD) training intervention on physical and cognitive function in community-dwelling adults aged 60 years and older.
- Trial name
- TKD 60+ (NCT07451288)
- Testing
- Taekwondo training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vegard Vereide Iversen
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lifestyle, Cognitive Decline
Brain-Health Lifestyle Restructuring Intervention
With population aging, the number of older persons with cognitive impairments increases. Literature support the effectiveness of a lifestyle approach to promote the health of persons with cognitive impairment, as well as a…
- Conditions
- Lifestyle, Cognitive Decline, Aging
- Trial name
- NCT04576624
- Testing
- Lifestyle Intervention, social activity
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- National Cheng Kung University
Aging, Age-Related Cognitive Decline
Multidomain Interventions for Elderly Individuals in Residential Structures
The "Multidomain Interventions to improve the COgnitive and fUNctional well-being of elderly individuals in residential sTructures" (I-COUNT) study aims to test the feasibility and the effectiveness of a multidisciplinary…
- Conditions
- Aging, Age-Related Cognitive Decline, Sarcopenia, Long Term Care Facility
- Trial name
- I-COUNT (NCT06820710)
- Testing
- Physical activity, Cognitive stimulation, Nutritional Intervention
- Where
- 2 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche