MigraineNCT07657377
The Effects of Physiotherapy in Migraine
A study testing Physiotherapy program in people with Migraine, run by Ankara Yildirim Beyazıt University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to investigate the effects of a physiotherapy program including cervical muscle training and transcutaneous auricular vagus nerve stimulation (taVNS) on pain, functional status, quality of life, psychological status, and sleep quality in individuals with migraine. Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Migraine
- What is being tested?
- Physiotherapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Aug 2026to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Volunteering to participate in the study
- Being between 18 and 55 years of age
- Being diagnosed with migraine by a neurologist according to the International Classification of Headache Disorders 3 (ICHD-3) criteria
Who cannot join
- Diagnosis of other primary and/or secondary headaches in addition to migraine,
- Coexisting neurological and/or rheumatological diseases,
- Severe psychiatric disorders (bipolar disorder, schizophrenia, psychosis, etc.),
- Pregnancy or lactation,
- Malignancy,
- Known arrhythmia or presence of any implanted electronic device,
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- Presence of sensory loss in the application area,
- Having received physiotherapy or any other treatment in the head/neck region within the last 12 months,
- History of head/neck trauma or surgery within the last 12 months.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Gazi Mustafa Kemal Occupational and Environmental Diseases Hospital
Ankara, 06560
Nuriye Kayalı Şendur, +90 312 212 66 66, ankaradhs7@saglik.gov.tr
About this study
Official title: The Effects of Physiotherapy Applications in Individuals With Migraine
The aim of this study is to investigate the effects of a physiotherapy program including cervical muscle training and transcutaneous auricular vagus nerve stimulation (taVNS) on pain, functional status, quality of life, psychological status, and sleep quality in individuals with migraine.
- Conditions
- Migraine
- Being tested
- Physiotherapy program
- Medical subject headings
- Migraine Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physiotherapy programOther
A physiotherapy program including taVNS and cervical muscle exercises
| Study group | Role | What they receive |
|---|---|---|
| Control Group | No intervention | The control group will receive no intervention and will continue with their routine treatment. |
| Treatment Group | Experimental | In addition to routine treatments, a physiotherapy program including transcutaneous auricular vagus nerve stimulation and cervical muscle exercises will be implemented. Receives: Other: Physiotherapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Assessment
Individuals' pain parameters will be assessed using a pain diary.
Measured: Baseline, 8th week (after treatment)
Secondary outcomes (4)
Assessment of Functional Status
The Migraine Disability Assessment Scale will be used to determine the functional status associated with migraine. This scale aims to evaluate headache-related disability and the functionality of individuals diagnosed with migraine in daily and social activities. Score ranges are calculated as follows: Grade I: no loss or very little loss (0-5 days); Grade II: mild loss (6-10 days); Grade III: moderate loss (11-20 days); Grade IV: severe loss (21 days or more)
Measured: Baseline, 8th week (after treatment)
Quality of Life Assessment
The Migraine-Specific Quality of Life Scale (Version 2.1) will be used to assess quality of life. The 14-item scale comprises three sections: role-limiting, role-preventing, and emotional function. Scores for each subsection range from 0 to 100. Higher scores indicate better health-related quality of life.
Measured: Baseline, 8th week (after treatment)
Assessment of Psychological State
The Hospital Anxiety and Depression Scale will be used to assess psychological status. Of the 14 items comprising the scale, the 7 odd-numbered items assess anxiety disorder, while the 7 even-numbered items assess depression. The minimum and maximum scores patients can obtain on either subscale are 0 and 21, respectively. Higher scores indicate higher levels of depression and anxiety.
Measured: Baseline, 8th week (after treatment)
Sleep Quality Assessment
The Single-Item Sleep Quality Scale will be used to assess sleep quality.In this scale, participants are asked the question, "How would you rate your sleep quality overall over the past 7 days?" Responses are obtained using a numerical rating ranging from 0 (Terrible) to 10 (Excellent) .
Measured: Baseline, 8th week (after treatment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2026
- Study start10 Aug 2026
- Primary completionAug 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MigraineStudies of the same condition, open and under way.
- More trials run by Ankara Yildirim Beyazıt UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ankara Yildirim Beyazıt University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Beyza Avcı, Ankara Yildirim Beyazıt University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07657377
- Sponsor's protocol ID
- AYBU-2026-05
- Status last verified
- Sep 2026
- First submitted
- 13 Jun 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Physiotherapy Applications in Individuals With Migraine
- ClinicalTrials.gov ID
- NCT07657377
- Acronym / sponsor ID
- AYBU-2026-05
- Conditions
- Migraine
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Ankara Yildirim Beyazıt UniversityUniversity, hospital or other
- Study start
- 10 Aug 2026 (actual)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 18 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effects of a physiotherapy program including cervical muscle training and transcutaneous auricular vagus nerve stimulation (taVNS) on pain, functional status, quality of life, psychological status, and sleep quality in individuals with migraine.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control Group | No intervention | –The control group will receive no intervention and will continue with their routine treatment. |
| Treatment Group | Experimental | Other: Physiotherapy programIn addition to routine treatments, a physiotherapy program including transcutaneous auricular vagus nerve stimulation and cervical muscle exercises will be implemented. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Volunteering to participate in the study
- Being between 18 and 55 years of age
- Being diagnosed with migraine by a neurologist according to the International Classification of Headache Disorders 3 (ICHD-3) criteria
Key exclusion criteria (9 listed)
- Diagnosis of other primary and/or secondary headaches in addition to migraine,
- Coexisting neurological and/or rheumatological diseases,
- Severe psychiatric disorders (bipolar disorder, schizophrenia, psychosis, etc.),
- Pregnancy or lactation,
- Malignancy,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physiotherapy programA physiotherapy program including taVNS and cervical muscle exercises | Other | Treatment Group |
Primary outcome
Pain Assessment
Time frame: Baseline, 8th week (after treatment)
Individuals' pain parameters will be assessed using a pain diary.
4 secondary outcomes
Assessment of Functional Status
Time frame: Baseline, 8th week (after treatment)
Quality of Life Assessment
Time frame: Baseline, 8th week (after treatment)
Assessment of Psychological State
Time frame: Baseline, 8th week (after treatment)
Sleep Quality Assessment
Time frame: Baseline, 8th week (after treatment)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Gazi Mustafa Kemal Occupational and Environmental Diseases Hospital
Ankara, Turkey (Türkiye)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Physiotherapy program in people with Migraine, run by Ankara Yildirim Beyazıt University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Assessment (time frame: Baseline, 8th week (after treatment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.