Emergency LaparotomyNCT07650461
Enhanced Recovery Versus Standard Care After Emergency Abdominal Surgery in Patients Requiring Emergency Laparotomy
A study testing Enhanced Recovery After Surgery and Conventional Postoperative Care in people with Emergency Laparotomy and Intestinal Obstruction, run by Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh at 1 site in Pakistan.
Trial summary
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Emergency Laparotomy, Intestinal Obstruction, Intestinal Perforation
- What is being tested?
- Enhanced Recovery After Surgery and Conventional Postoperative Care
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 102 participants
- Where
- 1 sitePakistan
- Study dates
- 1 May 2025to 30 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- acute intestinal obstruction or intestinal perforation
- planned for emergency laparotomy
Who cannot join
- Pregnant women
- Patients on chronic steroids
- Chronic obstructive pulmonary disease
- Malignant ulcers confirmed by histopathological examination
- laparoscopic surgeries
- Acute abdominal trauma
- Patients who require postoperative intensive care unit (ICU) care
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Recep Tayyip Erdogan Hospital Muzaffargarh
Muzaffargarh, Punjab Province, 34200
About this study
Official title: Comparison of Enhanced Recovery Protocol After Surgery Versus Conventional Care in Emergency Laparotomy
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation.
The main question this study aims to answer is:
Read more
- Does the ERAS protocol reduce surgical site infections compared with conventional care after emergency laparotomy?
Researchers will also compare other recovery outcomes between the two groups, including length of hospital stay, occurrence of paralytic ileus (temporary loss of bowel function), time to first bowel movement, and time to start taking fluids by mouth after surgery.
A total of 102 participants will be enrolled and randomly assigned to one of two groups. One group will receive postoperative care according to the ERAS protocol, while the other group will receive conventional postoperative care. All participants will undergo emergency laparotomy using standard surgical and anesthetic techniques.
Participants will:
- Undergo emergency laparotomy for intestinal obstruction or intestinal perforation.
- Receive either ERAS-based postoperative care or conventional postoperative care.
- Be monitored during their hospital stay for recovery and postoperative complications.
- Be assessed for bowel function recovery, ability to tolerate oral fluids, and length of hospital stay.
- Be followed for 30 days after surgery to determine whether a surgical site infection develops.
The researchers hypothesize that patients managed with the ERAS protocol will have a lower frequency of surgical site infections and improved postoperative recovery compared with those receiving conventional care.
- Conditions
- Emergency Laparotomy, Intestinal Obstruction, Intestinal Perforation, Enhanced Recovery After Surgery (ERAS) Protocol, Surgical Site Infection (SSI), Postoperative Recovery
- Being tested
- Enhanced Recovery After Surgery, Conventional Postoperative Care
- Keywords
- Enhanced Recovery After Surgery, Emergency Laparotomy, Surgical Site Infection, Postoperative complications, Intestinal Obstruction, Intestinal Perforation, Length of Hospital Stay, Postoperative Ileus
- Medical subject headings
- Intestinal Obstruction, Intestinal Perforation, Surgical Wound Infection, Postoperative Complications
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Enhanced Recovery After SurgeryProcedure or surgery
A standardized multimodal perioperative care pathway applied to patients undergoing emergency laparotomy. The protocol includes pre-defined components for preoperative optimization, intraoperative management, and postoperative care. Postoperative elements include early mobilization, early initiation of oral fluids and diet, optimized multimodal analgesia, early removal of tubes/drains when appropriate, and structured fluid management.
Conventional Postoperative CareProcedure or surgery
Standard postoperative management routinely practiced in the surgical unit for patients undergoing emergency laparotomy. Care includes traditional postoperative monitoring, routine analgesia, delayed initiation of oral intake, standard mobilization practices, and conventional fluid and supportive management.
