Knee Arthritis OsteoarthritisNCT07653841
Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis
A study testing Perturbation-Based Balance Training and Progressive Neuromuscular Training in people with Knee Arthritis Osteoarthritis and Knee Arthritis, Osteoarthritis, run by Ibadat International University, Islamabad at 1 site in Pakistan.
Trial summary
This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 70 years
- Conditions the study is for
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
- What is being tested?
- Perturbation-Based Balance Training and Progressive Neuromuscular Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePakistan
- Study dates
- 18 May 2026to 20 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male and female, aged between 40-70 years Diagnosed with knee osteoarthritis Grades I-III based on the Kellgren-Lawrence classification Chronic knee pain for ≥3 months Ability to walk independently
Who cannot join
- Grade IV osteoarthritis Previous knee surgery or joint replacement Rheumatoid arthritis or inflammatory joint disease Recent intra-articular injection (<6 months) Severe systemic illness, Neurological disorders and Vestibular disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Institute of Medical Rehabilitation (IMR)
Islamabad, ICT
Rashid Nawaz, DPT, MSPT MSK, +923160534195, nawazrashid158@gmail.com
About this study
This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis.
- Being tested
- Perturbation-Based Balance Training, Progressive Neuromuscular Training
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Perturbation-Based Balance TrainingOther
Also called (PBBT)
3 sessions/week 20-25 min (2 sets × 30 sec/activity) Starts with Low-Moderate (slow, predictable external perturbations) progress to Moderate-High (fast, unpredictable perturbations) 30-35 min (3 sets × 45-60 sec)
Progressive Neuromuscular TrainingOther
Also called (NMT)
3 sessions/week 20-25 min (2 sets × 10-12 reps) starts with Low-Moderate (RPE 9-11) then proceeds to Moderate (RPE 11-13)
| Study group | Role | What they receive |
|---|---|---|
| Perturbation-Based Balance Training (PBBT) | Experimental | Perturbation-Based Balance Training (PBBT) Static standing with manual perturbations: Therapist gives gentle pushes at pelvis/shoulders (anterior/posterior) Double-leg stance on foam: Maintain balance on a soft surface Tandem stance: Heel-to-toe standing with minimal support Supported balance board: Controlled weight shifting Weight-shift training: Side-to-side and forward-backward shifts Receives: Other: Perturbation-Based Balance Training |
| Progressive Neuromuscular Training (NMT) | Active comparator | Progressive Neuromuscular Training (NMT) Mini squats: Partial range knee flexion (0-30°) Sit-to-stand: From chair, controlled movement Double-leg stance balance: Eyes open → progress to reduced support Tandem walking: Straight line walking Heel-to-toe walking: Improves gait control Basic coordination drills: Marching in place Receives: Other: Progressive Neuromuscular Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain & Functional Ability
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Measured: Baseline to Week 6
Secondary outcomes (3)
Functional Mobility
Functional Mobility will be measured using Time Up \& Go test
Measured: Baseline to Week 6
Muscle strength
Handheld Dynamometer
Measured: Baseline to week 6
Balance
Functional Reach Test
Measured: Baseline to week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start18 May 2026 (estimated)
- Primary completion15 Sep 2026 (estimated)
- Study completion20 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee Arthritis OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two-arm parallel group randomized controlled trial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ibadat International University, Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07653841
- Sponsor's protocol ID
- IIUI/RERC/ADT/2026/05/259
- Status last verified
- May 2026
- First submitted
- 21 May 2026
- Last updated
- 17 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07653841
- Acronym / sponsor ID
- IIUI/RERC/ADT/2026/05/259
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Ibadat International University, IslamabadUniversity, hospital or other
- Study start
- 18 May 2026 (estimated)
- Primary completion
- 15 Sep 2026 (estimated)
- Study completion
- 20 Sep 2026 (estimated)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Two-arm parallel group randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Perturbation-Based Balance Training (PBBT) | Experimental | Other: Perturbation-Based Balance TrainingPerturbation-Based Balance Training (PBBT) Static standing with manual perturbations: Therapist gives gentle pushes at pelvis/shoulders (anterior/posterior) Double-leg stance on foam: Maintain balance on a soft surface Tandem stance: Heel-to-toe standing with minimal support Supported balance board: Controlled weight shifting Weight-shift training: Side-to-side and forward-backward shifts |
| Progressive Neuromuscular Training (NMT) | Active comparator | Other: Progressive Neuromuscular TrainingProgressive Neuromuscular Training (NMT) Mini squats: Partial range knee flexion (0-30°) Sit-to-stand: From chair, controlled movement Double-leg stance balance: Eyes open → progress to reduced support Tandem walking: Straight line walking Heel-to-toe walking: Improves gait control Basic coordination drills: Marching in place |
Who may qualify
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Male and female, aged between 40-70 years Diagnosed with knee osteoarthritis Grades I-III based on the Kellgren-Lawrence classification Chronic knee pain for ≥3 months Ability to walk independently
Key exclusion criteria (1 listed)
- Grade IV osteoarthritis Previous knee surgery or joint replacement Rheumatoid arthritis or inflammatory joint disease Recent intra-articular injection (<6 months) Severe systemic illness, Neurological disorders and Vestibular disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Perturbation-Based Balance TrainingAlso: (PBBT)3 sessions/week 20-25 min (2 sets × 30 sec/activity) Starts with Low-Moderate (slow, predictable external perturbations) progress to Moderate-High (fast, unpredictable perturbations) 30-35 min (3 sets × 45-60 sec) | Other | Perturbation-Based Balance Training (PBBT) |
| Progressive Neuromuscular TrainingAlso: (NMT)3 sessions/week 20-25 min (2 sets × 10-12 reps) starts with Low-Moderate (RPE 9-11) then proceeds to Moderate (RPE 11-13) | Other | Progressive Neuromuscular Training (NMT) |
Primary outcome
Pain & Functional Ability
Time frame: Baseline to Week 6
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
3 secondary outcomes
Functional Mobility
Time frame: Baseline to Week 6
Muscle strength
Time frame: Baseline to week 6
Balance
Time frame: Baseline to week 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Perturbation-Based Balance Training and Progressive Neuromuscular Training in people with Knee Arthritis Osteoarthritis and Knee Arthritis, Osteoarthritis, run by Ibadat International University, Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rashid Nawaz, DPT, MSPT MSK (+923160534195, nawazrashid158@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain & Functional Ability (time frame: Baseline to Week 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jun 2026.