MyopiaNCT07647146
Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors
An observational study of Myopia and Hyperopia, run by Sohag University at 1 site in Egypt.
Trial summary
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors. Read more about this study
- Who is it for?
- Ages 18 to 99 yearsHealthy volunteers can take part
- Conditions the study is for
- Myopia, Hyperopia, Astigmatism
- How many people
- 360 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2026to 1 May 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.
Who may be able to join
- Age ≥ 18 years-
- Patients diagnosed with myopia or hyperopia by refraction
- Clear cornea with no evidence of corneal pathology
- Ability to undergo reliable anterior segment imaging
Who cannot join
- Inability to fixate or follow instructions
- Family history of keratoconus
- Glaucoma,Cataract
- Previous ocular surgery including refractive surgery
- Keratoconus or suspected corneal ectasia
- Corneal opacities or scars
Show all 9Show fewer
- Contact lens wear within the last two weeks
- Ocular trauma
- systemic disease affecting the cornea ( Such as diabetes)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Sohag University Hospital
Sohag, Sohag Governorate, 82524
Engy Mohamed Mostafa, Professor, 01005643587, Engymostafa@yahoo.com
Amin Abu-Ali Hassan, Assistant Professor, 01015437008
About this study
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Read the detailed description
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
- Conditions
- Myopia, Hyperopia, Astigmatism, Emmetropia
- Keywords
- Corneal epithelial thickness, AS-OCT, anterior segment optical coherence tomography, refractive errors, myopia, hyperopia, astigmatism, cornea
- Medical subject headings
- Myopia, Hyperopia, Astigmatism, Refractive Errors, Corneal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| All Participants | All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measurement of corneal epithelial thickness using AS-OCT
Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.
Measured: At baseline during a single study visit when participants undergo AS-OCT examination.
Secondary outcomes (4)
Comparison of epithelial thickness between myopic and hyperopic eyes
Corneal epithelial thickness will be compared between myopic and hyperopic eyes using AS-OCT measurements.
Measured: At baseline (single visit)
Comparison of epithelial thickness in eyes with and without astigmatism
Corneal epithelial thickness will be evaluated and compared between eyes with astigmatism and those without astigmatism using AS-OCT.
Measured: At baseline (single visit)
Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison
Epithelial thickness will be assessed across different corneal regions and compared between both eyes to evaluate inter-eye asymmetry.
Measured: At baseline (single visit)
Comparison of epithelial thickness in low and high refractive errors
Corneal epithelial thickness profiles will be compared between low and high degrees of myopia and hyperopia using AS-OCT measurements.
Measured: At baseline (single visit)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jun 2026
- Study start1 Jul 2026 (estimated)
- Primary completion1 May 2027 (estimated)
- Study completion1 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MyopiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 360 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Merna Romany Kamel, Sohag University
- Investigators
- Engy Mohamed Mostafa, Professor, Principal investigator, Department of Ophthalmology, Faculty of Medicine, Sohag UniversityAmin Abu-Ali Hassan, Assistant Professor, Study director, Department of Ophthalmology, Faculty of Medicine, Sohag UniversityYasmeen Gamal Abd-El latif, Lecturer, Study director, Department of Ophthalmology, Faculty of Medicine, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07647146
- Sponsor's protocol ID
- Soh-Med-26-5-7MS
- Status last verified
- Jun 2026
- First submitted
- 9 Jun 2026
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared.
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors
- ClinicalTrials.gov ID
- NCT07647146
- Acronym / sponsor ID
- Soh-Med-26-5-7MS
- Conditions
- Myopia, Hyperopia, Astigmatism, Emmetropia
- Keywords
- Corneal epithelial thickness, AS-OCT, anterior segment optical coherence tomography, refractive errors, myopia, hyperopia, astigmatism, cornea
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 360 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 1 May 2027 (estimated)
- Study completion
- 1 May 2027 (estimated)
- First posted
- 15 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Detailed description
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| All Participants | – | –All participants diagnosed with refractive errors (myopia, hyperopia, astigmatism) and emmetropia will be included in the study. All subjects will undergo anterior segment optical coherence tomography (AS-OCT) for corneal epithelial thickness mapping. Participants will then be analyzed according to their refractive status. |
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adult participants (≥18 years) with refractive errors, including myopia, hyperopia, and astigmatism, as well as emmetropic subjects, recruited from the Ophthalmology Department and undergoing anterior segment optical coherence tomography (AS-OCT) examination.
Key inclusion criteria (4 listed)
- Age ≥ 18 years-
- Patients diagnosed with myopia or hyperopia by refraction
- Clear cornea with no evidence of corneal pathology
- Ability to undergo reliable anterior segment imaging
Key exclusion criteria (9 listed)
- Inability to fixate or follow instructions
- Family history of keratoconus
- Glaucoma,Cataract
- Previous ocular surgery including refractive surgery
- Keratoconus or suspected corneal ectasia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Measurement of corneal epithelial thickness using AS-OCT
Time frame: At baseline during a single study visit when participants undergo AS-OCT examination.
Corneal epithelial thickness will be measured using anterior segment optical coherence tomography (AS-OCT). Measurements will include central and regional epithelial thickness values in microns in patients with different refractive errors.
4 secondary outcomes
Comparison of epithelial thickness between myopic and hyperopic eyes
Time frame: At baseline (single visit)
Comparison of epithelial thickness in eyes with and without astigmatism
Time frame: At baseline (single visit)
Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison
Time frame: At baseline (single visit)
Comparison of epithelial thickness in low and high refractive errors
Time frame: At baseline (single visit)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Engy Mohamed Mostafa, Professor principal investigator
Department of Ophthalmology, Faculty of Medicine, Sohag University
Amin Abu-Ali Hassan, Assistant Professor study director
Department of Ophthalmology, Faculty of Medicine, Sohag University
Yasmeen Gamal Abd-El latif, Lecturer study director
Department of Ophthalmology, Faculty of Medicine, Sohag University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Myopia and Hyperopia, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 15 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Merna romany loza, MBBCh, Ophthalmology Resident (01275800331, mernaromany54@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measurement of corneal epithelial thickness using AS-OCT (time frame: At baseline during a single study visit when participants undergo AS-OCT examination.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2026; AzTrials last refreshed its copy on 26 Oct 2026.