| Study group | Role | What they receive |
|---|---|---|
| ERAS Protocol Group | Experimental | Participants undergoing emergency laparotomy will receive postoperative care according to the Enhanced Recovery After Surgery (ERAS) protocol. Receives: Procedure: Enhanced Recovery After Surgery |
| Conventional Care Group | Active comparator | Participants undergoing emergency laparotomy will receive standard postoperative care as routinely practiced in the surgical unit. Receives: Procedure: Conventional Postoperative Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Surgical Site Infection
Frequency of surgical site infection (superficial and deep) occurring within 30 days after emergency laparotomy will be assessed and compared between the Enhanced Recovery After Surgery (ERAS) group and the conventional care group. Surgical site infection will be defined and classified according to standard surgical infection criteria as specified in the study protocol
Measured: From enrollment within 30 days postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jun 2026
- Study start1 May 2025
- Primary completion30 Oct 2025
- Study completion30 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Emergency LaparotomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 102 participants (actual)
Sponsor and investigators
- Lead sponsor
- Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sarfraz Hussain, Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
- Investigators
- Muhammad I Seerat, FCPS, Study chair, Recep tayyip Erdogan Hospital Muzaffargarh
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07650461
- Sponsor's protocol ID
- U1111-1342-1146
- Status last verified
- Jun 2026
- First submitted
- 10 Jun 2026
- Last updated
- 16 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Enhanced Recovery Protocol After Surgery Versus Conventional Care in Emergency Laparotomy
- ClinicalTrials.gov ID
- NCT07650461
- Acronym / sponsor ID
- U1111-1342-1146
- Conditions
- Emergency Laparotomy, Intestinal Obstruction, Intestinal Perforation, Enhanced Recovery After Surgery (ERAS) Protocol, Surgical Site Infection (SSI), Postoperative Recovery
- Keywords
- Enhanced Recovery After Surgery, Emergency Laparotomy, Surgical Site Infection, Postoperative complications, Intestinal Obstruction, Intestinal Perforation, Length of Hospital Stay, Postoperative Ileus
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 102 participants (actual)
- Lead sponsor
- Recep Tayyip Erdogan Hospital Pakistan - MuzaffargarhUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 30 Oct 2025 (actual)
- Study completion
- 30 Oct 2025 (actual)
- First posted
- 16 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation.
The main question this study aims to answer is:
- Does the ERAS protocol reduce surgical site infections compared with conventional care after emergency laparotomy?
Researchers will also compare other recovery outcomes between the two groups, including length of hospital stay, occurrence of paralytic ileus (temporary loss of bowel function), time to first bowel movement, and time to start taking fluids by mouth after surgery.
A total of 102 participants will be enrolled and randomly assigned to one of two groups. One group will receive postoperative care according to the ERAS protocol, while the other group will receive conventional postoperative care. All participants will undergo emergency laparotomy using standard surgical and anesthetic techniques.
Participants will:
- Undergo emergency laparotomy for intestinal obstruction or intestinal perforation.
- Receive either ERAS-based postoperative care or conventional postoperative care.
- Be monitored during their hospital stay for recovery and postoperative complications.
- Be assessed for bowel function recovery, ability to tolerate oral fluids, and length of hospital stay.
- Be followed for 30 days after surgery to determine whether a surgical site infection develops.
The researchers hypothesize that patients managed with the ERAS protocol will have a lower frequency of surgical site infections and improved postoperative recovery compared with those receiving conventional care.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ERAS Protocol Group | Experimental | Procedure: Enhanced Recovery After SurgeryParticipants undergoing emergency laparotomy will receive postoperative care according to the Enhanced Recovery After Surgery (ERAS) protocol. |
| Conventional Care Group | Active comparator | Procedure: Conventional Postoperative CareParticipants undergoing emergency laparotomy will receive standard postoperative care as routinely practiced in the surgical unit. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- acute intestinal obstruction or intestinal perforation
- planned for emergency laparotomy
Key exclusion criteria (7 listed)
- Pregnant women
- Patients on chronic steroids
- Chronic obstructive pulmonary disease
- Malignant ulcers confirmed by histopathological examination
- laparoscopic surgeries
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Enhanced Recovery After SurgeryA standardized multimodal perioperative care pathway applied to patients undergoing emergency laparotomy. The protocol includes pre-defined components for preoperative optimization, intraoperative management, and postoperative care. Postoperative elements include early mobilization, early initiation of oral fluids and diet, optimized multimodal analgesia, early removal of tubes/drains when appropriate, and structured fluid management. | Procedure or surgery | ERAS Protocol Group |
| Conventional Postoperative CareStandard postoperative management routinely practiced in the surgical unit for patients undergoing emergency laparotomy. Care includes traditional postoperative monitoring, routine analgesia, delayed initiation of oral intake, standard mobilization practices, and conventional fluid and supportive management. | Procedure or surgery | Conventional Care Group |
Primary outcome
Surgical Site Infection
Time frame: From enrollment within 30 days postoperatively
Frequency of surgical site infection (superficial and deep) occurring within 30 days after emergency laparotomy will be assessed and compared between the Enhanced Recovery After Surgery (ERAS) group and the conventional care group. Surgical site infection will be defined and classified according to standard surgical infection criteria as specified in the study protocol
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2026.
- Individual participant dataSharing planned: No
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Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
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Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Muhammad I Seerat, FCPS study chair
Recep tayyip Erdogan Hospital Muzaffargarh
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Enhanced Recovery After Surgery and Conventional Postoperative Care in people with Emergency Laparotomy and Intestinal Obstruction, run by Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Surgical Site Infection (time frame: From enrollment within 30 days postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2026.