Clinical trials: Intestinal Perforation
Appendicolith, Appendicitis
Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome
Laparoscopy has revolutionized the approach to a number of surgical problems causing a re-evaluation of several clinical strategies.
- Conditions
- Appendicolith, Appendicitis, Appendicitis With Perforation, Appendicitis Peritonitis
- Trial name
- LAPSUS (NCT03770897)
- Testing
- 3D Laparoscopic Appendectomy, 2D Laparoscopic Appendectomy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Incarcerated Hernia, Appendicitis Acute
Prevention of Postoperative Hernias in Emergency Surgery
The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery.
- Conditions
- Incarcerated Hernia, Appendicitis Acute, Cholecystitis, Acute, Ileus
- Trial name
- PROPHECY (NCT06815822)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Jan Kochanowski University
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Short Bowel Syndrome, Necrotizing Enterocolitis
Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy
Necrotizing enterocolitis (NEC) and intestinal perforation are common in premature infants. Often surgery is needed to remove the dead bowel and create an ostomy (a temporary intestinal opening on the infant's abdomen).
- Conditions
- Short Bowel Syndrome, Necrotizing Enterocolitis, Small Intestine Perforation
- Trial name
- EMLFO (NCT01306838)
- Testing
- MicroLipid and fish oil, Routine care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University
Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer
Domestic Surgical Robot Clinical Study
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Conditions
- Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer, Cholecystolithiasis, Appendicitis
- Trial name
- NCT02752698
- Testing
- Micro Hand S robotic surgery, laparoscopic surgery, da Vinci robotic surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Patent Ductus Arteriosus, Surgery
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
The primary goal of the trial is to compare two different Patent Ductus Arteriosus (PDA) treatment approaches: 1) an "early treatment" approach or 2) a "conservative" approach.
- Conditions
- Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
- Trial name
- PDA:TOLERATE (NCT01958320)
- Testing
- pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID
- Where
- 18 sites in United States, Sweden and 2 more
- Volunteers
- 202 people
- Sponsor
- University of California, San Francisco
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital
Acute Appendicitis, Appendicitis Perforated
Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
- Trial name
- NCT06956638
- Testing
- Non-interventional
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- Nepalese Army Institute of Health Sciences
Perforated Peptic Ulcer
Open vs Laparoscopic Repair of Perforated Peptic Ulcer
comparison between outcomes of both open and laparoscopic repair of perforated peptic ulcer
- Trial name
- NCT05767320
- Testing
- open repair(exploration), abdominal laparoscopy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Perforated Appendicitis
The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations
Patients admitted at Marshall Health - Cabell Huntington Hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the IV…
- Trial name
- NCT04253899
- Testing
- Appendectomy, Observation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Marshall University
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Perforated Appendicitis
APPI-Cost Trial for Perforated Appendicitis
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI…
- Trial name
- NCT06705842
- Testing
- PVI, Usual Care
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perforated Peptic Ulcer, Peptic Ulcer Perforation
Laparoscopic Falciform Ligament Flap Versus Omental Patch for Perforated Peptic Ulcers
Peptic ulcer perforation is a serious complication of peptic ulcer disease that requires urgent surgical treatment. The standard minimally invasive method is laparoscopic omental patch repair, in which a portion of the patient's…
- Conditions
- Perforated Peptic Ulcer, Peptic Ulcer Perforation, Duodenal Ulcer Perforation, Gastric Ulcer Perforation
- Trial name
- NCT07813780
- Testing
- Laparoscopic Falciform Ligament Flap Repair, Laparoscopic Omental Patch Repair
- Volunteers
- 70 people
- Sponsor
- Assiut University
Intestinal Perforation, Necrotizing Enterocolitis
IRT in Infants With Intestinal Perforation
This study is designed to evaluate a novel tool to aid in the diagnosis of intestinal perforation in infants who are at high risk.
- Trial name
- NCT01530828
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Tympanic Membrane Perforation, Tympanoplasty
Comparison of Results of Myringoplasty Using Biodesign - an Otologic Graft Made From Porcine Small Intestinal Submucosa, Temporalis Fascia, or Tragal Perichondrium - a Retrospective Cohort Analysis
The goal of this observational, retrospective study is to learn whether a ready-made graft patch (Biodesign, made from porcine small intestinal submucosa) works as well as a participant's own tissue graft (such as tragal…
- Conditions
- Tympanic Membrane Perforation, Tympanoplasty, Myringoplasty
- Trial name
- Biodesign (NCT07698171)
- Testing
- tympanoplasty using Biodesign, tympanoplasty using autologous tissue graft
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Wolfson Medical Center
Peptic Ulcers
Risk Factors Affecting Mortality in Perforated Peptic Ulcer
Perforation is one of the most severe and life-threatening complications of peptic ulcer disease. This study aims to evaluate the risk factors associated with postoperative morbidity and mortality in patients undergoing surgery…
- Trial name
- NCT07050199
- Testing
- Emergency laparotomy
- Where
- Nepal
- Volunteers
- 85 people
- Sponsor
- Maharajgunj Medical Campus
Perforated Appendicitis
Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.
- Trial name
- NCT00528138
- Testing
- Laboratory Test
- Where
- Chile
- Volunteers
- 132 people
- Sponsor
- Cirujanos la Serena
Intraabdominal Abscess After Procedure, Leakage
Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation
Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal…
- Conditions
- Intraabdominal Abscess After Procedure, Leakage, Pneumonia, Operation Wound; Infection
- Trial name
- NCT05147870
- Testing
- Peritoneal irrigation, Suction only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Wei-Jung
Acute, Perforated Appendicitis
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of…
- Trial name
- PAPPA (NCT04200729)
- Testing
- Irrigation with PVI, Usual care
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- The University of Texas Health Science Center, Houston