Clinical trials: Emphysema or COPD
Chronic Obstructive Pulmonary Disease (COPD), Smoking
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Idiopathic Pulmonary Fibrosis (IPF)
- Trial name
- NCT01776398
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Emphysema or COPD
Improve Muscle Weakness in Patient With COPD
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07649850
- Testing
- Aerobic Exercise Combined with Blood Flow Restriction, Aerobic exercise
- Sponsor
- Al-Zaytoonah University of Jordan
COPD, Emphysema
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea…
- Trial name
- BREATHE-3 (NCT06891755)
- Testing
- Apreo BREATHE Airway Scaffold, Optimal Medical Management (OMM)
- Where
- 23 sites in United States, Austria and 3 more
- Volunteers
- 250 people
- Sponsor
- Apreo Health, Inc.
Emphysema or COPD, Emphysema
A Multi Center Study Testing a New Implant for Adults With Severe Emphysema
A study taking place at multiple sites in the United States, Europe and Brazil to evaluate how well a new therapy for severe COPD/emphysema works, and how safe it is.
- Conditions
- Emphysema or COPD, Emphysema, COPD
- Trial name
- IAB-2 (NCT07119229)
- Testing
- Implantable Artificial Bronchus
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pulmair Medical, Inc.
COPD
COPD Resources, Education, and Activity Designed for You Study
Although COPD self-management treatment programs are effective in reducing COPD-related hospitalizations and increasing quality of life, there is a limited understanding of 'how and why' they work.
- Trial name
- COPD READY (NCT07125053)
- Testing
- Education (self-guided), Education (counselor-led), Physical Activity
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Rush University Medical Center
Interstitial Lung Disease, COPD
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as…
- Conditions
- Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- GUARDIANLUNG (NCT04930289)
- Testing
- LungGuard, BAROGuard
- Where
- 15 sites in United States, Belgium
- Volunteers
- 3,500 people
- Sponsor
- Paragonix Technologies
Emphysema, Pulmonary, Emphysema or COPD
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe.
- Trial name
- CONVERT_II (NCT06035120)
- Testing
- AeriSeal System
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 200 people
- Sponsor
- Pulmonx Corporation
Emphysema, COPD
Zephyr Valve Japan Post-Marketing Surveillance
This is a multicenter, prospective, observational surveillance enrolling 140 consecutive patients with severe emphysema who are candidates for bronchoscopic lung volume reduction using Zephyr Endobronchial Valve at up to 20…
- Conditions
- Emphysema, COPD, Severe Emphysema
- Trial name
- NCT06332885
- Testing
- Zephyr Endobronchial Valve
- Where
- 17 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Pulmonx Corporation
Emphysema or COPD
Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction
The purpose of this protocol is to perform a pilot prospective controlled clinical trial to evaluate the potential role of lung fissure completion with pleural adhesiolysis strategy (experimental intervention) in severe…
- Trial name
- SAVED-1 (NCT05257681)
- Testing
- Interlobar fissure completion and pleural adhesiolysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
DIVision of the Interlobar Fissure in Patients Who Do Not Respond to Endobronchial Lung Volume Reduction
Surgical division of fissure is hypothesized to be safe and feasible. However, there is no preparatory study to test this hypothesis.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Lung Volume Reduction Surgery
- Trial name
- DIVIDE (NCT07682168)
- Testing
- Surgical Lung Fissure Division
- Volunteers
- 15 people
- Sponsor
- Rocco Bilancia
COPD
Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves
Chronic obstructive pulmonary disease (COPD) affects 3.5 million people and is the third leading cause of death worldwide. Emphysema involves air retention in the lungs and is ultimately responsible for a major deterioration in…
- Trial name
- REPEAT (NCT06181357)
- Testing
- Endoscopic lung volume reduction in 2 stages, Endoscopic lung volume reduction in 1 stage
- Where
- 17 sites in France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Limoges
COPD, Emphysema
A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema
A Study at Two Hospitals Testing the Safety and Effectiveness of the IAB 50 Flex, a New Implant for Adults with Severe COPD or Emphysema
- Trial name
- IAB-3 (NCT07086339)
- Testing
- Implantable pulmonary stent
- Where
- 2 sites in France, Netherlands
- Volunteers
- 20 people
- Sponsor
- Pulmair Medical, Inc.
Interstitial Lung Disease, Interstitial Lung Diseases
Ultrasound and Respiratory Physiological Signals in Lung Diseases
The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted.
- Conditions
- Interstitial Lung Disease, Interstitial Lung Diseases, Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease
- Trial name
- SAURON (NCT06068647)
- Testing
- Lung ultrasound, computed tomographic scan and patch-based cardio-respiratory evaluations
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COPD, Emphysema
Anti-Platelets in Chronic Obstructive Pulmonary Disease
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e.
- Conditions
- COPD, Emphysema, Emphysema or COPD
- Trial name
- NCT05567562
- Testing
- dual anti-platelet therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
COPD
Change in Task-related Oxygen Uptake After EBV Treatment
Rationale: Bronchoscopic lung volume reduction using endobronchial valves (EBV) has emerged as a viable treatment option for eligible patients with severe emphysema.
- Trial name
- CROCODILE (NCT06702072)
- Testing
- Endobronchial valve treatment
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESA
The purpose of the MESA Lung Study is to assess the role of endothelial dysfunction and genetic susceptibility to subclinical COPD and emphysema.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Endothelial Dysfunction
- Trial name
- MESA-LUNG (NCT00843271)
- Volunteers
- 4,359 people
- Sponsor
- Columbia University
Emphysema or COPD
Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema
The purpose of this protocol is to perform a pilot prospective randomized controlled clinical trial to evaluate the potential role of lung fissure completion strategy (experimental intervention) in addition to endobronchial valve…
- Trial name
- COMPLETE-1 (NCT04801108)
- Testing
- Robotic or VATS lobar fissure completion, Endobronchial valves placement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Emphysema or COPD
First in Human Study to Assess an Implant to Treat Severe Emphysema
The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants. The main questions it aims to answer are: Is it safe? Does it work? Participants who meet eligibility…
- Trial name
- BREATHE-1 (NCT05854550)
- Testing
- Apreo Implant Group
- Where
- 2 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Apreo Health, Inc.
Emphysema or COPD
Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema
The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants at up to 5 study centers located in Europe and the United Kingdom.
- Trial name
- BREATHE-2 (NCT05949645)
- Testing
- Apreo Implant Group
- Where
- 3 sites in Austria, Netherlands and 1 more
- Volunteers
- 30 people
- Sponsor
- Apreo Health, Inc.