Emphysema or COPDNCT07649850
Improve Muscle Weakness in Patient With COPD
A study testing Aerobic Exercise Combined with Blood Flow Restriction and Aerobic exercise in people with Emphysema or COPD, run by Al-Zaytoonah University of Jordan.
Trial summary
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). Read more about this study
- Who is it for?
- Ages 50 to 70 years
- Conditions the study is for
- Emphysema or COPD
- What is being tested?
- Aerobic Exercise Combined with Blood Flow Restriction and Aerobic exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- 10 Jun 2026to 30 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
- Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
- Mild to moderate disease severity according to GOLD criteria.
- Ability to participate safely in aerobic exercise training.
- Medically stable and cleared by a physician for pulmonary rehabilitation.
- Ability to understand and follow study instructions.
Who cannot join
- Acute COPD exacerbation or respiratory infection during the study period.
- Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
- Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
- Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
- Cognitive impairment affecting cooperation or informed consent.
- Participation in another structured rehabilitation program during the study period.
- Severe hypoxemia requiring continuous oxygen therapy during exercise.
- History of deep vein thrombosis or clotting disorders.
About this study
Official title: Aerobic Exercise Combined With Blood Flow Restriction Improves Muscle Strength and Functional Capacity In Patients With Emphysematous COPD: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
- Conditions
- Emphysema or COPD
- Being tested
- Aerobic Exercise Combined with Blood Flow Restriction, Aerobic exercise
- Keywords
- emphysematous COPD, lood flow restriction (BFR), aerobic exercise
- Medical subject headings
- Emphysema, Pulmonary Disease, Chronic Obstructive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aerobic Exercise Combined with Blood Flow RestrictionOther
Aerobic exercise combined with blood flow restriction (BFR) is a rehabilitation technique in which patients perform low- to moderate-intensity aerobic exercise, such as treadmill or cycling training, while a specialized cuff is applied around the proximal part of the limb to partially restrict blood flow. This method aims to enhance muscle strength and functional performance using lower exercise intensity, making it suitable for patients with limited exercise tolerance, such as individuals with COPD.
Aerobic exerciseOther
The control group performed conventional aerobic exercise training at low to moderate intensity without the application of blood flow restriction. The program included activities such as treadmill walking or cycling to improve cardiovascular endurance, functional capacity, and overall physical fitness in patients with COPD.
| Study group | Role | What they receive |
|---|---|---|
| experimental group | Experimental | aerobic exercise with blood flow restriction (BFR) training Procedure: Aerobic Exercise Training Device: Blood Flow Restriction Cuff Receives: Other: Aerobic Exercise Combined with Blood Flow Restriction |
| control group | Experimental | aerobic exercise Receives: Other: Aerobic exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
muscle strength
quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s. Participants will perform three to five maximal concentric knee extension efforts after familiarization. Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis
Measured: 8 weeks
Secondary outcomes (1)
function capacity
Functional capacity will be assessed using the 1-Minute Sit-to-Stand Test (1STS). Participants will be instructed to sit and stand from a standard chair as many times as possible within one minute without using their upper limbs for assistance. The total number of completed repetitions will be recorded, with higher scores indicating better functional capacity.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jun 2026
- Study start10 Jun 2026 (estimated)
- Primary completion15 Aug 2026 (estimated)
- Study completion30 Aug 2026 (estimated)
Why it stopped: no participant enrolled
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Emphysema or COPDStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Zaytoonah University of Jordan
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hanan Hosny M Battesha, Al-Zaytoonah University of Jordan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07649850
- Sponsor's protocol ID
- COPD
- Status last verified
- Oct 2026
- First submitted
- 14 May 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Aerobic Exercise Combined With Blood Flow Restriction Improves Muscle Strength and Functional Capacity In Patients With Emphysematous COPD: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07649850
- Acronym / sponsor ID
- COPD
- Conditions
- Emphysema or COPD
- Keywords
- emphysematous COPD, lood flow restriction (BFR), aerobic exercise
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: no participant enrolled
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Al-Zaytoonah University of JordanUniversity, hospital or other
- Study start
- 10 Jun 2026 (estimated)
- Primary completion
- 15 Aug 2026 (estimated)
- Study completion
- 30 Aug 2026 (estimated)
- First posted
- 16 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| experimental group | Experimental | Other: Aerobic Exercise Combined with Blood Flow Restrictionaerobic exercise with blood flow restriction (BFR) training Procedure: Aerobic Exercise Training Device: Blood Flow Restriction Cuff |
| control group | Experimental | Other: Aerobic exerciseaerobic exercise |
Who may qualify
- Ages
- 50 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
- Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
- Mild to moderate disease severity according to GOLD criteria.
- Ability to participate safely in aerobic exercise training.
- Medically stable and cleared by a physician for pulmonary rehabilitation.
Key exclusion criteria (8 listed)
- Acute COPD exacerbation or respiratory infection during the study period.
- Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
- Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
- Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
- Cognitive impairment affecting cooperation or informed consent.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aerobic Exercise Combined with Blood Flow RestrictionAerobic exercise combined with blood flow restriction (BFR) is a rehabilitation technique in which patients perform low- to moderate-intensity aerobic exercise, such as treadmill or cycling training, while a specialized cuff is applied around the proximal part of the limb to partially restrict blood flow. This method aims to enhance muscle strength and functional performance using lower exercise intensity, making it suitable for patients with limited exercise tolerance, such as individuals with COPD. | Other | experimental group |
| Aerobic exerciseThe control group performed conventional aerobic exercise training at low to moderate intensity without the application of blood flow restriction. The program included activities such as treadmill walking or cycling to improve cardiovascular endurance, functional capacity, and overall physical fitness in patients with COPD. | Other | control group |
Primary outcome
muscle strength
Time frame: 8 weeks
quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s. Participants will perform three to five maximal concentric knee extension efforts after familiarization. Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis
1 secondary outcome
function capacity
Time frame: 8 weeks
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Aerobic Exercise Combined with Blood Flow Restriction and Aerobic exercise in people with Emphysema or COPD, run by Al-Zaytoonah University of Jordan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
muscle strength (time frame: 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.