Dentin Desensitizing AgentsNCT07641322
Dentin Hypersensitivity in Orthodontic Patients: Triple-Blinded, Randomized Trial of Three Desensitizing Agents.
A study testing TOOTH PASTE(NHA), TOOTH PASTE (NOVAMIN) and TOOTH PASTE (PROARGIN) in people with Dentin Desensitizing Agents, run by Nishtar Medical University.
Trial summary
The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Dentin Desensitizing Agents
- What is being tested?
- TOOTH PASTE(NHA), TOOTH PASTE (NOVAMIN) and TOOTH PASTE (PROARGIN)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 200 participants
- Where
- No sites listed yet
- Study dates
- 15 Jul 2026to 15 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Orthodontic patients aged 18-40 years.
- Presence of mild to moderate dentin hypersensitivity (VAS ≥ 4).
- Willingness to comply with a 12-week follow-up period.
- No active periodontal disease or untreated caries.
- Not pregnant or breastfeeding.
- No history of allergy to desensitizing agents
Who cannot join
- o Patients with systemic conditions affecting oral health (e.g., diabetes, immunocompromised).
- Patients using medications that affect tooth sensitivity (e.g., anti-inflammatory drugs).
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Dentin Hypersensitivity: Triple-Blinded, Multicenter Randomized Trial of Three Desensitizing Dentifrices vs Non-Desensitizing Control
The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group.
- Conditions
- Dentin Desensitizing Agents
- Being tested
- TOOTH PASTE(NHA), TOOTH PASTE (NOVAMIN), TOOTH PASTE (PROARGIN), TOOTH PASTE ( NON DESENSITIZING)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
TOOTH PASTE(NHA)Other
TOOTH PASTES CONTAINING NHA.
TOOTH PASTE (NOVAMIN)Other
TOOTH PASTE CONTAINING NOVAMIN
TOOTH PASTE (PROARGIN)Other
TOOTH PASTE CONTAINING PROARGIN.
TOOTH PASTE ( NON DESENSITIZING)Other
TOOTH PASTE A NON-DESENSITIZING CONTROL
| Study group | Role | What they receive |
|---|---|---|
| TEST TOOTHPASTE GROUP 1 | Experimental | Participants in this arm will use the test toothpaste twice daily for 8 weeks. Receives: Other: TOOTH PASTE(NHA) |
| TEST TOOTH PASTE GROUP 2 | Active comparator | Participants in this arm will use the test toothpaste twice daily for 8 weeks. Receives: Other: TOOTH PASTE (NOVAMIN) |
| TEST TOOTH PASTE GROUP 3 | Active comparator | Participants in this arm will use the test toothpaste twice daily for 8 weeks. Receives: Other: TOOTH PASTE (PROARGIN) |
| TEST TOOTH PASTE GROUP 4 | Placebo comparator | Participants in this arm will use the test toothpaste twice daily for 8 weeks. Receives: Other: TOOTH PASTE ( NON DESENSITIZING) |
What is being measured
The primary outcome is the main question the study is designed to answer.
REDUCTION IN DENTIN HYPERSENSITIVITY
Change in dentin hypersensitivity scores from baseline to 8 weeks using the Visual Analog Scale (VAS) and Schiff Cold Air Sensitivity Scale.
Measured: 8 WEEKS
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2026
- Study start15 Jul 2026 (estimated)
- Primary completion15 Oct 2026 (estimated)
- Study completion15 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dentin Desensitizing AgentsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nishtar Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Fatima Khalid, Nishtar Medical University
- Investigators
- Dr. Zubair Hassan Awaisi, FCPS, Study chair, PRINCIPAL NID MULTAN
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07641322
- Sponsor's protocol ID
- room 203 fk orthodontics
- Status last verified
- Jun 2026
- First submitted
- 7 Jun 2026
- Last updated
- 11 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: IM NOT COMFORTABLE
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dentin Hypersensitivity: Triple-Blinded, Multicenter Randomized Trial of Three Desensitizing Dentifrices vs Non-Desensitizing Control
- ClinicalTrials.gov ID
- NCT07641322
- Acronym / sponsor ID
- room 203 fk orthodontics
- Conditions
- Dentin Desensitizing Agents
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Nishtar Medical UniversityUniversity, hospital or other
- Study start
- 15 Jul 2026 (estimated)
- Primary completion
- 15 Oct 2026 (estimated)
- Study completion
- 15 Dec 2026 (estimated)
- First posted
- 11 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| TEST TOOTHPASTE GROUP 1 | Experimental | Other: TOOTH PASTE(NHA)Participants in this arm will use the test toothpaste twice daily for 8 weeks. |
| TEST TOOTH PASTE GROUP 2 | Active comparator | Other: TOOTH PASTE (NOVAMIN)Participants in this arm will use the test toothpaste twice daily for 8 weeks. |
| TEST TOOTH PASTE GROUP 3 | Active comparator | Other: TOOTH PASTE (PROARGIN)Participants in this arm will use the test toothpaste twice daily for 8 weeks. |
| TEST TOOTH PASTE GROUP 4 | Placebo comparator | Other: TOOTH PASTE ( NON DESENSITIZING)Participants in this arm will use the test toothpaste twice daily for 8 weeks. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Orthodontic patients aged 18-40 years.
- Presence of mild to moderate dentin hypersensitivity (VAS ≥ 4).
- Willingness to comply with a 12-week follow-up period.
- No active periodontal disease or untreated caries.
- Not pregnant or breastfeeding.
Key exclusion criteria (2 listed)
- o Patients with systemic conditions affecting oral health (e.g., diabetes, immunocompromised).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| TOOTH PASTE(NHA)TOOTH PASTES CONTAINING NHA. | Other | TEST TOOTHPASTE GROUP 1 |
| TOOTH PASTE (NOVAMIN)TOOTH PASTE CONTAINING NOVAMIN | Other | TEST TOOTH PASTE GROUP 2 |
| TOOTH PASTE (PROARGIN)TOOTH PASTE CONTAINING PROARGIN. | Other | TEST TOOTH PASTE GROUP 3 |
| TOOTH PASTE ( NON DESENSITIZING)TOOTH PASTE A NON-DESENSITIZING CONTROL | Other | TEST TOOTH PASTE GROUP 4 |
Primary outcome
REDUCTION IN DENTIN HYPERSENSITIVITY
Time frame: 8 WEEKS
Change in dentin hypersensitivity scores from baseline to 8 weeks using the Visual Analog Scale (VAS) and Schiff Cold Air Sensitivity Scale.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
- Individual participant dataSharing planned: Undecided. IM NOT COMFORTABLE
Related trials for Dentin Desensitizing Agents
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Dr. Zubair Hassan Awaisi, FCPS study chair
PRINCIPAL NID MULTAN
Questions about this trial
What is this clinical trial studying?
A study testing TOOTH PASTE(NHA), TOOTH PASTE (NOVAMIN) and TOOTH PASTE (PROARGIN) in people with Dentin Desensitizing Agents, run by Nishtar Medical University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact FATIMA KHALID, BDS (03128287657, fatimakhalid9921@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
REDUCTION IN DENTIN HYPERSENSITIVITY (time frame: 8 WEEKS). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026; AzTrials last refreshed its copy on 6 Nov 2026.